A Sclafani

Summary

Affiliation: City University of New York
Country: USA

Publications

  1. pmc Maltodextrin and Fat Preference Deficits in "Taste-Blind" P2X2/P2X3 Knockout Mice
    Anthony Sclafani
    Department of Psychology, Brooklyn College of CUNY, 2900 Bedford Avenue, Brooklyn, NY 11210, USA
    Chem Senses 39:507-14. 2014
  2. pmc Sucrose-conditioned flavor preferences in sweet ageusic T1r3 and Calhm1 knockout mice
    Anthony Sclafani
    Department of Psychology, Brooklyn College, City University of New York, Brooklyn, NY 11210, USA Electronic address
    Physiol Behav 126:25-9. 2014
  3. pmc Gut-brain nutrient signaling. Appetition vs. satiation
    Anthony Sclafani
    Department of Psychology, Brooklyn College and the Graduate School, City University of New York, 2900 Bedford Avenue, Brooklyn, NY 11210, USA Electronic address
    Appetite 71:454-8. 2013
  4. pmc Impact of T1r3 and Trpm5 on carbohydrate preference and acceptance in C57BL/6 mice
    Steven Zukerman
    Department of Psychology, Brooklyn College of CUNY, Brooklyn, NY 11210, USA
    Chem Senses 38:421-37. 2013
  5. pmc Flavor preferences conditioned by intragastric glucose but not fructose or galactose in C57BL/6J mice
    Anthony Sclafani
    Brooklyn College, City University of New York, Brooklyn, New York 11210, USA
    Physiol Behav 106:457-61. 2012
  6. pmc Role of gut nutrient sensing in stimulating appetite and conditioning food preferences
    Anthony Sclafani
    Department of Psychology, Brooklyn College, City University of New York, Brooklyn, NY 11210, USA
    Am J Physiol Regul Integr Comp Physiol 302:R1119-33. 2012
  7. ncbi request reprint The sixth taste?
    Anthony Sclafani
    Department of Psychology, Brooklyn College of the City University of New York, 2900 Bedford Ave, Brooklyn, NY 11210, USA
    Appetite 43:1-3. 2004
  8. ncbi request reprint Female rats show a bimodal preference response to the artificial sweetener sucralose
    Anthony Sclafani
    Department of Psychology, Brooklyn College of CUNY, 2900 Bedford Ave, Brooklyn, NY 11210, USA
    Chem Senses 29:523-8. 2004
  9. ncbi request reprint Sugar and fat conditioned flavor preferences in C57BL/6J and 129 mice: oral and postoral interactions
    Anthony Sclafani
    Dept of Psychology, Brooklyn College of CUNY, 2900 Bedford Avenue, Brooklyn, NY 11210, USA
    Am J Physiol Regul Integr Comp Physiol 289:R712-20. 2005
  10. ncbi request reprint The relationship between food reward and satiation revisited
    Anthony Sclafani
    Department of Psychology, Brooklyn College, Brooklyn, NY 11210 2889, USA
    Physiol Behav 82:89-95. 2004

Research Grants

  1. Neuropharmacology of Learned Food Preferences
    Anthony Sclafani; Fiscal Year: 2005
  2. Neuropharmacology of Learned Food Preferences
    Anthony Sclafani; Fiscal Year: 2006
  3. Neuropharmacology of Learned Food Preferences
    Anthony Sclafani; Fiscal Year: 2007
  4. Carbohydrate Appetite Fat Appetite and Obesity
    Anthony Sclafani; Fiscal Year: 2007
  5. Neuropharmacology of Learned Food Preferences
    Anthony Sclafani; Fiscal Year: 2009

Collaborators

Detail Information

Publications90

  1. pmc Maltodextrin and Fat Preference Deficits in "Taste-Blind" P2X2/P2X3 Knockout Mice
    Anthony Sclafani
    Department of Psychology, Brooklyn College of CUNY, 2900 Bedford Avenue, Brooklyn, NY 11210, USA
    Chem Senses 39:507-14. 2014
    ..With experience, however, P2X double knockout mice develop strong preferences for the nontaste flavor qualities of maltodextrin and fat conditioned by the postoral actions of these nutrients. ..
  2. pmc Sucrose-conditioned flavor preferences in sweet ageusic T1r3 and Calhm1 knockout mice
    Anthony Sclafani
    Department of Psychology, Brooklyn College, City University of New York, Brooklyn, NY 11210, USA Electronic address
    Physiol Behav 126:25-9. 2014
    ..Thus, sweet taste signaling elements are not needed in the gut for sugar conditioning, but sweet taste signaling in the mouth is essential for the full expression of sugar appetite. ..
  3. pmc Gut-brain nutrient signaling. Appetition vs. satiation
    Anthony Sclafani
    Department of Psychology, Brooklyn College and the Graduate School, City University of New York, 2900 Bedford Avenue, Brooklyn, NY 11210, USA Electronic address
    Appetite 71:454-8. 2013
    ..Newly developed rapid conditioning protocols may facilitate the study of postoral appetition processes. ..
  4. pmc Impact of T1r3 and Trpm5 on carbohydrate preference and acceptance in C57BL/6 mice
    Steven Zukerman
    Department of Psychology, Brooklyn College of CUNY, Brooklyn, NY 11210, USA
    Chem Senses 38:421-37. 2013
    ..The findings further demonstrate that although Trpm5 (but not T1r3) signaling is essential for starch preference, Trpm5 KO mice can learn to prefer starch based on its postoral effects...
  5. pmc Flavor preferences conditioned by intragastric glucose but not fructose or galactose in C57BL/6J mice
    Anthony Sclafani
    Brooklyn College, City University of New York, Brooklyn, New York 11210, USA
    Physiol Behav 106:457-61. 2012
    ..The effectiveness of glucose to condition preferences suggests an important role for glucose-specific sensors rather than gut "sweet" taste receptors in the postoral modulation of carbohydrate appetite...
  6. pmc Role of gut nutrient sensing in stimulating appetite and conditioning food preferences
    Anthony Sclafani
    Department of Psychology, Brooklyn College, City University of New York, Brooklyn, NY 11210, USA
    Am J Physiol Regul Integr Comp Physiol 302:R1119-33. 2012
    ..Continued research on the postoral stimulatory actions of nutrients may enhance our understanding of human food preference learning...
  7. ncbi request reprint The sixth taste?
    Anthony Sclafani
    Department of Psychology, Brooklyn College of the City University of New York, 2900 Bedford Ave, Brooklyn, NY 11210, USA
    Appetite 43:1-3. 2004
    ..Recent studies indicate that sweet taste is mediated by a T1R2 and T1R3 receptor complex but the identity of the hypothesized polysaccharide taste receptor remains to be established...
  8. ncbi request reprint Female rats show a bimodal preference response to the artificial sweetener sucralose
    Anthony Sclafani
    Department of Psychology, Brooklyn College of CUNY, 2900 Bedford Ave, Brooklyn, NY 11210, USA
    Chem Senses 29:523-8. 2004
    ..Both subgroups preferred saccharin to sucralose. Sucralose appears to have an aversive off-taste that reduces its palatability to rats...
  9. ncbi request reprint Sugar and fat conditioned flavor preferences in C57BL/6J and 129 mice: oral and postoral interactions
    Anthony Sclafani
    Dept of Psychology, Brooklyn College of CUNY, 2900 Bedford Avenue, Brooklyn, NY 11210, USA
    Am J Physiol Regul Integr Comp Physiol 289:R712-20. 2005
    ....
  10. ncbi request reprint The relationship between food reward and satiation revisited
    Anthony Sclafani
    Department of Psychology, Brooklyn College, Brooklyn, NY 11210 2889, USA
    Physiol Behav 82:89-95. 2004
    ..Food intake and preference are controlled by a complex interaction of positive and negative signals generated by nutrients in the mouth and at postingestive sites...
  11. ncbi request reprint Oral and postoral determinants of food reward
    Anthony Sclafani
    Department of Psychology, Brooklyn College and the Graduate School, The City University of New York, 2900 Bedford Ave, Brooklyn, NY 11210 2889, USA
    Physiol Behav 81:773-9. 2004
    ..Thus, food reward is determined by oral and postoral stimuli and may override the homeostatic regulation of energy balance...
  12. ncbi request reprint CD36 gene deletion reduces fat preference and intake but not post-oral fat conditioning in mice
    A Sclafani
    Dept of Psychology, Brooklyn College of City University of New York, Brooklyn, NY 11210, USA
    Am J Physiol Regul Integr Comp Physiol 293:R1823-32. 2007
    ..Finally, CD36 deletion decreased fat consumption and enhanced the ability of the mice to compensate for the calories provided by their optional fat intake...
  13. ncbi request reprint Flavor preferences conditioned in C57BL/6 mice by intragastric carbohydrate self-infusion
    Anthony Sclafani
    Department of Psychology, Brooklyn College and the Graduate School, The City University of New York, 2900 Bedford Avenue, Brooklyn, NY 11210 2889, USA
    Physiol Behav 79:783-8. 2003
    ..Our understanding of flavor-nutrient learning can be advanced by studying this process in selected mouse strains and genetically modified animals...
  14. ncbi request reprint Reinforcement value of sucrose measured by progressive ratio operant licking in the rat
    Anthony Sclafani
    Department of Psychology, Brooklyn College and the Graduate School, The City University of New York, 2900 Bedford Avenue, Brooklyn, NY 11210 2889, USA
    Physiol Behav 79:663-70. 2003
    ..These results are similar to those reported with PR lever-pressing tasks. Thus, PR operant licking, which requires minimal training and equipment, is a useful alternate measure of fluid reward in rodents...
  15. ncbi request reprint Enhanced sucrose and Polycose preference in sweet "sensitive" (C57BL/6J) and "subsensitive" (129P3/J) mice after experience with these saccharides
    Anthony Sclafani
    Department of Psychology, Brooklyn College and the Graduate School, The City University of New York, 2900 Bedford Ave, Brooklyn, NY 11210 2889, USA
    Physiol Behav 87:745-56. 2006
    ..Whether the 129 mice responded to the taste or other properties (e.g., odor) of the dilute saccharide solutions is not certain but their gustatory sensitivity needs to be reconsidered...
  16. ncbi request reprint Sucrose motivation in sweet "sensitive" (C57BL/6J) and "subsensitive" (129P3/J) mice measured by progressive ratio licking
    Anthony Sclafani
    Department of Psychology, Brooklyn College and the Graduate School, The City University of New York, 2900 Bedford Ave, Brooklyn, NY 11210 2889, USA
    Physiol Behav 87:734-44. 2006
    ..This suggests that the strains differ in their central reward processing of sweet taste...
  17. pmc Rapid post-oral stimulation of intake and flavor conditioning by glucose and fat in the mouse
    Steven Zukerman
    Department of Psychology, Brooklyn College, City University of New York, Brooklyn, New York 11210, USA
    Am J Physiol Regul Integr Comp Physiol 301:R1635-47. 2011
    ..The test procedures developed here can be used to investigate the peripheral and central processes involved in stimulation of intake by post-oral nutrients...
  18. pmc Dopamine and learned food preferences
    Anthony Sclafani
    Cognition, Brain and Behavior Doctoral Subprogram, Graduate Center, City University of New York, NY, United States
    Physiol Behav 104:64-8. 2011
    ..The findings suggest that DA signaling within different components of a distributed brain network is involved in sugar-based flavor preferences. A possible role of DA in conditioned increases in flavor acceptance is discussed...
  19. pmc Stevia and saccharin preferences in rats and mice
    Anthony Sclafani
    Department of Psychology, Brooklyn College, Brooklyn, NY 11210, USA
    Chem Senses 35:433-43. 2010
    ..The preference response of rodents to stevia sweeteners is notable in view of their minimal response to some other noncaloric sweeteners (aspartame and cyclamate)...
  20. pmc Sweet taste signaling in the gut
    Anthony Sclafani
    Department of Psychology, Brooklyn College of the City University of New York, Brooklyn, NY 11210, USA
    Proc Natl Acad Sci U S A 104:14887-8. 2007
  21. pmc Fat and carbohydrate preferences in mice: the contribution of alpha-gustducin and Trpm5 taste-signaling proteins
    Anthony Sclafani
    Dept of Psychology, Brooklyn College of the City University of New York, Brooklyn, NY 11210, USA
    Am J Physiol Regul Integr Comp Physiol 293:R1504-13. 2007
    ..The experience-induced rescue of fat and Polycose preferences in the KO mice likely reflects the action of a postoral-conditioning mechanism, which functions in the absence of alpha-gustducin and Trpm5...
  22. ncbi request reprint Fat and sugar flavor preference and acceptance in C57BL/6J and 129 mice: experience attenuates strain differences
    Anthony Sclafani
    Department of Psychology, Brooklyn College and the Graduate School, The City University of New York, Brooklyn, NY 11210 2889, USA
    Physiol Behav 90:602-11. 2007
    ..These findings along with intragastric infusion data suggest that B6 and 129 mice differ in their oral but not their post-oral response to fat and sugar...
  23. pmc Oral, post-oral and genetic interactions in sweet appetite
    Anthony Sclafani
    Department of Psychology, Brooklyn College and the Graduate School, The City University of New York, Brooklyn, NY 11210, USA
    Physiol Behav 89:525-30. 2006
    ..These findings indicate that experiential and nutritional factors can, to some degree, override genetic differences in peripheral taste sensitivity in determining food appetite...
  24. ncbi request reprint Nutrient-conditioned flavor preference and incentive value measured by progressive ratio licking in rats
    Anthony Sclafani
    Department of Psychology, Brooklyn College and the Graduate School, The City University of New York, Brooklyn, NY 11210, United States
    Physiol Behav 88:88-94. 2006
    ....
  25. ncbi request reprint Selective effects of vagal deafferentation and celiac-superior mesenteric ganglionectomy on the reinforcing and satiating action of intestinal nutrients
    Anthony Sclafani
    Department of Psychology, Brooklyn College and the Graduate School, City University of New York, Brooklyn, NY 11210 2889, USA
    Physiol Behav 78:285-94. 2003
    ....
  26. ncbi request reprint Psychobiology of food preferences
    A Sclafani
    Department of Psychology, Brooklyn College and The Graduate School City, University of New York Brooklyn, New York 11210 2889, USA
    Int J Obes Relat Metab Disord 25:S13-6. 2001
    ..Thus, food preferences and overeating result from interactions between the orosensory and nutritional properties of food...
  27. ncbi request reprint George H. Collier: 50 years of discovery
    Anthony Sclafani
    Department of Psychology, Brooklyn College and the Graduate School, City University of New York, Brooklyn, NY 11210, USA
    Appetite 38:131-5. 2002
  28. ncbi request reprint Conditioned flavor avoidance, preference, and indifference produced by intragastric infusions of galactose, glucose, and fructose in rats
    A Sclafani
    Department of Psychology, Brooklyn College and the Graduate School, City University of New York, NY 11210, USA
    Physiol Behav 67:227-34. 1999
    ..This may be due to the slow and incomplete hepatic metabolism of this sugar in adult rats. Conceivably, galactose intolerance may contribute to the lactose avoidance in adult animals...
  29. ncbi request reprint Flavor preferences conditioned by sucrose depend upon training and testing methods: two-bottle tests revisited
    Anthony Sclafani
    Department of Psychology, Brooklyn College of the City University of New York, Brooklyn, NY 11210, USA
    Physiol Behav 76:633-44. 2002
    ..This appears to be the case with 5% and 30% sucrose solutions because the satiating effect of the concentrated solution tends to counteract its nutrient reinforcing action...
  30. ncbi request reprint Parabrachial nucleus lesions block taste and attenuate flavor preference and aversion conditioning in rats
    A Sclafani
    Department of Psychology, Brooklyn College and the Graduate School, City University of New York, 11210 2889, USA
    Behav Neurosci 115:920-33. 2001
    ..These data indicate that the PBN is essential for forming orosensory-viscerosensory associations when taste is the primary cue but is less critical when more complex flavor cues are available...
  31. pmc Gut T1R3 sweet taste receptors do not mediate sucrose-conditioned flavor preferences in mice
    Anthony Sclafani
    Dept of Psychology, Brooklyn College of CUNY, 2900 Bedford Ave, Brooklyn, NY 11210, USA
    Am J Physiol Regul Integr Comp Physiol 299:R1643-50. 2010
    ....
  32. ncbi request reprint Post-ingestive positive controls of ingestive behavior
    A Sclafani
    Department of Psychology, Brooklyn College and the Graduate School, City University of New York, Brooklyn, NY, 11210, USA
    Appetite 36:79-83. 2001
    ..Post-ingestive positive controls need to be incorporated into theoretical models of ingestive behavior...
  33. pmc Critical role of NMDA but not opioid receptors in the acquisition of fat-conditioned flavor preferences in rats
    J A D Dela Cruz
    Neuropsychology Doctoral Sub Program, The Graduate Center, City University of New York, USA
    Neurobiol Learn Mem 98:341-7. 2012
    ....
  34. ncbi request reprint Conditioned enhancement of flavor evaluation reinforced by intragastric glucose. II. Taste reactivity analysis
    K P Myers
    Department of Psychology, Brooklyn College of the City University of New York, Brooklyn, NY 11210-2889, USA
    Physiol Behav 74:495-505. 2001
    ..These findings support the idea that pairing flavored saccharin with the postingestive effects of glucose produces a learned shift in palatability comparable to that produced by increasing the concentration of a sugar solution...
  35. ncbi request reprint Conditioned flavor preferences: evaluating postingestive reinforcement by nutrients
    K Ackroff
    Brooklyn College of the City University of New York, Brooklyn, New York, USA
    Curr Protoc Neurosci . 2001
    ..This protocol concentrates on controlling stimulus presentation in associative conditioning, pairing a flavor with positive postingestive effects...
  36. ncbi request reprint Conditioned enhancement of flavor evaluation reinforced by intragastric glucose: I. Intake acceptance and preference analysis
    K P Myers
    Department of Psychology, Brooklyn College of the City University of New York, Brooklyn, NY 11210, USA
    Physiol Behav 74:481-93. 2001
    ..These findings provide novel evidence for a robust learned shift in flavor evaluation reinforced by the postingestive actions of glucose...
  37. pmc Sucrose taste but not Polycose taste conditions flavor preferences in rats
    Kristine B Bonacchi
    Department of Psychology, Brooklyn College, Brooklyn, NY 11210 USA
    Physiol Behav 95:235-44. 2008
    ..Why attractive sweet and poly tastes differ in their ability to condition flavor preferences is not certain, although some findings suggest that they differentially activate dopamine and/or serotonin circuits involved in flavor learning...
  38. pmc Role of dopamine D1 and D2 receptors in the nucleus accumbens shell on the acquisition and expression of fructose-conditioned flavor-flavor preferences in rats
    Sonia Y Bernal
    Neuropsychology Doctoral Subprogram, Graduate Center, City University of New York, New York, NY, USA
    Behav Brain Res 190:59-66. 2008
    ..These data indicate that NAcS D1 and D2 antagonists significantly attenuated the expression of the fructose-CFP and did not block acquisition, but hastened extinction of fructose-CFP...
  39. pmc Roles of dopamine D1 and D2 receptors in the acquisition and expression of fat-conditioned flavor preferences in rats
    J A D Dela Cruz
    Neuropsychology Doctoral Sub Program, The Graduate Center, City University of New York, USA
    Neurobiol Learn Mem 97:332-7. 2012
    ..These data indicate limited DA D1 and D2 receptor signaling involvement in the expression and acquisition of a fat-CFP relative to previous robust effects for sugar-CFP...
  40. ncbi request reprint Flavor preferences conditioned by intragastric fructose and glucose: differences in reinforcement potency
    K Ackroff
    Department of Psychology, Brooklyn College of the City University of New York, 2900 Bedford Avenue, Brooklyn, NY 11210, USA
    Physiol Behav 72:691-703. 2001
    ..These data indicate that both fructose and glucose generate postingestive reinforcing signals, but that the fructose signals are weaker and/or delayed relative to those produced by glucose...
  41. ncbi request reprint The rat's acceptance and preference for sucrose, maltodextrin, and saccharin solutions and mixtures
    A Sclafani
    Department of Psychology, Brooklyn College and the Graduate School, City University of New York, 11210, USA
    Physiol Behav 63:499-503. 1998
    ..The palatability of the S + M mixture is thought to be related to the activation of separate "sweet" and "maltodextrin" tastes...
  42. ncbi request reprint Critical role of amygdala in flavor but not taste preference learning in rats
    Khalid Touzani
    Department of Psychology, Brooklyn College and the Graduate School, City University of New York, Brooklyn, NY 11210, USA
    Eur J Neurosci 22:1767-74. 2005
    ..Collectively, these data provide evidence that AMY is essential for flavor- but not taste-nutrient preference learning...
  43. ncbi request reprint Flavor preferences conditioned by intragastric nutrient infusions in food restricted and free-feeding rats
    Yeh Min Yiin
    Department of Psychology, Brooklyn College and the Graduate School, The City University of New York, Brooklyn, NY 11210 2889, USA
    Physiol Behav 84:217-31. 2005
    ..These findings indicate that the postoral actions of nutrients are reinforcing in food sated as well as hungry rats...
  44. ncbi request reprint D1 but not D2 dopamine receptor antagonism blocks the acquisition of a flavor preference conditioned by intragastric carbohydrate infusions
    A V Azzara
    Department of Psychology, Brooklyn College of City University of New York, USA
    Pharmacol Biochem Behav 68:709-20. 2001
    ..We conclude that D1, but not D2, dopamine receptors are critically involved in the acquisition of a sucrose-conditioned flavor preference, and both receptor subtypes have a more limited role in the expression of this preference...
  45. ncbi request reprint Palatability and foraging cost interact to control caloric intake
    K Ackroff
    Department of Psychology, Brooklyn College of the City University of New York 11210, USA
    J Exp Psychol Anim Behav Process 25:28-36. 1999
    ..Without the usual differential postingestive effects of foods that differ in palatability, making food more costly blunts rats' response to its flavor...
  46. ncbi request reprint Dopamine D1 and D2 antagonists reduce the acquisition and expression of flavor-preferences conditioned by fructose in rats
    Robert M Baker
    Neuropsychology Doctoral Subprogram, Department of Psychology, Queens College, City University of New York, 65 30 Kissena Boulevard, Flushing, New York, NY 11367, USA
    Pharmacol Biochem Behav 75:55-65. 2003
    ..These findings indicate that D(1) and D(2) antagonists block flavor-preference conditioning by sweet taste and that D(1), and to a lesser extent D(2), receptor antagonists attenuate the expression of a previously acquired preference...
  47. pmc T1R3 taste receptor is critical for sucrose but not Polycose taste
    Steven Zukerman
    Dept of Psychology, Brooklyn College of CUNY, Brooklyn, NY 11210, USA
    Am J Physiol Regul Integr Comp Physiol 296:R866-76. 2009
    ..These results indicate that the T1R3 receptor plays a critical role in the taste-mediated response to sucrose but not Polycose...
  48. pmc Role of amygdala dopamine D1 and D2 receptors in the acquisition and expression of fructose-conditioned flavor preferences in rats
    Sonia Bernal
    Neuropsychology Doctoral Subprogram, Graduate Center, City University of New York, New York, NY 11367, United States
    Behav Brain Res 205:183-90. 2009
    ..The results are similar to those produced by dopamine D1-like and D2-like antagonist injections into the nucleus accumbens shell which suggests that flavor conditioning involves a regionally distributed brain network...
  49. pmc Role of olfaction in the conditioned sucrose preference of sweet-ageusic T1R3 knockout mice
    Steven Zukerman
    Department of Psychology, Brooklyn College of CUNY, Brooklyn, NY 11210, USA
    Chem Senses 34:685-94. 2009
    ..Further, the fact that OBx-KO mice preferred concentrated sucrose solutions in the absence of normal sweet taste and olfactory sensations underscores the potency of postoral nutritive signals in promoting ingestion...
  50. pmc Genetic variance contributes to dopamine receptor antagonist-induced inhibition of sucrose intake in inbred and outbred mouse strains
    Cheryl T Dym
    Department of Psychology, Queens College, The Graduate Center, City University of New York, Flushing, NY 11367, USA
    Brain Res 1257:40-52. 2009
    ....
  51. pmc Oxytocin knockout mice demonstrate enhanced intake of sweet and nonsweet carbohydrate solutions
    Anthony Sclafani
    Department of Psychology, City University of New York, Brooklyn College, Brooklyn, NY, USA
    Am J Physiol Regul Integr Comp Physiol 292:R1828-33. 2007
    ..Instead, the absence of OT may increase daily intake of palatable sweet and nonsweet solutions of carbohydrate (but not fat) by selectively blunting or masking processes that contribute to postingestive satiety...
  52. ncbi request reprint Cypha [propionic acid, 2-(4-methoxyphenol) salt] inhibits sweet taste in humans, but not in rats
    A Sclafani
    Department of Psychology, Brooklyn College, NY 11210, USA
    Physiol Behav 61:25-9. 1997
    ..These findings are consistent with other reported differences between rats and humans in their response to other sweetness inhibitors, as well as to artificial sweeteners...
  53. ncbi request reprint Flavor preferences conditioned by intragastric infusion of ethanol in rats
    K Ackroff
    Brooklyn College and the Graduate School, City University of New York, Brooklyn, NY 11210, USA
    Pharmacol Biochem Behav 68:327-38. 2001
    ..The ethanol-based conditioned flavor preference resembled those conditioned by carbohydrate and fat infusions, suggesting that at least some of reinforcing ability of ethanol may be related to its postingestive nutritive effects...
  54. ncbi request reprint Saccharin as a sugar surrogate revisited
    James C Smith
    Department of Psychology, The Florida State University, Tallahassee, FL 32306 1270, USA
    Appetite 38:155-60. 2002
    ..4% (19.5 mM). Furthermore, saccharin versus sucrose choice tests indicate that optimal saccharin solutions (0.2-0.4%) are "isopreferred" to only dilute sucrose solutions (2-4%). Thus, at best, saccharin is only a weak surrogate for sugar...
  55. ncbi request reprint Pharmacology of sucrose-reinforced place-preference conditioning: effects of naltrexone
    A R Delamater
    Experimental Psychology, Brooklyn College, Brooklyn, NY 11210, USA
    Pharmacol Biochem Behav 65:697-704. 2000
    ..Together, the results indicate that the opioid system modulates the expression but not the acquisition of sucrose-reinforced CPPs...
  56. ncbi request reprint Flavor preferences conditioned by postingestive effects of nutrients in preweanling rats
    Kevin P Myers
    Department of Psychology, Bucknell University, Lewisburg, PA 17837, United States
    Physiol Behav 84:407-19. 2005
    ..Thus nutrient conditioning may be one way that early experience (such as flavors from the maternal diet transmitted in milk) influences later dietary preferences...
  57. doi request reprint Role of systemic endocannabinoid CB-1 receptor antagonism in the acquisition and expression of fructose-conditioned flavor-flavor preferences in rats
    Patricia Miner
    Neuropsychology Doctoral Sub Program, The Graduate Center, City University of New York, United States
    Pharmacol Biochem Behav 90:318-24. 2008
    ..The endogenous endocannabinoid system is therefore implicated in the maintenance of this form of learned flavor preferences...
  58. pmc Genetic variance contributes to dopamine and opioid receptor antagonist-induced inhibition of intralipid (fat) intake in inbred and outbred mouse strains
    Cheryl T Dym
    Department of Psychology, Queens College, The Graduate Center, City University of New York, Flushing, NY 11367, USA
    Brain Res 1316:51-61. 2010
    ....
  59. ncbi request reprint The composition of the maintenance diet alters flavor-preference conditioning by intragastric fat infusions in rats
    F Lucas
    Department of Psychology, Brooklyn College, City University of New York 11210, USA
    Physiol Behav 60:1151-7. 1996
    ..In contrast, adding a fatty flavor to the conditioning stimuli did not improve fat conditioning...
  60. ncbi request reprint Conditioned flavor preference and aversion: role of the lateral hypothalamus
    K Touzani
    Department of Psychology, Brooklyn College, City University of New York 11210, USA
    Behav Neurosci 115:84-93. 2001
    ..These data indicate that the LH is not essential for all types of flavor-postingestive consequence conditioning but is critical for learning to associate flavors with delayed nutrient feedback...
  61. ncbi request reprint Miglitol (BAY m 1099) treatment of diabetic hypothalamic-dietary obese rats improves islet response to glucose
    K V Axen
    Department of Health and Nutrition Sciences, Brooklyn College of the City University of New York 11210, USA
    Obes Res 7:83-9. 1999
    ....
  62. pmc Post-oral infusion sites that support glucose-conditioned flavor preferences in rats
    Karen Ackroff
    Department of Psychology, Brooklyn College, 2900 Bedford Avenue, Brooklyn, New York 11210, USA
    Physiol Behav 99:402-11. 2010
    ..Thus, there may be multiple sites for glucose conditioning with the upper or mid-intestines being the first site of action...
  63. pmc Lateral hypothalamus dopamine D1-like receptors and glucose-conditioned flavor preferences in rats
    Khalid Touzani
    Department of Psychology, Brooklyn College, City University of New York, Brooklyn, NY 11210, USA
    Neurobiol Learn Mem 92:464-7. 2009
    ..These results show that D1-like receptor activation in the lateral hypothalamus modulates the acquisition, but not the expression of flavor preference learning induced by the post-oral reinforcing properties of glucose...
  64. pmc Rapid acquisition of conditioned flavor preferences in rats
    Karen Ackroff
    Department of Psychology, Brooklyn College CUNY, Brooklyn, NY 11210, USA
    Physiol Behav 97:406-13. 2009
    ..A significant 74% preference for the CS+ flavor was apparent by the second test. Together these studies show that the acquisition of flavor preferences, whether based on flavor-taste or flavor-nutrient associations, can be quite rapid...
  65. pmc Rats' preferences for high fructose corn syrup vs. sucrose and sugar mixtures
    Karen Ackroff
    Brooklyn College, City University of New York, Brooklyn, NY 11210, USA
    Physiol Behav 102:548-52. 2011
    ..This shift, and the relatively small magnitude of differences in preference for HFCS and sucrose, suggest that palatability factors probably do not contribute to any possible difference in weight gain responses to these sweeteners...
  66. ncbi request reprint Naltrexone suppresses the late but not early licking response to a palatable sweet solution: opioid hedonic hypothesis reconsidered
    Pasquale G Frisina
    Department of Psychology, Brooklyn College and the Graduate School, City University of New York, Brooklyn, NY 11210, USA
    Pharmacol Biochem Behav 74:163-72. 2002
    ..Together, these findings suggest that opioid antagonists do not affect all aspects of flavor hedonics, but may primarily alter the intake-maintaining action of palatable flavors...
  67. doi request reprint Dopamine D1-like receptor antagonism in amygdala impairs the acquisition of glucose-conditioned flavor preference in rats
    Khalid Touzani
    Department of Psychology, Brooklyn College, City University of New York, Brooklyn, NY 11210, USA
    Eur J Neurosci 30:289-98. 2009
    ..A distributed network mediating flavor-nutrient incentive learning is discussed...
  68. pmc Acquisition of glucose-conditioned flavor preference requires the activation of dopamine D1-like receptors within the medial prefrontal cortex in rats
    Khalid Touzani
    Department of Psychology, Brooklyn College, City University of New York, NY 11210, USA
    Neurobiol Learn Mem 94:214-9. 2010
    ..74%). Collectively, the results show that D1-like receptor activation in the medial prefrontal cortex plays a crucial role in the acquisition of flavor preference learning induced by the post-oral reinforcing properties of glucose...
  69. ncbi request reprint Lateral hypothalamic lesions impair flavour-nutrient and flavour-toxin trace learning in rats
    Khalid Touzani
    Department of Psychology, Brooklyn College and the Graduate School, The City University of New York, Brooklyn, NY 11210, USA
    Eur J Neurosci 16:2425-33. 2002
    ..Lateral hypothalamus lesions might specifically impair the processing of nutrient-generated unconditioned stimuli and, more generally, could interfere with the maintenance of flavour memories...
  70. ncbi request reprint Ethanol flavor preference conditioned by intragastric carbohydrate in rats
    Karen Ackroff
    Department of Psychology, Brooklyn College of the City University of New York, 2900 Bedford Avenue, Brooklyn, NY 11210, USA
    Pharmacol Biochem Behav 74:41-51. 2002
    ..Thus, ethanol flavor avoidance can be reversed or reduced by postingestive nutritive conditioning, which may combine with the pharmacological effects of ethanol to produce the acquired appetite for the flavor of alcoholic beverages...
  71. ncbi request reprint Conditioned acceptance and preference but not altered taste reactivity responses to bitter and sour flavors paired with intragastric glucose infusion
    Kevin P Myers
    Department of Psychology, Bucknell University, Lewisburg, PA 17837, USA
    Physiol Behav 78:173-83. 2003
    ..Therefore, nonhedonic processes, perhaps increased incentive salience, appear to mediate the enhanced preference and acceptance conditioned by postingestive nutrient actions...
  72. ncbi request reprint Ethanol-conditioned flavor preferences compared with sugar- and fat-conditioned preferences in rats
    Karen Ackroff
    Department of Psychology, Brooklyn College and the Graduate School of the City University of New York, 2900 Bedford Avenue, Brooklyn, NY 11210, USA
    Physiol Behav 81:699-713. 2004
    ..The marked individual differences in ethanol-conditioned preferences may be related to the impact of the sugar or fat infusions on the reward evaluation of the ethanol-paired flavor...
  73. ncbi request reprint Flavor preference conditioning as a function of fat source
    Karen Ackroff
    Department of Psychology, Brooklyn College and the Graduate School, The City University of New York, Brooklyn, NY 11210 2889, USA
    Physiol Behav 85:448-60. 2005
    ..These findings demonstrate that many different fat sources can condition flavor preferences. Fats with high polyunsaturated content and/or lower saturated fat content are the most reinforcing...
  74. pmc Unconditioned stimulus devaluation effects in nutrient-conditioned flavor preferences
    Andrew R Delamater
    Department of Psychology, Brooklyn College of the City University of New York CUNY, NY 11210, USA
    J Exp Psychol Anim Behav Process 32:295-306. 2006
    ..Results suggest that CS flavors are able to form associations with the sensory features of nutrient USs under a wide variety of circumstances...
  75. ncbi request reprint Energy density and macronutrient composition determine flavor preference conditioned by intragastric infusions of mixed diets
    Karen Ackroff
    Department of Psychology, Brooklyn College and The Graduate Center, City University of New York, Brooklyn, NY 11210, USA
    Physiol Behav 89:250-60. 2006
    ..The differential satiating effects of fat and carbohydrate may contribute to these density-dependent preferences...
  76. pmc Obesity by choice revisited: effects of food availability, flavor variety and nutrient composition on energy intake
    Karen Ackroff
    Brooklyn College and the Graduate School of the City University of New York, Brooklyn, NY 11210, USA
    Physiol Behav 92:468-78. 2007
    ..The nature of optional foods (nutrient composition and physical form) was markedly more important than the number of food sources available to the animals, and is a better contender as the reason for "obesity by choice"...
  77. ncbi request reprint Flavor quality and ethanol concentration affect ethanol-conditioned flavor preferences
    Karen Ackroff
    Department of Psychology, Brooklyn College and the Graduate School of the City University of New York, 2900 Bedford Avenue, Brooklyn, NY 11210, USA
    Pharmacol Biochem Behav 74:229-40. 2002
    ..Thus, sweet taste contributes to the development of ethanol-conditioned flavor preferences, and this effect is not explained by a simple enhancement of ethanol intake...
  78. ncbi request reprint High dietary fat promotes syndrome X in nonobese rats
    Kathleen V Axen
    Department of Health and Nutrition Sciences, Brooklyn College of the City University of New York, Brooklyn, NY 11210, USA
    J Nutr 133:2244-9. 2003
    ....
  79. pmc Insular cortex lesions fail to block flavor and taste preference learning in rats
    Khalid Touzani
    Department of Psychology, Brooklyn College and the Graduate School, City University of New York, Brooklyn, NY 11210, USA
    Eur J Neurosci 26:1692-700. 2007
    ..Collectively, these data provided no evidence that IC is essential for flavor preference learning based on associations between the orosensory cues and the oral and post-oral reinforcing properties of nutrients...
  80. ncbi request reprint Flavor preferences conditioned by intragastric ethanol with limited access training
    Karen Ackroff
    Brooklyn College and the Graduate School, City University of New York, 2900 Bedford Avenue, Brooklyn, NY 11210, USA
    Pharmacol Biochem Behav 75:223-33. 2003
    ..The preference reinforcing actions of ethanol may develop slowly and are thus most effective with long training sessions or when intense CS flavors are used in short training sessions...
  81. doi request reprint Activation of dopamine D1-like receptors in nucleus accumbens is critical for the acquisition, but not the expression, of nutrient-conditioned flavor preferences in rats
    Khalid Touzani
    Cognition, Brain and Behaviour Doctoral Subprogram, Department of Psychology, Brooklyn College, City University of New York, Brooklyn, NY 11210, USA
    Eur J Neurosci 27:1525-33. 2008
    ..89% preference). These results demonstrate that D1-like receptors in the NAc shell and core are greatly involved in the acquisition, but less so in the expression, of a flavor preference conditioned by postingestive effects of glucose...
  82. ncbi request reprint Fructose-conditioned flavor preferences in male and female rats: effects of sweet taste and sugar concentration
    Karen Ackroff
    Department of Psychology, Brooklyn College and the Graduate School, City University of New York, Brooklyn, NY 11210, USA
    Appetite 42:287-97. 2004
    ..Possible mechanisms for the sweet-taste enhancement of conditioning include increasing CS intakes in training, facilitating fructose metabolism and increasing flavor salience...
  83. ncbi request reprint Rats integrate meal cost and postoral changes in caloric density
    K Ackroff
    Department of Psychology, Brooklyn College, NY, USA
    Physiol Behav 60:927-32. 1996
    ..Rats can, thus, integrate the cost of obtaining food and its postingestive benefits in the absence of mediating orosensory cues...
  84. ncbi request reprint Area postrema lesions impair flavor-toxin aversion learning but not flavor-nutrient preference learning
    Khalid Touzani
    Department of Psychology, City University of New York, Brooklyn College and the Graduate School, New York 11210, USA
    Behav Neurosci 116:256-66. 2002
    ..These findings confirm the important role of the area postrema in flavor-toxin learning but provide no evidence for its involvement in flavor-nutrient conditioning...
  85. ncbi request reprint Food deprivation enhances the expression but not acquisition of flavor acceptance conditioning in rats
    Yeh Min Yiin
    Department of Psychology, Brooklyn College of the City University of New York, 2900 Bedford Avenue, Brooklyn, NY 11210, USA
    Appetite 45:152-60. 2005
    ..g. glucose infusions but does not fundamentally alter the learned association between the CS+ flavor and the post-oral nutrient stimulus...
  86. pmc Opioid mediation of starch and sugar preference in the rat
    Kristine B Bonacchi
    Department of Psychology, Queens College, City University of New York, Flushing, NY 11210, USA
    Pharmacol Biochem Behav 96:507-14. 2010
    ..These findings suggest that the reward value of starch in liquid form is more dependent upon opioid signaling than is that of sugar...
  87. ncbi request reprint Development of learned flavor preferences
    Kevin P Myers
    Department of Psychology, Bucknell University, Lewisburg, PA, USA
    Dev Psychobiol 48:380-8. 2006
    ..Thus, from an early age, learning processes shape the feeding behavior of animals. While primarily serving an adaptive function, learning may play a role in biasing individuals towards excessive intake and weight gain...
  88. ncbi request reprint Naltrexone does not prevent acquisition or expression of flavor preferences conditioned by fructose in rats
    Robert W Baker
    Department of Psychology, Queens College, City University of New York, CUNY, 65 30 Kissena Boulevard, Flushing, NY 11367, USA
    Pharmacol Biochem Behav 78:239-46. 2004
    ..These data indicate that the endogenous opioid system, unlike the dopamine system, does not play a major role in either the acquisition or expression of flavor preference learning as measured in two-bottle choice tests...
  89. pmc Opioid receptor antagonism in the nucleus accumbens fails to block the expression of sugar-conditioned flavor preferences in rats
    Sonia Y Bernal
    Neuropsychology Doctoral Subprogram, Graduate Center, City University of New York, New York, NY, USA
    Pharmacol Biochem Behav 95:56-62. 2010
    ..Therefore, while opioid drugs can have potent effects on sugar intake they appear less effective in altering sugar-conditioned flavor preferences...
  90. pmc Intragastric infusion of denatonium conditions flavor aversions and delays gastric emptying in rodents
    John I Glendinning
    Department of Biological Sciences, Barnard College, Columbia University, 3009 Broadway, New York, NY 10027, USA
    Physiol Behav 93:757-65. 2008
    ..This study provides the first evidence that rodents respond to the presence of "bitter" substances in their gastrointestinal tract by generating both behavioral and physiological responses...

Research Grants7

  1. Neuropharmacology of Learned Food Preferences
    Anthony Sclafani; Fiscal Year: 2005
    ..It will advance our understanding of the basic mechanisms involved in the development of food preferences and may provide insights into the clinical treatment of overeating and obesity. ..
  2. Neuropharmacology of Learned Food Preferences
    Anthony Sclafani; Fiscal Year: 2006
    ..It will advance our understanding of the basic mechanisms involved in the development of food preferences and may provide insights into the clinical treatment of overeating and obesity. ..
  3. Neuropharmacology of Learned Food Preferences
    Anthony Sclafani; Fiscal Year: 2007
    ..It will advance our understanding of the basic mechanisms involved in the development of food preferences and may provide insights into the clinical treatment of overeating and obesity. ..
  4. Carbohydrate Appetite Fat Appetite and Obesity
    Anthony Sclafani; Fiscal Year: 2007
    ..The findings may provide practical benefits for current attempts to alter dietary fat and carbohydrate intake and control adiposity in humans. ..
  5. Neuropharmacology of Learned Food Preferences
    Anthony Sclafani; Fiscal Year: 2009
    ..It will advance our understanding of the basic mechanisms involved in the development of food preferences and may provide insights into the clinical treatment of overeating and obesity. ..