Samuel Rahbar

Summary

Affiliation: City of Hope National Medical Center
Country: USA

Publications

  1. ncbi request reprint Novel inhibitors of advanced glycation endproducts
    Samuel Rahbar
    Department of Diabetes, Beckman Research Institute of the City of Hope National Medical Center, 1500 E Duarte Road, Duarte, CA 91010, USA
    Arch Biochem Biophys 419:63-79. 2003
  2. ncbi request reprint Novel inhibitors of advanced glycation endproducts
    S Rahbar
    Endocrinology and Metabolism, City of Hope National Medical Center, Duarte, California, 91010 0269, USA
    Biochem Biophys Res Commun 262:651-6. 1999
  3. ncbi request reprint A new rapid method to detect inhibition of Amadori product generated by delta-gluconolactone
    S Rahbar
    Department of Diabetes, Endocrinology and Metabolism, Gonda Diabetes Center, City of Hope National Medical Center, Duarte, CA 91010, USA
    Clin Chim Acta 287:123-30. 1999
  4. ncbi request reprint Evidence that pioglitazone, metformin and pentoxifylline are inhibitors of glycation
    S Rahbar
    Department of Diabetes, Endocrinology and Metabolism, The Leslie and Susan Gonda Goldschmied Diabetes and Genetic Research Building, City of Hope National Medical Center, Duarte, CA 91010, USA
    Clin Chim Acta 301:65-77. 2000
  5. ncbi request reprint Novel inhibitors of advanced glycation endproducts (part II)
    S Rahbar
    Department of Diabetes, City of Hope National Medical Center, Duarte, California, 91010, USA
    Mol Cell Biol Res Commun 3:360-6. 2000
  6. ncbi request reprint Novel inhibitors of glycation and AGE formation
    Samuel Rahbar
    Department of Diabetes, Endocrinology and Metabolism, Beckman Research Institute, City of Hope National Medical Center, Duarte, CA, USA
    Cell Biochem Biophys 48:147-57. 2007
  7. ncbi request reprint The discovery of glycated hemoglobin: a major event in the study of nonenzymatic chemistry in biological systems
    Samuel Rahbar
    City of Hope National Medical Center and Beckman Research Institute, 1500 E Duarte Road, Duarte, CA 91010, USA
    Ann N Y Acad Sci 1043:9-19. 2005
  8. ncbi request reprint Renoprotective and lipid-lowering effects of LR compounds, novel advanced glycation end product inhibitors, in streptozotocin-induced diabetic rats
    James Lester Figarola
    Department of Diabetes, Endocrinology, and Metabolism, Gonda Building, City of Hope National Medical Center, 1500 E Duarte Road, Duarte, CA 91010, USA
    Ann N Y Acad Sci 1043:767-76. 2005
  9. ncbi request reprint Prevention of early renal disease, dyslipidaemia and lipid peroxidation in STZ-diabetic rats by LR-9 and LR-74, novel AGE inhibitors
    James Lester Figarola
    Department of Diabetes, Endocrinology and Metabolism, City of Hope National Medical Center, Duarte, CA 91010, USA
    Diabetes Metab Res Rev 21:533-44. 2005
  10. doi request reprint Small‑molecule COH-SR4 inhibits adipocyte differentiation via AMPK activation
    James L Figarola
    Division of Diabetes, Endocrinology and Metabolism, Beckman Research Institute, City of Hope National Medical Center, Duarte, CA 91010, USA
    Int J Mol Med 31:1166-76. 2013

Collaborators

Detail Information

Publications18

  1. ncbi request reprint Novel inhibitors of advanced glycation endproducts
    Samuel Rahbar
    Department of Diabetes, Beckman Research Institute of the City of Hope National Medical Center, 1500 E Duarte Road, Duarte, CA 91010, USA
    Arch Biochem Biophys 419:63-79. 2003
    ....
  2. ncbi request reprint Novel inhibitors of advanced glycation endproducts
    S Rahbar
    Endocrinology and Metabolism, City of Hope National Medical Center, Duarte, California, 91010 0269, USA
    Biochem Biophys Res Commun 262:651-6. 1999
    ....
  3. ncbi request reprint A new rapid method to detect inhibition of Amadori product generated by delta-gluconolactone
    S Rahbar
    Department of Diabetes, Endocrinology and Metabolism, Gonda Diabetes Center, City of Hope National Medical Center, Duarte, CA 91010, USA
    Clin Chim Acta 287:123-30. 1999
    ....
  4. ncbi request reprint Evidence that pioglitazone, metformin and pentoxifylline are inhibitors of glycation
    S Rahbar
    Department of Diabetes, Endocrinology and Metabolism, The Leslie and Susan Gonda Goldschmied Diabetes and Genetic Research Building, City of Hope National Medical Center, Duarte, CA 91010, USA
    Clin Chim Acta 301:65-77. 2000
    ..We show that that three compounds; pioglitazone, metformin and pentoxifylline are also inhibitors of glycation...
  5. ncbi request reprint Novel inhibitors of advanced glycation endproducts (part II)
    S Rahbar
    Department of Diabetes, City of Hope National Medical Center, Duarte, California, 91010, USA
    Mol Cell Biol Res Commun 3:360-6. 2000
    ..All 29 compounds show some degrees of inhibitory activities as detected by the four assay methods, 9 compounds demonstrated high percent inhibition (PI) in all tests, 30 to 40 times stronger than aminoguanidine...
  6. ncbi request reprint Novel inhibitors of glycation and AGE formation
    Samuel Rahbar
    Department of Diabetes, Endocrinology and Metabolism, Beckman Research Institute, City of Hope National Medical Center, Duarte, CA, USA
    Cell Biochem Biophys 48:147-57. 2007
    ....
  7. ncbi request reprint The discovery of glycated hemoglobin: a major event in the study of nonenzymatic chemistry in biological systems
    Samuel Rahbar
    City of Hope National Medical Center and Beckman Research Institute, 1500 E Duarte Road, Duarte, CA 91010, USA
    Ann N Y Acad Sci 1043:9-19. 2005
    ....
  8. ncbi request reprint Renoprotective and lipid-lowering effects of LR compounds, novel advanced glycation end product inhibitors, in streptozotocin-induced diabetic rats
    James Lester Figarola
    Department of Diabetes, Endocrinology, and Metabolism, Gonda Building, City of Hope National Medical Center, 1500 E Duarte Road, Duarte, CA 91010, USA
    Ann N Y Acad Sci 1043:767-76. 2005
    ..These compounds may have an additional beneficial effect as an antioxidant against lipid peroxidation, and thus may provide alternative therapeutic options for the treatment of various diabetic macrovascular complications...
  9. ncbi request reprint Prevention of early renal disease, dyslipidaemia and lipid peroxidation in STZ-diabetic rats by LR-9 and LR-74, novel AGE inhibitors
    James Lester Figarola
    Department of Diabetes, Endocrinology and Metabolism, City of Hope National Medical Center, Duarte, CA 91010, USA
    Diabetes Metab Res Rev 21:533-44. 2005
    ..We examined the effects of two new AGE/ALE inhibitors, LR-9 and LR-74, on the development of early renal disease and lipid metabolism in streptozotocin (STZ)-induced diabetic rats...
  10. doi request reprint Small‑molecule COH-SR4 inhibits adipocyte differentiation via AMPK activation
    James L Figarola
    Division of Diabetes, Endocrinology and Metabolism, Beckman Research Institute, City of Hope National Medical Center, Duarte, CA 91010, USA
    Int J Mol Med 31:1166-76. 2013
    ..Taken together, these results suggest that COH-SR4 inhibits 3T3-L1 adipogenesis via AMPK activation. COH-SR4 may be a promising compound for the treatment of obesity and related metabolic disorders...
  11. doi request reprint Novel compound 1,3-bis (3,5-dichlorophenyl) urea inhibits lung cancer progression
    Sharad S Singhal
    Departments of Diabetes and Metabolic Diseases Research, and Medical Oncology, Beckman Research Institute, City of Hope, Comprehensive Cancer Center, Duarte, CA 91010, USA Electronic address
    Biochem Pharmacol 86:1664-72. 2013
    ..The results from our in-vitro and in-vivo studies reveal that COH-SR4 represents a novel candidate with strong mechanistic relevance to target aggressive and drug-resistant lung tumors. ..
  12. ncbi request reprint Anti-inflammatory effects of the advanced glycation end product inhibitor LR-90 in human monocytes
    James L Figarola
    Department of Diabetes, Endocrinology and Metabolism, City of Hope National Medical Center, 1500 E Duarte Road, Duarte, CA 91010, USA
    Diabetes 56:647-55. 2007
    ..These new data show that, in addition to its AGE inhibitory effects, LR-90 has novel anti-inflammatory properties and might therefore have additional protective effects against diabetic vascular complications...
  13. pmc Advanced glycation end products of DNA: quantification of N2-(1-Carboxyethyl)-2'-deoxyguanosine in biological samples by liquid chromatography electrospray ionization tandem mass spectrometry
    Timothy Synold
    Division of Clinical and Molecular Pharmacology, City of Hope Medical Center, 1500 East Duarte Road, Duarte, California 91010, USA
    Chem Res Toxicol 21:2148-55. 2008
    ..Strategies for dealing with artifactual adduct formation due to oxoaldehyde generation during DNA isolation and enzymatic workup procedures are described...
  14. pmc COH-SR4 Reduces Body Weight, Improves Glycemic Control and Prevents Hepatic Steatosis in High Fat Diet-Induced Obese Mice
    James Lester Figarola
    Departments of Diabetes and Metabolic Diseases Research, Beckman Research Institute, City of Hope National Medical Center, Duarte, California, United States of America
    PLoS ONE 8:e83801. 2013
    ..Together, these data suggest that SR4, a novel AMPK activator, may be a promising therapeutic compound for treatment of obesity, fatty liver disease, and related metabolic disorders. ..
  15. pmc 1,3-Bis(3,5-dichlorophenyl) urea compound 'COH-SR4' inhibits proliferation and activates apoptosis in melanoma
    Sharad S Singhal
    Department of Diabetes and Metabolic Diseases Research, Beckman Research Institute, City of Hope, Comprehensive Cancer Center, Duarte, CA 91010, United States
    Biochem Pharmacol 84:1419-27. 2012
    ..Thus, SR4 represents a novel candidate for the further development of mono and combinatorial therapies to effectively target aggressive and therapeutically refractory melanomas...
  16. doi request reprint Novel dichlorophenyl urea compounds inhibit proliferation of human leukemia HL-60 cells by inducing cell cycle arrest, differentiation and apoptosis
    James L Figarola
    Division of Diabetes, Endocrinology and Metabolism, Beckman Research Institute of the City of Hope National Medical Center, Duarte, CA 91010, USA
    Invest New Drugs 30:1413-25. 2012
    ..Collectively, these results provide evidence that SR4 and SR9 have the potential for the treatment of human leukemia and merit further investigation as therapeutic agents against other types of cancer...
  17. ncbi request reprint LR-90 a new advanced glycation endproduct inhibitor prevents progression of diabetic nephropathy in streptozotocin-diabetic rats
    J L Figarola
    Department of Diabetes and Endocrinology, City of Hope National Medical Center, Duarte, California 91010, USA
    Diabetologia 46:1140-52. 2003
    ..LR-90, a new advanced glycation endproduct inhibitor, was investigated for its effects on the development of renal disease in diabetic rats...
  18. ncbi request reprint Association of hemoglobin H disease with Hb J-Iran (beta 77 His----Asp): impact on subunit assembly
    S Rahbar
    Department of Hematology and Bone Marrow Transplantation, City of Hope National Medical Center, Duarte, CA 91010 0269
    Blood 70:1790-1. 1987
    ..This observation provides further support for an electrostatic model of Hb subunit assembly...