Research Topics
| V PullarkatSummaryAffiliation: City of Hope National Medical Center Country: USA Publications
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Detail Information
Publications
Nontyphoidal Salmonella infection among recipients of hematopoietic SCTS S Dadwal
Department of Hematology and Hematopoietic Cell Transplantation, City of Hope Medical Center, Duarte, CA 9100, USA
Bone Marrow Transplant 46:880-3. 2011..Food safety practices to prevent NTS infection are important in HSCT recipients, particularly for those who have chronic GVHD after allogeneic HSCT...
Therapy-related, mixed-lineage leukaemia translocation-positive, monoblastic myeloid sarcoma of the uterusVinod Pullarkat
Division of Haematology, City of Hope National Medical Center, Duarte, California 91010, USA
J Clin Pathol 60:562-4. 2007..This case illustrates that t-AML can rarely present as isolated extramedullary tumours, and the detection of specific chromosomal abnormalities in these myeloid sarcomas can be useful for risk assessment and guiding definitive therapy...
Neoplastic mast cells in systemic mastocytosis associated with t(8;21) acute myeloid leukemia are derived from the leukemic cloneVinod Pullarkat
Division of Hematology and Hematopoietic Cell Transplantation, Department of Cytogenetics, Division of Pathology, City of Hope Comprehensive Cancer Center, 1500 East Duarte Road, Duarte, CA 91010, United States
Leuk Res 31:261-5. 2007..We also show that after successful allogeneic hematopoietic stem cell transplantation, these neoplastic bone marrow mast cells can persist without adverse consequences and gradually decline with time...- Impact of cytogenetics on the outcome of adult acute lymphoblastic leukemia: results of Southwest Oncology Group 9400 studyVinod Pullarkat
Division of Hematology and Hematopoietic Cell Transplantation, Department of Cytogenetics, City of Hope Comprehensive Cancer Center, 1500 East Duarte Road, Duarte, CA 91010, USA
Blood 111:2563-72. 2008..This trial was registered at www.ClinicalTrials.gov as #NCT00002665... - Iron overload adversely affects outcome of allogeneic hematopoietic cell transplantationV Pullarkat
Division of Hematology and Hematopoietic Cell Transplantation, City of Hope National Medical Center, Duarte, CA 91010, USA
Bone Marrow Transplant 42:799-805. 2008..99, P=0.032). The results remained similar when serum ferritin was considered a continuous variable. Elevated serum ferritin adversely impacts on overall survival and increases the likelihood of acute GVHD and BSI after allogeneic HCT... - Body cavity-based presentation of natural killer cell lymphomaVinod A Pullarkat
Division of Hematology, Department of Medicine, University of Southern California School of Medicine, Los Angeles, USA
Leuk Lymphoma 46:293-6. 2005..As demonstrated in the case reported, extranodal NK/T-cell lymphomas of nasal-type can be clinically aggressive and may be associated with paraneoplastic phenomena... - Acute leukemia and myelodysplasia after adjuvant chemotherapy for breast cancer: durable remissions after hematopoietic stem cell transplantationV Pullarkat
Division of Hematology and Hematopoietic Cell Transplantation, City of Hope National Medical Center, Duarte, CA 91010, USA
Ann Oncol 20:2000-6. 2009..We examined the clinical and pathological features as well as the treatment results of a series of patients with acute leukemia/myelodysplasia arising after adjuvant chemotherapy for breast cancer... - Objectives of iron chelation therapy in myelodysplastic syndromes: more than meets the eye?Vinod Pullarkat
Division of Hematology and Hematopoietic Cell Transplantation, City of Hope Medical Center, Duarte, CA, USA
Blood 114:5251-5. 2009.... - A phase II pilot study of tacrolimus/sirolimus GVHD prophylaxis for sibling donor hematopoietic stem cell transplantation using 3 conditioning regimensRoberto Rodriguez
Department of Hematology Hematopoietic Cell Transplantation, City of Hope National Medical Center, Duarte, CA 91010, USA
Blood 115:1098-105. 2010..Thrombotic microangiopathy is a significant complication with this regimen, particularly in patients receiving busulfan/cyclophosphamide... - Reduced-intensity conditioning for allogeneic hematopoietic stem cell transplantation with fludarabine and melphalan is associated with durable disease control in myelodysplastic syndromeR Nakamura
Division of Hematology Hematopoietic Cell Transplantation, City of Hope Comprehensive Cancer Center, Duarte, CA 91010, USA
Bone Marrow Transplant 40:843-50. 2007..5 versus 7%, P=0.02). RIC with fludarabine plus melphalan was associated with durable disease control and acceptable toxicity in this high-risk cohort... - Improved outcomes using tacrolimus/sirolimus for graft-versus-host disease prophylaxis with a reduced-intensity conditioning regimen for allogeneic hematopoietic cell transplant as treatment of myelofibrosisDavid S Snyder
City of Hope Cancer Center, Department of Hematology HCT, Duarte, California 91010, USA
Biol Blood Marrow Transplant 16:281-6. 2010..We conclude that the combination of tacrolimus/sirolimus+/-MTX for GVHD prophylaxis in the setting of RIC HCT for MF appears to reduce the incidence of severe aGVHD and NRM, and leads to improved OS compared to CSA/MMF+/-MTX... - Allogeneic hematopoietic cell transplantation following reduced intensity conditioning for treatment of myelofibrosisDavid S Snyder
Division of Hematology Hematopoietic Cell Transplant, City of Hope Cancer Center, Duarte, California 91010, USA
Biol Blood Marrow Transplant 12:1161-8. 2006..2 months for the living patients. Overall survival probability at 1 year was 55.6% (95% confidence interval, 31.3%-77.4%). These results suggest that RIC MUD HCT using PBSCs can be an effective treatment for older patients with MF... - Impact of graft cell dose on transplant outcomes following unrelated donor allogeneic peripheral blood stem cell transplantation: higher CD34+ cell doses are associated with decreased relapse ratesRyotaro Nakamura
Division of Hematology Hematopoietic Cell Transplantation, City of Hope National Medical Center, Duarte, California 91010 3000, USA
Biol Blood Marrow Transplant 14:449-57. 2008.... - A phase 1/2 trial of high-dose yttrium-90-ibritumomab tiuxetan in combination with high-dose etoposide and cyclophosphamide followed by autologous stem cell transplantation in patients with poor-risk or relapsed non-Hodgkin lymphomaAuayporn Nademanee
Division of Hematology and Hemapoietic Cell Transplantation, City of Hope National Medical Center, 1500 E Duarte Rd, Duarte, CA 91010, USA
Blood 106:2896-902. 2005..We conclude that high-dose 90Y-ibritumomab tiuxetan can be combined safely with high-dose etoposide and cyclophosphamide without an increase in transplant-related toxicity or delayed engraftment... - Distinct clonal origins of systemic mastocytosis and associated B-cell lymphomaYoung Kim
Division of Pathology, City of Hope National Medical Center, 1500 East Duarte Road, Duarte, CA 91010, USA
Leuk Res 31:1749-54. 2007..We also highlight the clinical and pathologic differences between SM associated with lymphoid as opposed to myeloid neoplasms and discuss their pathogenesis... - Transduction of acute myeloid leukemia cells with third generation self-inactivating lentiviral vectors expressing CD80 and GM-CSF: effects on proliferation, differentiation, and stimulation of allogeneic and autologous anti-leukemia immune responsesR C Koya
Institute for Genetic Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
Leukemia 16:1645-54. 2002..These pre-clinical data demonstrate the potential feasibility of third generation SIN vectors for use in AML immunotherapy... - Pathology of autoimmune myelofibrosis. A report of three cases and a review of the literatureR D Bass
Department of Pathology, LAC + USC Medical Center and University of Southern California, Los Angeles, USA
Am J Clin Pathol 116:211-6. 2001.... - Maribavir prophylaxis for prevention of cytomegalovirus infection in allogeneic stem cell transplant recipients: a multicenter, randomized, double-blind, placebo-controlled, dose-ranging studyDrew J Winston
University of California, Los Angeles Medical Center, Los Angeles, CA 90095, USA
Blood 111:5403-10. 2008..Maribavir had no adverse effect on neutrophil or platelet counts. These results show that maribavir can reduce the incidence of CMV infection and, unlike ganciclovir, does not cause myelosuppression... - Efficacy of mycophenolate mofetil in the treatment of chronic graft-versus-host diseaseFrancisco Lopez
Division of Hematology and Hematopoietic Cell Transplantation, City of Hope National Medical Center, Duarte, California 91010, USA
Biol Blood Marrow Transplant 11:307-13. 2005..These data suggest that MMF is an active, well-tolerated agent in the treatment of cGVHD and may have a beneficial effect on the survival of patients with this complication... - Primary autoimmune myelofibrosis: definition of a distinct clinicopathologic syndromeVinod Pullarkat
Division of Hematology, Keck School of Medicine, University of Southern California, Los Angeles, California 91010 300, USA
Am J Hematol 72:8-12. 2003..Primary AIMF appears to have an excellent prognosis, with all patients reported in this series responding to a short course of corticosteroid therapy... - Successful application of a direct detection slide-based sequential phenotype/genotype assay using archived bone marrow smears and paraffin embedded tissue sectionsVictoria Bedell
Department of Cytogenetics, City of Hope National Medical Center, 1500 E Duarte Road, Duarte, CA 91010, USA
J Mol Diagn 9:589-97. 2007..Furthermore, the method has proved reliable and reproducible on test samples regardless of specimen age, tissue type, or referring institution... - Large-scale monocyte enrichment coupled with a closed culture system for the generation of human dendritic cellsVinod Pullarkat
Division of Hematology, University of Southern California, Norris Cancer Center, 1441 Eastlake Avenue, MS 34, Los Angeles 90033, USA
J Immunol Methods 267:173-83. 2002..Due to the closed nature of the enrichment and culture systems, the potential for contamination is minimized. This protocol is well suited for culturing large numbers of DC for clinical immunotherapy trials... - Systemic mastocytosis with associated clonal hematological non-mast-cell lineage disease: analysis of clinicopathologic features and activating c-kit mutationsVinod A Pullarkat
Division of Hematology, University of Southern California Keck School of Medicine, Los Angeles, CA, USA
Am J Hematol 73:12-7. 2003..As clinically effective tyrosine kinase inhibitors that inhibit enzymatic-type c-kit mutations are being developed, detection of mast cell proliferation associated with myeloid malignancy may have important therapeutic implications...