Keiko Omori

Summary

Affiliation: City of Hope National Medical Center
Country: USA

Publications

  1. ncbi Improvement of human islet cryopreservation by a p38 MAPK inhibitor
    K Omori
    Southern California Islet Cell Resources Center, Department of Diabetes, Endocrinology and Metabolism, City of Hope National Medical Center Beckman Research Institute, Duarte, CA, USA
    Am J Transplant 7:1224-32. 2007
  2. ncbi Microassay for glucose-induced preproinsulin mRNA expression to assess islet functional potency for islet transplantation
    Keiko Omori
    Department of Diabetes, Endocrinology and Metabolism, Southern California Islet Cell Resources Center, Beckman Research Institute of the City of Hope, Duarte, CA 91010, USA
    Transplantation 89:146-54. 2010
  3. ncbi mRNA of the pro-apoptotic gene BBC3 serves as a molecular marker for TNF-α-induced islet damage in humans
    K Omori
    Beckman Research Institute of the City of Hope, 1500 East Duarte Rd, Duarte, CA 91010, USA
    Diabetologia 54:2056-66. 2011
  4. ncbi P38alpha-selective mitogen-activated protein kinase inhibitor for improvement of cultured human islet recovery
    Keiko Omori
    Southern California Islet Cell Resources Center, Department of Diabetes, Endocrinology and Metabolism, Beckman Research Institute of the City of Hope, Duarte, CA 91010, USA
    Pancreas 39:436-43. 2010
  5. ncbi Improvement of canine islet yield by donor pancreas infusion with a p38MAPK inhibitor
    Taihei Ito
    Southern California Islet Cell Resources Center, Department of Diabetes, Endocrinology and Metabolism, Beckman Research Institute of the City of Hope, Duarte, CA 91010, USA
    Transplantation 86:321-9. 2008
  6. ncbi Generation of human islets through expansion and differentiation of non-islet pancreatic cells discarded (pancreatic discard) after islet isolation
    Ivan Todorov
    Southern California Islet Cell Resources Center, Department of Diabetes, Endocrinology and Metabolism, City of Hope National Medical Center Beckman Research Institute, Duarte, CA 91010, USA
    Pancreas 32:130-8. 2006
  7. ncbi Quantitative assessment of β-cell apoptosis and cell composition of isolated, undisrupted human islets by laser scanning cytometry
    Ivan Todorov
    Department of Diabetes and Metabolic Diseases Research, Beckman Research Institute of the City of Hope, Duarte, CA, USA
    Transplantation 90:836-42. 2010
  8. ncbi Inhibition of p38 pathway suppresses human islet production of pro-inflammatory cytokines and improves islet graft function
    Takeru Matsuda
    Southern California Islet Cell Resources Center, Department of Diabetes, Endocrinology and Metabolism, City of Hope National Medical Center/Beckman Research Institute, Duarte, CA, USA
    Am J Transplant 5:484-93. 2005
  9. ncbi Liver natural killer cells play a role in the destruction of islets after intraportal transplantation
    Kohei Ishiyama
    Department of Diabetes, Endocrinology and Metabolism, Southern California Islet Cell Resource Center, Beckman Research Institute of the City of Hope, Duarte, CA 91010, USA
    Transplantation 91:952-60. 2011

Collaborators

Detail Information

Publications9

  1. ncbi Improvement of human islet cryopreservation by a p38 MAPK inhibitor
    K Omori
    Southern California Islet Cell Resources Center, Department of Diabetes, Endocrinology and Metabolism, City of Hope National Medical Center Beckman Research Institute, Duarte, CA, USA
    Am J Transplant 7:1224-32. 2007
    ..This improvement may provide an opportunity to establish islet banks and allow the use of cryopreserved islets for clinical transplantation...
  2. ncbi Microassay for glucose-induced preproinsulin mRNA expression to assess islet functional potency for islet transplantation
    Keiko Omori
    Department of Diabetes, Endocrinology and Metabolism, Southern California Islet Cell Resources Center, Beckman Research Institute of the City of Hope, Duarte, CA 91010, USA
    Transplantation 89:146-54. 2010
    ..We developed a microassay that evaluates the potency of human islets by measuring changes in glucose-induced human insulin gene (INS) expression using a single islet in octuplicate samples...
  3. ncbi mRNA of the pro-apoptotic gene BBC3 serves as a molecular marker for TNF-α-induced islet damage in humans
    K Omori
    Beckman Research Institute of the City of Hope, 1500 East Duarte Rd, Duarte, CA 91010, USA
    Diabetologia 54:2056-66. 2011
    ..In light of this, we examined the involvement of a pro-apoptotic gene, BBC3 (also known as PUMA), in TNF-α-mediated beta cell dysfunction and destruction in human islets...
  4. ncbi P38alpha-selective mitogen-activated protein kinase inhibitor for improvement of cultured human islet recovery
    Keiko Omori
    Southern California Islet Cell Resources Center, Department of Diabetes, Endocrinology and Metabolism, Beckman Research Institute of the City of Hope, Duarte, CA 91010, USA
    Pancreas 39:436-43. 2010
    ..We investigated whether the recovery of cultured human islets is improved through the addition of a p38alpha-selective mitogen-activated protein kinase inhibitor, SD-282, to clinically used serum-free culture medium...
  5. ncbi Improvement of canine islet yield by donor pancreas infusion with a p38MAPK inhibitor
    Taihei Ito
    Southern California Islet Cell Resources Center, Department of Diabetes, Endocrinology and Metabolism, Beckman Research Institute of the City of Hope, Duarte, CA 91010, USA
    Transplantation 86:321-9. 2008
    ..This damage may be prevented by treating pancreata with a p38MAPK inhibitor (p38IH) before cold preservation...
  6. ncbi Generation of human islets through expansion and differentiation of non-islet pancreatic cells discarded (pancreatic discard) after islet isolation
    Ivan Todorov
    Southern California Islet Cell Resources Center, Department of Diabetes, Endocrinology and Metabolism, City of Hope National Medical Center Beckman Research Institute, Duarte, CA 91010, USA
    Pancreas 32:130-8. 2006
    ..Islet transplantation is hampered by the shortage of donor tissues. Our objective was to generate islet-like cell clusters (ICCs) from cultures of non-islet pancreatic cells...
  7. ncbi Quantitative assessment of β-cell apoptosis and cell composition of isolated, undisrupted human islets by laser scanning cytometry
    Ivan Todorov
    Department of Diabetes and Metabolic Diseases Research, Beckman Research Institute of the City of Hope, Duarte, CA, USA
    Transplantation 90:836-42. 2010
    ..We have developed fluorescence-based assays using laser scanning cytometry for assessing β-cell apoptosis and islet cell composition on serial sections of intact isolated islets...
  8. ncbi Inhibition of p38 pathway suppresses human islet production of pro-inflammatory cytokines and improves islet graft function
    Takeru Matsuda
    Southern California Islet Cell Resources Center, Department of Diabetes, Endocrinology and Metabolism, City of Hope National Medical Center/Beckman Research Institute, Duarte, CA, USA
    Am J Transplant 5:484-93. 2005
    ..These results suggest that inhibition of the p38 pathway may become a new therapeutic strategy to improve graft survival in clinical islet transplantation...
  9. ncbi Liver natural killer cells play a role in the destruction of islets after intraportal transplantation
    Kohei Ishiyama
    Department of Diabetes, Endocrinology and Metabolism, Southern California Islet Cell Resource Center, Beckman Research Institute of the City of Hope, Duarte, CA 91010, USA
    Transplantation 91:952-60. 2011
    ..We hypothesize that natural killer (NK) cells in the liver play a role in the islet graft destruction...