- Exposure of neurons to excitotoxic levels of glutamate induces cleavage of the RNA editing enzyme, adenosine deaminase acting on RNA 2, and loss of GLUR2 editingS S Mahajan
School of Health Sciences, Hunter College, CUNY, New York, NY 10010, USA
Neuroscience 189:305-15. 2011..We demonstrate that cleaved ADAR2 leads to a decrease or loss of GluR2 editing, which will further result in high Ca2+ influx and excitotoxic neuronal death...
- Novel toxicity of the unedited GluR2 AMPA receptor subunit dependent on surface trafficking and increased Ca2+-permeabilityS S Mahajan
The Department of Biochemistry, New York University School of Medicine, 550 First Avenue, New York, NY 1006, USA
Mol Cell Neurosci 35:470-81. 2007..Peptide block of trafficking provides a model for design of drugs to reduce unedited GluR2 excitotoxicity in neurodegenerative diseases that result from editing failure...