S S Mahajan

Summary

Affiliation: City University of New York
Country: USA

Publications

  1. pmc Exposure of neurons to excitotoxic levels of glutamate induces cleavage of the RNA editing enzyme, adenosine deaminase acting on RNA 2, and loss of GLUR2 editing
    S S Mahajan
    School of Health Sciences, Hunter College, CUNY, New York, NY 10010, USA
    Neuroscience 189:305-15. 2011
  2. pmc Novel toxicity of the unedited GluR2 AMPA receptor subunit dependent on surface trafficking and increased Ca2+-permeability
    S S Mahajan
    The Department of Biochemistry, New York University School of Medicine, 550 First Avenue, New York, NY 1006, USA
    Mol Cell Neurosci 35:470-81. 2007

Collaborators

Detail Information

Publications2

  1. pmc Exposure of neurons to excitotoxic levels of glutamate induces cleavage of the RNA editing enzyme, adenosine deaminase acting on RNA 2, and loss of GLUR2 editing
    S S Mahajan
    School of Health Sciences, Hunter College, CUNY, New York, NY 10010, USA
    Neuroscience 189:305-15. 2011
    ..We demonstrate that cleaved ADAR2 leads to a decrease or loss of GluR2 editing, which will further result in high Ca2+ influx and excitotoxic neuronal death...
  2. pmc Novel toxicity of the unedited GluR2 AMPA receptor subunit dependent on surface trafficking and increased Ca2+-permeability
    S S Mahajan
    The Department of Biochemistry, New York University School of Medicine, 550 First Avenue, New York, NY 1006, USA
    Mol Cell Neurosci 35:470-81. 2007
    ..Peptide block of trafficking provides a model for design of drugs to reduce unedited GluR2 excitotoxicity in neurodegenerative diseases that result from editing failure...