Young-Ho Lee

Summary

Affiliation: University of Southern California
Location: Los Angeles, USA

Publications

  1. ncbi Co-operation between protein-acetylating and protein-methylating co-activators in transcriptional activation
    M R Stallcup
    Department of Pathology, University of Southern California, 2011 Zonal Avenue, Los Angeles, CA 90089, USA
    Biochem Soc Trans 28:415-8. 2000
  2. pmc Regulated recruitment of tumor suppressor BRCA1 to the p21 gene by coactivator methylation
    Young Ho Lee
    Department of Biochemistry and Molecular Biology, University of Southern California, Los Angeles, California 90089, USA
    Genes Dev 25:176-88. 2011
  3. pmc Recruitment of the SWI/SNF chromatin remodeling complex to steroid hormone-regulated promoters by nuclear receptor coactivator flightless-I
    Kwang Won Jeong
    Department of Biochemistry and Molecular Biology, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA
    J Biol Chem 284:29298-309. 2009
  4. pmc Minireview: protein arginine methylation of nonhistone proteins in transcriptional regulation
    Young Ho Lee
    Department of Biochemistry and Molecular Biology, Norris Comprehensive Cancer Center, Los Angeles, California 90089 9176, USA
    Mol Endocrinol 23:425-33. 2009
  5. pmc Inhibitors and inactivators of protein arginine deiminase 4: functional and structural characterization
    Yuan Luo
    Department of Chemistry and Biochemistry, University of South Carolina, 631 Sumter Street, Columbia, South Carolina 29208, USA
    Biochemistry 45:11727-36. 2006
  6. pmc Interplay of Fli-I and FLAP1 for regulation of beta-catenin dependent transcription
    Young Ho Lee
    Department of Biochemistry and Molecular Biology, University of Southern California, 1333 San Pablo Avenue, MCA 51A, Los Angeles, CA 90089, USA
    Nucleic Acids Res 34:5052-9. 2006
  7. pmc A fluoroacetamidine-based inactivator of protein arginine deiminase 4: design, synthesis, and in vitro and in vivo evaluation
    Yuan Luo
    Department of Chemistry and Biochemistry, University of South Carolina, Columbia, 29208, USA
    J Am Chem Soc 128:1092-3. 2006
  8. pmc Regulation of coactivator complex assembly and function by protein arginine methylation and demethylimination
    Young Ho Lee
    Department of Pathology, University of Southern California, 2011 Zonal Avenue, HMR 301, Los Angeles, CA 90089, USA
    Proc Natl Acad Sci U S A 102:3611-6. 2005
  9. ncbi Human PAD4 regulates histone arginine methylation levels via demethylimination
    Yanming Wang
    Department of Genetic Medicine, Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA
    Science 306:279-83. 2004
  10. pmc Developmentally essential protein flightless I is a nuclear receptor coactivator with actin binding activity
    Young Ho Lee
    Department of Pathology, University of Southern California, Los Angeles, California 90089 9092, USA
    Mol Cell Biol 24:2103-17. 2004

Detail Information

Publications16

  1. ncbi Co-operation between protein-acetylating and protein-methylating co-activators in transcriptional activation
    M R Stallcup
    Department of Pathology, University of Southern California, 2011 Zonal Avenue, Los Angeles, CA 90089, USA
    Biochem Soc Trans 28:415-8. 2000
    ..We propose that the synergy of co-activator function between p300, CARM1 and PRMT1 is due to their different but complementary protein modification activities...
  2. pmc Regulated recruitment of tumor suppressor BRCA1 to the p21 gene by coactivator methylation
    Young Ho Lee
    Department of Biochemistry and Molecular Biology, University of Southern California, Los Angeles, California 90089, USA
    Genes Dev 25:176-88. 2011
    ..Thus, coactivator methylation may be crucial for fine-tuning the tumor suppressor function of BRCA1 and other BRCT domain proteins...
  3. pmc Recruitment of the SWI/SNF chromatin remodeling complex to steroid hormone-regulated promoters by nuclear receptor coactivator flightless-I
    Kwang Won Jeong
    Department of Biochemistry and Molecular Biology, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA
    J Biol Chem 284:29298-309. 2009
    ..These results begin to establish the functional relationships and interdependencies that coordinate the actions of the many coactivators participating in the transcriptional activation process...
  4. pmc Minireview: protein arginine methylation of nonhistone proteins in transcriptional regulation
    Young Ho Lee
    Department of Biochemistry and Molecular Biology, Norris Comprehensive Cancer Center, Los Angeles, California 90089 9176, USA
    Mol Endocrinol 23:425-33. 2009
    ..Thus, protein arginine methylation is critical for regulation of transcription and potentially for various physiological/pathological processes...
  5. pmc Inhibitors and inactivators of protein arginine deiminase 4: functional and structural characterization
    Yuan Luo
    Department of Chemistry and Biochemistry, University of South Carolina, 631 Sumter Street, Columbia, South Carolina 29208, USA
    Biochemistry 45:11727-36. 2006
    ..In addition, they represent potential lead compounds for the treatment of rheumatoid arthritis because a growing body of evidence supports a role for PAD4 in the onset and progression of this chronic autoimmune disorder...
  6. pmc Interplay of Fli-I and FLAP1 for regulation of beta-catenin dependent transcription
    Young Ho Lee
    Department of Biochemistry and Molecular Biology, University of Southern California, 1333 San Pablo Avenue, MCA 51A, Los Angeles, CA 90089, USA
    Nucleic Acids Res 34:5052-9. 2006
    ....
  7. pmc A fluoroacetamidine-based inactivator of protein arginine deiminase 4: design, synthesis, and in vitro and in vivo evaluation
    Yuan Luo
    Department of Chemistry and Biochemistry, University of South Carolina, Columbia, 29208, USA
    J Am Chem Soc 128:1092-3. 2006
    ..The fact that inhibition is of an irreversible nature suggests that, with appropriate functionalization, F-amidine analogues will be robust activity-based protein-profiling and proteomic capture reagents...
  8. pmc Regulation of coactivator complex assembly and function by protein arginine methylation and demethylimination
    Young Ho Lee
    Department of Pathology, University of Southern California, 2011 Zonal Avenue, HMR 301, Los Angeles, CA 90089, USA
    Proc Natl Acad Sci U S A 102:3611-6. 2005
    ....
  9. ncbi Human PAD4 regulates histone arginine methylation levels via demethylimination
    Yanming Wang
    Department of Genetic Medicine, Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA
    Science 306:279-83. 2004
    ..Moreover, PAD4 activity is linked with the transcriptional regulation of estrogen-responsive genes in MCF-7 cells. These data suggest that PAD4 mediates gene expression by regulating Arg methylation and citrullination in histones...
  10. pmc Developmentally essential protein flightless I is a nuclear receptor coactivator with actin binding activity
    Young Ho Lee
    Department of Pathology, University of Southern California, Los Angeles, California 90089 9092, USA
    Mol Cell Biol 24:2103-17. 2004
    ..These data suggest that Fli-I may facilitate interaction of the p160 coactivator complex with other coactivators or coactivator complexes containing actin or actin-like proteins...
  11. ncbi The roles of protein-protein interactions and protein methylation in transcriptional activation by nuclear receptors and their coactivators
    Michael R Stallcup
    Department of Pathology, University of Southern California, HMR 301, 2011 Zonal Avenue, Los Angeles, CA 90089 9092, USA
    J Steroid Biochem Mol Biol 85:139-45. 2003
    ..We also defined the N-terminal region of p160 coactivators as another signal output domain, which binds a novel coactivator called coiled-coil coactivator (CoCoA). CoCoA acts synergistically with p160 coactivators to enhance NR function...
  12. pmc Synergy among nuclear receptor coactivators: selective requirement for protein methyltransferase and acetyltransferase activities
    Young Ho Lee
    Department of Biochemistry and Molecular Biology, University of Southern California, Los Angeles, California 90089, USA
    Mol Cell Biol 22:3621-32. 2002
    ....
  13. ncbi Synergistic coactivator function by coactivator-associated arginine methyltransferase (CARM) 1 and beta-catenin with two different classes of DNA-binding transcriptional activators
    Stephen S Koh
    Department of Pathology, University of Southern California, Los Angeles, California 90089, USA
    J Biol Chem 277:26031-5. 2002
    ..The synergistic coactivator function of beta-catenin and CARM1 is not restricted to steroid receptors because these two coactivators can also act synergistically with another type of DNA binding transcriptional activator, LEF-1/TCF-4...
  14. ncbi Synergistic enhancement of nuclear receptor function by p160 coactivators and two coactivators with protein methyltransferase activities
    S S Koh
    Department of Pathology, University of Southern California, Los Angeles, California 90089, USA
    J Biol Chem 276:1089-98. 2001
    ..Because multiple coactivators are presumably required to mediate transcriptional activation of native genes in vivo, the low-NR conditions may provide a more physiologically relevant assay for coactivator function...
  15. pmc Roles of protein arginine methylation in DNA damage signaling pathways: Is CARM1 a life-or-death decision point?
    Young Ho Lee
    Department of Biochemistry and Molecular Biology Norris Comprehensive Cancer Center University of Southern California Los Angeles, CA, USA
    Cell Cycle 10:1343-4. 2011