Sean K Lau

Summary

Affiliation: City of Hope National Medical Center
Country: USA

Publications

  1. doi Oncocytoma of the kidney with prominent intracytoplasmic lumina
    Sean K Lau
    Department of Pathology, City of Hope National Medical Center, Duarte, CA 91010, USA
    Ann Diagn Pathol 15:485-9. 2011
  2. doi Immunohistochemical evaluation of CON6D/B5: a new CD30 monoclonal antibody
    Sean K Lau
    Department of Pathology, City of Hope National Medical Center, Duarte, CA 91010, USA
    Appl Immunohistochem Mol Morphol 18:273-7. 2010
  3. ncbi Schwannoma of the adrenal gland: report of two cases
    Sean K Lau
    Department of Pathology, City of Hope National Medical Center, 1500 East Duarte Road, Duarte, CA 91010, USA
    Am J Surg Pathol 30:630-4. 2006
  4. ncbi Calcifying fibrous tumor of the adrenal gland
    Sean K Lau
    Department of Pathology, City of Hope National Medical Center, Duarte, CA 91010, USA
    Hum Pathol 38:656-9. 2007
  5. ncbi D2-40 immunohistochemistry in the differential diagnosis of seminoma and embryonal carcinoma: a comparative immunohistochemical study with KIT (CD117) and CD30
    Sean K Lau
    Department of Pathology, City of Hope National Medical Center, Duarte, CA 91010, USA
    Mod Pathol 20:320-5. 2007
  6. ncbi Low frequency of BK virus in prostatic adenocarcinomas
    Sean K Lau
    Department of Pathology, Beckman Research Institute, City of Hope National Medical Center, Duarte, California 91010, USA
    APMIS 115:743-9. 2007
  7. ncbi Association of intratubular seminoma and intratubular embryonal carcinoma with invasive testicular germ cell tumors
    Sean K Lau
    Department of Pathology, City of Hope National Medical Center, Duarte, CA 91010, USA
    Am J Surg Pathol 31:1045-9. 2007
  8. doi Mixed cortical adenoma and composite pheochromocytoma-ganglioneuroma: an unusual corticomedullary tumor of the adrenal gland
    Sean K Lau
    Department of Pathology, City of Hope National Medical Center, Duarte, CA 91010, USA
    Ann Diagn Pathol 15:185-9. 2011
  9. doi Immunohistochemical expression of Langerin in Langerhans cell histiocytosis and non-Langerhans cell histiocytic disorders
    Sean K Lau
    Department of Pathology, City of Hope National Medical Center, Duarte, CA 91010, USA
    Am J Surg Pathol 32:615-9. 2008
  10. doi Myxoid solitary fibrous tumor: a clinicopathologic study of three cases
    Sean K Lau
    Department of Pathology, City of Hope National Medical Center, 1500 East Duarte Road, Duarte, CA, 91010, USA
    Virchows Arch 454:189-94. 2009

Detail Information

Publications49

  1. doi Oncocytoma of the kidney with prominent intracytoplasmic lumina
    Sean K Lau
    Department of Pathology, City of Hope National Medical Center, Duarte, CA 91010, USA
    Ann Diagn Pathol 15:485-9. 2011
    ..Awareness of this phenomenon should allow for improved recognition of oncocytomas exhibiting this type of unusual morphology...
  2. doi Immunohistochemical evaluation of CON6D/B5: a new CD30 monoclonal antibody
    Sean K Lau
    Department of Pathology, City of Hope National Medical Center, Duarte, CA 91010, USA
    Appl Immunohistochem Mol Morphol 18:273-7. 2010
    ..The monoclonal antibody CON6D/B5 offers a suitable alternative to Ber-H2 for the immunohistochemical detection of CD30 expression...
  3. ncbi Schwannoma of the adrenal gland: report of two cases
    Sean K Lau
    Department of Pathology, City of Hope National Medical Center, 1500 East Duarte Road, Duarte, CA 91010, USA
    Am J Surg Pathol 30:630-4. 2006
    ..Because of its rarity, schwannoma occurring at this particular site can pose problems in diagnosis and should be distinguished from other spindle cell lesions of the adrenal gland...
  4. ncbi Calcifying fibrous tumor of the adrenal gland
    Sean K Lau
    Department of Pathology, City of Hope National Medical Center, Duarte, CA 91010, USA
    Hum Pathol 38:656-9. 2007
    ..Although rare, awareness that calcifying fibrous tumor may occur at this particular site is important so as not to confuse this lesion with other mesenchymal neoplasms of the adrenal gland...
  5. ncbi D2-40 immunohistochemistry in the differential diagnosis of seminoma and embryonal carcinoma: a comparative immunohistochemical study with KIT (CD117) and CD30
    Sean K Lau
    Department of Pathology, City of Hope National Medical Center, Duarte, CA 91010, USA
    Mod Pathol 20:320-5. 2007
    ..Although a highly sensitive marker for seminomas, D2-40 positivity was also observed in a subset of embryonal carcinomas, thus limiting the utility of this antibody for discriminating between these two malignancies...
  6. ncbi Low frequency of BK virus in prostatic adenocarcinomas
    Sean K Lau
    Department of Pathology, Beckman Research Institute, City of Hope National Medical Center, Duarte, California 91010, USA
    APMIS 115:743-9. 2007
    ..However, lack of localization of BKV to a large population of the neoplastic cells and absence of BKV large tumor antigen expression suggest that the virus does not play a role in the pathogenesis of prostate cancer...
  7. ncbi Association of intratubular seminoma and intratubular embryonal carcinoma with invasive testicular germ cell tumors
    Sean K Lau
    Department of Pathology, City of Hope National Medical Center, Duarte, CA 91010, USA
    Am J Surg Pathol 31:1045-9. 2007
    ..The low incidence of intratubular embryonal carcinoma supports the theory that most nonseminomatous germ cell tumors evolve initially as seminomas, rather than directly from a differentiated intratubular neoplastic lesion...
  8. doi Mixed cortical adenoma and composite pheochromocytoma-ganglioneuroma: an unusual corticomedullary tumor of the adrenal gland
    Sean K Lau
    Department of Pathology, City of Hope National Medical Center, Duarte, CA 91010, USA
    Ann Diagn Pathol 15:185-9. 2011
    ..The present case serves to broaden the morphologic spectrum of mixed tumors that may be encountered in the adrenal gland...
  9. doi Immunohistochemical expression of Langerin in Langerhans cell histiocytosis and non-Langerhans cell histiocytic disorders
    Sean K Lau
    Department of Pathology, City of Hope National Medical Center, Duarte, CA 91010, USA
    Am J Surg Pathol 32:615-9. 2008
    ..Immunohistochemical evaluation of Langerin expression may have utility in substantiating a diagnosis of Langerhans cell histiocytosis and separating this disorder from other non-Langerhans cell histiocytic proliferations...
  10. doi Myxoid solitary fibrous tumor: a clinicopathologic study of three cases
    Sean K Lau
    Department of Pathology, City of Hope National Medical Center, 1500 East Duarte Road, Duarte, CA, 91010, USA
    Virchows Arch 454:189-94. 2009
    ..The data suggest that myxoid solitary fibrous tumors are associated with an indolent clinical course and favorable prognosis...
  11. doi Nested variant of urothelial carcinoma of the renal pelvis
    Sean K Lau
    Department of Pathology, City of Hope National Medical Center, 1500 East Duarte Road, Duarte, CA 91010, USA
    Pathol Res Pract 205:508-12. 2009
    ..Although rare, awareness that the nested variant of urothelial carcinoma may occur at this particular site is important so as not to confuse this unusual form of urothelial carcinoma with other pathologic lesions of the renal pelvis...
  12. doi Cytomorphologic features of the plasmacytoid variant of urothelial carcinoma: a case report
    Sean K Lau
    Department of Pathology, City of Hope National Medical Center, Duarte, CA 91010, USA
    Diagn Cytopathol 37:359-64. 2009
    ..Although rare, the plasmacytoid variant of urothelial carcinoma should be a diagnostic consideration when atypical cells with plasmacytoid features are encountered in a urinary specimen...
  13. doi The Weiss system for evaluating adrenocortical neoplasms: 25 years later
    Sean K Lau
    Department of Pathology, City of Hope National Medical Center, Duarte, CA 91010, USA
    Hum Pathol 40:757-68. 2009
    ..Considerable advances in the understanding of the pathology of adrenocortical neoplasia have occurred since delineation of the Weiss system, offering alternative approaches to the contemporary assessment of adrenocortical tumors...
  14. doi Myopericytoma of the kidney
    Sean K Lau
    Department of Pathology, City of Hope National Medical Center, Duarte, CA 91010, USA
    Hum Pathol 41:1500-4. 2010
    ..The present case serves to expand the anatomical distribution of myopericytoma and also broadens the spectrum of primary mesenchymal neoplasms that may be encountered in the kidney...
  15. ncbi OCT4: a sensitive and specific immunohistochemical marker for metastatic germ cell tumors
    Sean K Lau
    Department of Pathology, City of Hope National Medical Center, Duarte, CA 91010, USA
    Adv Anat Pathol 13:76-9. 2006
  16. ncbi Immunohistochemical expression of estrogen receptor in pulmonary adenocarcinoma
    Sean K Lau
    Department of Pathology, City of Hope National Medical Center, Duarte, CA 91010, USA
    Appl Immunohistochem Mol Morphol 14:83-7. 2006
    ..In the context of an ER-positive lung neoplasm, strong and extensive TTF-1 immunoreactivity can be regarded as strong supportive evidence for a primary bronchogenic adenocarcinoma...
  17. ncbi Sustentaculoma: report of a case of a distinctive neoplasm of the adrenal medulla
    Sean K Lau
    Department of Pathology, City of Hope National Medical Center, Duarte, CA 91010, USA
    Am J Surg Pathol 30:268-73. 2006
    ..We propose the designation "sustentaculoma" for this hitherto undescribed neoplasm of the adrenal gland...
  18. ncbi Epstein-Barr virus infection is not associated with fibroadenomas of the breast in immunosuppressed patients after organ transplantation
    Sean K Lau
    Department of Pathology, City of Hope National Medical Center, Duarte, California 91010, USA
    Mod Pathol 16:1242-7. 2003
    ..The findings of the present study argue against a significant relationship between Epstein-Barr virus and fibroadenomas of the breast in the setting of transplant-associated immunosuppression...
  19. ncbi Pathologic quiz case. A 73-year-old man with a bladder mass. Combined primary small cell neuroendocrine carcinoma and high-grade papillary urothelial carcinoma of the urinary bladder
    Sean K Lau
    Department of Pathology, City of Hope National Medical Center, Duarte, Calif 91010, USA
    Arch Pathol Lab Med 128:1055-6. 2004
  20. ncbi Lack of association of cytomegalovirus with human brain tumors
    Sean K Lau
    Department of Pathology, City of Hope National Medical Center, Duarte, CA 91010, USA
    Mod Pathol 18:838-43. 2005
    ..None of the carcinomas or sarcomas evaluated were positive for CMV by immunohistochemistry, in situ hybridization, or PCR. The findings of the present study suggest that CMV is not significantly associated with brain tumors in humans...
  21. ncbi Prolymphocytoid transformation of follicular lymphoma with coexpression of CD5 and CD10
    Sean K Lau
    Department of Pathology, City of Hope National Medical Center, Duarte, CA 91010, USA
    Leuk Lymphoma 47:541-7. 2006
    ..Prolymphocytoid transformation, similar to other histologic forms of transformation of follicular lymphoma, appears to accompany clinical progression of disease...
  22. doi Detection of clonal lymphoid receptor gene rearrangements in langerhans cell histiocytosis
    Wei Chen
    Department of Pathology, City of Hope National Medical Center, Duarte, CA 91010, USA
    Am J Surg Pathol 34:1049-57. 2010
    ..The results provide genotypic evidence supporting the current notion of lineage plasticity of hematopoietic cells and their associated neoplasms...
  23. doi Overlapping features between dedifferentiated liposarcoma and undifferentiated high-grade pleomorphic sarcoma
    Lawrance Chung
    Department of Pathology, City of Hope National Medical Center, Duarte, CA 91010, USA
    Am J Surg Pathol 33:1594-600. 2009
    ....
  24. ncbi Urothelial carcinoma of the urinary bladder with a component of acinar/tubular type differentiation simulating prostatic adenocarcinoma
    Qin Huang
    Division of Pathology, City of Hope National Medical Center, Duarte, California 91010, USA
    Hum Pathol 35:769-73. 2004
    ..Although bladder carcinomas composed of mixed morphologic patterns are not uncommon, to our knowledge, the presence of acinar/tubular type features simulating prostatic adenocarcinoma in such tumors has not been described elsewhere...
  25. doi Distinction of hepatocellular carcinoma from benign hepatic mimickers using Glypican-3 and CD34 immunohistochemistry
    Wanda M P Coston
    Department of Pathology, City of Hope National Medical Center, Duarte, CA 91010, USA
    Am J Surg Pathol 32:433-44. 2008
    ..GPC3 immunoreactivity, in combination with a complete CD34 immunostaining pattern, greatly facilitates the accuracy of distinguishing between malignant hepatic lesions and benign mimickers...
  26. pmc Protein kinase A activation confers resistance to trastuzumab in human breast cancer cell lines
    Long Gu
    Division of Tumor Cell Biology, City of Hope Comprehensive Cancer Center, Duarte, California 91107, USA
    Clin Cancer Res 15:7196-206. 2009
    ..The current work addresses the mechanism of sustained signaling in BT/Her(R) cells, focusing on the protein kinase A (PKA) pathway...
  27. doi TCL1 protein expression in testicular germ cell tumors
    Sean K Lau
    Dept of Pathology, City of Hope National Medical Center, 1500 E Duarte Rd, Duarte, CA 91010, USA
    Am J Clin Pathol 133:762-6. 2010
    ..Immunohistochemical evaluation of TCL1 expression may have usefulness in substantiating a diagnosis of IGCNU or seminoma and in the separation of seminoma from nonseminomatous germ cell tumors...
  28. ncbi CD163: a specific marker of macrophages in paraffin-embedded tissue samples
    Sean K Lau
    Department of Pathology, City of Hope National Medical Center, Duarte, CA 91010, USA
    Am J Clin Pathol 122:794-801. 2004
    ..However, immunohistochemical evaluation of CD163 expression does not seem to be a sensitive means of determining monocytic differentiation in AMLs in paraffin sections or establishing a diagnosis of myeloid sarcoma...
  29. ncbi Immunohistochemical staining in the diagnosis of pancreatobiliary and ampulla of Vater adenocarcinoma: application of CDX2, CK17, MUC1, and MUC2
    Peiguo G Chu
    Division of Pathology, City of Hope National Medical Center, Duarte, CA 91010, USA
    Am J Surg Pathol 29:359-67. 2005
    ..MUC2+/CDX2+ can be used as positive markers for the intestinal-type adenocarcinoma of duodenal papillary origin with a positive predictive value of 82%...
  30. doi Napsin A expression in primary mucin-producing adenocarcinomas of the lung: an immunohistochemical study
    Jeffrey Wu
    Department of Pathology, City of Hope National Medical Center, Duarte, CA, USA
    Am J Clin Pathol 139:160-6. 2013
    ....
  31. ncbi Thyroid transcription factor-1: a review
    Sean K Lau
    Department of Pathology, Cedar Sinai Medical Center, Los Angeles, CA, USA
    Appl Immunohistochem Mol Morphol 10:97-102. 2002
    ..It may also be useful in distinguishing neuroendocrine (NE) tumors of the lung from well-differentiated NE tumors from other sites, such as the intestine...
  32. doi Intestinal type of mucinous borderline tumor arising from mixed epithelial and stromal tumor of kidney
    Peiguo G Chu
    Department of Pathology, City of Hope National Medical Center, 1500 East Duarte Road, Duarte, CA 91010, USA
    Virchows Arch 455:389-94. 2009
    ..There was no invasive mucinous tumor identified. We believe that this case represents the first reported example of mucinous borderline tumor arising from a MESTK...
  33. ncbi Differential expression of MUC1, MUC2, and MUC5AC in carcinomas of various sites: an immunohistochemical study
    Sean K Lau
    Department of Pathology, City of Hope National Medical Center, Duarte, CA 91010, USA
    Am J Clin Pathol 122:61-9. 2004
    ....
  34. doi Malignant PEComa of the adrenal gland
    Sean K Lau
    Department of Pathology, City of Hope National Medical Center, 1500 East Duarte Road, Duarte, CA 91010, United States
    Pathol Res Pract 208:113-7. 2012
    ..The present case serves to emphasize the potential of PEComa for clinically aggressive behavior and the importance of distinguishing this tumor from other epithelioid neoplasms that are more commonly encountered in the adrenal gland...
  35. doi Assessment of low prostate weight as a determinant of a higher positive margin rate after laparoscopic radical prostatectomy: a prospective pathologic study of 1,500 cases
    Peiguo G Chu
    Division of Pathology, City of Hope National Medical Center, Duarte, CA 91010, USA
    Surg Endosc 23:1058-64. 2009
    ..The assessment of prostate weight as a determinant of a high prostate margin rate after laparoscopic radical prostatectomy has not been studied...
  36. doi High frequency of clonal immunoglobulin receptor gene rearrangements in sporadic histiocytic/dendritic cell sarcomas
    Wei Chen
    Department of Pathology, City of Hope National Medical Center, Duarte, CA 91010, USA
    Am J Surg Pathol 33:863-73. 2009
    ..The findings suggest that a large subset of H/DC sarcomas have inherited B-cell genotypes, thus providing new insights for the pathogenesis of these rare but aggressive neoplasms...
  37. doi Expression of CD56 and WT1 in ovarian stroma and ovarian stromal tumors
    Huiying He
    Division of Pathology, City of Hope National Medical Center, Los Angeles, CA, USA
    Am J Surg Pathol 32:884-90. 2008
    ..CD56 is strongly expressed in ovarian stromal cells but not in endometrial stromal cells. CD56 is often expressed by a wide variety of spindle cell sarcomas, thus, it has no value in differentiating GYN from non-GYN spindle cell tumors...
  38. doi Determining the site of origin of mucinous adenocarcinoma: an immunohistochemical study of 175 cases
    Peiguo G Chu
    Department of Pathology, City of Hope National Medical Center, Duarte, CA 91010, USA
    Am J Surg Pathol 35:1830-6. 2011
    ..As is the case in appendiceal MAs, the upper GI tract MAs may also be heterogenously positive for CDX-2. Breast MAs are positive for ER and WT-1, whereas gynecologic MAs are positive for PAX-8 and negative for WT-1...
  39. pmc Multiple biomarker expression on circulating tumor cells in comparison to tumor tissues from primary and metastatic sites in patients with locally advanced/inflammatory, and stage IV breast cancer, using a novel detection technology
    George Somlo
    Department of Medical Oncology and Therapeutics Research, City of Hope Cancer Center, Duarte, CA, 91010 3000, USA
    Breast Cancer Res Treat 128:155-63. 2011
    ....
  40. doi Keratin expression in endocrine organs and their neoplasms
    Peiguo G Chu
    Department of Pathology, City of Hope National Medical Center, Duarte, CA 91010, USA
    Endocr Pathol 20:1-10. 2009
    ..In this review article, we will first briefly review the molecular biology and protein chemistry of the keratins. We will then review the expression patterns of keratins in normal endocrine tissue and endocrine neoplasms...
  41. ncbi Malignant monotypic epithelioid angiomyolipoma of the retroperitoneum
    Sean K Lau
    Division of Pathology, City of Hope National Medical Center, Duarte, California, USA
    Int J Surg Pathol 11:223-8. 2003
    ..This case represents, to our knowledge, the first description of metastatic disease occurring in an EAML of this particular site...
  42. pmc Homeobox gene methylation in lung cancer studied by genome-wide analysis with a microarray-based methylated CpG island recovery assay
    Tibor Rauch
    Division of Biology, Beckman Research Institute of the City of Hope, Duarte, CA 91010, USA
    Proc Natl Acad Sci U S A 104:5527-32. 2007
    ..The finding of widespread methylation of homeobox genes lends support to the hypothesis that a substantial fraction of genes methylated in human cancer are targets of the Polycomb complex...
  43. ncbi EGFR mutations in non-small cell lung carcinomas may predict response to gefitinib: extension of an emerging paradigm
    Karen L Chang
    Department of Pathology, City of Hope National Medical Center, Duarte, California 91010, USA
    Adv Anat Pathol 12:47-52. 2005
  44. ncbi Thymoma-associated severe aplastic anemia treated with surgical resection followed by allogeneic stem-cell transplantation
    Vijay Trisal
    Department of Surgical Oncology, City of Hope National Medical Center, Duarte, CA, USA
    J Clin Oncol 25:3374-5. 2007
  45. pmc Papillary carcinoma of the breast: an overview
    Sumanta Kumar Pal
    Department of Medical Oncology and Therapeutics Research, City of Hope Comprehensive Cancer Center, 1500 East Duarte Road, Duarte, CA 91010, USA
    Breast Cancer Res Treat 122:637-45. 2010
    ..The scarcity of information underscores the need for further treatment- and outcome-related studies in papillary carcinoma of the breast...
  46. ncbi Comparative immunohistochemical profile of hepatocellular carcinoma, cholangiocarcinoma, and metastatic adenocarcinoma
    Sean K Lau
    Department of Pathology and Laboratory Medicine, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Hum Pathol 33:1175-81. 2002
    ..CK 7 and CK 20 were also useful in this differential diagnosis, particularly when dealing with MA of colonic origin. AE1/AE3, CAM 5.2, B72.3, inhibin, and factor XIIIa were noncontributory in differentiating these entities...
  47. ncbi Prostatic tissue ectopia within the seminal vesicle: a potential source of confusion with seminal vesicle involvement by prostatic adenocarcinoma
    Sean K Lau
    Virchows Arch 449:600-2. 2006
  48. ncbi Expression of thyroid transcription factor-1, cytokeratin 7, and cytokeratin 20 in bronchioloalveolar carcinomas: an immunohistochemical evaluation of 67 cases
    Sean K Lau
    Department of Pathology and Laboratory Medicine, Cedars Sinai Medical Center, Los Angeles, California 90048, USA
    Mod Pathol 15:538-42. 2002
    ..This suggests that in the context of differentiating mucinous BACs from extrapulmonary mucinous tumors metastatic to the lung, evaluation of TTF-1 and CK 20 expression may have limited diagnostic utility...
  49. ncbi Adrenocortical oncocytic tumors: report of 10 cases and review of the literature
    Michele Bisceglia
    Department of Pathology, IRCCS Casa Sollievo della Sofferenza Hospital, San Giovanni Rotondo FG, Italy
    Int J Surg Pathol 12:231-43. 2004
    ..7 months). The 2 benign tumors have a follow-up of 25 and 30 months, respectively. Diagnostic difficulties are delineated and a complete review of the literature on this topic has also been performed...