R R Klevecz

Summary

Affiliation: City of Hope National Medical Center
Country: USA

Publications

  1. pmc Collective behavior in gene regulation: the cell is an oscillator, the cell cycle a developmental process
    Robert R Klevecz
    Dynamic Systems Group, Department of Biology, Beckman Research Institute, City of Hope Medical Center, Duarte CA 91010, USA
    FEBS J 275:2372-84. 2008
  2. ncbi request reprint Generation and maintenance of synchrony in Saccharomyces cerevisiae continuous culture
    Douglas B Murray
    Faculty of Engineering, Science and Technology, South Bank University, 103 Borough Road, SE1 OAA, London, UK
    Exp Cell Res 287:10-5. 2003
  3. pmc A genomewide oscillation in transcription gates DNA replication and cell cycle
    Robert R Klevecz
    Dynamics Group, Department of Biology, Beckman Research Institute of the City of Hope Medical Center, Duarte, CA 91010, USA
    Proc Natl Acad Sci U S A 101:1200-5. 2004
  4. pmc A rapid genome-scale response of the transcriptional oscillator to perturbation reveals a period-doubling path to phenotypic change
    Caroline M Li
    Dynamic Systems Group, Department of Biology, Beckman Research Institute, City of Hope Medical Center, Duarte, CA 91010, USA
    Proc Natl Acad Sci U S A 103:16254-9. 2006
  5. ncbi request reprint Genome wide oscillations in expression. Wavelet analysis of time series data from yeast expression arrays uncovers the dynamic architecture of phenotype
    R R Klevecz
    Department of Biology, Beckman Research Institute, City of Hope National Medical Center, Duarte, CA 91010, USA
    Mol Biol Rep 28:73-82. 2001
  6. pmc Evolution of the clock from yeast to man by period-doubling folds in the cellular oscillator
    R R Klevecz
    Department of Biology, Beckman Research Institute of the City of Hope Medical Center, Duarte, California 91010, USA
    Cold Spring Harb Symp Quant Biol 72:421-9. 2007
  7. ncbi request reprint Tuning in the transcriptome: basins of attraction in the yeast cell cycle
    R R Klevecz
    Department of Biology, Beckman Research Institute of the City of Hope, Duarte, CA 91010, USA
    Cell Prolif 33:209-18. 2000
  8. ncbi request reprint Dynamic architecture of the yeast cell cycle uncovered by wavelet decomposition of expression microarray data
    R R Klevecz
    Dynamics Group, Department of Biology, Beckman Research Institute of the City of Hope, 1450 East Duarte Road, Duarte, CA 91010, USA
    Funct Integr Genomics 1:186-92. 2000
  9. ncbi request reprint Signal processing and the design of microarray time-series experiments
    Robert R Klevecz
    Dynamics Group, Department of Biology, Beckman Research Institute of City of Hope Medical Center, Duarte, CA, USA
    Methods Mol Biol 377:75-94. 2007

Research Grants

  1. Folding and unfolding cellular phenotype
    ROBERT KLEVECZ; Fiscal Year: 2007

Collaborators

Detail Information

Publications9

  1. pmc Collective behavior in gene regulation: the cell is an oscillator, the cell cycle a developmental process
    Robert R Klevecz
    Dynamic Systems Group, Department of Biology, Beckman Research Institute, City of Hope Medical Center, Duarte CA 91010, USA
    FEBS J 275:2372-84. 2008
    ..We suggest that the information contained in this genome-wide oscillation is the dynamic code that organizes a stable phenotype from an otherwise passive genome...
  2. ncbi request reprint Generation and maintenance of synchrony in Saccharomyces cerevisiae continuous culture
    Douglas B Murray
    Faculty of Engineering, Science and Technology, South Bank University, 103 Borough Road, SE1 OAA, London, UK
    Exp Cell Res 287:10-5. 2003
    ..It is concluded that endogenously produced acetaldehyde and sulfite tune the oscillation of mitochondrial energization state whereas sulfide mediates population synchrony...
  3. pmc A genomewide oscillation in transcription gates DNA replication and cell cycle
    Robert R Klevecz
    Dynamics Group, Department of Biology, Beckman Research Institute of the City of Hope Medical Center, Duarte, CA 91010, USA
    Proc Natl Acad Sci U S A 101:1200-5. 2004
    ..Restriction of DNA synthesis to the reductive phase of the cycle may be an evolutionarily important mechanism for reducing oxidative damage to DNA during replication...
  4. pmc A rapid genome-scale response of the transcriptional oscillator to perturbation reveals a period-doubling path to phenotypic change
    Caroline M Li
    Dynamic Systems Group, Department of Biology, Beckman Research Institute, City of Hope Medical Center, Duarte, CA 91010, USA
    Proc Natl Acad Sci U S A 103:16254-9. 2006
    ..As a practical matter, low-amplitude, genome-wide oscillations, a ubiquitous but often unrecognized attribute of phenotype, could be a source of seemingly intractable biological noise in microarray studies...
  5. ncbi request reprint Genome wide oscillations in expression. Wavelet analysis of time series data from yeast expression arrays uncovers the dynamic architecture of phenotype
    R R Klevecz
    Department of Biology, Beckman Research Institute, City of Hope National Medical Center, Duarte, CA 91010, USA
    Mol Biol Rep 28:73-82. 2001
    ....
  6. pmc Evolution of the clock from yeast to man by period-doubling folds in the cellular oscillator
    R R Klevecz
    Department of Biology, Beckman Research Institute of the City of Hope Medical Center, Duarte, California 91010, USA
    Cold Spring Harb Symp Quant Biol 72:421-9. 2007
    ....
  7. ncbi request reprint Tuning in the transcriptome: basins of attraction in the yeast cell cycle
    R R Klevecz
    Department of Biology, Beckman Research Institute of the City of Hope, Duarte, CA 91010, USA
    Cell Prolif 33:209-18. 2000
    ....
  8. ncbi request reprint Dynamic architecture of the yeast cell cycle uncovered by wavelet decomposition of expression microarray data
    R R Klevecz
    Dynamics Group, Department of Biology, Beckman Research Institute of the City of Hope, 1450 East Duarte Road, Duarte, CA 91010, USA
    Funct Integr Genomics 1:186-92. 2000
    ..Gene expression and events within the yeast cell cycle may be regulated by an attractor whose fundamental period is an emergent property of dynamic interactions within the yeast transcriptome...
  9. ncbi request reprint Signal processing and the design of microarray time-series experiments
    Robert R Klevecz
    Dynamics Group, Department of Biology, Beckman Research Institute of City of Hope Medical Center, Duarte, CA, USA
    Methods Mol Biol 377:75-94. 2007
    ....

Research Grants1

  1. Folding and unfolding cellular phenotype
    ROBERT KLEVECZ; Fiscal Year: 2007
    ....