Abraham L Kierszenbaum

Summary

Affiliation: City University of New York
Country: USA

Publications

  1. ncbi request reprint Genomic origin, processing and developmental expression of testicular outer dense fiber 2 (ODF2) transcripts and a novel nucleolar localization of ODF2 protein
    Eugene Rivkin
    Department of Cell Biology and Anatomy, The Sophie Davis School of Biomedical Education, The City University of New York Medical School, New York, New York 10031, USA
    Mol Reprod Dev 75:1591-606. 2008
  2. pmc Testis-expressed profilins 3 and 4 show distinct functional characteristics and localize in the acroplaxome-manchette complex in spermatids
    Martina Behnen
    Department of Andrology, University Hospital Hamburg Eppendorf, Germany
    BMC Cell Biol 10:34. 2009
  3. pmc GMAP210 and IFT88 are present in the spermatid golgi apparatus and participate in the development of the acrosome-acroplaxome complex, head-tail coupling apparatus and tail
    Abraham L Kierszenbaum
    Department of Cell Biology and Anatomy, The Sophie Davis School of Biomedical Education, The City University of New York, New York, New York, USA
    Dev Dyn 240:723-36. 2011
  4. ncbi request reprint Genomic imprinting and epigenetic reprogramming: unearthing the garden of forking paths
    Abraham L Kierszenbaum
    Department of Cell Biology and Anatomical Sciences, The City University of New York Medical School, New York, New York 10031, USA
    Mol Reprod Dev 63:269-72. 2002
  5. ncbi request reprint Epididymal G protein-coupled receptor (GPCR): two hats and a two-piece suit tailored at the GPS motif
    Abraham L Kierszenbaum
    Department of Cell Biology and Anatomical Sciences, The City University of New York Medical School, New York, New York 10031, USA
    Mol Reprod Dev 64:1-3. 2003
  6. pmc Acroplaxome, an F-actin-keratin-containing plate, anchors the acrosome to the nucleus during shaping of the spermatid head
    Abraham L Kierszenbaum
    Department of Cell Biology and Anatomical Sciences, The Sophie Davis School of Biomedical Education The City University of New York Medical School, New York New York 10031, USA
    Mol Biol Cell 14:4628-40. 2003
  7. ncbi request reprint The acroplaxome is the docking site of Golgi-derived myosin Va/Rab27a/b- containing proacrosomal vesicles in wild-type and Hrb mutant mouse spermatids
    Abraham L Kierszenbaum
    Department of Cell Biology and Anatomical Sciences, The Sophie Davis School of Biomedical Education City University of New York Medical School, New York, New York 10031, USA
    Biol Reprod 70:1400-10. 2004
  8. ncbi request reprint Polycystins: what polycystic kidney disease tells us about sperm
    Abraham L Kierszenbaum
    Department of Cell Biology and Anatomical Sciences, The Sophie Davis School of Biomedical Education The City University of New York Medical School, New York, NY, USA
    Mol Reprod Dev 67:385-8. 2004
  9. ncbi request reprint The actin-based motor myosin Va is a component of the acroplaxome, an acrosome-nuclear envelope junctional plate, and of manchette-associated vesicles
    A L Kierszenbaum
    Department of Cell Biology and Anatomical Sciences, The City University of New York Medical School The Sophie Davis School of Biomedical Education, New York, NY 10031, USA
    Cytogenet Genome Res 103:337-44. 2003
  10. ncbi request reprint The acrosome-acroplaxome-manchette complex and the shaping of the spermatid head
    Abraham L Kierszenbaum
    Department of Cell Biology and Anatomical Sciences, The Sophie Davis School of Biomedical Education The City University of New York Medical School, New York, NY 10031, USA
    Arch Histol Cytol 67:271-84. 2004

Research Grants

  1. MICROTUBULE/KERATIN INTERACTIONS DURING SPERMATOGENESIS
    ABRAHAM KIERSZENBAUM; Fiscal Year: 1999
  2. MICROTUBULE/KERATIN INTERACTIONS DURING SPERMATOGENESIS
    ABRAHAM KIERSZENBAUM; Fiscal Year: 2000
  3. MICROTUBULE/KERATIN INTERACTIONS DURING SPERMATOGENESIS
    ABRAHAM KIERSZENBAUM; Fiscal Year: 2001
  4. MICROTUBULE/KERATIN INTERACTIONS DURING SPERMATOGENESIS
    ABRAHAM KIERSZENBAUM; Fiscal Year: 2002

Collaborators

Detail Information

Publications38

  1. ncbi request reprint Genomic origin, processing and developmental expression of testicular outer dense fiber 2 (ODF2) transcripts and a novel nucleolar localization of ODF2 protein
    Eugene Rivkin
    Department of Cell Biology and Anatomy, The Sophie Davis School of Biomedical Education, The City University of New York Medical School, New York, New York 10031, USA
    Mol Reprod Dev 75:1591-606. 2008
    ....
  2. pmc Testis-expressed profilins 3 and 4 show distinct functional characteristics and localize in the acroplaxome-manchette complex in spermatids
    Martina Behnen
    Department of Andrology, University Hospital Hamburg Eppendorf, Germany
    BMC Cell Biol 10:34. 2009
    ..The testis-specific isoforms profilin-3 (PFN3) and profilin-4 (PFN4) may have specialized roles in spermatogenic cells which are distinct from known functions fulfilled by the "somatic" profilins, profilin-1 (PFN1) and profilin-2 (PFN2)...
  3. pmc GMAP210 and IFT88 are present in the spermatid golgi apparatus and participate in the development of the acrosome-acroplaxome complex, head-tail coupling apparatus and tail
    Abraham L Kierszenbaum
    Department of Cell Biology and Anatomy, The Sophie Davis School of Biomedical Education, The City University of New York, New York, New York, USA
    Dev Dyn 240:723-36. 2011
    ....
  4. ncbi request reprint Genomic imprinting and epigenetic reprogramming: unearthing the garden of forking paths
    Abraham L Kierszenbaum
    Department of Cell Biology and Anatomical Sciences, The City University of New York Medical School, New York, New York 10031, USA
    Mol Reprod Dev 63:269-72. 2002
    ....
  5. ncbi request reprint Epididymal G protein-coupled receptor (GPCR): two hats and a two-piece suit tailored at the GPS motif
    Abraham L Kierszenbaum
    Department of Cell Biology and Anatomical Sciences, The City University of New York Medical School, New York, New York 10031, USA
    Mol Reprod Dev 64:1-3. 2003
    ..It is also conceivable that events taking place in the epididymal lumen can be surveyed by the long adhesive rod and subsequently coupled inside principal cells to a signaling cascade...
  6. pmc Acroplaxome, an F-actin-keratin-containing plate, anchors the acrosome to the nucleus during shaping of the spermatid head
    Abraham L Kierszenbaum
    Department of Cell Biology and Anatomical Sciences, The Sophie Davis School of Biomedical Education The City University of New York Medical School, New York New York 10031, USA
    Mol Biol Cell 14:4628-40. 2003
    ..The acroplaxome may also provide a mechanical planar scaffold modulating external clutching forces generated by a stack of Sertoli cell F-actin-containing hoops encircling the elongating spermatid nucleus...
  7. ncbi request reprint The acroplaxome is the docking site of Golgi-derived myosin Va/Rab27a/b- containing proacrosomal vesicles in wild-type and Hrb mutant mouse spermatids
    Abraham L Kierszenbaum
    Department of Cell Biology and Anatomical Sciences, The Sophie Davis School of Biomedical Education City University of New York Medical School, New York, New York 10031, USA
    Biol Reprod 70:1400-10. 2004
    ..We suggest that nucleopodes develop at a site where a keratin 5-deficient acroplaxome may not withstand tension forces operating during spermatid nuclear shaping...
  8. ncbi request reprint Polycystins: what polycystic kidney disease tells us about sperm
    Abraham L Kierszenbaum
    Department of Cell Biology and Anatomical Sciences, The Sophie Davis School of Biomedical Education The City University of New York Medical School, New York, NY, USA
    Mol Reprod Dev 67:385-8. 2004
    ..Future studies leading to the identification of specific ligands for polycystins, including the signaling pathways, might define the puzzling relationship between renal tubular morphogenesis and sperm development and function...
  9. ncbi request reprint The actin-based motor myosin Va is a component of the acroplaxome, an acrosome-nuclear envelope junctional plate, and of manchette-associated vesicles
    A L Kierszenbaum
    Department of Cell Biology and Anatomical Sciences, The City University of New York Medical School The Sophie Davis School of Biomedical Education, New York, NY 10031, USA
    Cytogenet Genome Res 103:337-44. 2003
    ....
  10. ncbi request reprint The acrosome-acroplaxome-manchette complex and the shaping of the spermatid head
    Abraham L Kierszenbaum
    Department of Cell Biology and Anatomical Sciences, The Sophie Davis School of Biomedical Education The City University of New York Medical School, New York, NY 10031, USA
    Arch Histol Cytol 67:271-84. 2004
    ....
  11. ncbi request reprint Tyrosine protein kinases and spermatogenesis: truncation matters
    Abraham L Kierszenbaum
    Department of Cell Biology and Anatomical Sciences, The Sophie Davis School of Biomedical Education The City University of New York Medical School, New York, NY 10031, USA
    Mol Reprod Dev 73:399-403. 2006
    ..The production of compound and viable mutant mice, lacking the expression of two or more tyrosine kinases, may shed light on this intriguing issue...
  12. ncbi request reprint Cell-cycle regulation and mammalian gametogenesis: a lesson from the unexpected
    Abraham L Kierszenbaum
    Department of Cell Biology and Anatomical Sciences, The Sophie Davis School of Biomedical Education, The City University of New York Medical School, New York, New York 10031, USA
    Mol Reprod Dev 73:939-42. 2006
    ....
  13. ncbi request reprint Molecular biology of sperm head shaping
    Abraham L Kierszenbaum
    Department of Cell Biology and Anatomical Sciences, The Sophie Davis School of Biomedical Education The City University of New York Medical School, New York, NY 10031, USA
    Soc Reprod Fertil Suppl 65:33-43. 2007
    ..The acroplaxome-manchette perinuclear rings may reduce their diameter to balance exogenous constriction forces generated by the embracing Sertoli cell F-actin hoops and guide nuclear elongation...
  14. ncbi request reprint Expression of Fer testis (FerT) tyrosine kinase transcript variants and distribution sites of FerT during the development of the acrosome-acroplaxome-manchette complex in rat spermatids
    Abraham L Kierszenbaum
    Department of Cell Biology and Anatomy, CUNY Medical School, Harris Hall Suite 306, 160 Convent Avenue, New York, NY 10031, USA
    Dev Dyn 237:3882-91. 2008
    ..We propose that FerT participates in acrosome development and that phosphorylated cortactin may contribute to structural changes in F-actin in the acroplaxome during spermatid head shaping...
  15. doi request reprint Expression of full-length and truncated Fyn tyrosine kinase transcripts and encoded proteins during spermatogenesis and localization during acrosome biogenesis and fertilization
    Abraham L Kierszenbaum
    Department of Cell Biology and Anatomy, The Sophie Davis School of Biomedical Education The City University of New York Medical School, New York, New York 10031, USA
    Mol Reprod Dev 76:832-43. 2009
    ..During fertilization, full-length Fyn in the acroplaxome may contribute to a transient local signaling burst during the early events of sperm-egg interaction...
  16. ncbi request reprint Ran, a GTP-binding protein involved in nucleocytoplasmic transport and microtubule nucleation, relocates from the manchette to the centrosome region during rat spermiogenesis
    Abraham L Kierszenbaum
    Department of Cell Biology and Anatomical Sciences, CUNY Medical School, New York, New York 10031, USA
    Mol Reprod Dev 63:131-40. 2002
    ....
  17. ncbi request reprint Intramanchette transport (IMT): managing the making of the spermatid head, centrosome, and tail
    Abraham L Kierszenbaum
    Department of Cell Biology and Anatomical Sciences, The City University of New York Medical School, New York, New York 10031, USA
    Mol Reprod Dev 63:1-4. 2002
    ..Details of specific role of Ran GTPase in nucleocytoplasmic transport and its relocation from the manchette to the centrosome to the sperm tail await elucidation...
  18. ncbi request reprint Fusion of membranes during the acrosome reaction: a tale of two SNAREs
    A L Kierszenbaum
    Department of Cell Biology and Anatomical Sciences, The City University of New York Medical School, New York, NY 10031, USA
    Mol Reprod Dev 57:309-10. 2000
    ..Syntaxin 2, a v-SNARE member, and Rab3A, a member of the Rab GTPases, have been localized in the acrosome of rodent sperm...
  19. ncbi request reprint The 26S proteasome: ubiquitin-mediated proteolysis in the tunnel
    A L Kierszenbaum
    Department of Cell Biology and Anatomical Sciences, The City University of New York Medical School, New York, NY 10031, USA
    Mol Reprod Dev 57:109-10. 2000
    ..The 26S proteasome is a representative of emerging group of giant proteases, including tricorn protease, multicorn protease, and TPPII (tripeptidyl peptidase II)...
  20. ncbi request reprint Apoptosis during spermatogenesis: the thrill of being alive
    A L Kierszenbaum
    Department of Cell Biology and Anatomical Sciences, The City University of New York Medical School, New York 10031, USA
    Mol Reprod Dev 58:1-3. 2001
    ....
  21. ncbi request reprint Transition nuclear proteins during spermiogenesis: unrepaired DNA breaks not allowed
    A L Kierszenbaum
    Department of Cell Biology and Anatomical Sciences, The City University of New York Medical School, New York, NY 10031, USA
    Mol Reprod Dev 58:357-8. 2001
    ..TP1 seems to hold the broken ends together until an as-yet-unidentified ligase bridges the gap...
  22. ncbi request reprint Galactosyl receptor, a cell surface C-type lectin of normal and tumoral prostate epithelial cells with binding affinity to endothelial cells
    A L Kierszenbaum
    Department of Cell Biology and Anatomical Sciences, City University of New York Medical School, New York, NY 10031, USA
    Prostate 43:175-83. 2000
    ..The use of inhibitors targeting the CRD would be very valuable in hindering the binding of prostate cancer cells to endothelial cells, thus decreasing the incidence of hematogenous metastasis to bone...
  23. ncbi request reprint Spermatid manchette: plugging proteins to zero into the sperm tail
    A L Kierszenbaum
    Department of Cell Biology and Anatomical Sciences, The City University of New York Medical School, 138th Street and Convent Avenue, New York, NY 10031, USA
    Mol Reprod Dev 59:347-9. 2001
    ..Mol. Reprod. Dev. 59: 347-349, 2001...
  24. ncbi request reprint Primordial germ cell-somatic cell partnership: a balancing cell signaling act
    A L Kierszenbaum
    Department of Cell Biology and Anatomical Sciences, The City University of New York Medical School, 138th St Convent Avenue, New York, NY 10031, USA
    Mol Reprod Dev 60:277-80. 2001
    ..Information on other inducers of primordial cell survival, such as TER (teratoma) factor, is beginning to emerge...
  25. ncbi request reprint Nuclear transfer and cell transplantation: making more with less
    A L Kierszenbaum
    Department of Cell Biology and Anatomical Sciences, The City University of New York Medical School, New York, NY 10031, USA
    Mol Reprod Dev 57:211-3. 2000
    ....
  26. ncbi request reprint Sperm axoneme: a tale of tubulin posttranslation diversity
    Abraham L Kierszenbaum
    Department of Cell Biology and Anatomical Sciences, The City University of New York Medical School, 138th Street and Convent Ave, New York, NY 10031, USA
    Mol Reprod Dev 62:1-3. 2002
    ..It remains to be determined whether other newcomers to the superfamily of tubulins contain sites prone to posttranslational modification...
  27. ncbi request reprint Keratins: unraveling the coordinated construction of scaffolds in spermatogenic cells
    Abraham L Kierszenbaum
    Department of Cell Biology and Anatomical Sciences, The City University of New York Medical School, New York, New York 10031, USA
    Mol Reprod Dev 61:1-2. 2002
    ....
  28. ncbi request reprint Caspase activity inhibition delays programmed spermatogenic cell death in vitro
    Laura L Tres
    Department of Cell Biology and Anatomical Sciences, The Sophie Davis School of Biomedical Education The City University of New York Medical School, New York, NY 10031, USA
    Arch Histol Cytol 67:315-24. 2004
    ....
  29. ncbi request reprint The ADAM-integrin-tetraspanin complex in fetal and postnatal testicular cords
    Laura L Tres
    Department of Cell Biology and Anatomical Sciences, The Sophie Davis School of Biomedical Education The City University of New York Medical School, 138th Street and Convent Avenue, New York, NY 10031, USA
    Birth Defects Res C Embryo Today 75:130-41. 2005
    ..In apoptotic prespermatogonia, immunoreactive clusters are restricted to sites where the attachment of prespermatogonia/spermatogonia to Sertoli cell surfaces is still preserved...
  30. ncbi request reprint Rnf19a, a ubiquitin protein ligase, and Psmc3, a component of the 26S proteasome, tether to the acrosome membranes and the head-tail coupling apparatus during rat spermatid development
    Eugene Rivkin
    Department of Cell Biology and Anatomy, The Sophie Davis School of Biomedical Education, New York, New York 10031, USA
    Dev Dyn 238:1851-61. 2009
    ....
  31. ncbi request reprint Chronological gene expression of ADAMs during testicular development: prespermatogonia (gonocytes) express fertilin beta (ADAM2)
    Carolina Rosselot
    Department of Cell Biology and Anatomical Sciences, The Sophie Davis School of Biomedical Education The City University of New York Medical School, New York, New York, USA
    Dev Dyn 227:458-67. 2003
    ..These observations indicate that PSG in coculture with Sertoli cells provide a suitable approach for analyzing cell-cell adhesive responses involving spermatogenic cell-specific ADAMs...
  32. ncbi request reprint Role of integrins, tetraspanins, and ADAM proteins during the development of apoptotic bodies by spermatogenic cells
    Abraham L Kierszenbaum
    Department of Cell Biology and Anatomical Sciences, The Sophie Davis School of Biomedical Education The City University of New York Medical School, New York, NY 10031, USA
    Mol Reprod Dev 73:906-17. 2006
    ..As a result, Sertoli cell reduction in surface area may be a limiting factor of spermatogenic cell survival and in the developmental regulation of spermatogenic cell progenies in the intact seminiferous epithelium...
  33. ncbi request reprint Sperm tail abnormalities in mutant mice with neo(r) gene insertion into an intron of the keratin 9 gene
    Eugene Rivkin
    Department of Cell Biology and Anatomical Sciences, The Sophie Davis School of Biomedical Education, The City University of New York Medical School, 138th Street and Convent Avenue, Harris Hall 306, New York, NY, USA
    Mol Reprod Dev 72:259-71. 2005
    ..Results of this study support the view that intron 6 influences the transcriptional efficiency of the K9 gene by decreasing production of wild-type K9 and changing the expression of K9 proteins...
  34. ncbi request reprint Primordial germ cells: what does it take to be alive?
    Laura L Tres
    Department of Cell Biology and Anatomical Sciences, The Sophie Davis School of Biomedical Education, The City University of New York Medical School, New York, New York 10031, USA
    Mol Reprod Dev 68:1-4. 2004
    ....
  35. ncbi request reprint Bypassing natural sperm selection during fertilization: the azh mutant offspring experience and the alternative of spermiogenesis in vitro
    Abraham L Kierszenbaum
    Department of Cell Biology and Anatomical Sciences, The City University of New York Medical School, 138th Street and Convent Avenue, J 903, New York, NY 10031, USA
    Mol Cell Endocrinol 187:133-8. 2002
    ..Available data indicate that the manchette is a highly dynamic structure providing microtubular tracks to structural proteins participating in the sperm tail development...
  36. ncbi request reprint Molecular cloning of rat sperm galactosyl receptor, a C-type lectin with in vitro egg binding activity
    E Rivkin
    Department of Cell Biology and Anatomical Sciences, The City University of New York Medical School, New York, New York
    Mol Reprod Dev 56:401-11. 2000
    ....
  37. ncbi request reprint A protein associated with the manchette during rat spermiogenesis is encoded by a gene of the TBP-1-like subfamily with highly conserved ATPase and protease domains
    E Rivkin
    Department of Cell Biology and Anatomical Sciences, The City University of New York Medical School, New York 10031, USA
    Mol Reprod Dev 48:77-89. 1997
    ....
  38. ncbi request reprint Keratin 9 is a component of the perinuclear ring of the manchette of rat spermatids
    K Mochida
    Department of Cell Biology and Anatomical Sciences, The City University of New York Medical School, New York, New York 10031, USA
    Dev Biol 227:510-9. 2000
    ..Results of this study show that rat testis expresses K9 and that this protein is a component the perinuclear ring of the manchette of rat spermatids...

Research Grants4

  1. MICROTUBULE/KERATIN INTERACTIONS DURING SPERMATOGENESIS
    ABRAHAM KIERSZENBAUM; Fiscal Year: 1999
    ..Engineering mouse models in which the expression of K9 is null, is important for both reproductive biology and cancer research. ..
  2. MICROTUBULE/KERATIN INTERACTIONS DURING SPERMATOGENESIS
    ABRAHAM KIERSZENBAUM; Fiscal Year: 2000
    ..Engineering mouse models in which the expression of K9 is null, is important for both reproductive biology and cancer research. ..
  3. MICROTUBULE/KERATIN INTERACTIONS DURING SPERMATOGENESIS
    ABRAHAM KIERSZENBAUM; Fiscal Year: 2001
    ..Engineering mouse models in which the expression of K9 is null, is important for both reproductive biology and cancer research. ..
  4. MICROTUBULE/KERATIN INTERACTIONS DURING SPERMATOGENESIS
    ABRAHAM KIERSZENBAUM; Fiscal Year: 2002
    ..Engineering mouse models in which the expression of K9 is null, is important for both reproductive biology and cancer research. ..