Research Topics
Genomes and Genes
| Abraham L KierszenbaumSummaryAffiliation: City University of New York Country: USA Publications
Research Grants
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Detail Information
Publications
Genomic origin, processing and developmental expression of testicular outer dense fiber 2 (ODF2) transcripts and a novel nucleolar localization of ODF2 proteinEugene Rivkin
Department of Cell Biology and Anatomy, The Sophie Davis School of Biomedical Education, The City University of New York Medical School, New York, New York 10031, USA
Mol Reprod Dev 75:1591-606. 2008....
Testis-expressed profilins 3 and 4 show distinct functional characteristics and localize in the acroplaxome-manchette complex in spermatidsMartina Behnen
Department of Andrology, University Hospital Hamburg Eppendorf, Germany
BMC Cell Biol 10:34. 2009....- GMAP210 and IFT88 are present in the spermatid golgi apparatus and participate in the development of the acrosome-acroplaxome complex, head-tail coupling apparatus and tailAbraham L Kierszenbaum
Department of Cell Biology and Anatomy, The Sophie Davis School of Biomedical Education, The City University of New York, New York, New York, USA
Dev Dyn 240:723-36. 2011.... 
Genomic imprinting and epigenetic reprogramming: unearthing the garden of forking pathsAbraham L Kierszenbaum
Department of Cell Biology and Anatomical Sciences, The City University of New York Medical School, New York, New York 10031, USA
Mol Reprod Dev 63:269-72. 2002....- Epididymal G protein-coupled receptor (GPCR): two hats and a two-piece suit tailored at the GPS motifAbraham L Kierszenbaum
Department of Cell Biology and Anatomical Sciences, The City University of New York Medical School, New York, New York 10031, USA
Mol Reprod Dev 64:1-3. 2003..It is also conceivable that events taking place in the epididymal lumen can be surveyed by the long adhesive rod and subsequently coupled inside principal cells to a signaling cascade... - Acroplaxome, an F-actin-keratin-containing plate, anchors the acrosome to the nucleus during shaping of the spermatid headAbraham L Kierszenbaum
Department of Cell Biology and Anatomical Sciences, The Sophie Davis School of Biomedical Education The City University of New York Medical School, New York New York 10031, USA
Mol Biol Cell 14:4628-40. 2003..The acroplaxome may also provide a mechanical planar scaffold modulating external clutching forces generated by a stack of Sertoli cell F-actin-containing hoops encircling the elongating spermatid nucleus... - The acroplaxome is the docking site of Golgi-derived myosin Va/Rab27a/b- containing proacrosomal vesicles in wild-type and Hrb mutant mouse spermatidsAbraham L Kierszenbaum
Department of Cell Biology and Anatomical Sciences, The Sophie Davis School of Biomedical Education City University of New York Medical School, New York, New York 10031, USA
Biol Reprod 70:1400-10. 2004..We suggest that nucleopodes develop at a site where a keratin 5-deficient acroplaxome may not withstand tension forces operating during spermatid nuclear shaping... - Polycystins: what polycystic kidney disease tells us about spermAbraham L Kierszenbaum
Department of Cell Biology and Anatomical Sciences, The Sophie Davis School of Biomedical Education The City University of New York Medical School, New York, NY, USA
Mol Reprod Dev 67:385-8. 2004..Future studies leading to the identification of specific ligands for polycystins, including the signaling pathways, might define the puzzling relationship between renal tubular morphogenesis and sperm development and function... - The actin-based motor myosin Va is a component of the acroplaxome, an acrosome-nuclear envelope junctional plate, and of manchette-associated vesiclesA L Kierszenbaum
Department of Cell Biology and Anatomical Sciences, The City University of New York Medical School The Sophie Davis School of Biomedical Education, New York, NY 10031, USA
Cytogenet Genome Res 103:337-44. 2003.... - The acrosome-acroplaxome-manchette complex and the shaping of the spermatid headAbraham L Kierszenbaum
Department of Cell Biology and Anatomical Sciences, The Sophie Davis School of Biomedical Education The City University of New York Medical School, New York, NY 10031, USA
Arch Histol Cytol 67:271-84. 2004.... - Tyrosine protein kinases and spermatogenesis: truncation mattersAbraham L Kierszenbaum
Department of Cell Biology and Anatomical Sciences, The Sophie Davis School of Biomedical Education The City University of New York Medical School, New York, NY 10031, USA
Mol Reprod Dev 73:399-403. 2006..The production of compound and viable mutant mice, lacking the expression of two or more tyrosine kinases, may shed light on this intriguing issue... - Cell-cycle regulation and mammalian gametogenesis: a lesson from the unexpectedAbraham L Kierszenbaum
Department of Cell Biology and Anatomical Sciences, The Sophie Davis School of Biomedical Education, The City University of New York Medical School, New York, New York 10031, USA
Mol Reprod Dev 73:939-42. 2006.... - Molecular biology of sperm head shapingAbraham L Kierszenbaum
Department of Cell Biology and Anatomical Sciences, The Sophie Davis School of Biomedical Education The City University of New York Medical School, New York, NY 10031, USA
Soc Reprod Fertil Suppl 65:33-43. 2007..The acroplaxome-manchette perinuclear rings may reduce their diameter to balance exogenous constriction forces generated by the embracing Sertoli cell F-actin hoops and guide nuclear elongation... - Expression of Fer testis (FerT) tyrosine kinase transcript variants and distribution sites of FerT during the development of the acrosome-acroplaxome-manchette complex in rat spermatidsAbraham L Kierszenbaum
Department of Cell Biology and Anatomy, CUNY Medical School, Harris Hall Suite 306, 160 Convent Avenue, New York, NY 10031, USA
Dev Dyn 237:3882-91. 2008..We propose that FerT participates in acrosome development and that phosphorylated cortactin may contribute to structural changes in F-actin in the acroplaxome during spermatid head shaping... - Expression of full-length and truncated Fyn tyrosine kinase transcripts and encoded proteins during spermatogenesis and localization during acrosome biogenesis and fertilizationAbraham L Kierszenbaum
Department of Cell Biology and Anatomy, The Sophie Davis School of Biomedical Education The City University of New York Medical School, New York, New York 10031, USA
Mol Reprod Dev 76:832-43. 2009..During fertilization, full-length Fyn in the acroplaxome may contribute to a transient local signaling burst during the early events of sperm-egg interaction... - Ran, a GTP-binding protein involved in nucleocytoplasmic transport and microtubule nucleation, relocates from the manchette to the centrosome region during rat spermiogenesisAbraham L Kierszenbaum
Department of Cell Biology and Anatomical Sciences, CUNY Medical School, New York, New York 10031, USA
Mol Reprod Dev 63:131-40. 2002.... - Intramanchette transport (IMT): managing the making of the spermatid head, centrosome, and tailAbraham L Kierszenbaum
Department of Cell Biology and Anatomical Sciences, The City University of New York Medical School, New York, New York 10031, USA
Mol Reprod Dev 63:1-4. 2002..Details of specific role of Ran GTPase in nucleocytoplasmic transport and its relocation from the manchette to the centrosome to the sperm tail await elucidation... - Fusion of membranes during the acrosome reaction: a tale of two SNAREsA L Kierszenbaum
Department of Cell Biology and Anatomical Sciences, The City University of New York Medical School, New York, NY 10031, USA
Mol Reprod Dev 57:309-10. 2000..Syntaxin 2, a v-SNARE member, and Rab3A, a member of the Rab GTPases, have been localized in the acrosome of rodent sperm... - The 26S proteasome: ubiquitin-mediated proteolysis in the tunnelA L Kierszenbaum
Department of Cell Biology and Anatomical Sciences, The City University of New York Medical School, New York, NY 10031, USA
Mol Reprod Dev 57:109-10. 2000..The 26S proteasome is a representative of emerging group of giant proteases, including tricorn protease, multicorn protease, and TPPII (tripeptidyl peptidase II)... - Apoptosis during spermatogenesis: the thrill of being aliveA L Kierszenbaum
Department of Cell Biology and Anatomical Sciences, The City University of New York Medical School, New York 10031, USA
Mol Reprod Dev 58:1-3. 2001.... - Transition nuclear proteins during spermiogenesis: unrepaired DNA breaks not allowedA L Kierszenbaum
Department of Cell Biology and Anatomical Sciences, The City University of New York Medical School, New York, NY 10031, USA
Mol Reprod Dev 58:357-8. 2001..TP1 seems to hold the broken ends together until an as-yet-unidentified ligase bridges the gap... - Galactosyl receptor, a cell surface C-type lectin of normal and tumoral prostate epithelial cells with binding affinity to endothelial cellsA L Kierszenbaum
Department of Cell Biology and Anatomical Sciences, City University of New York Medical School, New York, NY 10031, USA
Prostate 43:175-83. 2000..The use of inhibitors targeting the CRD would be very valuable in hindering the binding of prostate cancer cells to endothelial cells, thus decreasing the incidence of hematogenous metastasis to bone... - Spermatid manchette: plugging proteins to zero into the sperm tailA L Kierszenbaum
Department of Cell Biology and Anatomical Sciences, The City University of New York Medical School, 138th Street and Convent Avenue, New York, NY 10031, USA
Mol Reprod Dev 59:347-9. 2001..Mol. Reprod. Dev. 59: 347-349, 2001... - Primordial germ cell-somatic cell partnership: a balancing cell signaling actA L Kierszenbaum
Department of Cell Biology and Anatomical Sciences, The City University of New York Medical School, 138th St Convent Avenue, New York, NY 10031, USA
Mol Reprod Dev 60:277-80. 2001..Information on other inducers of primordial cell survival, such as TER (teratoma) factor, is beginning to emerge... - Nuclear transfer and cell transplantation: making more with lessA L Kierszenbaum
Department of Cell Biology and Anatomical Sciences, The City University of New York Medical School, New York, NY 10031, USA
Mol Reprod Dev 57:211-3. 2000.... - Sperm axoneme: a tale of tubulin posttranslation diversityAbraham L Kierszenbaum
Department of Cell Biology and Anatomical Sciences, The City University of New York Medical School, 138th Street and Convent Ave, New York, NY 10031, USA
Mol Reprod Dev 62:1-3. 2002..It remains to be determined whether other newcomers to the superfamily of tubulins contain sites prone to posttranslational modification... - Keratins: unraveling the coordinated construction of scaffolds in spermatogenic cellsAbraham L Kierszenbaum
Department of Cell Biology and Anatomical Sciences, The City University of New York Medical School, New York, New York 10031, USA
Mol Reprod Dev 61:1-2. 2002.... - Caspase activity inhibition delays programmed spermatogenic cell death in vitroLaura L Tres
Department of Cell Biology and Anatomical Sciences, The Sophie Davis School of Biomedical Education The City University of New York Medical School, New York, NY 10031, USA
Arch Histol Cytol 67:315-24. 2004.... - The ADAM-integrin-tetraspanin complex in fetal and postnatal testicular cordsLaura L Tres
Department of Cell Biology and Anatomical Sciences, The Sophie Davis School of Biomedical Education The City University of New York Medical School, 138th Street and Convent Avenue, New York, NY 10031, USA
Birth Defects Res C Embryo Today 75:130-41. 2005..In apoptotic prespermatogonia, immunoreactive clusters are restricted to sites where the attachment of prespermatogonia/spermatogonia to Sertoli cell surfaces is still preserved... - Rnf19a, a ubiquitin protein ligase, and Psmc3, a component of the 26S proteasome, tether to the acrosome membranes and the head-tail coupling apparatus during rat spermatid developmentEugene Rivkin
Department of Cell Biology and Anatomy, The Sophie Davis School of Biomedical Education, New York, New York 10031, USA
Dev Dyn 238:1851-61. 2009.... - Chronological gene expression of ADAMs during testicular development: prespermatogonia (gonocytes) express fertilin beta (ADAM2)Carolina Rosselot
Department of Cell Biology and Anatomical Sciences, The Sophie Davis School of Biomedical Education/The City University of New York Medical School, New York, New York, USA
Dev Dyn 227:458-67. 2003..These observations indicate that PSG in coculture with Sertoli cells provide a suitable approach for analyzing cell-cell adhesive responses involving spermatogenic cell-specific ADAMs... - Role of integrins, tetraspanins, and ADAM proteins during the development of apoptotic bodies by spermatogenic cellsAbraham L Kierszenbaum
Department of Cell Biology and Anatomical Sciences, The Sophie Davis School of Biomedical Education The City University of New York Medical School, New York, NY 10031, USA
Mol Reprod Dev 73:906-17. 2006..As a result, Sertoli cell reduction in surface area may be a limiting factor of spermatogenic cell survival and in the developmental regulation of spermatogenic cell progenies in the intact seminiferous epithelium... - Sperm tail abnormalities in mutant mice with neo(r) gene insertion into an intron of the keratin 9 geneEugene Rivkin
Department of Cell Biology and Anatomical Sciences, The Sophie Davis School of Biomedical Education, The City University of New York Medical School, 138th Street and Convent Avenue, Harris Hall 306, New York, NY, USA
Mol Reprod Dev 72:259-71. 2005..Results of this study support the view that intron 6 influences the transcriptional efficiency of the K9 gene by decreasing production of wild-type K9 and changing the expression of K9 proteins... - Primordial germ cells: what does it take to be alive?Laura L Tres
Department of Cell Biology and Anatomical Sciences, The Sophie Davis School of Biomedical Education, The City University of New York Medical School, New York, New York 10031, USA
Mol Reprod Dev 68:1-4. 2004.... - Bypassing natural sperm selection during fertilization: the azh mutant offspring experience and the alternative of spermiogenesis in vitroAbraham L Kierszenbaum
Department of Cell Biology and Anatomical Sciences, The City University of New York Medical School, 138th Street and Convent Avenue, J 903, New York, NY 10031, USA
Mol Cell Endocrinol 187:133-8. 2002..Available data indicate that the manchette is a highly dynamic structure providing microtubular tracks to structural proteins participating in the sperm tail development... - Molecular cloning of rat sperm galactosyl receptor, a C-type lectin with in vitro egg binding activityE Rivkin
Department of Cell Biology and Anatomical Sciences, The City University of New York Medical School, New York, New York
Mol Reprod Dev 56:401-11. 2000.... - A protein associated with the manchette during rat spermiogenesis is encoded by a gene of the TBP-1-like subfamily with highly conserved ATPase and protease domainsE Rivkin
Department of Cell Biology and Anatomical Sciences, The City University of New York Medical School, New York 10031, USA
Mol Reprod Dev 48:77-89. 1997.... - Keratin 9 is a component of the perinuclear ring of the manchette of rat spermatidsK Mochida
Department of Cell Biology and Anatomical Sciences, The City University of New York Medical School, New York, New York 10031, USA
Dev Biol 227:510-9. 2000..Results of this study show that rat testis expresses K9 and that this protein is a component the perinuclear ring of the manchette of rat spermatids...
Research Grants
- MICROTUBULE/KERATIN INTERACTIONS DURING SPERMATOGENESISABRAHAM KIERSZENBAUM; Fiscal Year: 2002..Engineering mouse models in which the expression of K9 is null, is important for both reproductive biology and cancer research. ..