B Kest

Summary

Affiliation: City University of New York
Country: USA

Publications

  1. ncbi request reprint Assessment of acute and chronic morphine dependence in male and female mice
    B Kest
    Department of Psychology and Center for Developmental Neuroscience, College of Staten Island City University of New York, Staten Island, NY 10314, USA
    Pharmacol Biochem Behav 70:149-56. 2001
  2. ncbi request reprint Genetic variation in morphine analgesic tolerance: a survey of 11 inbred mouse strains
    Benjamin Kest
    Department of Psychology and Center for Developmental Neuroscience, The College of Staten Island, City University of New York, Staten Island, NY 10314, USA
    Pharmacol Biochem Behav 73:821-8. 2002
  3. ncbi request reprint Mapping of a quantitative trait locus for morphine withdrawal severity
    Benjamin Kest
    Department of Psychology, The College of Staten Island, City University of New York, 10314, USA
    Mamm Genome 15:610-7. 2004
  4. ncbi request reprint Morphine tolerance and dependence in nociceptin/orphanin FQ transgenic knock-out mice
    B Kest
    Department of Psychology and Center for Developmental Neuroscience, The College of Staten Island, City University of New York, Staten Island 10314 USA
    Neuroscience 104:217-22. 2001
  5. ncbi request reprint Morphine tolerance after chronic intracerebroventricular injection in male and female mice
    B Kest
    Department of Psychology and Center for Developmental Neuroscience, 4S 223, The College of Staten Island City University of New York, 2800 Victory Blvd, Staten Island, New York, NY 10314, USA
    Brain Res 892:208-10. 2001
  6. ncbi request reprint A comparison of morphine analgesic tolerance in male and female mice
    B Kest
    Department of Psychology 4S 223, The College of Staten Island City University of New York, 2800 Victory Blvd, Staten Island, NY 10314, USA
    Brain Res 879:17-22. 2000
  7. ncbi request reprint Sex differences in thermoregulation after acute and chronic morphine administration in mice
    B Kest
    Department of Psychology and Center for Developmental Neuroscience, The College of Staten Island, City University of New York, NY 10314, Staten Island, USA
    Neurosci Lett 291:126-8. 2000
  8. ncbi request reprint Sex differences in supraspinal morphine analgesia are dependent on genotype
    B Kest
    The College of Staten Island City University of New York and College of Staten Island Institute for Basic Research Center for Developmental Neuroscience, Staten Island, New York, USA
    J Pharmacol Exp Ther 289:1370-5. 1999
  9. ncbi request reprint Mu and delta opioid receptor analgesia, binding density, and mRNA levels in mice selectively bred for high and low analgesia
    B Kest
    The College of Staten Island City University of New York, Staten Island, NY 10314, USA
    Brain Res 816:381-9. 1999
  10. ncbi request reprint Acute morphine dependence in mice selectively-bred for high and low analgesia
    B Kest
    Department of Psychology, The College of Staten Island CUNY, NY 10314, USA
    Neurosci Lett 256:120-2. 1998

Collaborators

Detail Information

Publications29

  1. ncbi request reprint Assessment of acute and chronic morphine dependence in male and female mice
    B Kest
    Department of Psychology and Center for Developmental Neuroscience, College of Staten Island City University of New York, Staten Island, NY 10314, USA
    Pharmacol Biochem Behav 70:149-56. 2001
    ..The present study demonstrates the development of greater physical dependence in male relative to female mice following acute but not chronic morphine administration...
  2. ncbi request reprint Genetic variation in morphine analgesic tolerance: a survey of 11 inbred mouse strains
    Benjamin Kest
    Department of Psychology and Center for Developmental Neuroscience, The College of Staten Island, City University of New York, Staten Island, NY 10314, USA
    Pharmacol Biochem Behav 73:821-8. 2002
    ..The present work demonstrates that the presence and magnitude of morphine analgesic tolerance is genotype-dependent and identifies strains with widely divergent liabilities that should facilitate identification of trait-relevant genes...
  3. ncbi request reprint Mapping of a quantitative trait locus for morphine withdrawal severity
    Benjamin Kest
    Department of Psychology, The College of Staten Island, City University of New York, 10314, USA
    Mamm Genome 15:610-7. 2004
    ..The significant quantitative trait locus for naloxone-precipitated withdrawal severity in morphine-dependent mice, which we name Depmq1, may prove to be of considerable heuristic value once the underlying gene or genes are identified...
  4. ncbi request reprint Morphine tolerance and dependence in nociceptin/orphanin FQ transgenic knock-out mice
    B Kest
    Department of Psychology and Center for Developmental Neuroscience, The College of Staten Island, City University of New York, Staten Island 10314 USA
    Neuroscience 104:217-22. 2001
    ..Use of nociception/orphaninFQ transgenic knock-out mice thus demonstrate the differential involvement of nociceptin/orphanin FQ in morphine tolerance and dependence...
  5. ncbi request reprint Morphine tolerance after chronic intracerebroventricular injection in male and female mice
    B Kest
    Department of Psychology and Center for Developmental Neuroscience, 4S 223, The College of Staten Island City University of New York, 2800 Victory Blvd, Staten Island, New York, NY 10314, USA
    Brain Res 892:208-10. 2001
    ..The data suggest that spinal opioid analgesic mechanisms, acting alone or in synergy with supraspinal loci, may contribute to pharmacodynamic explanations of sex differences in systemic morphine tolerance...
  6. ncbi request reprint A comparison of morphine analgesic tolerance in male and female mice
    B Kest
    Department of Psychology 4S 223, The College of Staten Island City University of New York, 2800 Victory Blvd, Staten Island, NY 10314, USA
    Brain Res 879:17-22. 2000
    ..Furthermore, the duration and/or cumulative dose of morphine treatment does not affect the expression of sex differences in morphine tolerance...
  7. ncbi request reprint Sex differences in thermoregulation after acute and chronic morphine administration in mice
    B Kest
    Department of Psychology and Center for Developmental Neuroscience, The College of Staten Island, City University of New York, NY 10314, Staten Island, USA
    Neurosci Lett 291:126-8. 2000
    ..Acute and chronic saline injections had no effect on colorectal temperature. The data demonstrate sex differences in the thermoregulatory responses to acute and chronic morphine administration in mice...
  8. ncbi request reprint Sex differences in supraspinal morphine analgesia are dependent on genotype
    B Kest
    The College of Staten Island City University of New York and College of Staten Island Institute for Basic Research Center for Developmental Neuroscience, Staten Island, New York, USA
    J Pharmacol Exp Ther 289:1370-5. 1999
    ....
  9. ncbi request reprint Mu and delta opioid receptor analgesia, binding density, and mRNA levels in mice selectively bred for high and low analgesia
    B Kest
    The College of Staten Island City University of New York, Staten Island, NY 10314, USA
    Brain Res 816:381-9. 1999
    ..The data are discussed with regard to the utility of in vitro biological markers and genetic models of analgesia...
  10. ncbi request reprint Acute morphine dependence in mice selectively-bred for high and low analgesia
    B Kest
    Department of Psychology, The College of Staten Island CUNY, NY 10314, USA
    Neurosci Lett 256:120-2. 1998
    ..Further, these data suggest that analgesic sensitivity may not predict sensitivity to morphine dependence...
  11. doi request reprint Gnao1 (G alphaO protein) is a likely genetic contributor to variation in physical dependence on opioids in mice
    B Kest
    Department of Psychology and Center for Developmental Neuroscience, The College of Staten Island, City University of New York, Staten Island, NY 10314, USA
    Neuroscience 162:1255-64. 2009
    ..These data strongly implicate the G alpha(o) protein in the locus coeruleus as contributing to interindividual variability in physical dependence on opioids in mice...
  12. ncbi request reprint Naloxone-precipitated withdrawal jumping in 11 inbred mouse strains: evidence for common genetic mechanisms in acute and chronic morphine physical dependence
    B Kest
    Department of Psychology and Center for Developmental Neuroscience, The College of Staten Island, City University of New York, 10314, USA
    Neuroscience 115:463-9. 2002
    ..The data also demonstrate that the differential genetic liability to morphine physical dependence begins with, and is predicted by, the first morphine exposure...
  13. ncbi request reprint Nociception increases during opioid infusion in opioid receptor triple knock-out mice
    A Juni
    Neuropsychology Doctoral Program, Queens College, City University of New York, Flushing, NY 11367, USA
    Neuroscience 147:439-44. 2007
    ....
  14. ncbi request reprint Differences in delta opioid receptor antinociception, binding, and mRNA levels between BALB/c and CXBK mice
    B Kest
    Department of Psychology 4S 223, The College of Staten Island City University of New York, 2800 Victory Blvd, Staten Island, NY 10314, USA
    Brain Res 805:131-7. 1998
    ..Whether these observations are causally related remains to be clarified...
  15. ncbi request reprint Sex differences in systemic morphine analgesic tolerance following intrathecal morphine injections
    Eileen Hopkins
    Neuropsychology Doctoral Subprogram, Queens College, City University of New York, Flushing, NY 11367, USA
    Brain Res 1014:244-6. 2004
    ..Intrathecal injection alone had no effect on morphine analgesia. The data suggest that spinal mechanisms contribute to sex differences in analgesic tolerance following systemic morphine administration...
  16. ncbi request reprint Sex differences in opioid analgesia, hyperalgesia, tolerance and withdrawal: central mechanisms of action and roles of gonadal hormones
    Richard J Bodnar
    Department of Psychology, Queens College, The Graduate Center, City University of New York, NY 11367, USA
    Horm Behav 58:72-81. 2010
    ....
  17. ncbi request reprint Assessment of delta opioid antinociception and receptor mRNA levels in mouse after chronic naltrexone treatment
    S Jenab
    Department of Pharmacology, Cornell University Medical College, New York, NY 10021, USA
    Brain Res 691:69-75. 1995
    ..These data demonstrate that DOR mRNA levels are not altered during and after chronic naltrexone treatment and therefore are not associated with opioid-induced DOR up-regulation or DOR functional supersensitivity...
  18. doi request reprint Sex differences in hyperalgesia during morphine infusion: effect of gonadectomy and estrogen treatment
    Aaron Juni
    Neuropsychology Program, Queens College, City University of New York, Flushing, NY 11367, USA
    Neuropharmacology 54:1264-70. 2008
    ..Finally, the finding that each morphine infusion dose was characterized by a unique sex difference provides additional evidence for distinct multiple hyperalgesic systems...
  19. ncbi request reprint Morphine hyperalgesia in mice is unrelated to opioid activity, analgesia, or tolerance: evidence for multiple diverse hyperalgesic systems
    Aaron Juni
    Doctoral Program in Neuropsychology, Queens College, City University of New York, Flushing, NY 11367, USA
    Brain Res 1070:35-44. 2006
    ..Furthermore, the lack of hyperalgesic cross-adaptation between high and low morphine doses, and their differential cross-adaptation with M3G hyperalgesia, also suggests distinct morphine dose-dependent hyperalgesic systems...
  20. doi request reprint Sex-specific mediation of opioid-induced hyperalgesia by the melanocortin-1 receptor
    Aaron Juni
    Neuropsychology Doctoral Program, Queens College, City University of New York, Flushing, New York, USA
    Anesthesiology 112:181-8. 2010
    ....
  21. doi request reprint Acute and chronic fentanyl administration causes hyperalgesia independently of opioid receptor activity in mice
    Amanda R Waxman
    Neuropsychology Program, Queens College, City University of New York, Flushing, NY 11367, USA
    Neurosci Lett 462:68-72. 2009
    ..Since the biotransformation of fentanyl does not yield any known pronociceptive metabolites, these data challenge assumptions regarding the role of neuroexcitatory metabolites in opioid-induced hyperalgesia...
  22. ncbi request reprint Genetic variance contributes to ingestive processes: a survey of eleven inbred mouse strains for fat (Intralipid) intake
    Sarah R Lewis
    Neuropsychology Doctoral Sub Program, City University of New York, Flushing, NY 11367, USA
    Physiol Behav 90:82-94. 2007
    ..The identification of strains with diverging abilities to regulate kilocalorie intake when presented with high Intralipid concentrations may lead to the successful mapping of genes related to hedonics and obesity...
  23. ncbi request reprint Genetic variance contributes to naltrexone-induced inhibition of sucrose intake in inbred and outbred mouse strains
    Cheryl T Dym
    Department of Psychology, Queens College, The Graduate Center, City University of New York, Flushing NY 11367, USA
    Brain Res 1135:136-45. 2007
    ..These data indicate the importance of genetic variability in opioid modulation of sucrose intake...
  24. ncbi request reprint Genetic variance contributes to ingestive processes: A survey of mercaptoacetate-induced feeding in eleven inbred and one outbred mouse strains
    Sarah R Lewis
    Neuropsychology Doctoral Sub Program and Department of Psychology, City University of New York, USA
    Physiol Behav 88:516-22. 2006
    ..The demonstration of genotype-dependent variability in this lipoprivic response may provide the basis for the subsequent identification of trait-relevant genes...
  25. pmc Acute and chronic heroin dependence in mice: contribution of opioid and excitatory amino acid receptors
    Gad Klein
    Neuropsychology Doctoral Subprogram, Queens College, City University of New York, Flushing, NY 11367, USA
    Eur J Pharmacol 586:179-88. 2008
    ..Elucidating the substrates contributing to heroin dependence, and identifying their similarities and differences with those of other opioids such as morphine, may yield effective treatment strategies to the problem of heroin dependency...
  26. pmc A survey of acute and chronic heroin dependence in ten inbred mouse strains: evidence of genetic correlation with morphine dependence
    Gad Klein
    Neuropsychology Doctoral Subprogram, Queens College, City University of New York, Flushing, NY 11367, United States
    Pharmacol Biochem Behav 90:447-52. 2008
    ..These data suggest that the genetic liability to heroin dependence remains constant across a period of heroin intake, and that heroin and morphine dependence may benefit from common treatment strategies...
  27. ncbi request reprint Inbred mouse strain survey of sucrose intake
    Sarah R Lewis
    Neuropsychology Doctoral Sub Program and Department of Psychology, City University of New York 11367, USA
    Physiol Behav 85:546-56. 2005
    ..The identification of strains with diverging abilities to regulate kilocalorie intake when presented with high sucrose concentrations may lead to the successful QTL mapping of this trait...
  28. doi request reprint Sex-specific responses to opiates: animal and human studies
    Albert Dahan
    Department of Anesthesiology, Leiden University Medical Center, P5 Q, 2300 RC Leiden, The Netherlands
    Anesth Analg 107:83-95. 2008
    ....
  29. ncbi request reprint Alfentanil and placebo analgesia: no sex differences detected in models of experimental pain
    Erik Olofsen
    Department of Anesthesiology, Leiden University Medical Center, Leiden, The Netherlands
    Anesthesiology 103:130-9. 2005
    ....