Mitsuo Kato

Summary

Affiliation: City of Hope National Medical Center
Country: USA

Publications

  1. pmc TGF-beta activates Akt kinase through a microRNA-dependent amplifying circuit targeting PTEN
    Mitsuo Kato
    Gonda Diabetes Center, Beckman Research Institute of the City of Hope, Duarte, CA 91010, USA
    Nat Cell Biol 11:881-9. 2009
  2. pmc Enhanced levels of microRNA-125b in vascular smooth muscle cells of diabetic db/db mice lead to increased inflammatory gene expression by targeting the histone methyltransferase Suv39h1
    Louisa M Villeneuve
    Department of Diabetes, Beckman Research Institute of City of Hope, Duarte, California, USA
    Diabetes 59:2904-15. 2010
  3. pmc Post-transcriptional up-regulation of Tsc-22 by Ybx1, a target of miR-216a, mediates TGF-{beta}-induced collagen expression in kidney cells
    Mitsuo Kato
    Gonda Diabetes Center, Beckman Research Institute of City of Hope, Duarte, California 91010, USA
    J Biol Chem 285:34004-15. 2010
  4. pmc TGF-β induces acetylation of chromatin and of Ets-1 to alleviate repression of miR-192 in diabetic nephropathy
    Mitsuo Kato
    Department of Diabetes and Division of Molecular Diabetes Research, Beckman Research Institute of the City of Hope, Duarte, CA 91010, USA
    Sci Signal 6:ra43. 2013
  5. pmc A microRNA circuit mediates transforming growth factor-β1 autoregulation in renal glomerular mesangial cells
    Mitsuo Kato
    Gonda Diabetes Center, Beckman Research Institute of the City of Hope, Duarte, California, USA
    Kidney Int 80:358-68. 2011
  6. pmc MicroRNAs and their role in progressive kidney diseases
    Mitsuo Kato
    Gonda Diabetes Center, Beckman Research Institute of the City of Hope, Duarte, CA 91010, USA
    Clin J Am Soc Nephrol 4:1255-66. 2009
  7. pmc Inhibiting microRNA-192 ameliorates renal fibrosis in diabetic nephropathy
    Sumanth Putta
    Department of Diabetes, Division of Molecular Diabetes Research, Beckman Research Institute of the City of Hope, Duarte, CA 91010, USA
    J Am Soc Nephrol 23:458-69. 2012
  8. pmc MicroRNA-192 in diabetic kidney glomeruli and its function in TGF-beta-induced collagen expression via inhibition of E-box repressors
    Mitsuo Kato
    Gonda Diabetes Center, Division of Molecular Biology, Graduate School of Biological Sciences, Beckman Research Institute of the City of Hope, Duarte, CA 91010, USA
    Proc Natl Acad Sci U S A 104:3432-7. 2007
  9. pmc FOG2 protein down-regulation by transforming growth factor-β1-induced microRNA-200b/c leads to Akt kinase activation and glomerular mesangial hypertrophy related to diabetic nephropathy
    Jung Tak Park
    Division of Molecular Diabetes Research, Department of Diabetes, Beckman Research Institute of City of Hope, Duarte, California 91010, USA
    J Biol Chem 288:22469-80. 2013
  10. pmc Pro-inflammatory role of microrna-200 in vascular smooth muscle cells from diabetic mice
    Marpadga A Reddy
    Department of Diabetes, Beckman Research Institute of the City of Hope, 1500 East Duarte Road, Duarte, CA 91010, USA
    Arterioscler Thromb Vasc Biol 32:721-9. 2012

Collaborators

Detail Information

Publications22

  1. pmc TGF-beta activates Akt kinase through a microRNA-dependent amplifying circuit targeting PTEN
    Mitsuo Kato
    Gonda Diabetes Center, Beckman Research Institute of the City of Hope, Duarte, CA 91010, USA
    Nat Cell Biol 11:881-9. 2009
    ..Due to the diversity of PTEN function, this miR-amplifying circuit may have key roles, not only in kidney disorders, but also in other diseases...
  2. pmc Enhanced levels of microRNA-125b in vascular smooth muscle cells of diabetic db/db mice lead to increased inflammatory gene expression by targeting the histone methyltransferase Suv39h1
    Louisa M Villeneuve
    Department of Diabetes, Beckman Research Institute of City of Hope, Duarte, California, USA
    Diabetes 59:2904-15. 2010
    ..Here we examined the role of microRNAs (miRs) in Suv39h1 regulation and function in MVSMC from diabetic mice...
  3. pmc Post-transcriptional up-regulation of Tsc-22 by Ybx1, a target of miR-216a, mediates TGF-{beta}-induced collagen expression in kidney cells
    Mitsuo Kato
    Gonda Diabetes Center, Beckman Research Institute of City of Hope, Duarte, California 91010, USA
    J Biol Chem 285:34004-15. 2010
    ..These results demonstrate that post-transcriptional regulation of Tsc-22 mediated through Ybx1, a miR-216a target, plays a key role in TGF-β-induced Col1a2 in MC related to the pathogenesis of diabetic nephropathy...
  4. pmc TGF-β induces acetylation of chromatin and of Ets-1 to alleviate repression of miR-192 in diabetic nephropathy
    Mitsuo Kato
    Department of Diabetes and Division of Molecular Diabetes Research, Beckman Research Institute of the City of Hope, Duarte, CA 91010, USA
    Sci Signal 6:ra43. 2013
    ..These findings provide insight into the regulation of miRNAs through signaling-mediated changes in transcription factor activity and in epigenetic histone acetylation under normal and disease states...
  5. pmc A microRNA circuit mediates transforming growth factor-β1 autoregulation in renal glomerular mesangial cells
    Mitsuo Kato
    Gonda Diabetes Center, Beckman Research Institute of the City of Hope, Duarte, California, USA
    Kidney Int 80:358-68. 2011
    ..Thus, miRNA-regulated circuits may amplify TGF-β1 signaling, accelerating chronic fibrotic diseases such as diabetic nephropathy...
  6. pmc MicroRNAs and their role in progressive kidney diseases
    Mitsuo Kato
    Gonda Diabetes Center, Beckman Research Institute of the City of Hope, Duarte, CA 91010, USA
    Clin J Am Soc Nephrol 4:1255-66. 2009
    ..The major goal of this review is to highlight key functions of these miRs and their relationships to human diseases, with special emphasis on diabetic kidney disease...
  7. pmc Inhibiting microRNA-192 ameliorates renal fibrosis in diabetic nephropathy
    Sumanth Putta
    Department of Diabetes, Division of Molecular Diabetes Research, Beckman Research Institute of the City of Hope, Duarte, CA 91010, USA
    J Am Soc Nephrol 23:458-69. 2012
    ..In summary, the specific reduction of renal miR-192 decreases renal fibrosis and improves proteinuria, lending support for the possibility of an anti-miRNA-based translational approach to the treatment of diabetic nephropathy...
  8. pmc MicroRNA-192 in diabetic kidney glomeruli and its function in TGF-beta-induced collagen expression via inhibition of E-box repressors
    Mitsuo Kato
    Gonda Diabetes Center, Division of Molecular Biology, Graduate School of Biological Sciences, Beckman Research Institute of the City of Hope, Duarte, CA 91010, USA
    Proc Natl Acad Sci U S A 104:3432-7. 2007
    ..These results uncover a role for miRs in the kidney and DN in controlling TGF-beta-induced Col1a2 expression by down-regulating E-box repressors...
  9. pmc FOG2 protein down-regulation by transforming growth factor-β1-induced microRNA-200b/c leads to Akt kinase activation and glomerular mesangial hypertrophy related to diabetic nephropathy
    Jung Tak Park
    Division of Molecular Diabetes Research, Department of Diabetes, Beckman Research Institute of City of Hope, Duarte, California 91010, USA
    J Biol Chem 288:22469-80. 2013
    ..These data suggest a new mechanism for TGF-β-induced Akt activation through FOG2 down-regulation by miR-200b/c, which can lead to glomerular mesangial hypertrophy in the progression of diabetic nephropathy. ..
  10. pmc Pro-inflammatory role of microrna-200 in vascular smooth muscle cells from diabetic mice
    Marpadga A Reddy
    Department of Diabetes, Beckman Research Institute of the City of Hope, 1500 East Duarte Road, Duarte, CA 91010, USA
    Arterioscler Thromb Vasc Biol 32:721-9. 2012
    ..We examined the role of microRNA(miR)-200 family members and their target Zeb1, an E-box binding transcriptional repressor, in these events...
  11. pmc Effects of cholesterol-tagged small interfering RNAs targeting 12/15-lipoxygenase on parameters of diabetic nephropathy in a mouse model of type 1 diabetes
    Hang Yuan
    Department of Diabetes, Beckman Research Institute, City of Hope, Duarte, California, USA
    Am J Physiol Renal Physiol 295:F605-17. 2008
    ..Our results show for the first time that systemic delivery of cholesterol-tagged siRNAs targeting 12/15-LO has renoprotective effects under diabetic conditions and therefore could be a novel therapeutic approach for DN...
  12. pmc Involvement of p300/CBP and epigenetic histone acetylation in TGF-β1-mediated gene transcription in mesangial cells
    Hang Yuan
    Dept of Diabetes, Beckman Research Institute of the City of Hope, 1500 East Duarte Rd, Duarte, CA 91010, USA
    Am J Physiol Renal Physiol 304:F601-13. 2013
    ..This in turn can augment glomerular dysfunction linked to diabetic nephropathy...
  13. pmc Products of 12/15-lipoxygenase upregulate the angiotensin II receptor
    Zhong Gao Xu
    Gonda Diabetes Research Center, Beckman Research Institute of the City of Hope, 1500 East Duarte Road, Duarte, CA 91010, USA
    J Am Soc Nephrol 19:559-69. 2008
    ..Therefore, oxidized lipids generated by the 12/15-lipoxygenase-mediated metabolism of arachidonic acid can enhance AT1R expression in mesangial cells and augment the profibrotic effects of angiotensin II...
  14. pmc Epigenetic histone methylation modulates fibrotic gene expression
    Guangdong Sun
    Gonda Diabetes Center, Beckman Research Institute of the City of Hope, Duarte, California 91010, USA
    J Am Soc Nephrol 21:2069-80. 2010
    ..Pharmacologic and other therapies that reverse these modifications could have potential renoprotective effects for diabetic nephropathy...
  15. pmc Transforming growth factor-β-induced cross talk between p53 and a microRNA in the pathogenesis of diabetic nephropathy
    Supriya D Deshpande
    Irell and Manella Graduate School of Biological Sciences, Beckman Research Institute of the City of Hope, Duarte, California, USA
    Diabetes 62:3151-62. 2013
    ..Our results demonstrate for the first time a TGF-β-induced feedback amplification circuit between p53 and miR-192 related to the pathogenesis of DN, and that miR-192-knockout mice are protected from key features of DN. ..
  16. pmc Small RNA sequencing reveals microRNAs that modulate angiotensin II effects in vascular smooth muscle cells
    Wen Jin
    Irell and Manella Graduate School of Biological Sciences, Beckman Research Institute of City of Hope, Duarte, California 91010, USA
    J Biol Chem 287:15672-83. 2012
    ..These results suggest that miR132/212 can serve as a novel cellular node to fine-tune and amplify Ang II actions in VSMC...
  17. pmc MicroRNA circuits in transforming growth factor-β actions and diabetic nephropathy
    Mitsuo Kato
    Department of Diabetes, Beckman Research Institute of City of Hope, Duarte, CA 91010, USA
    Semin Nephrol 32:253-60. 2012
    ..This review covers the recent studies on the roles of miRNAs and miRNA circuits in transforming growth factor-β actions and in DN...
  18. pmc MicroRNAs: potential mediators and biomarkers of diabetic complications
    Mitsuo Kato
    Department of Diabetes, Beckman Research Institute, City of Hope, Duarte, CA 91010, USA
    Free Radic Biol Med 64:85-94. 2013
    ....
  19. ncbi request reprint Role of the Akt/FoxO3a pathway in TGF-beta1-mediated mesangial cell dysfunction: a novel mechanism related to diabetic kidney disease
    Mitsuo Kato
    Department of Diabetes, Beckman Research Institute of the City of Hope, 1500 East Duarte Road, Duarte, CA 91010, USA
    J Am Soc Nephrol 17:3325-35. 2006
    ..These new results suggest that Akt/FoxO pathway regulation may be a novel mechanism by which TGF-beta can induce unopposed MC survival and oxidant stress in early DN, thereby accelerating renal disease...
  20. pmc MicroRNAs and the glomerulus
    Mitsuo Kato
    Department of Diabetes, Beckman Research Institute of City of Hope, Duarte, CA 91010, USA
    Exp Cell Res 318:993-1000. 2012
    ..In this review, we summarize the biogenesis of miRNAs and their functions in the glomerulus, with particular emphasis on glomerular mesangial cells and podocytes related to the pathogenesis of DN...
  21. pmc MicroRNAs and diabetic complications
    Rama Natarajan
    Department of Diabetes, Beckman Research Institute of the City of Hope, Duarte, CA 91010, USA
    J Cardiovasc Transl Res 5:413-22. 2012
    ..In this review, we explore the role of miRNAs in the pathology of diabetic complications and also discuss the potential use of miRNAs as novel diagnostic and therapeutic targets for diabetic complications...
  22. ncbi request reprint Cell type and culture condition-dependent alternative splicing in human breast cancer cells revealed by splicing-sensitive microarrays
    Chunxia Li
    City of Hope Graduate School of Biological Sciences, Duarte, California, USA
    Cancer Res 66:1990-9. 2006
    ..Our findings also illustrate the potential for understanding gene expression with resolution of alternative splicing in the study of breast cancer...