Research Topics
| A HurriaSummaryAffiliation: City of Hope National Medical Center Country: USA Publications
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Detail Information
Publications
Pharmacokinetics of chemotherapy in the older patientArti Hurria
Cancer and Aging Research Program, City of Hope National Medical Center, Duarte, CA 91010, USA
Cancer Control 14:32-43. 2007..Age-related changes in physiology can affect chemotherapy pharmacokinetics and pharmacodynamics in older patients...- We need a geriatric assessment for oncologistsArti Hurria
Division of Medical Oncology and Therapeutics Research, City of Hope Comprehensive Cancer Center, 1500 East Duarte Road, Duarte, CA 91010, USA
Nat Clin Pract Oncol 3:642-3. 2006 - Adjuvant treatment recommendations in older women with breast cancer: a survey of oncologistsArti Hurria
Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
Crit Rev Oncol Hematol 61:255-60. 2007..Previous studies demonstrate differing treatment patterns between older and younger patients with breast cancer. To explore the reasons for these disparities we conducted a survey of 28 oncologists specializing in breast cancer... - Is cognitive dysfunction a complication of adjuvant chemotherapy in the older patient with breast cancer?Arti Hurria
City of Hope, Duarte, CA 91010, USA
Breast Cancer Res Treat 103:259-68. 2007..Since aging is the number one risk factor for breast cancer, future studies of the neuropsychological impact of chemotherapy should include older patients... - Renaming "chemobrain"Arti Hurria
City of Hope, Duarte, CA 91010, USA
Cancer Invest 25:373-7. 2007..We propose that the phenomenon commonly referred to as "chemobrain" would be more accurately labeled "cancer- or cancer-therapy-associated cognitive change.".. 
Clinical pharmacology of cancer therapies in older adultsA Hurria
The Department of Medical Oncology and Therapeutics Research, City of Hope, Duarte, CA 91010, USA
Br J Cancer 98:517-22. 2008..We also provide an overview of studies that have been conducted evaluating the pharmacology of anticancer therapies in older adults, and issue a call for further research...- Role of age and health in treatment recommendations for older adults with breast cancer: the perspective of oncologists and primary care providersArti Hurria
City of Hope National Medical Center, Duarte, CA 91010, USA
J Clin Oncol 26:5386-92. 2008..To determine the impact of age and health status on adjuvant treatment recommendations for older patients with breast cancer from the perspective of medical oncologists and primary care physicians with geriatric expertise... 
Adjuvant chemotherapy and hormonal therapy for older adults with breast cancerArti Hurria
City of Hope, Duarte, CA 91010, USA
Semin Oncol 35:618-24. 2008....- Distress in older patients with cancerArti Hurria
Cancer and Aging Research Program, City of Hope, 1500 E Duarte Rd, Duarte, CA 91001, USA
J Clin Oncol 27:4346-51. 2009..To determine the predictors of distress in older patients with cancer... - Perspectives and attitudes on the use of adjuvant chemotherapy and trastuzumab in older adults with HER-2+ breast cancer: a survey of oncologistsArti Hurria
City of Hope, Duarte, California 91010, USA
Oncologist 14:883-90. 2009..The goal of the current study was to understand how patient age and health status impact oncologists' decisions to recommend adjuvant therapy in older women with HER-2(+) breast cancer... - Geriatric assessment in oncology practiceArti Hurria
Department of Medical Oncology and Therapeutics Research, City of Hope, Duarte, CA 91010, USA
J Am Geriatr Soc 57:S246-9. 2009..Doing so will help develop targeted interventions and optimize cancer outcomes in this rapidly growing population... - Predicting chemotherapy toxicity in older adults with cancer: a prospective multicenter studyArti Hurria
City of Hope Comprehensive Cancer Center and Beckman Research Institute, Duarte, CA 91010, USA
J Clin Oncol 29:3457-65. 2011..The goals of this study are to identify risk factors for chemotherapy toxicity in older adults and develop a risk stratification schema for chemotherapy toxicity... - Identifying vulnerable older adults with cancer: integrating geriatric assessment into oncology practiceArti Hurria
Division of Medical Oncology and Therapeutics Research, City of Hope, Duarte, California 91010, USA
J Am Geriatr Soc 55:1604-8. 2007..To integrate the principles of geriatric assessment into the care of older patients with cancer in order to identify vulnerable older adults and develop interventions to optimize cancer treatment... - Implementing a geriatric assessment in cooperative group clinical cancer trials: CALGB 360401Arti Hurria
City of Hope, 1500 E Duarte Rd, Duarte, CA 91010, USA
J Clin Oncol 29:1290-6. 2011..This study evaluated the implementation of a geriatric assessment tool in the cooperative group setting... - Cognitive function of older patients receiving adjuvant chemotherapy for breast cancer: a pilot prospective longitudinal studyArti Hurria
Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
J Am Geriatr Soc 54:925-31. 2006..To report on the longitudinal cognitive functioning of older women receiving adjuvant chemotherapy for breast cancer... - Evaluating the older patient with cancer: understanding frailty and the geriatric assessmentSumanta Kumar Pal
Division of Genitourinary Malignancies, Department of Medical Oncology and Experimental Therapeutics, City of Hope Comprehensive Cancer Center, Duarte, CA 91010, USA
CA Cancer J Clin 60:120-32. 2010..This review describes key studies from the geriatric literature that provide principles for assessing health status in the older patient, and ways that these principles can be applied to oncology care in an older population are proposed... - A prospective, longitudinal study of the functional status and quality of life of older patients with breast cancer receiving adjuvant chemotherapyArti Hurria
Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
J Am Geriatr Soc 54:1119-24. 2006..To examine the toxicity experienced by a cohort of older women receiving adjuvant chemotherapy for breast cancer and the longitudinal effect on their functional status and quality of life (QOL)... - Paclitaxel efficacy and toxicity in older women with metastatic breast cancer: combined analysis of CALGB 9342 and 9840S M Lichtman
Department of Medicine, Memorial Sloan Kettering Cancer Center, New York 11725, USA
Ann Oncol 23:632-8. 2012..Two Cancer and Leukemia Group B (CALGB) studies were utilized to determine the efficacy and tolerability of paclitaxel (Taxol) in older patients with metastatic breast cancer... - Patterns of toxicity in older patients with breast cancer receiving adjuvant chemotherapyArti Hurria
Memorial Sloan Kettering Cancer Center, NY 10021, New York, USA
Breast Cancer Res Treat 92:151-6. 2005..To retrospectively determine the relationship of age to toxicity from adjuvant chemotherapy for breast cancer... - Feasibility and toxicity of dose-dense adjuvant chemotherapy in older women with breast cancerMarjorie Zauderer
NewYork Presbyterian Hospital, New York, USA
Breast Cancer Res Treat 117:205-10. 2009..The objective of this study was to examine the feasibility and toxicity of adjuvant dose-dense chemotherapy in older women with breast cancer... - Effect of adjuvant breast cancer chemotherapy on cognitive function from the older patient's perspectiveArti Hurria
Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
Breast Cancer Res Treat 98:343-8. 2006..This longitudinal prospective study describes the older breast cancer patient's perception of the cognitive impact of adjuvant chemotherapy... - Factors influencing treatment patterns of breast cancer patients age 75 and olderArti Hurria
Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
Crit Rev Oncol Hematol 46:121-6. 2003..To retrospectively determine the factors influencing treatment decisions in older breast cancer patients at a single center... - Clinical trials in older adults with cancer: past and futureArti Hurria
Cancer and Aging Research Program, City of Hope Cancer Center, Duarte, California 91010, USA
Oncology (Williston Park) 21:351-8; discussion 363-4, 367. 2007..This article examines the demographics of cancer and aging, the barriers to enrollment of older adults on clinical trials, and approaches for future trials to address the needs of the older patient... - Management of lung cancer in older adultsArti Hurria
Memorial Sloan-Kettering Cancer Center, Weill Medical College of Cornell University, New York, NY, USA
CA Cancer J Clin 53:325-41. 2003..This article reviews the available data regarding surgery, radiation, and systemic treatment for older patients with lung cancer and considers the role of geriatric assessment in the evaluation of older patients... - Geriatric assessment for oncologists: rationale and future directionsArti Hurria
Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
Crit Rev Oncol Hematol 59:211-7. 2006..Our eventual goal is to determine if this geriatric assessment measure can identify factors independent of age that predict cancer treatment morbidity and mortality and result in rationale interventions to optimize oncologic care... - Adjuvant chemotherapy and survival in older women with hormone receptor-negative breast cancer: assessing outcome in a population-based, observational cohortElena B Elkin
Health Outcomes Research Group and Biostatistics Service, Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
J Clin Oncol 24:2757-64. 2006..Our goal was to assess the relationship between adjuvant chemotherapy use and survival in a large, population-based cohort of older women with hormone receptor (HR) -negative breast cancer... - Developing a cancer-specific geriatric assessment: a feasibility studyArti Hurria
Department of Medicine, Psychiatry and Behavioral Sciences, and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
Cancer 104:1998-2005. 2005.... - Effect of creatinine clearance on patterns of toxicity in older patients receiving adjuvant chemotherapy for breast cancerArti Hurria
Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
Drugs Aging 22:785-91. 2005..We sought to determine the association between calculated creatinine clearance (CL(CR)) and grade 3 or 4 toxicities during adjuvant chemotherapy in women > or =65 years of age with breast cancer... - Impact of age, sex, and comorbidity on cancer therapy and disease progressionSumanta Kumar Pal
Experimental Therapeutics and Cancer Control and Population Sciences Program, Cancer and Aging Research Program, City of Hope Comprehensive Cancer Center, 1500 E Duarte Rd, Duarte, CA, USA
J Clin Oncol 28:4086-93. 2010..Taken together, age, sex, and comorbidity each encompass a complex array of physiologic and molecular variations that may each aid in personalizing care for the patient with cancer... - A phase I/II prospective, single arm trial of gefitinib, trastuzumab, and docetaxel in patients with stage IV HER-2 positive metastatic breast cancerG Somlo
Department of Medical Oncology and Therapeutics Research, City of Hope Comprehensive Cancer Center, 1500 E Duarte Rd, Duarte, California, 91010, USA
Breast Cancer Res Treat 131:899-906. 2012..We conclude that the combination of gefitinib, trastuzumab, and docetaxel is feasible and effective. Expression of the biomarkers examined did not predict outcome in this sample of HER-2 overexpressing metastatic breast cancer... - Mentoring junior faculty in geriatric oncology: report from the Cancer and Aging Research GroupArti Hurria
City of Hope, Duarte, CA, USA
J Clin Oncol 26:3125-7. 2008 - Change in cycle 1 to cycle 2 haematological counts predicts toxicity in older patients with breast cancer receiving adjuvant chemotherapyArti Hurria
Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA
Drugs Aging 22:709-15. 2005..CONCLUSIONS: In this cohort of older patients who received chemotherapy for breast cancer, changes in blood counts from cycle 1 to cycle 2 were associated with increased risk of treatment-related grade 3 or 4 toxicity... - Phase II study of feasibility of dose-dense FEC followed by alternating weekly taxanes in high-risk, four or more node-positive breast cancerChau T Dang
Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA
Clin Cancer Res 10:5754-61. 2004..The primary objective was to determine the feasibility of the regimen; the secondary objective was to estimate the disease-free and overall survival... - Follow-up care of breast cancer survivorsArti Hurria
Memorial Sloan Kettering Cancer Center, 1275 York Avenue 815, New York, NY 10021, USA
Crit Rev Oncol Hematol 48:89-99. 2003..In this article, we will discuss the principles of follow-up care of the breast cancer survivor... - Pharmacokinetics and toxicity of weekly docetaxel in older patientsArti Hurria
Department of Medicine, Memorial Sloan Kettering Cancer Center, New York City, New York 10021, USA
Clin Cancer Res 12:6100-5. 2006.... - Cognitive effects of hormonal therapy in older adultsNicholas Mitsiades
Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
Semin Oncol 35:569-81. 2008.... - Prolonged dose-dense epirubicin and cyclophosphamide followed by paclitaxel in breast cancer is feasibleChau Dang
Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
Clin Breast Cancer 8:418-24. 2008..Dose-dense EC (without the 5-FU) is not associated with pneumonitis, and dose-dense paclitaxel (alone) is feasible. Primary objective was feasibility... - Screening chest imaging studies are not effective in the follow-up of breast cancer patientsArti Hurria
Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
J Oncol Manag 12:13-5. 2003..To determine the utility of chest imaging after adjuvant therapy for breast cancer in detection of recurrent disease... - Polypharmacy in older adults with cancerRonald J Maggiore
Yale Comprehensive Cancer Center and Yale University School of Medicine, New Haven, Connecticut, USA
Oncologist 15:507-22. 2010..We also examine the strengths and weaknesses of these definitions and explore the relationships among these definitions and what is known about the prevalence and impact of polypharmacy... - Management of breast cancer in elderly individuals: recommendations of the International Society of Geriatric OncologyHans Wildiers
Department of General Medical Oncology, University Hospital Gasthuisberg, Leuven, Belgium
Lancet Oncol 8:1101-15. 2007..The available evidence was reviewed and synthesised to provide consensus recommendations regarding the care of breast cancer in older adults... - Incorporation of geriatric principles in oncology clinical trialsArti Hurria
J Clin Oncol 25:5350-1. 2007 - NCCN Task Force Report: breast cancer in the older womanRobert W Carlson
J Natl Compr Canc Netw 6:S1-S25; quiz S26-S27. 2008.... - Do age and ethnicity predict breast cancer treatment received? A cross-sectional urban population based study. Breast cancer treatment: age and ethnicityArash Naeim
Division of Hematology Oncology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095 1687, USA
Crit Rev Oncol Hematol 59:234-42. 2006..To evaluate the treatment patterns of women aged 55 years or older with newly diagnosed breast cancer and to examine the association between age and ethnicity/race on treatment selection... - Functional assessment of the older patient with cancerCathy C Schubert
Department of Internal Medicine and Geriatrics, Indiana University School of Medicine, Indianapolis, Indiana, USA
Oncology (Williston Park) 22:916-22; discussion 925, 928. 2008..Including these tools in daily oncology practice could help physicians to better assess and treat vulnerable older adults... - Comprehensive geriatric assessment for older patients with cancerMartine Extermann
H Lee Moffitt Cancer Center, University of South Florida, Tampa, FL 33612, USA
J Clin Oncol 25:1824-31. 2007..This article discusses recent advances on the use of a CGA in older patients with cancer... - Postmastectomy radiation and survival in older women with breast cancerBenjamin D Smith
Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, CT, USA
J Clin Oncol 24:4901-7. 2006..As recent evidence suggests that certain adjuvant treatments appropriate for younger women may only be marginally beneficial for older women, we sought to determine whether PMRT improves survival for older women with breast cancer... - Use of postmastectomy radiotherapy in older womenBenjamin D Smith
Radiation Oncology Flight, Wilford Hall Medical Center, Lackland Air Force Base, TX, USA
Int J Radiat Oncol Biol Phys 71:98-106. 2008..Using the Surveillance, Epidemiology, and End Results-Medicare cohort, we sought to characterize the adoption of PMRT from 1992 to 2002 and identify risk factors for PMRT omission among high-risk older patients...