Research Topics
Genomes and Genes | Qin HuangSummaryAffiliation: City of Hope National Medical Center Country: USA Publications
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Publications
Promoter hypermethylation and protein expression of the p16 gene: analysis of 43 cases of B-cell primary gastric lymphomas from ChinaQin Huang
Division of Pathology, City of Hope National Medical Center, Duarte, CA 91010, USA
Mod Pathol 17:416-22. 2004..Despite limited pathologic data, loss of p16 protein expression appears not to be correlated with extragastric involvements...- Chronic myelogenous leukemia in accelerated phaseQin Huang
Division of Pathology, City of Hope National Medical Center, Duarte, Calif 91010, USA
Arch Pathol Lab Med 129:710. 2005 - Extranodal Rosai-Dorfman disease involving the bone marrow: a case reportQin Huang
Division of Pathology, City of Hope National Medical Center, Duarte, CA 91010, USA
Am J Surg Pathol 30:1189-92. 2006..The bone marrow biopsy demonstrates the distinctive and characteristic morphologic and immunophenotypic features of extranodal SHML... - Pure erythroid leukemiaQin Huang
Division of Pathology, City of Hope National Medical Center, Duarte, Calif 91010, USA
Arch Pathol Lab Med 128:241-2. 2004 - An aggressive extranodal NK-cell lymphoma arising from indolent NK-cell lymphoproliferative disorderQin Huang
Division of Pathology, City of Hope National Medical Center, Duarte, CA, USA
Am J Surg Pathol 29:1540-3. 2005..To the best of our knowledge, such aggressive lymphomatous transformation in an indolent NK-cell lymphoproliferative disorder has not been previously reported... - KSHV/HHV8-associated lymphoma simulating anaplastic large cell lymphomaQin Huang
Division of Pathology, City of Hope National Medical Center, Duarte, CA 91010, USA
Am J Surg Pathol 28:693-7. 2004..Molecular study clearly demonstrated B-cell lineage with immunoglobulin heavy and kappa light chain gene rearrangements. This case may add to the spectrum of the heterogeneous category of KSHV/HHV8-associated B-cell lymphomas... - Burkitt leukemiaQin Huang
Division of Pathology, City of Hope National Medical Center, Duarte, Calif 91010, USA
Arch Pathol Lab Med 128:1459-60. 2004 
CD3-positive large B-cell lymphomaJun Wang
Department of Pathology and Laboratory Medicine, Loma Linda University Medical Center, Loma Linda, CA, USA
Am J Surg Pathol 33:505-12. 2009..Immunohistochemistry using additional cell lineage specific markers or molecular analysis for antigen receptor gene rearrangements are necessary for correct determination of the cell lineage in such cases...- Detection of clonal lymphoid receptor gene rearrangements in langerhans cell histiocytosisWei Chen
Department of Pathology, City of Hope National Medical Center, Duarte, CA 91010, USA
Am J Surg Pathol 34:1049-57. 2010..The results provide genotypic evidence supporting the current notion of lineage plasticity of hematopoietic cells and their associated neoplasms... 
Polyploid cells rewire DNA damage response networks to overcome replication stress-induced barriers for tumour progressionLi Zheng
Department of Cancer Biology, City of Hope National Medical Center and Beckman Research Institute, 1500 East Duarte Road, Duarte, California 91010, USA
Nat Commun 3:815. 2012..These molecular changes rewire DNA damage response and repair gene networks in polyploid tumour cells, enabling them to escape replication stress-induced senescence barriers...- Lineage determination of CD20- B-Cell neoplasms: an immunohistochemical studyPeiguo G Chu
Division of Pathology, City of Hope National Medical Center, Duarte, CA 91010, USA
Am J Clin Pathol 126:534-44. 2006..If negative, OCT.2 or BOB.1 may be useful. The newly identified B-lineage markers, OCT.2 and BOB.1, may be the most useful for the B-lineage determination of CD20- plasmablastic or primary effusion subtypes of DLBCL... - Persistence of leukemia stem cells in chronic myelogenous leukemia patients in prolonged remission with imatinib treatmentSu Chu
Division of Hematopoietic Stem Cell and Leukemia Research, City of Hope National Medical Center, Duarte, CA, USA
Blood 118:5565-72. 2011..These results directly demonstrate that BCR-ABL(+) stem cells persist in CML patients despite prolonged treatment with imatinib, and support ongoing efforts to target this population... - Complete absence of KSHV/HHV-8 in posttransplant lymphoproliferative disorders: an immunohistochemical and molecular study of 52 casesWei Chen
Department of Anatomic Pathology, City of Hope National Medical Center, Duarte, CA, USA
Am J Clin Pathol 131:632-9. 2009..None of the 51 tested specimens showed expression of KSHV/HHV-8 LNA-1. Furthermore, all 46 specimens tested demonstrated complete absence of the KSHV/HHV-8 genome. Our data clearly indicated that KSHV/HHV-8 is not associated with PTLDs... - Granular acute lymphoblastic leukemia: a case report and literature reviewSean D Pitman
Division of Pathology, City of Hope National Medical Center, Duarte, California 91010, USA
Am J Hematol 82:834-7. 2007..Ten cases of adult granular acute lymphoblastic leukemia described to date in the literature were also reviewed... - C/EBPA gene mutation and C/EBPA promoter hypermethylation in acute myeloid leukemia with normal cytogeneticsYing Lu
Department of Pathology, City of Hope National Medical Center, Duarte, California 91010, USA
Am J Hematol 85:426-30. 2010.... - Therapy-related acute lymphoblastic leukemia without 11q23 abnormality: report of six cases and a literature reviewWei Chen
Division of Pathology, Departments of Pathology, City of Hope National Medical Center, Duarte, CA 91010, USA
Am J Clin Pathol 133:75-82. 2010.... - Composite recurrent hodgkin lymphoma and diffuse large B-cell lymphoma: one clone, two facesQin Huang
Division of Pathology, City of Hope National Medical Center, Duarte, CA 91010, USA
Am J Clin Pathol 126:222-9. 2006..Such distinctly different morphology, immunophenotype, and EBV status in different components within a clonally related single tumor mass is striking... - Altered microenvironmental regulation of leukemic and normal stem cells in chronic myelogenous leukemiaBin Zhang
Division of Hematopoietic Stem Cell and Leukemia Research, City of Hope National Medical Center, Duarte, CA 91010, USA
Cancer Cell 21:577-92. 2012..These results were validated using human CML samples and provide improved understanding of microenvironmental regulation of normal and leukemic LTHSC and their response to IM in CML... - High frequency of clonal immunoglobulin receptor gene rearrangements in sporadic histiocytic/dendritic cell sarcomasWei Chen
Department of Pathology, City of Hope National Medical Center, Duarte, CA 91010, USA
Am J Surg Pathol 33:863-73. 2009..The findings suggest that a large subset of H/DC sarcomas have inherited B-cell genotypes, thus providing new insights for the pathogenesis of these rare but aggressive neoplasms... - Promoter hypermethylation of multiple genes in gastric lymphomaQin Huang
Division of Pathology, City of Hope National Medical Center, Duarte, CA 91010, USA
Leuk Lymphoma 48:1988-96. 2007..The promoter methylation at MGMT gene was significantly higher in the PGLs without extragastric involvement (61%) as compared to those with extragastric involvement (26%)... - Aberrant expression of CD7 in myeloblasts is highly associated with de novo acute myeloid leukemias with FLT3/ITD mutationVeronica Rausei-Mills
Division of Pathology, City of Hope National Medical Center, Duarte, CA 91010, USA
Am J Clin Pathol 129:624-9. 2008..Close association of aberrant CD7 expression and FLT3/ITD mutation in the myeloblasts of FLT3/ITD+ AML suggests that FLT3/ITD- mediated leukemic transformation occurs in the more early stage of myeloid progenitor cells... - Prolymphocytoid transformation of follicular lymphoma with coexpression of CD5 and CD10Sean K Lau
Department of Pathology, City of Hope National Medical Center, Duarte, CA 91010, USA
Leuk Lymphoma 47:541-7. 2006..Prolymphocytoid transformation, similar to other histologic forms of transformation of follicular lymphoma, appears to accompany clinical progression of disease... - Histiocytic lesions involving the bone marrowKaren L Chang
Department of Pathology, City of Hope National Medical Center, Duarte, CA 91010, USA
Semin Diagn Pathol 20:226-36. 2003..Apart from acute and chronic monocytic leukemias, the bone marrow is rarely involved by malignant histiocytic disorders, of which Langerhans cell histiocytosis is the most common... - t(11;14) Plasma cell disorder presents as a true nonsecretory, nonproducer multiple myelomaWei Chen
Department of Pathology, City of Hope National Medical Center, Duarte, CA 91010, USA
Clin Lymphoma Myeloma 9:243-6. 2009..Chromosomal analysis and dual fluorescence in situ hybridization studies clearly demonstrated the presence of t(11;14)(q13;q32) translocation in the neoplastic plasma cells... - BCR-ABL gene expression is required for its mutations in a novel KCL-22 cell culture model for acquired resistance of chronic myelogenous leukemiaHongfeng Yuan
Department of Cancer Biology, City of Hope, Duarte, California 91010, USA
J Biol Chem 285:5085-96. 2010..Our study suggests important roles of BCR-ABL gene expression and its native chromosomal locus for acquisition of BCR-ABL mutations and provides a new tool for further studying resistance mechanisms... - Clinical and pathologic analysis of 16 cases of relapsed chronic myeloid leukemia after stem cell transplantationQin Huang
Division of Pathology, City of Hope National Medical Center, Duarte, CA 91010, USA
Am J Clin Pathol 128:565-70. 2007..Disease mortality in patients with relapsed CML after HCT was closely associated with advanced disease and HCT-related complications... - Overexpression and hypomethylation of flap endonuclease 1 gene in breast and other cancersPurnima Singh
Department of Radiation Biology, City of Hope National Medical Center and Beckman Research Institute, Duarte, California 91010, USA
Mol Cancer Res 6:1710-7. 2008..The overexpression and promoter hypomethylation of FEN1 may serve as biomarkers for monitoring the progression of cancers... - Incidental and concurrent malignant lymphomas discovered at the time of prostatectomy and prostate biopsy: a study of 29 casesPeiguo G Chu
Department of Pathology, City of Hope National Medical Center, Duarte, CA 91010, USA
Am J Surg Pathol 29:693-9. 2005..The diagnosis was usually easily established in these cases. Of 11 cases, 4 were SLL/CLL, 4 were follicular lymphoma, 2 were mantle cell lymphoma, and 1 was diffuse large B-cell lymphoma... - Disruption of the FEN-1/PCNA interaction results in DNA replication defects, pulmonary hypoplasia, pancytopenia, and newborn lethality in miceLi Zheng
City of Hope National Medical Center, Department of Molecular Biology, 1500 East Duarte Rd, Duarte, CA 91010, USA
Mol Cell Biol 27:3176-86. 2007..All newborn FFAA mutant pups died at birth, likely due to pulmonary hypoplasia and pancytopenia. Collectively, our data demonstrate the importance of the FEN-1/PCNA complex in DNA replication and in the embryonic development of mice... - ALK-negative anaplastic large cell lymphoma with extensive peripheral blood and bone marrow involvements manifested as "leukemic phase"Ying Lu
Department of Pathology, City of Hope National Medical Center, Duarte, CA 91010, United States
Leuk Res 34:475-82. 2010..Leukemic ALCL patients usually have unfavourable prognosis, regardless of ALK expression... - Fen1 mutations that specifically disrupt its interaction with PCNA cause aneuploidy-associated cancerLi Zheng
Department of Cancer Biology, City of Hope National Medical Center and Beckman Research Institute, Duarte, CA 91010, USA
Cell Res 21:1052-67. 2011..Thus, this study establishes an exemplary case for investigating the biological significance of protein-protein interactions by knock-in of a point mutation rather than knock-out of a whole gene... - Primary effusion lymphoma with subsequent development of a small bowel mass in an HIV-seropositive patient: a case report and literature reviewQin Huang
Division of Pathology, City of Hope National Medical Center, Duarte, California 91010, USA
Am J Surg Pathol 26:1363-7. 2002.... - Urothelial carcinoma of the urinary bladder with a component of acinar/tubular type differentiation simulating prostatic adenocarcinomaQin Huang
Division of Pathology, City of Hope National Medical Center, Duarte, California 91010, USA
Hum Pathol 35:769-73. 2004..Although bladder carcinomas composed of mixed morphologic patterns are not uncommon, to our knowledge, the presence of acinar/tubular type features simulating prostatic adenocarcinoma in such tumors has not been described elsewhere... - Fen1 mutations result in autoimmunity, chronic inflammation and cancersLi Zheng
Department of Radiation Biology, City of Hope National Medical Center and Beckman Research Institute, 1500 East Duarte Road, Duarte, California 91010, USA
Nat Med 13:812-9. 2007.... - Primary anaplastic large-cell lymphoma associated with breast implantsLeslie Popplewell
Department of Hematology Hematopoietic Cell Transplantation, City of Hope, Duarte, CA 91030, USA
Leuk Lymphoma 52:1481-7. 2011.... - [Clinicopathologic and immunohistochemical study of primary non-Hodgkin lymphoma of the female genital system]Xue Feng Jiang
Department of Gynaecology and Obstetrics, West China Second Hospital of Sichuan University, Chengdu 610041, China
Zhonghua Fu Chan Ke Za Zhi 42:222-6. 2007..To investigate the clinicopathology and immunophenotype of primary non-Hodgkin lymphoma (NHL) of the female genital system, and to analyze the prognosis of such tumors... - Hodgkin lymphoma-like posttransplant lymphoproliferative disorder (HL-like PTLD) simulates monomorphic B-cell PTLD both clinically and pathologicallySean D Pitman
Department of Pathology and Laboratory Medicine, Loma Linda University Medical Center, Loma Linda, CA 92354, USA
Am J Surg Pathol 30:470-6. 2006..Distinction between HL and HL-like PTLD may be important for clinical management and prognosis... - Comparison of ancillary studies in the detection of residual disease in plasma cell myeloma in bone marrowXiaohui Zhao
Department of Pathology, UCI Medical Center, Orange, CA 92868, USA
Am J Clin Pathol 125:895-904. 2006..Among the ancillary studies, immunohistochemical analysis and FC were the most helpful ancillary studies for detection of residual disease in myeloma, with immunohistochemical analysis the most effective single method... - Anaplastic large cell lymphoma associated with Epstein-Barr virus following cardiac transplantSean D Pitman
Department of Pathology and Laboratory Medicine, Loma Linda University Medical Center, Loma Linda, CA 92354, USA
Am J Surg Pathol 28:410-5. 2004..To our knowledge, this is the first reported case of an EBV-positive T cell lymphoma of the anaplastic large cell subtype following organ transplant... - Gene transfer to the gastrointestinal tract after peroral administration of recombinant adeno-associated virus type 2 vectorsGuohong Shao
Center for Gene Therapy, Columbus Children's Research Institute, OH, USA
J Pediatr Gastroenterol Nutr 43:168-79. 2006..Despite these changes, transduction of the GI tract after peroral rAAV2 administration remained low... - Progressive loss of malignant behavior in telomerase-negative tumorigenic adrenocortical cells and restoration of tumorigenicity by human telomerase reverse transcriptaseBeicheng Sun
Department of Physiology, University of Texas Health Science Center, San Antonio, Texas 78245, USA
Cancer Res 64:6144-51. 2004.... - The histopathologic spectrum of carcinomas involving the gastroesophageal junction in the ChineseQin Huang
Department of Pathology and Laboratory Medicine, Boston Veterans Affairs Health Care System, West Roxbury, Massachusetts and Brown Medical School, Providence, Rhode Island, USA
Int J Surg Pathol 15:38-52. 2007..Dysplasia was uncommon (n = 6). Barrett esophagus was not identified. Carcinomas involving the gastroesophageal junction in the Chinese are morphologically distinct, heterogeneous, and may be of esophageal origin... - Transplantation of embryonic stem cells improves cardiac function in postinfarcted ratsJiang-Yong Min
The Charles A. Dana Research Institute and the Harvard-Thorndike Laboratory, Boston Massachusetts 02215, USA
J Appl Physiol 92:288-96. 2002..The present data demonstrate that ES cell transplantation is a feasible and novel approach to improve ventricular function in infarcted failing hearts... - Significance of blood analysis in hemophiliacs co-infected with human immunodeficiency virus and hepatitis virusesFang Shen
Shanghai Medical College and Shanghai Public Health Center, Fudan University, Shanghai 201508, China
World J Gastroenterol 13:1862-6. 2007..To study the effect of hepatitis virus infection on cirrhosis and liver function markers in HIV-infected hemophiliacs... - Clinical and genetic characterization of measles viruses isolated from adult patients in Shanghai in 2006Xuelian Yu
Scientific Research Unit, Shanghai Public Health Clinical Center, Public Health Clinical Center Affiliated to Fudan University, Shanghai, PR China
J Clin Virol 40:146-51. 2007..Although there have been many studies analyzing the genotype of measles virus from pediatric patients in various parts of China, there is little information on the clinical findings and genetic makeup of adult measles... - High-fidelity DNA histograms in neoplastic progression in Barrett's esophagusChenggong Yu
Department of Medicine, VA Boston Healthcare System, Boston, MA 02132 4927, USA
Lab Invest 87:466-72. 2007.... - Invasive fungal infections among inpatients with acquired immune deficiency syndrome at a Chinese university hospitalYin Zhong Shen
Department of Infectious Diseases, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China
Mycoses 50:475-80. 2007..The majority of IFIs occur in the digestive tract. The most common pathogen causing IFI is C. albicans. The mortality rate remains high although antiretroviral therapy and many newer antifungals are available in China... - Comparative analysis of common CFTR polymorphisms poly-T, TG-repeats and M470V in a healthy Chinese populationQin Huang
Department of Traditional Chinese Medicine, The First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing 210029, Jiangsu Province, China
World J Gastroenterol 14:1925-30. 2008.... - Estrogen receptor alpha gene polymorphism associated with type 2 diabetes mellitus and the serum lipid concentration in Chinese women in GuangzhouQin Huang
Department of Physiology, Sun Yat Sen Memorial Hospital, Sun Yat Sen University, Guangzhou 510080, China
Chin Med J (Engl) 119:1794-801. 2006..The aim of this study was to determine whether ERX gene polymorphisms are associated with type 2 diabetes mellitus and serum lipid level... - Telomerase is not required for experimental tumorigenesis of human and bovine adrenocortical cellsMeizhen Chen
Department of Physiology and Sam and Ann Barshop Center for Longevity and Aging Studies, University of Texas Health Science Center, San Antonio, Texas, USA
Endocr Res 30:555-65. 2004.... - Successful implantation of intravenously administered stem cells correlates with severity of inflammation in murine myocarditisSohail Malek
Charles A. Dana Research Institute and the Harvard-Thorndike Laboratories of Beth Israel Deaconess Medical Center, The Cardiovascular Division, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02135, USA
Pflugers Arch 452:268-75. 2006..We conclude that factors released from myocardium during inflammation are important for enhancing the homing, migration, and implantation of systemically infused stem cells...