L C Hsu

Summary

Affiliation: City of Hope National Medical Center
Country: USA

Publications

  1. ncbi request reprint Mouse type-2 retinaldehyde dehydrogenase (RALDH2): genomic organization, tissue-dependent expression, chromosome assignment and comparison to other types
    L C Hsu
    Division of Molecular Medicine, Beckman Research Institute of the City of Hope, 1450 E Duarte Road, Duarte, CA 91010, USA
    Biochim Biophys Acta 1492:289-93. 2000
  2. ncbi request reprint Human gamma-aminobutyraldehyde dehydrogenase (ALDH9): cDNA sequence, genomic organization, polymorphism, chromosomal localization, and tissue expression
    S W Lin
    Department of Biochemical Genetics, Beckman Research Institute of the City of Hope, Duarte, California, 91010, USA
    Genomics 34:376-80. 1996
  3. ncbi request reprint Sequencing and expression of the human ALDH8 encoding a new member of the aldehyde dehydrogenase family
    L C Hsu
    Department of Biochemical Genetics, Beckman Research Institute of the City of Hope, Duarte, CA 91010, USA
    Gene 174:319-22. 1996
  4. ncbi request reprint Human aldehyde dehydrogenase genes, ALDH7 and ALDH8: genomic organization and gene structure comparison
    L C Hsu
    Department of Biochemical Genetics, Beckman Research Institute of the City of Hope, Duarte, CA 91010, USA
    Gene 189:89-94. 1997
  5. ncbi request reprint Human stomach aldehyde dehydrogenase, ALDH3
    L C Hsu
    Department of Biochemical Genetics, Beckman Research Institute of the City of Hope, Duarte, CA 91010
    Adv Exp Med Biol 328:141-52. 1993
  6. ncbi request reprint Cloning and characterization of genes encoding four additional human aldehyde dehydrogenase isozymes
    L C Hsu
    Department of Biochemical Genetics, Beckman Research Institute, City of Hope, Duarte, California, USA
    Adv Exp Med Biol 372:159-68. 1995
  7. pmc Molecular analysis of two closely related mouse aldehyde dehydrogenase genes: identification of a role for Aldh1, but not Aldh-pb, in the biosynthesis of retinoic acid
    L C Hsu
    Department of Biochemical Genetics, Beckman Research Institute of the City of Hope, Duarte, CA 91010, USA
    Biochem J 339:387-95. 1999
  8. ncbi request reprint Molecular cloning, genomic organization, and chromosomal localization of an additional human aldehyde dehydrogenase gene, ALDH6
    L C Hsu
    Department of Biochemical Genetics, Beckman Research Institute of the City of Hope, Duarte, California 91010
    Genomics 24:333-41. 1994
  9. ncbi request reprint Cloning of a cDNA encoding human ALDH7, a new member of the aldehyde dehydrogenase family
    L C Hsu
    Department of Biochemical Genetics, Beckman Research Institute of the City of Hope, Duarte, CA 91010
    Gene 151:285-9. 1994
  10. ncbi request reprint Cloning and characterization of a new functional human aldehyde dehydrogenase gene
    L C Hsu
    Department of Biochemical Genetics, Beckman Research Institute of the City of Hope, Duarte, California 91010
    J Biol Chem 266:12257-65. 1991

Collaborators

  • C L Hsieh
  • G Duester
  • A Yoshida
  • C Chang
  • S W Lin
  • V Dave
  • A Rzhetsky
  • D Sherman
  • J C Chen
  • T J Peters
  • Y Yanagawa
  • L Raghunathan
  • K Tani
  • I Klisak
  • R S Sparkes
  • M Ikawa
  • T Mohandas

Detail Information

Publications23

  1. ncbi request reprint Mouse type-2 retinaldehyde dehydrogenase (RALDH2): genomic organization, tissue-dependent expression, chromosome assignment and comparison to other types
    L C Hsu
    Division of Molecular Medicine, Beckman Research Institute of the City of Hope, 1450 E Duarte Road, Duarte, CA 91010, USA
    Biochim Biophys Acta 1492:289-93. 2000
    ....
  2. ncbi request reprint Human gamma-aminobutyraldehyde dehydrogenase (ALDH9): cDNA sequence, genomic organization, polymorphism, chromosomal localization, and tissue expression
    S W Lin
    Department of Biochemical Genetics, Beckman Research Institute of the City of Hope, Duarte, California, 91010, USA
    Genomics 34:376-80. 1996
    ..4 kb and that the gene is expressed at high levels in adult liver, skeletal muscle, and kidney and low levels in heart, pancreas, lung, and brain. The gene is polymorphic, i.e., C or T at nt 327 and C or G at nt 344...
  3. ncbi request reprint Sequencing and expression of the human ALDH8 encoding a new member of the aldehyde dehydrogenase family
    L C Hsu
    Department of Biochemical Genetics, Beckman Research Institute of the City of Hope, Duarte, CA 91010, USA
    Gene 174:319-22. 1996
    ..The expression of the ALDH8 transcripts is restricted to the salivary gland among the human tissues examined...
  4. ncbi request reprint Human aldehyde dehydrogenase genes, ALDH7 and ALDH8: genomic organization and gene structure comparison
    L C Hsu
    Department of Biochemical Genetics, Beckman Research Institute of the City of Hope, Duarte, CA 91010, USA
    Gene 189:89-94. 1997
    ..The human ALDH7 and -8 genes have a closer evolutionary relationship with the human ALDH3...
  5. ncbi request reprint Human stomach aldehyde dehydrogenase, ALDH3
    L C Hsu
    Department of Biochemical Genetics, Beckman Research Institute of the City of Hope, Duarte, CA 91010
    Adv Exp Med Biol 328:141-52. 1993
  6. ncbi request reprint Cloning and characterization of genes encoding four additional human aldehyde dehydrogenase isozymes
    L C Hsu
    Department of Biochemical Genetics, Beckman Research Institute, City of Hope, Duarte, California, USA
    Adv Exp Med Biol 372:159-68. 1995
  7. pmc Molecular analysis of two closely related mouse aldehyde dehydrogenase genes: identification of a role for Aldh1, but not Aldh-pb, in the biosynthesis of retinoic acid
    L C Hsu
    Department of Biochemical Genetics, Beckman Research Institute of the City of Hope, Duarte, CA 91010, USA
    Biochem J 339:387-95. 1999
    ..Thus our results indicate that Aldh1 can function in retinoic acid synthesis under physiological conditions, but that the closely related Aldh-pb does not share this property...
  8. ncbi request reprint Molecular cloning, genomic organization, and chromosomal localization of an additional human aldehyde dehydrogenase gene, ALDH6
    L C Hsu
    Department of Biochemical Genetics, Beckman Research Institute of the City of Hope, Duarte, California 91010
    Genomics 24:333-41. 1994
    ..The ALDH6 gene was assigned to chromosome 15q26 using fluorescence in situ hybridization...
  9. ncbi request reprint Cloning of a cDNA encoding human ALDH7, a new member of the aldehyde dehydrogenase family
    L C Hsu
    Department of Biochemical Genetics, Beckman Research Institute of the City of Hope, Duarte, CA 91010
    Gene 151:285-9. 1994
    ..The degree of identity between the two isozymes is 52% with a positional alignment of 453 aa. Northern blot analysis demonstrated that lung is another major tissue expressing ALDH7...
  10. ncbi request reprint Cloning and characterization of a new functional human aldehyde dehydrogenase gene
    L C Hsu
    Department of Biochemical Genetics, Beckman Research Institute of the City of Hope, Duarte, California 91010
    J Biol Chem 266:12257-65. 1991
    ..Primary extension and S1 mapping analysis indicate the existence of at least two 5'-UT exons. The new ALDHx gene was assigned to chromosome 9 by Southern blot hybridization of DNA samples from a panel of rodent-human hybrid cell lines...
  11. ncbi request reprint Human aldehyde dehydrogenase gene family
    A Yoshida
    Beckman Research Institute of the City of Hope, Duarte, CA 91010, USA
    Eur J Biochem 251:549-57. 1998
    ..Separations of ALDH3/ALDH10 and that of ALDH7/ALDH8 had occurred during the period of appearance and radiation of mammalian species...
  12. ncbi request reprint Genomic structure of the human mitochondrial aldehyde dehydrogenase gene
    L C Hsu
    Department of Biochemical Genetics, Beckman Research Institute of the City of Hope, Duarte, California 91010
    Genomics 2:57-65. 1988
    ..Primer extension and S1 nuclease mapping were performed to characterize the 5'-region of the gene...
  13. ncbi request reprint Biological role of human cytosolic aldehyde dehydrogenase 1: hormonal response, retinal oxidation and implication in testicular feminization
    A Yoshida
    Department of Biochemical Genetics, Beckman Research Institute of the City of Hope, Duarte, CA 91010
    Adv Exp Med Biol 328:37-44. 1993
  14. ncbi request reprint Genomic structure of the human cytosolic aldehyde dehydrogenase gene
    L C Hsu
    Department of Biochemical Genetics, Beckman Research Institute of the City of Hope, Duarte, California 91010
    Genomics 5:857-65. 1989
    ..This is consistent with the model that the two isozyme genes evolved after the duplication of a common ancestor gene...
  15. ncbi request reprint Expression of human aldehyde dehydrogenase-3 associated with hepatocellular carcinoma: promoter regions and nuclear protein factors related to the expression
    C Chang
    Department of Biochemical Genetics, Beckman Research Institute of the City of Hope, Duarte, CA 91010, USA
    Int J Mol Med 2:333-8. 1998
    ..These findings suggest that a high level of expression of ALDH3 in cancerous liver tissues resulted from the expression or activation of at least two nuclear proteins reacting to the ALDH3 promoter region...
  16. ncbi request reprint Human stomach aldehyde dehydrogenase cDNA and genomic cloning, primary structure, and expression in Escherichia coli
    L C Hsu
    Department of Biochemical Genetics, Beckman Research Institute of the City of Hope, Duarte, California 91010
    J Biol Chem 267:3030-7. 1992
    ....
  17. ncbi request reprint Diverse polymorphism within a short coding region of the human aldehyde dehydrogenase-5 (ALDH5) gene
    D Sherman
    Department of Clinical Biochemistry, King s College School of Medicine and Dentistry, London, UK
    Hum Genet 92:477-80. 1993
    ..001). No significant difference was found in the genotypes of the three nucleotide positions between alcoholic and nonalcoholic Caucasians within the limited numbers of subjects examined...
  18. ncbi request reprint Molecular abnormality and cDNA cloning of human aldehyde dehydrogenases
    A Yoshida
    Alcohol 2:103-6. 1985
    ..The molecular abnormality of the inactive ALDH2(2) is found to be the substitution of Glu at the 14th position from the COOH-terminal of the protein by Lys which resulted from G----A transition in the gene...
  19. ncbi request reprint Regional localization of the human genes for aldehyde dehydrogenase-1 and aldehyde dehydrogenase-2
    L Raghunathan
    Division of Medical Genetics, Harbor UCLA Medical Center, Torrance 90509
    Genomics 2:267-9. 1988
    ..Results presented here allow localization of ALDH1 to band q21 on chromosome 9 and ALDH2 to band q24 on chromosome 12...
  20. pmc Chromosomal assignment of the genes for human aldehyde dehydrogenase-1 and aldehyde dehydrogenase-2
    L C Hsu
    Am J Hum Genet 38:641-8. 1986
    ..Based on the distribution pattern of ALDH1 and ALDH2 in cell hybrids, ALDH1 was assigned to the long arm of human chromosome 9 and ALDH2 to chromosome 12...
  21. pmc Cloning of cDNAs for human aldehyde dehydrogenases 1 and 2
    L C Hsu
    Proc Natl Acad Sci U S A 82:3771-5. 1985
    ..The degree of homology between human ALDH1 and ALDH2 is 66% for the coding regions of their cDNAs and 69% at the protein level. No significant homology was found in their 3' untranslated regions...
  22. pmc Cloning a plant amino acid transporter by functional complementation of a yeast amino acid transport mutant
    L C Hsu
    Department of Plant Biology, University of Illinois, Urbana 61801
    Proc Natl Acad Sci U S A 90:7441-5. 1993
    ..Interestingly, however, there are small regions of sequence that exhibit significant levels of similarity with at least seven other integral membrane proteins...
  23. ncbi request reprint Identification of a gamma-tubulin-binding domain in BRCA1
    L C Hsu
    Department of Oncological Sciences, University of Utah, Salt Lake City, Utah 84112, USA
    Cancer Res 61:7713-8. 2001
    ..Thus, attenuating the interaction between BRCA1 and gamma-tubulin, and their association with mitotic centrosomes, may induce an increase of aneuploid cell population and contribute to tumorigenesis...