Margarita Gutova

Summary

Affiliation: City of Hope National Medical Center
Country: USA

Publications

  1. doi request reprint Neural stem cell-mediated CE/CPT-11 enzyme/prodrug therapy in transgenic mouse model of intracerebellar medulloblastoma
    M Gutova
    Department of Neurosciences, Beckman Research Institute of the City of Hope, Duarte, CA 91010 3000, USA
    Gene Ther 20:143-50. 2013
  2. pmc Identification of uPAR-positive chemoresistant cells in small cell lung cancer
    Margarita Gutova
    Division of Hematology Hematopoietic Cell Transplantation, City of Hope National Medical Center and Beckman Research Institute, Duarte, California, United States of America
    PLoS ONE 2:e243. 2007
  3. ncbi request reprint Urokinase plasminogen activator and urokinase plasminogen activator receptor mediate human stem cell tropism to malignant solid tumors
    Margarita Gutova
    Division of Hematology Hematopoietic Cell Transplantation, City of Hope National Medical Center and Beckman Research Institute, 1500 East Duarte Road, Duarte, California 91010 3000, USA
    Stem Cells 26:1406-13. 2008
  4. ncbi request reprint Therapeutic targeting of melanoma cells using neural stem cells expressing carboxylesterase, a CPT-11 activating enzyme
    Margarita Gutova
    Division of Hematology and Hematopoietic Cell Transplantation, City of Hope National Medical Center and Beckman Research Institute, Duarte, CA 91010 3000, USA
    Curr Stem Cell Res Ther 5:273-6. 2010
  5. ncbi request reprint Human neural stem cell tropism to metastatic breast cancer
    Donghong Zhao
    Department of Neurosciences, City of Hope National Medical Center and Beckman Research Institute, Duarte, California 91010 3000, USA
    Stem Cells 30:314-25. 2012
  6. ncbi request reprint Neural stem cell tropism to glioma: critical role of tumor hypoxia
    Donghong Zhao
    Division of Hematology Hematopoietic Cell Transplantation, City of Hope National Medical Center and Beckman Research Institute, 1500 East Duarte Road, Duarte, CA 91010 3000, USA
    Mol Cancer Res 6:1819-29. 2008
  7. pmc Cellular host responses to gliomas
    Joseph Najbauer
    Department of Neurosciences, City of Hope National Medical Center and Beckman Research Institute, Duarte, California, United States of America
    PLoS ONE 7:e35150. 2012
  8. pmc Iron labeling and pre-clinical MRI visualization of therapeutic human neural stem cells in a murine glioma model
    Mya S Thu
    Department of Hematology and Hematopoietic Cell Transplantation, Beckman Research Institute, City of Hope National Medical Center, Duarte, California, United States of America
    PLoS ONE 4:e7218. 2009
  9. pmc Neural stem cell-mediated enzyme/prodrug therapy for glioma: preclinical studies
    Karen S Aboody
    Department of Neurosciences, City of Hope National Medical Center and Beckman Research Institute, Duarte, CA 91010, USA
    Sci Transl Med 5:184ra59. 2013
  10. doi request reprint Neural stem cells improve intracranial nanoparticle retention and tumor-selective distribution
    Rachael Mooney
    Department of Neurosciences, Beckman Research Institute at City of Hope, 1500 East Duarte Road, Duarte, CA, 91010, USA
    Future Oncol 10:401-15. 2014

Collaborators

Detail Information

Publications10

  1. doi request reprint Neural stem cell-mediated CE/CPT-11 enzyme/prodrug therapy in transgenic mouse model of intracerebellar medulloblastoma
    M Gutova
    Department of Neurosciences, Beckman Research Institute of the City of Hope, Duarte, CA 91010 3000, USA
    Gene Ther 20:143-50. 2013
    ..Thus, this study provides proof-of-concept for NSC-mediated CE/CPT-11 treatment of medulloblastoma, and serves as a foundation for further studies toward potential clinical application...
  2. pmc Identification of uPAR-positive chemoresistant cells in small cell lung cancer
    Margarita Gutova
    Division of Hematology Hematopoietic Cell Transplantation, City of Hope National Medical Center and Beckman Research Institute, Duarte, California, United States of America
    PLoS ONE 2:e243. 2007
    ..However, little is known about the role of uPA/uPAR in small cell lung cancer (SCLC), the most aggressive type of lung cancer. We therefore determined whether uPA and uPAR are involved in generation of drug resistant SCLC cell phenotype...
  3. ncbi request reprint Urokinase plasminogen activator and urokinase plasminogen activator receptor mediate human stem cell tropism to malignant solid tumors
    Margarita Gutova
    Division of Hematology Hematopoietic Cell Transplantation, City of Hope National Medical Center and Beckman Research Institute, 1500 East Duarte Road, Duarte, California 91010 3000, USA
    Stem Cells 26:1406-13. 2008
    ..Disclosure of potential conflicts of interest is found at the end of this article...
  4. ncbi request reprint Therapeutic targeting of melanoma cells using neural stem cells expressing carboxylesterase, a CPT-11 activating enzyme
    Margarita Gutova
    Division of Hematology and Hematopoietic Cell Transplantation, City of Hope National Medical Center and Beckman Research Institute, Duarte, CA 91010 3000, USA
    Curr Stem Cell Res Ther 5:273-6. 2010
    ..Future experiments will evaluate the therapeutic efficacy of NSC-mediated melanoma therapy in animal models, which will provide the basis for targeted therapy in patients with advanced melanoma...
  5. ncbi request reprint Human neural stem cell tropism to metastatic breast cancer
    Donghong Zhao
    Department of Neurosciences, City of Hope National Medical Center and Beckman Research Institute, Duarte, California 91010 3000, USA
    Stem Cells 30:314-25. 2012
    ..These data suggest that NSC-mediated enzyme/prodrug therapy may be more effective and less toxic than currently available chemotherapy strategies for breast cancer metastases...
  6. ncbi request reprint Neural stem cell tropism to glioma: critical role of tumor hypoxia
    Donghong Zhao
    Division of Hematology Hematopoietic Cell Transplantation, City of Hope National Medical Center and Beckman Research Institute, 1500 East Duarte Road, Duarte, CA 91010 3000, USA
    Mol Cancer Res 6:1819-29. 2008
    ..These results have significant implications for development of stem cell-mediated tumor-selective gene therapies...
  7. pmc Cellular host responses to gliomas
    Joseph Najbauer
    Department of Neurosciences, City of Hope National Medical Center and Beckman Research Institute, Duarte, California, United States of America
    PLoS ONE 7:e35150. 2012
    ..Marker-specific, anatomical and morphological analyses revealed a robust influx of host cells into the main tumor bed and tumor satellites...
  8. pmc Iron labeling and pre-clinical MRI visualization of therapeutic human neural stem cells in a murine glioma model
    Mya S Thu
    Department of Hematology and Hematopoietic Cell Transplantation, Beckman Research Institute, City of Hope National Medical Center, Duarte, California, United States of America
    PLoS ONE 4:e7218. 2009
    ..Thus we aimed to iron-label therapeutic NSCs without affecting their cellular physiology using a method likely to gain United States Federal Drug Administration (FDA) approval...
  9. pmc Neural stem cell-mediated enzyme/prodrug therapy for glioma: preclinical studies
    Karen S Aboody
    Department of Neurosciences, City of Hope National Medical Center and Beckman Research Institute, Duarte, CA 91010, USA
    Sci Transl Med 5:184ra59. 2013
    ..These data have led to approval of a first-in-human study of an allogeneic NSC-mediated enzyme/prodrug-targeted cancer therapy in patients with recurrent high-grade glioma...
  10. doi request reprint Neural stem cells improve intracranial nanoparticle retention and tumor-selective distribution
    Rachael Mooney
    Department of Neurosciences, Beckman Research Institute at City of Hope, 1500 East Duarte Road, Duarte, CA, 91010, USA
    Future Oncol 10:401-15. 2014
    ..The purpose of this work is to determine if tumor-tropic neural stem cells (NSCs) can improve the tumor-selective distribution and retention of nanoparticles (NPs) within invasive brain tumors...