Sanna Goyert

Summary

Affiliation: CUNY Medical School/Sopohie Davis School of Biomedical Education
Location: New York, USA
Summary:
Medical Professor and Chair, Department of Microbiology and Immunology
Grants:
Role of CD14 and Other LPS Receptors in Endotoxin Shock, 2011
Role of CD14 and Other LPS Receptors in Endotoxin Shock, 2010
Role of CD14 and Other LPS Receptors in Endotoxin Shock, 2009
Role of CD14 and Other LPS Receptors in Endotoxin Shock, 2008

Publications

  1. ncbi request reprint Menopause. A positive change
    C Mendham
    Nurs Times 88:34-5. 1992
  2. ncbi request reprint Editorial: PD-1, a new target for sepsis treatment: better late than never
    Sanna M Goyert
    J Leukoc Biol 88:225-6. 2010
  3. doi request reprint Analysis of Cd14 as a genetic modifier of experimental inflammatory bowel disease (IBD) in mice
    Maike F de Buhr
    Insitute for Laboratory Animal Science, Hannover Medical School, Hannover, Germany
    Inflamm Bowel Dis 15:1824-36. 2009
  4. pmc Pivotal role of the alpha(2A)-adrenoceptor in producing inflammation and organ injury in a rat model of sepsis
    Michael Miksa
    Center for Immunology and Inflammation, The Feinstein Institute for Medical Research, Department of Surgery, North Shore University Hospital and Long Island Jewish Medical Center, Manhasset, NY, USA
    PLoS ONE 4:e5504. 2009
  5. ncbi request reprint Injection of lipopolysaccharide induces the migration of splenic neutrophils to the T cell area of the white pulp: role of CD14 and CXC chemokines
    Nicolas Kesteman
    Institut de Biologie et Médecine Moléculaires, Universite Libre de Bruxelles, Rue des Prof Jeener et Brachet 12, Gosselies, Belgium
    J Leukoc Biol 83:640-7. 2008
  6. ncbi request reprint Expression of Legionella pneumophila paralogous lipid A biosynthesis genes under different growth conditions
    Urs Albers
    ETH Zurich, Institute of Microbiology, Wolfgang Pauli Strasse 10, HCI G405, 8093 Zurich, Switzerland
    Microbiology 153:3817-29. 2007
  7. pmc Role of CD14 in responses to clinical isolates of Escherichia coli: effects of K1 capsule expression
    Shalaka Metkar
    Department of Microbiology and Immunology, CUNY Medical School, and Sophie Davis School for Biomedical Sciences, City College of New York, New York, New York, USA
    Infect Immun 75:5415-24. 2007
  8. pmc In silico and in vivo approach to elucidate the inflammatory complexity of CD14-deficient mice
    Jose M Prince
    Department of Surgery, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Mol Med 12:88-96. 2006
  9. ncbi request reprint Signaling through CD14 attenuates the inflammatory response to Borrelia burgdorferi, the agent of Lyme disease
    Mohammed Rafii El Idrissi Benhnia
    Center for Immunology and Microbial Disease, Albany Medical College, Albany, NY12208, USA
    J Immunol 174:1539-48. 2005
  10. ncbi request reprint Bacterial endotoxin stimulates macrophages to release HMGB1 partly through CD14- and TNF-dependent mechanisms
    Guoqian Chen
    Department of Emergency Medicine, North Shore University Hospital, New York University School of Medicine, 350 Community Drive, Manhasset, NY 11030, USA
    J Leukoc Biol 76:994-1001. 2004

Collaborators

Detail Information

Publications13

  1. ncbi request reprint Menopause. A positive change
    C Mendham
    Nurs Times 88:34-5. 1992
  2. ncbi request reprint Editorial: PD-1, a new target for sepsis treatment: better late than never
    Sanna M Goyert
    J Leukoc Biol 88:225-6. 2010
  3. doi request reprint Analysis of Cd14 as a genetic modifier of experimental inflammatory bowel disease (IBD) in mice
    Maike F de Buhr
    Insitute for Laboratory Animal Science, Hannover Medical School, Hannover, Germany
    Inflamm Bowel Dis 15:1824-36. 2009
    ..The aim of the present study was to analyze the molecular mechanisms leading to differential intestinal expression of Cd14 and its contribution to IBD development...
  4. pmc Pivotal role of the alpha(2A)-adrenoceptor in producing inflammation and organ injury in a rat model of sepsis
    Michael Miksa
    Center for Immunology and Inflammation, The Feinstein Institute for Medical Research, Department of Surgery, North Shore University Hospital and Long Island Jewish Medical Center, Manhasset, NY, USA
    PLoS ONE 4:e5504. 2009
    ..e., alpha(2A), alpha(2B) or alpha(2C)) is responsible for the upregulation of TNF-alpha production. The aim of this study was to determine the contribution of alpha(2A)-AR in this process...
  5. ncbi request reprint Injection of lipopolysaccharide induces the migration of splenic neutrophils to the T cell area of the white pulp: role of CD14 and CXC chemokines
    Nicolas Kesteman
    Institut de Biologie et Médecine Moléculaires, Universite Libre de Bruxelles, Rue des Prof Jeener et Brachet 12, Gosselies, Belgium
    J Leukoc Biol 83:640-7. 2008
    ..We conclude that neutrophils may interact with naïve T cells upon infection/inflammation and that the migration of neutrophils in the lymphoid organs and in the periphery is regulated differently by a signal transduced by CD14...
  6. ncbi request reprint Expression of Legionella pneumophila paralogous lipid A biosynthesis genes under different growth conditions
    Urs Albers
    ETH Zurich, Institute of Microbiology, Wolfgang Pauli Strasse 10, HCI G405, 8093 Zurich, Switzerland
    Microbiology 153:3817-29. 2007
    ..The differential regulation of lpxB or lpxA paralogues in response to changing environmental conditions might allow L. pneumophila to adapt its lipid A structure...
  7. pmc Role of CD14 in responses to clinical isolates of Escherichia coli: effects of K1 capsule expression
    Shalaka Metkar
    Department of Microbiology and Immunology, CUNY Medical School, and Sophie Davis School for Biomedical Sciences, City College of New York, New York, New York, USA
    Infect Immun 75:5415-24. 2007
    ..These studies show that different bacterial isolates can use distinctly different mechanisms to cause disease and suggest that new, nonantibiotic therapeutics need to be directed against multiple targets...
  8. pmc In silico and in vivo approach to elucidate the inflammatory complexity of CD14-deficient mice
    Jose M Prince
    Department of Surgery, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Mol Med 12:88-96. 2006
    ....
  9. ncbi request reprint Signaling through CD14 attenuates the inflammatory response to Borrelia burgdorferi, the agent of Lyme disease
    Mohammed Rafii El Idrissi Benhnia
    Center for Immunology and Microbial Disease, Albany Medical College, Albany, NY12208, USA
    J Immunol 174:1539-48. 2005
    ..Continued study of CD14-independent signaling pathways may provide mechanistic insight into the inflammatory processes that underlie development of chronic inflammation...
  10. ncbi request reprint Bacterial endotoxin stimulates macrophages to release HMGB1 partly through CD14- and TNF-dependent mechanisms
    Guoqian Chen
    Department of Emergency Medicine, North Shore University Hospital, New York University School of Medicine, 350 Community Drive, Manhasset, NY 11030, USA
    J Leukoc Biol 76:994-1001. 2004
    ..g., 10 ng/ml). Taken together, these data suggest that LPS stimulates macrophages to release HMGB1 partly through CD14- and TNF-dependent mechanisms...
  11. pmc CD14 mediates the innate immune responses to arthritopathogenic peptidoglycan-polysaccharide complexes of Gram-positive bacterial cell walls
    Xiangli Li
    Department of Nutrition, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    Arthritis Res Ther 6:R273-81. 2004
    ..These results support an essential role for CD14 in the innate immune responses to PG-PS and indicate an important role for CD14 in PG-PS induced arthropathy...
  12. ncbi request reprint CD14-deficient mice are protected against lipopolysaccharide-induced cardiac inflammation and left ventricular dysfunction
    Pascal Knuefermann
    Department of Medicine, Baylor College of Medicine, Houston, Tex, USA
    Circulation 106:2608-15. 2002
    ..CD14 mediates the inflammatory response to lipopolysaccharide (LPS) in various organs including the heart. In this study we investigated the role of CD14 in LPS-induced myocardial dysfunction in vivo...
  13. pmc Differential expression of CD14-dependent and independent pathways for chemokine induction regulates neutrophil trafficking in infection
    Shalaka Metkar
    Department of Microbiology and Immunology, Sophie Davis School of Biomedical Education, The City College of New York, New York, New York, USA
    J Leukoc Biol 92:389-96. 2012
    ..coli infection. Thus, stimulation of a local CD14-independent chemokine induction pathway without triggering a systemic CD14-dependent chemokine pathway can protect against severe E. coli infections...

Research Grants22

  1. STRUCTURE AND FUNCTION OF MONOCYTE/GRANULOCYTE ANTIGENS
    Sanna Goyert; Fiscal Year: 1993
    ..The effects of this abnormal expression on hematopoiesis and the cellularity of various tissues will be analyzed...
  2. CHARACTERIZATION OF THE LPS RECEPTOR FOR ACUTE PHASE
    Sanna Goyert; Fiscal Year: 2000
    ..abstract_text> ..
  3. ROLE OF CD14 AND OTHER LPS RECEPTORS IN ENDOTOXIC SHOCK
    Sanna Goyert; Fiscal Year: 2001
    ..Studies suggest that there are two pathways for activation with LPS; One that stimulates via membrane CD14 and one that stimulates via another pathway and requires a complex of performance sites. ..
  4. CHARACTERIZATION OF THE LPS RECEPTOR FOR ACUTE PHASE
    Sanna Goyert; Fiscal Year: 2001
    ..abstract_text> ..
  5. ROLE OF CD14 AND OTHER LPS RECEPTORS IN ENDOTOXIC SHOCK
    Sanna Goyert; Fiscal Year: 2002
    ..Studies suggest that there are two pathways for activation with LPS; One that stimulates via membrane CD14 and one that stimulates via another pathway and requires a complex of performance sites. ..
  6. CHARACTERIZATION OF THE LPS RECEPTOR FOR ACUTE PHASE
    Sanna Goyert; Fiscal Year: 2002
    ..abstract_text> ..
  7. ROLE OF CD14 AND OTHER LPS RECEPTORS IN ENDOTOXIC SHOCK
    Sanna Goyert; Fiscal Year: 2003
    ..Studies suggest that there are two pathways for activation with LPS; One that stimulates via membrane CD14 and one that stimulates via another pathway and requires a complex of performance sites. ..
  8. ROLE OF CD14 AND OTHER LPS RECEPTORS IN ENDOTOXIC SHOCK
    Sanna Goyert; Fiscal Year: 2004
    ..Studies suggest that there are two pathways for activation with LPS; One that stimulates via membrane CD14 and one that stimulates via another pathway and requires a complex of performance sites. ..
  9. ROLE OF CD14 AND OTHER LPS RECEPTORS IN ENDOTOXIC SHOCK
    Sanna Goyert; Fiscal Year: 2005
    ..Studies suggest that there are two pathways for activation with LPS; One that stimulates via membrane CD14 and one that stimulates via another pathway and requires a complex of performance sites. ..
  10. Role of CD14 and other innate immune receptors in severe sepsis
    Sanna Goyert; Fiscal Year: 2009
    ..The neutrophil is an important cell that serves as a first line of defense against invading bacteria. This proposal aims to identify the molecules and mechanisms that regulate neutrophil recruitment to the site of infection. ..
  11. STRUCTURE AND FUNCTION OF MONOCYTE/GRANULOCYTE ANTIGENS
    Sanna Goyert; Fiscal Year: 1992
    ..The effects of this abnormal expression on hematopoiesis and the cellularity of various tissues will be analyzed...
  12. CD14 AND OTHER LPS RECEPTORS AND ENDOTOXIN SHOCK
    Sanna Goyert; Fiscal Year: 1999
    ..What is the three-dimensional structure of CD14? 4. What is the nature of the endothelial cell receptor for the complex of LPS-soluble CD14 and is it present on other cell types that also respond to this complex? ..
  13. STRUCTURE AND FUNCTION OF MONOCYTE/GRANULOCYTE ANTIGENS
    Sanna Goyert; Fiscal Year: 1990
    ..The effects of this abnormal expression on hematopoiesis and the cellularity of various tissues will be analyzed...
  14. STRUCTURE AND FUNCTION OF MONOCYTE/GRANULOCYTE ANTIGENS
    Sanna Goyert; Fiscal Year: 1991
    ..The effects of this abnormal expression on hematopoiesis and the cellularity of various tissues will be analyzed...
  15. Role of CD14 and other innate immune receptors in severe sepsis
    Sanna M Goyert; Fiscal Year: 2010
    ..The neutrophil is an important cell that serves as a first line of defense against invading bacteria. This proposal aims to identify the molecules and mechanisms that regulate neutrophil recruitment to the site of infection. ..