C-X Gong

Summary

Affiliation: City University of New York
Country: USA

Publications

  1. pmc Hyperphosphorylation of microtubule-associated protein tau: a promising therapeutic target for Alzheimer disease
    C X Gong
    Department of Neurochemistry, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, New York, USA
    Curr Med Chem 15:2321-8. 2008
  2. pmc Tau exon 10 alternative splicing and tauopathies
    Fei Liu
    Department of Neurochemistry, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, New York 10314, USA
    Mol Neurodegener 3:8. 2008
  3. ncbi request reprint Post-translational modifications of tau protein in Alzheimer's disease
    C X Gong
    Department of Neurochemistry, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, NY 10314, USA
    J Neural Transm 112:813-38. 2005
  4. ncbi request reprint Aberrant glycosylation modulates phosphorylation of tau by protein kinase A and dephosphorylation of tau by protein phosphatase 2A and 5
    F Liu
    Department of Neurochemistry, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, NY 10314, USA
    Neuroscience 115:829-37. 2002
  5. pmc Decreased glucose transporters correlate to abnormal hyperphosphorylation of tau in Alzheimer disease
    Ying Liu
    Department of Neurochemistry, New York State Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, NY 10314, USA
    FEBS Lett 582:359-64. 2008
  6. pmc Decrease of protein phosphatase 2A and its association with accumulation and hyperphosphorylation of tau in Down syndrome
    Zhihou Liang
    Department of Neurochemistry, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, New York 10314 6399, USA
    J Alzheimers Dis 13:295-302. 2008
  7. ncbi request reprint Contributions of protein phosphatases PP1, PP2A, PP2B and PP5 to the regulation of tau phosphorylation
    Fei Liu
    Department of Neurochemistry, New York State Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, New York 10314, USA
    Eur J Neurosci 22:1942-50. 2005
  8. ncbi request reprint Bilateral injection of isoproterenol into hippocampus induces Alzheimer-like hyperphosphorylation of tau and spatial memory deficit in rat
    Li Sun
    Department of Pathophysiology, Institute of Neuroscience, Tongji Medical College, Huazhong University of Science and Technology, 13 Hang Kong Road, Wuhan 430030, PR China
    FEBS Lett 579:251-8. 2005
  9. ncbi request reprint Tau pathology in Alzheimer disease and other tauopathies
    Khalid Iqbal
    Department of Neurochemistry, New York State Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, NY 10314 6399, USA
    Biochim Biophys Acta 1739:198-210. 2005
  10. ncbi request reprint Dephosphorylation of tau by protein phosphatase 5: impairment in Alzheimer's disease
    Fei Liu
    New York State Institute for Basic Research in Developmental Disabilities, Staten Island, New York 10314, USA
    J Biol Chem 280:1790-6. 2005

Collaborators

Detail Information

Publications29

  1. pmc Hyperphosphorylation of microtubule-associated protein tau: a promising therapeutic target for Alzheimer disease
    C X Gong
    Department of Neurochemistry, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, New York, USA
    Curr Med Chem 15:2321-8. 2008
    ..Development of drugs on the basis of these strategies is likely to lead to disease-modifying therapies for AD...
  2. pmc Tau exon 10 alternative splicing and tauopathies
    Fei Liu
    Department of Neurochemistry, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, New York 10314, USA
    Mol Neurodegener 3:8. 2008
    ....
  3. ncbi request reprint Post-translational modifications of tau protein in Alzheimer's disease
    C X Gong
    Department of Neurochemistry, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, NY 10314, USA
    J Neural Transm 112:813-38. 2005
    ..Analyses of the current advances in tau modifications suggest that intervention addressing these abnormalities may offer promising therapeutic opportunities to prevent and treat neurofibrillary degeneration of AD and other tauopathies...
  4. ncbi request reprint Aberrant glycosylation modulates phosphorylation of tau by protein kinase A and dephosphorylation of tau by protein phosphatase 2A and 5
    F Liu
    Department of Neurochemistry, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, NY 10314, USA
    Neuroscience 115:829-37. 2002
    ..The combined impact of this modulation may be to make tau more susceptible to becoming abnormally hyperphosphorylated...
  5. pmc Decreased glucose transporters correlate to abnormal hyperphosphorylation of tau in Alzheimer disease
    Ying Liu
    Department of Neurochemistry, New York State Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, NY 10314, USA
    FEBS Lett 582:359-64. 2008
    ....
  6. pmc Decrease of protein phosphatase 2A and its association with accumulation and hyperphosphorylation of tau in Down syndrome
    Zhihou Liang
    Department of Neurochemistry, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, New York 10314 6399, USA
    J Alzheimers Dis 13:295-302. 2008
    ..Our results indicate that PP2A is down-regulated in DS brain and suggest that this down-regulation might be involved in the abnormal hyperphosphorylation and accumulation of tau...
  7. ncbi request reprint Contributions of protein phosphatases PP1, PP2A, PP2B and PP5 to the regulation of tau phosphorylation
    Fei Liu
    Department of Neurochemistry, New York State Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, New York 10314, USA
    Eur J Neurosci 22:1942-50. 2005
    ..Our findings indicate that PP2A is the major tau phosphatase that regulates its phosphorylation at multiple sites in human brain. The abnormal hyperphosphorylation of tau is partially due to a downregulation of PP2A activity in AD brain...
  8. ncbi request reprint Bilateral injection of isoproterenol into hippocampus induces Alzheimer-like hyperphosphorylation of tau and spatial memory deficit in rat
    Li Sun
    Department of Pathophysiology, Institute of Neuroscience, Tongji Medical College, Huazhong University of Science and Technology, 13 Hang Kong Road, Wuhan 430030, PR China
    FEBS Lett 579:251-8. 2005
    ..These findings suggest the involvement of PKA and PKA-mediated signaling pathway in the Alzheimer-like tau hyperphosphorylation and memory impairment...
  9. ncbi request reprint Tau pathology in Alzheimer disease and other tauopathies
    Khalid Iqbal
    Department of Neurochemistry, New York State Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, NY 10314 6399, USA
    Biochim Biophys Acta 1739:198-210. 2005
    ..Inhibition of this tau abnormality is one of the most promising therapeutic approaches to AD and other tauopathies...
  10. ncbi request reprint Dephosphorylation of tau by protein phosphatase 5: impairment in Alzheimer's disease
    Fei Liu
    New York State Institute for Basic Research in Developmental Disabilities, Staten Island, New York 10314, USA
    J Biol Chem 280:1790-6. 2005
    ..These results suggest that tau is probably a physiological substrate of PP5 and that the abnormal hyperphosphorylation of tau in AD might result in part from the decreased PP5 activity in the diseased brains...
  11. pmc Site-specific effects of tau phosphorylation on its microtubule assembly activity and self-aggregation
    Fei Liu
    Department of Neurochemistry, New York State Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, NY 10314, USA
    Eur J Neurosci 26:3429-36. 2007
    ..These studies reveal the differential regulation of tau's biological activity and self-aggregation by phosphorylation at various sites/regions...
  12. ncbi request reprint Significance and mechanism of Alzheimer neurofibrillary degeneration and therapeutic targets to inhibit this lesion
    Khalid Iqbal
    Department of Neurochemistry, New York State Institute for Basic Research in Developmental Disabilities, Staten Island 10314 6399, USA
    J Mol Neurosci 19:95-9. 2002
    ....
  13. pmc O-GlcNAcylation regulates phosphorylation of tau: a mechanism involved in Alzheimer's disease
    Fei Liu
    Department of Neurochemistry, New York State Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, NY 10314, USA
    Proc Natl Acad Sci U S A 101:10804-9. 2004
    ....
  14. ncbi request reprint Involvement of aberrant glycosylation in phosphorylation of tau by cdk5 and GSK-3beta
    Fei Liu
    Department of Neurochemistry, New York State Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island 10314, USA
    FEBS Lett 530:209-14. 2002
    ..These data suggest that aberrant glycosylation of tau in AD might be involved in neurofibrillary degeneration by promoting abnormal hyperphosphorylation by cdk5 and GSK-3beta...
  15. ncbi request reprint Alzheimer neurofibrillary degeneration: therapeutic targets and high-throughput assays
    Khalid Iqbal
    New York State Institute for Basic Research in Developmental Disabilities, Staten Island, New York 10314 6399, USA
    J Mol Neurosci 20:425-9. 2003
    ..Development of high-throughput screening assays for potential drugs aimed at these therapeutic targets is currently under way...
  16. ncbi request reprint Regulation of microtubule-associated proteins, protein kinases and protein phosphatases during differentiation of SY5Y cells
    Niloufar Haque
    Department of Neurochemistry, New York State Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, NY 10314 6399, USA
    Brain Res Mol Brain Res 129:163-70. 2004
    ..These results suggest that the expression, post-translational modifications and biological activities of various MAPs are differentially regulated to meet the biological needs during cell differentiation...
  17. pmc Down-regulation of cAMP-dependent protein kinase by over-activated calpain in Alzheimer disease brain
    Zhihou Liang
    Department of Neurochemistry, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, New York, USA
    J Neurochem 103:2462-70. 2007
    ....
  18. pmc Okadaic-acid-induced inhibition of protein phosphatase 2A produces activation of mitogen-activated protein kinases ERK1/2, MEK1/2, and p70 S6, similar to that in Alzheimer's disease
    Jin Jing Pei
    Division of Experimental Geriatrics, Karolinska Institutet, Neurotec, Huddinge, Sweden
    Am J Pathol 163:845-58. 2003
    ....
  19. ncbi request reprint Inhibition of protein phosphatase 2A induces phosphorylation and accumulation of neurofilaments in metabolically active rat brain slices
    Cheng Xin Gong
    Department of Neurochemistry, New York State Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, New York, NY 10314, USA
    Neurosci Lett 340:107-10. 2003
    ..These findings suggest that the hyperphosphorylation and accumulation of NF found in AD brain could have been caused by the down-regulation of PP2A...
  20. pmc Overexpression of Dyrk1A contributes to neurofibrillary degeneration in Down syndrome
    Fei Liu
    Department of Neurochemistry, New York State Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Rd, Staten Island, New York 10314, USA
    FASEB J 22:3224-33. 2008
    ..These findings strongly suggest a novel mechanism by which the overexpression of Dyrk1A in DS brain causes neurofibrillary degeneration via hyperphosphorylating tau...
  21. pmc Regulation between O-GlcNAcylation and phosphorylation of neurofilament-M and their dysregulation in Alzheimer disease
    Yanqiu Deng
    Department of Neurochemistry, New York State Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Rd, Staten Island, NY 10314, USA
    FASEB J 22:138-45. 2008
    ....
  22. pmc PKA modulates GSK-3beta- and cdk5-catalyzed phosphorylation of tau in site- and kinase-specific manners
    Fei Liu
    Department of Neurochemistry, New York State Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, NY 10314, USA
    FEBS Lett 580:6269-74. 2006
    ..These studies reveal the nature of the inter-regulation of tau phosphorylation by the three major tau kinases...
  23. ncbi request reprint Concurrent alterations of O-GlcNAcylation and phosphorylation of tau in mouse brains during fasting
    Xu Li
    Department of Pathophysiology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei, P R China
    Eur J Neurosci 23:2078-86. 2006
    ....
  24. ncbi request reprint Impaired brain glucose metabolism leads to Alzheimer neurofibrillary degeneration through a decrease in tau O-GlcNAcylation
    Cheng Xin Gong
    Department of Neurochemistry, New York State Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, NY 10314 6399, USA
    J Alzheimers Dis 9:1-12. 2006
    ..Further studies of this mechanism are likely to offer a novel therapeutic target for preventing and treating AD...
  25. ncbi request reprint Truncation and activation of calcineurin A by calpain I in Alzheimer disease brain
    Fei Liu
    Department of Neurochemistry, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, 10314, USA
    J Biol Chem 280:37755-62. 2005
    ..These findings suggest that the overactivation of calpain I and calcineurin may mediate the role of calcium homeostatic disturbance in the neurodegeneration of AD...
  26. ncbi request reprint Dephosphorylation of microtubule-associated protein tau by protein phosphatase 5
    Cheng Xin Gong
    New York State Institute for Basic Research in Developmental Disabilities, Staten Island, New York 10314, USA
    J Neurochem 88:298-310. 2004
    ..These results suggest that PP5 plays a role in the dephosphorylation of tau and might be involved in the molecular pathogenesis of Alzheimer's disease...
  27. ncbi request reprint Elevation of the level and activity of acid ceramidase in Alzheimer's disease brain
    Yu Huang
    Department of Neurochemistry, New York State Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, New York 10314 6399, USA
    Eur J Neurosci 20:3489-97. 2004
    ..Our findings suggest that AC might play a role in controlling neuronal apoptosis and that AC-mediated signalling pathways might be involved in the molecular mechanism of AD...
  28. ncbi request reprint NF-kappaB precursor, p105, and NF-kappaB inhibitor, IkappaBgamma, are both elevated in Alzheimer disease brain
    Yu Huang
    Department of Neurochemistry, New York State Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, NY 10314 6399, USA
    Neurosci Lett 373:115-8. 2005
    ..Our findings suggest that the NF-kappaB pathway might be involved in the molecular mechanism of AD...
  29. ncbi request reprint Up-regulation of cell division cycle (cdc) 2 kinase in neurons with early stage Alzheimer's disease neurofibrillary degeneration
    Jin Jing Pei
    Karolinska Institutet, Neurotec, Section of Experimental Geriatrics, KFC Plan 4, Novum, 141 86 Huddinge, Sweden
    Acta Neuropathol 104:369-76. 2002
    ....