Research Topics
Genomes and Genes | Julio Garcia-AguilarSummaryAffiliation: City of Hope National Medical Center Country: USA Publications
Research Grants
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Detail Information
Publications
Multicentric study on robotic tumor-specific mesorectal excision for the treatment of rectal cancerAlessio Pigazzi
Division of General and Oncologic Surgery, City of Hope National Medical Center, Duarte, CA, USA
Ann Surg Oncol 17:1614-20. 2010..The aim of the study was to verify on a multicentric basis the perioperative and oncologic outcome of RTSRS...
Optimal timing of surgery after chemoradiation for advanced rectal cancer: preliminary results of a multicenter, nonrandomized phase II prospective trialJulio Garcia-Aguilar
Department of Surgery, City of Hope, Duarte, CA 91010, USA
Ann Surg 254:97-102. 2011....- Optimal management of small rectal cancers: TAE, TEM, or TME?Julio Garcia-Aguilar
Department of Surgery, City of Hope, 1500 East Duarte Road, Duarte, CA 91010, USA
Surg Oncol Clin N Am 19:743-60. 2010..With LE, patients trade a higher cancer cure rate for a lower risk of mortality and lower morbidity. The role of chemoradiation and LE in the treatment of rectal cancer is still under study... - Identification of a biomarker profile associated with resistance to neoadjuvant chemoradiation therapy in rectal cancerJulio Garcia-Aguilar
Department of Surgery, City of Hope, Duarte, CA 91010, USA
Ann Surg 254:486-92; discussion 492-3. 2011..To identify a biomarker profile associated with tumor response to chemoradiation (CRT) in locally advanced rectal cancer... 
A pathologic complete response to preoperative chemoradiation is associated with lower local recurrence and improved survival in rectal cancer patients treated by mesorectal excisionJulio Garcia-Aguilar
Division of Colon and Rectal Surgery, Department of Surgery, University of Minnesota Medical School, Minneapolis, MN, USA
Dis Colon Rectum 46:298-304. 2003..We studied the prognostic value of pathologic complete response to preoperative chemoradiation in rectal cancer patients...- Racial and ethnic disparities in outcomes with radiation therapy for rectal adenocarcinomaWendy Lee
Department of Surgery, City of Hope Comprehensive Cancer Center, 1500 East Duarte Road, Duarte, CA 91010, USA
Int J Colorectal Dis 27:737-49. 2012..Our objective was to determine whether disparate rectal cancer outcomes result from variable efficacy of radiation therapy for major racial/ethnic groups... - An interaction of race and ethnicity with socioeconomic status in rectal cancer outcomesJoseph Kim
Division of Oncologic Surgery, Department of Surgery, City of Hope, Duarte, CA 91010, USA
Ann Surg 253:647-54. 2011..Because appropriate rectal cancer care and subsequent outcomes can be influenced by several variables, our objective was to investigate how race, ethnicity, and socioeconomic status (SES) may impact rectal cancer outcomes... - A phase II trial of neoadjuvant chemoradiation and local excision for T2N0 rectal cancer: preliminary results of the ACOSOG Z6041 trialJulio Garcia-Aguilar
Department of Surgery, City of Hope, Duarte, USA
Ann Surg Oncol 19:384-91. 2012..Here, we report tumor response, CRT-related toxicity, and perioperative complications (PCs)... - Endorectal ultrasound in the management of patients with malignant rectal polypsJulio Garcia-Aguilar
Department of Surgery, University of California, San Francisco, California, USA
Dis Colon Rectum 48:910-6; discussion 916-7. 2005..This study was designed to determine the efficacy of endorectal ultrasound in the management of patients with malignant rectal polyps removed by snare excision during colonoscopy... - Socioeconomic factors impact colon cancer outcomes in diverse patient populationsWendy Lee
Department of Oncologic Surgery, City of Hope Comprehensive Cancer Center, 1500 East Duarte Road, Duarte, CA 91010, USA
J Gastrointest Surg 16:692-704. 2012..Cancer disparities among racial and ethnic groups are major public health concerns. Our objective was to examine the impact of socioeconomic status (SES) on survival of colon cancer patients within major racial and ethnic groups... - Surgical complications and pathologic complete response after neoadjuvant chemoradiation in locally advanced rectal cancerMarjun P Duldulao
Department of Surgery, City of Hope Medical Center, Duarte, California 91010, USA
Am Surg 77:1281-5. 2011..In conclusion, postoperative complication rates do not differ between pCR and non-pCR groups. The occurrence of major postoperative complications is not associated with response to neoadjuvant CRT... - Validation of the risk index category as a predictor of surgical site infection in elective colorectal surgeryCarlos Pastor
Department of Surgery, City of Hope National Medical Center, Duarte, California, USA
Dis Colon Rectum 53:721-7. 2010..This study aims to validate the risk index category as a predictor of surgical site infection in a cohort of patients who underwent colorectal operations and were prospectively surveyed for surgical site infection... - Gene expression variations in microsatellite stable and unstable colon cancer cellsMarjun P Duldulao
Department of Surgery, City of Hope Medical Center, 1500 E Duarte Road, Duarte, CA 91010, USA
J Surg Res 174:1-6. 2012..We used ultra high-throughput sequencing (UHTS) to assess the expression of representative genes in MSI and MSS colon cancer cell lines... - Chromosomal copy number alterations are associated with persistent lymph node metastasis after chemoradiation in locally advanced rectal cancerZhenbin Chen
Department of Surgery, City of Hope, Duarte, California 91010, USA
Dis Colon Rectum 55:677-85. 2012..Lymph node metastasis is an important indicator of oncologic outcome for patients with rectal cancer. Identifying predictive biomarkers of lymph node metastasis could therefore be clinically useful... - Molecular diagnosis of response to neoadjuvant chemoradiation therapy in patients with locally advanced rectal cancerZhenbin Chen
Department of Surgery, City of Hope, Duarte, CA, USA
J Am Coll Surg 212:1008-1017.e1. 2011..However, it is uncertain if histopathological techniques accurately detect pCR. We tested a novel molecular approach for detecting pCR and compared it with current histopathological approaches... - Chromosomal copy number alterations are associated with tumor response to chemoradiation in locally advanced rectal cancerZhenbin Chen
Department of Surgery, City of Hope, 1500 E Duarte Road, Duarte, CA 91010, USA
Genes Chromosomes Cancer 50:689-99. 2011..Our data indicate that chromosomal CNAs can help identify rectal cancer patients more likely to develop a pCR to CRT... - Adjuvant chemotherapy improves survival in patients with American Joint Committee on Cancer stage II colon cancerShaun McKenzie
Department of Surgery, University of Kentucky School of Medicine, Lexington, Kentucky, USA
Cancer 117:5493-9. 2011..It is unclear whether the administration of adjuvant chemotherapy improves survival in patients with American Joint Committee on Cancer (AJCC) stage II colon cancer... - The effect of circumferential tumor location in clinical outcomes of rectal cancer patients treated with total mesorectal excisionSuk-Hawn Lee
Division of Colon and Rectal Surgery, Department of Surgery, University of Minnesota Cancer Center, University of Minnesota, Minneapolis, Minnesota, USA
Dis Colon Rectum 48:2249-57. 2005..Anterior tumors tend to be more advanced and, at least in male patients, has a higher risk of recurrence and death than tumors in other locations... - Local excision for rectal carcinomaEdward Kim
Department of Surgery, University of California, San Francisco, CA, USA
Clin Colorectal Cancer 7:376-85. 2008..An overview of local excision in the context of perioperative adjuvant therapies is included. Finally, we suggest a treatment algorithm for local excision in rectal cancer... - An appraisal of radiofrequency ablation and surgical resection for hepatocellular carcinoma: results from the surveillance, epidemiology, and end results registryMaithao Le
Division of Surgical Oncology, Department of Surgery, City of Hope Comprehensive Cancer Center, Duarte, California 91010, USA
Am Surg 78:1091-5. 2012.... - Distribution of residual cancer cells in the bowel wall after neoadjuvant chemoradiation in patients with rectal cancerMarjun P Duldulao
Department of General Oncologic Surgery, City of Hope Comprehensive Cancer Center, Duarte, California, USA
Dis Colon Rectum 56:142-9. 2013..However, these staging systems do not provide information about the distribution of residual cancer cells within the bowel wall... - Evaluation of lymphadenectomy in patients receiving neoadjuvant radiotherapy for rectal adenocarcinomaMaithao Le
Department of Surgery, City of Hope Comprehensive Cancer Center, Duarte, CA, USA
Ann Surg Oncol 19:3713-8. 2012..Because the exact number of examined lymph nodes (LNs) may vary with preoperative therapies, our objective was to measure the impact of neoadjuvant radiation on LN number for rectal adenocarcinoma... - An increase in compliance with the Surgical Care Improvement Project measures does not prevent surgical site infection in colorectal surgeryCarlos Pastor
Department of Surgery, City of Hope National Medical Center, Duarte, California 91010, USA
Dis Colon Rectum 53:24-30. 2010..This study was designed to test the hypothesis that an increase in compliance with quality process measures decreases the rate of surgical site infections in patients undergoing colorectal surgeries... - Endorectal ultrasound in the follow-up of rectal cancer patients treated by local excision or radical surgeryEnrique Hernandez de Anda
Department of Surgery, University of Minnesota Medical School and University of Minnesota Cancer Center, Minneapolis, Minnesota, USA
Dis Colon Rectum 47:818-24. 2004..However, the impact of the earlier diagnosis in patient survival can only be determined by a larger, prospective, randomized trial... - Surgical treatment of rectal cancer: local resectionSilvana Perretta
Department of Surgery, Section of Colon and Rectal Surgery, University of San Francisco, 2330 Post Street, Suite 260, San Francisco, CA 94143-0144, USA
Surg Oncol Clin N Am 15:67-93. 2006..Local treatment can also be used for palliation of patients with histological unfavorable or advanced tumors, and those who are medically unfit for radical surgery... - The evolution of surgical technique for total gastrectomy over a 12-year period: a single institution's experienceAmanda K Arrington
Department of Oncologic Surgery, City of Hope Comprehensive Cancer Center, Duarte, California 91010, USA
Am Surg 78:1054-8. 2012..After initiation of a laparoscopic total gastrectomy program in 2009, the majority of cases in our institution are now performed by laparoscopic techniques... - Prognostic and Predictive Roles of KRAS Mutation in Colorectal CancerAmanda K Arrington
Division of Surgical Oncology, City of Hope Comprehensive Cancer Center, Duarte, CA 91010, USA
Int J Mol Sci 13:12153-68. 2012..In this review we examine the history of KRAS, its prognostic value in patients with colorectal cancer, and evidence supporting its predictive value in determining appropriate therapies for patients with colorectal cancer... - Robot-assisted total mesorectal excision: is there a learning curve?Yasir Akmal
Department of General and Oncologic Surgery, City of Hope National Medical Center, 1500 East Duarte Road, Duarte, CA 91010, USA
Surg Endosc 26:2471-6. 2012..Laparoscopic total mesorectal excision (TME) is associated with a steep learning curve, but the learning curve for robotic TME is unknown. This study aimed to evaluate the learning curve for robotic TME... - Dartos muscle interposition flap for the treatment of rectourethral fistulasMadhulika G Varma
Department of Surgery, Section of Colon and Rectal Surgery, University of California San Francisco, 2330 Post Street, Suite 260, Box 0144, San Francisco, California 94143 0144, USA
Dis Colon Rectum 50:1849-55. 2007..The many techniques for repairing these fistulas vary in their success rates. Our goal was to describe the use of a dartos muscle interposition flap for repair of these fistulas... - Totally laparoscopic right colectomy with transvaginal specimen extraction: the authors' initial institutional experienceShaun McKenzie
Department of General and Oncologic Surgery, City of Hope National Medical Center, 1500 East Duarte Road, Duarte, CA 91010 3000, USA
Surg Endosc 24:2048-52. 2010..The authors present their technique and short-term outcomes for totally laparoscopic right colectomy with transvaginal specimen extraction in a series of four patients... - Selection criteria for complete cytoreduction after cytoreductive surgery for peritoneal surface malignancy: lessons learned from our first series of patientsShaun McKenzie
Departments of General Oncologic Surgery, City of Hope National Medical Center, Duarte, California 91010 3000, USA
Am Surg 77:430-7. 2011..Early evaluation of the small bowel, mesentery, and periportal region for resectability prevents unnecessary surgery... - An interaction of race and ethnicity with socioeconomic status in rectal cancer outcomesJoseph Kim
Division of Oncologic Surgery, Department of Surgery, City of Hope, Duarte, CA Michael E DeBakey Department of Surgery and Houston Health Services and Research Center of Excellence, Michael E DeBakey Veterans Affairs Medical Center, Baylor College of Medicine Houston, TX Department of Surgery, University of California Davis, Sacramento, CA and Department of Population Sciences, City of Hope, Duarte, CA Department of Population Sciences, City of Hope, Duarte, CA
Ann Surg 253:647-54. 2011..Because appropriate rectal cancer care and subsequent outcomes can be influenced by several variables, our objective was to investigate how race, ethnicity, and socioeconomic status (SES) may impact rectal cancer outcomes... - Accuracy of endorectal ultrasonography in preoperative staging of rectal tumorsJulio Garcia-Aguilar
Division of Colon and Rectal Surgery, Department of Surgery, University of Minnesota, and The University of Minnesota Cancer Center, Minneapolis, Minnesota, USA
Dis Colon Rectum 45:10-5. 2002..Differences in image interpretation may in part explain discrepancies in accuracy between studies... - Implementation of quality measures to reduce surgical site infection in colorectal patientsElizabeth C Wick
Department of Surgery, University of California, San Francisco, California, USA
Dis Colon Rectum 51:1004-9. 2008..The goal of this study was to determine the rate of surgical site infection and compliance with process measures designed to prevent infection in a defined population of patients undergoing colorectal operations... - Polyploid cells rewire DNA damage response networks to overcome replication stress-induced barriers for tumour progressionLi Zheng
Department of Cancer Biology, City of Hope National Medical Center and Beckman Research Institute, 1500 East Duarte Road, Duarte, California 91010, USA
Nat Commun 3:815. 2012..These molecular changes rewire DNA damage response and repair gene networks in polyploid tumour cells, enabling them to escape replication stress-induced senescence barriers... - The alpha2 and alpha3 integrins are required for morphologic differentiation of an intestinal epithelial cell lineXihong Zhang
University of Minnesota Cancer Center, Department of Surgery, University of Minnesota, Minneapolis, MN, USA
Surgery 133:429-37. 2003..We have taken advantage of the ability of the Caco-2 cell line to acquire a glandular phenotype in 3-dimensional (3-D) culture systems to investigate the role of alpha2 and alpha3 integrins in morphologic differentiation... - Treatment of transsphincteric anal fistulas: are fistula plugs an acceptable alternative?Jennifer Y Wang
Department of Surgery, University of California, San Francisco, San Francisco, California, USA
Dis Colon Rectum 52:692-7. 2009..To examine the benefit of the anal fistula plug, we compared its success rate with a standard treatment for transsphincteric fistulas with similar indications, the transanal mucosal advancement flap...
Research Grants
- Timing of Rectal Cancer Response to ChemoradiationJulio Garcia Aguilar; Fiscal Year: 2009..This information will help develop molecular assays to diagnose pathologic complete response in transrectal biopsies of the tumor bed before removing the rectum. ..