D L DiGiusto
Affiliation: City of Hope National Medical Center
- Genomic editing of the HIV-1 coreceptor CCR5 in adult hematopoietic stem and progenitor cells using zinc finger nucleasesLijing Li
Laboratory for Cellular Medicine, Beckman Research Institute of City of Hope, Duarte, California, USA
Mol Ther 21:1259-69. 2013..Together, these data establish the basis for improved approaches exploiting adenoviral vector delivery in the modification of HSPCs...
- Development of hematopoietic stem cell based gene therapy for HIV-1 infection: considerations for proof of concept studies and translation to standard medical practiceDavid L Digiusto
Department of Virology, Beckman Research Institute of the City of Hope, 1500 East Duarte Road, Duarte, CA 91010, USA
Viruses 5:2898-919. 2013..The important issues related to stem cell source, patient selection, conditioning regimen and post-infusion correlative studies become increasingly complex and are discussed herein. ..
- Current translational and clinical practices in hematopoietic cell and gene therapyDavid L Digiusto
Department of Virology and Laboratory for Cellular Medicine, Beckman Research Institute of the City of Hope, Duarte, California 91010, USA
Cytotherapy 14:775-90. 2012....
- Preparing clinical grade Ag-specific T cells for adoptive immunotherapy trialsD L DiGiusto
Division of Hematology and Hematopoietic Cell Transplantation, Beckman Research Institute and City of Hope National Medical Center, Duarte, CA 91010, USA
Cytotherapy 9:613-29. 2007..In this review we address salient issues related to the technical, immunologic, practical and regulatory aspects of manufacturing these advanced T-cell products for clinical use...