D L DiGiusto

Summary

Affiliation: City of Hope National Medical Center
Country: USA

Publications

  1. pmc Genomic editing of the HIV-1 coreceptor CCR5 in adult hematopoietic stem and progenitor cells using zinc finger nucleases
    Lijing Li
    Laboratory for Cellular Medicine, Beckman Research Institute of City of Hope, Duarte, California, USA
    Mol Ther 21:1259-69. 2013
  2. pmc Development of hematopoietic stem cell based gene therapy for HIV-1 infection: considerations for proof of concept studies and translation to standard medical practice
    David L Digiusto
    Department of Virology, Beckman Research Institute of the City of Hope, 1500 East Duarte Road, Duarte, CA 91010, USA
    Viruses 5:2898-919. 2013
  3. pmc Current translational and clinical practices in hematopoietic cell and gene therapy
    David L Digiusto
    Department of Virology and Laboratory for Cellular Medicine, Beckman Research Institute of the City of Hope, Duarte, California 91010, USA
    Cytotherapy 14:775-90. 2012
  4. pmc Preparing clinical grade Ag-specific T cells for adoptive immunotherapy trials
    D L DiGiusto
    Division of Hematology and Hematopoietic Cell Transplantation, Beckman Research Institute and City of Hope National Medical Center, Duarte, CA 91010, USA
    Cytotherapy 9:613-29. 2007

Collaborators

Detail Information

Publications4

  1. pmc Genomic editing of the HIV-1 coreceptor CCR5 in adult hematopoietic stem and progenitor cells using zinc finger nucleases
    Lijing Li
    Laboratory for Cellular Medicine, Beckman Research Institute of City of Hope, Duarte, California, USA
    Mol Ther 21:1259-69. 2013
    ..Together, these data establish the basis for improved approaches exploiting adenoviral vector delivery in the modification of HSPCs...
  2. pmc Development of hematopoietic stem cell based gene therapy for HIV-1 infection: considerations for proof of concept studies and translation to standard medical practice
    David L Digiusto
    Department of Virology, Beckman Research Institute of the City of Hope, 1500 East Duarte Road, Duarte, CA 91010, USA
    Viruses 5:2898-919. 2013
    ..The important issues related to stem cell source, patient selection, conditioning regimen and post-infusion correlative studies become increasingly complex and are discussed herein. ..
  3. pmc Current translational and clinical practices in hematopoietic cell and gene therapy
    David L Digiusto
    Department of Virology and Laboratory for Cellular Medicine, Beckman Research Institute of the City of Hope, Duarte, California 91010, USA
    Cytotherapy 14:775-90. 2012
    ....
  4. pmc Preparing clinical grade Ag-specific T cells for adoptive immunotherapy trials
    D L DiGiusto
    Division of Hematology and Hematopoietic Cell Transplantation, Beckman Research Institute and City of Hope National Medical Center, Duarte, CA 91010, USA
    Cytotherapy 9:613-29. 2007
    ..In this review we address salient issues related to the technical, immunologic, practical and regulatory aspects of manufacturing these advanced T-cell products for clinical use...