Fong Fong Chu

Summary

Affiliation: City of Hope National Medical Center
Country: USA

Publications

  1. ncbi Bacteria-induced intestinal cancer in mice with disrupted Gpx1 and Gpx2 genes
    Fong Fong Chu
    Department of Medical Oncology and Therapeutics Research, City of Hope Comprehensive Cancer Center, Duarte, California, USA
    Cancer Res 64:962-8. 2004
  2. ncbi Role of Se-dependent glutathione peroxidases in gastrointestinal inflammation and cancer
    Fong Fong Chu
    Department of Medical Oncology and Therapeutics Research, Beckman Research Institute of City of Hope, Duarte, CA 91010 3000, USA
    Free Radic Biol Med 36:1481-95. 2004
  3. ncbi Expression of lactoperoxidase in differentiated mouse colon epithelial cells
    Byung Wook Kim
    Department of Cancer Biology, Beckman Research Institute of City of Hope, Duarte, CA 91010, USA
    Free Radic Biol Med 52:1569-76. 2012
  4. ncbi Microflora trigger colitis in mice deficient in selenium-dependent glutathione peroxidase and induce Gpx2 gene expression
    R Steven Esworthy
    Department of Medical Oncology and Experimental Therapeutics, City of Hope Comprehensive Cancer Center, Duarte, CA 91010, USA
    Biol Chem 384:597-607. 2003
  5. ncbi Epithelium-specific glutathione peroxidase, Gpx2, is involved in the prevention of intestinal inflammation in selenium-deficient mice
    R Steven Esworthy
    Department of Medical Oncology and Therapeutics Research, City of Hope Comprehensive Cancer Center, Duarte, CA 91010 3000, USA
    J Nutr 135:740-5. 2005
  6. ncbi Mutation accumulation in the intestine and colon of mice deficient in two intracellular glutathione peroxidases
    Dong Hyun Lee
    Department of Biology and Department of Radiation Biology, City of Hope Cancer Center, Duarte, California 91010, USA
    Cancer Res 66:9845-51. 2006
  7. ncbi Atherogenic diets exacerbate colitis in mice deficient in glutathione peroxidase
    Qiang Gao
    Department of Radiation Biology, Beckman Research Institute of City of Hope, Duarte, California, USA
    Inflamm Bowel Dis 16:2043-54. 2010
  8. ncbi Colitis locus on chromosome 2 impacting the severity of early-onset disease in mice deficient in GPX1 and GPX2
    R Steven Esworthy
    Department of Cancer Biology, Beckman Research Institute of City of Hope, Duarte, California, USA
    Inflamm Bowel Dis 17:1373-86. 2011
  9. ncbi Methylation of polycomb target genes in intestinal cancer is mediated by inflammation
    Maria A Hahn
    Division of Biology, Beckman Research Institute of the City of Hope, Duarte, California 91010, USA
    Cancer Res 68:10280-9. 2008
  10. ncbi Analysis of candidate colitis genes in the Gdac1 locus of mice deficient in glutathione peroxidase-1 and -2
    R Steven Esworthy
    Department of Radiation Biology, Beckman Research Institute of City of Hope, Duarte, California, United States of America
    PLoS ONE 7:e44262. 2012

Research Grants

  1. The mechanism for Se-afforded protection against athero*
    Fong Fong Chu; Fiscal Year: 2002
  2. The role of glutathione peroxidase in the chemopreventi*
    Fong Fong Chu; Fiscal Year: 2006
  3. The role of glutathione peroxidase in the pathogenesis of intestinal cancer
    Fong Fong Chu; Fiscal Year: 2007
  4. The role of glutathione peroxidase in the pathogenesis of intestinal cancer
    Fong Fong Chu; Fiscal Year: 2010

Collaborators

  • James H Doroshow
  • David D Smith
  • Thomas L Leto
  • Min Li
  • Paul H Frankel
  • Mark Huycke
  • GERD PFEIFER
  • R Steven Esworthy
  • Byung Wook Kim
  • Maria A Hahn
  • Dong Hyun Lee
  • Qiang Gao
  • Tamas Kriska
  • Jennifer Walshe
  • Guillermo E Rivas
  • M L Richard Yip
  • Garrett P Larson
  • Timothy W Synold
  • Albert W Girotti
  • Arthur D Riggs
  • Torsten Hahn
  • Vladislav V Levchenko
  • Nicholas A Saunders
  • Ngari Teakle
  • Terry Russell
  • Magdalena M Serewko-Auret
  • Louise Smith
  • Kelly Minto
  • Philip C Burcham
  • Sarina Cameron
  • Geoffrey Strutton
  • Stephen Esworthy
  • Anthony Griffin
  • Vivienne Reeve
  • Christy Chu
  • Dong-Hyun Lee
  • Lixin Yang
  • Scott W Binder

Detail Information

Publications12

  1. ncbi Bacteria-induced intestinal cancer in mice with disrupted Gpx1 and Gpx2 genes
    Fong Fong Chu
    Department of Medical Oncology and Therapeutics Research, City of Hope Comprehensive Cancer Center, Duarte, California, USA
    Cancer Res 64:962-8. 2004
    ..The sensitivity exhibited in these mice suggests that peroxidative stress plays an important role in ileal and colonic pathology and inflammation, which can lead to tumorigenesis...
  2. ncbi Role of Se-dependent glutathione peroxidases in gastrointestinal inflammation and cancer
    Fong Fong Chu
    Department of Medical Oncology and Therapeutics Research, Beckman Research Institute of City of Hope, Duarte, CA 91010 3000, USA
    Free Radic Biol Med 36:1481-95. 2004
    ..This review summarizes the current view of GPX in inflammation and cancer with emphasis on the GI tract...
  3. ncbi Expression of lactoperoxidase in differentiated mouse colon epithelial cells
    Byung Wook Kim
    Department of Cancer Biology, Beckman Research Institute of City of Hope, Duarte, CA 91010, USA
    Free Radic Biol Med 52:1569-76. 2012
    ..Also, Lpo DNA methylation is not correlated with gene expression...
  4. ncbi Microflora trigger colitis in mice deficient in selenium-dependent glutathione peroxidase and induce Gpx2 gene expression
    R Steven Esworthy
    Department of Medical Oncology and Experimental Therapeutics, City of Hope Comprehensive Cancer Center, Duarte, CA 91010, USA
    Biol Chem 384:597-607. 2003
    ..Our results suggest that ileal Gpx2 mRNA and GPX-2 activity levels are induced by luminal microflora. This response is consistent with a role for GPX as an anti-inflammatory activity...
  5. ncbi Epithelium-specific glutathione peroxidase, Gpx2, is involved in the prevention of intestinal inflammation in selenium-deficient mice
    R Steven Esworthy
    Department of Medical Oncology and Therapeutics Research, City of Hope Comprehensive Cancer Center, Duarte, CA 91010 3000, USA
    J Nutr 135:740-5. 2005
    ..The results show that a trace amount of Gpx2 is protective against ileocolitis, and Se-deficient young Gpx1(+/-)Gpx2(-/-) mice will develop pathology and symptoms similar to Se-adequate Gpx1(-/-)Gpx2(-/-) mice...
  6. ncbi Mutation accumulation in the intestine and colon of mice deficient in two intracellular glutathione peroxidases
    Dong Hyun Lee
    Department of Biology and Department of Radiation Biology, City of Hope Cancer Center, Duarte, California 91010, USA
    Cancer Res 66:9845-51. 2006
    ..0% versus 40.1%; P < 0.001). Our results suggest that inflammation drives gene mutations, which leads to neoplastic transformation of intestinal epithelium in the B6.129 Gpx1/2-DKO mice but rarely in the B6 Gpx1/2-DKO mice...
  7. ncbi Atherogenic diets exacerbate colitis in mice deficient in glutathione peroxidase
    Qiang Gao
    Department of Radiation Biology, Beckman Research Institute of City of Hope, Duarte, California, USA
    Inflamm Bowel Dis 16:2043-54. 2010
    ..GPx1/2-double-knockout (DKO) mice deficient in 2 intracellular glutathione peroxidases, GPx1 and GPx2, on a C57BL/6 (B6) background, have mild ileocolitis on a conventional chow...
  8. ncbi Colitis locus on chromosome 2 impacting the severity of early-onset disease in mice deficient in GPX1 and GPX2
    R Steven Esworthy
    Department of Cancer Biology, Beckman Research Institute of City of Hope, Duarte, California, USA
    Inflamm Bowel Dis 17:1373-86. 2011
    ..The DKO mice on a B6 background have mild ileocolitis. We characterized the 129 DKO mice to identify a genetic locus affecting disease severity...
  9. ncbi Methylation of polycomb target genes in intestinal cancer is mediated by inflammation
    Maria A Hahn
    Division of Biology, Beckman Research Institute of the City of Hope, Duarte, California 91010, USA
    Cancer Res 68:10280-9. 2008
    ..In summary, inflammation creates a signature of aberrant DNA methylation, which is observed later in the malignant tissue and is directed by the PcG complex...
  10. ncbi Analysis of candidate colitis genes in the Gdac1 locus of mice deficient in glutathione peroxidase-1 and -2
    R Steven Esworthy
    Department of Radiation Biology, Beckman Research Institute of City of Hope, Duarte, California, United States of America
    PLoS ONE 7:e44262. 2012
    ..DUOX-1 and -2 control microbial populations in mammalian lung and in the gut of several insects and zebrafish. Dysbiosis is a phenotype that differentiates 129S1/SvImJ from C57BL/6J and may be due to strain differences in DUOX2 activity...
  11. ncbi Inactivation of glutathione peroxidase activity contributes to UV-induced squamous cell carcinoma formation
    Jennifer Walshe
    Epithelial Pathobiology Group, Cancer Biology Programme, Diamantina Institute for Cancer, Immunology and Metabolic Medicine, University of Queensland, Queensland, Australia
    Cancer Res 67:4751-8. 2007
    ..These studies showed that Gpx2 deficiency predisposed mice to UV-induced CSCC formation. These results suggest that inactivation of GPX2 in human skin may be an early event in UV-induced SCC formation...
  12. ncbi Novel enrichment of tumor cell transfectants expressing high levels of type 4 glutathione peroxidase using 7alpha-hydroperoxycholesterol as a selection agent
    Tamas Kriska
    Department of Biochemistry, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Free Radic Biol Med 45:700-7. 2008
    ..This approach should prove valuable for investigators interested in the peroxide regulatory properties of GPx4, in the context of both cytoprotection and redox signaling...

Research Grants7

  1. The mechanism for Se-afforded protection against athero*
    Fong Fong Chu; Fiscal Year: 2002
    ..The investigators will generate GpxS-knockout mice deficient in the plasma GPX isozyme, GPX-P, to study this activity as they have done for Gpx2-knockout mice. ..
  2. The role of glutathione peroxidase in the chemopreventi*
    Fong Fong Chu; Fiscal Year: 2006
    ..abstract_text> ..
  3. The role of glutathione peroxidase in the pathogenesis of intestinal cancer
    Fong Fong Chu; Fiscal Year: 2007
    ..About a million Americans suffer IBD, and have higher risks for cancer. Study of this novel mouse IBD model may provide new information on the etiology and treatment of IBD and IBD-related cancer. ..
  4. The role of glutathione peroxidase in the pathogenesis of intestinal cancer
    Fong Fong Chu; Fiscal Year: 2010
    ..About a million Americans suffer IBD, and have higher risks for cancer. Study of this novel mouse IBD model may provide new information on the etiology and treatment of IBD and IBD-related cancer. ..