Fong Fong Chu

Summary

Affiliation: City of Hope National Medical Center
Country: USA

Publications

  1. ncbi request reprint Bacteria-induced intestinal cancer in mice with disrupted Gpx1 and Gpx2 genes
    Fong Fong Chu
    Department of Medical Oncology and Therapeutics Research, City of Hope Comprehensive Cancer Center, Duarte, California, USA
    Cancer Res 64:962-8. 2004
  2. pmc Analysis of candidate colitis genes in the Gdac1 locus of mice deficient in glutathione peroxidase-1 and -2
    R Steven Esworthy
    Department of Radiation Biology, Beckman Research Institute of City of Hope, Duarte, California, United States of America
    PLoS ONE 7:e44262. 2012
  3. ncbi request reprint Role of Se-dependent glutathione peroxidases in gastrointestinal inflammation and cancer
    Fong Fong Chu
    Department of Medical Oncology and Therapeutics Research, Beckman Research Institute of City of Hope, Duarte, CA 91010 3000, USA
    Free Radic Biol Med 36:1481-95. 2004
  4. ncbi request reprint Microflora trigger colitis in mice deficient in selenium-dependent glutathione peroxidase and induce Gpx2 gene expression
    R Steven Esworthy
    Department of Medical Oncology and Experimental Therapeutics, City of Hope Comprehensive Cancer Center, Duarte, CA 91010, USA
    Biol Chem 384:597-607. 2003
  5. pmc Expression of lactoperoxidase in differentiated mouse colon epithelial cells
    Byung Wook Kim
    Department of Cancer Biology, Beckman Research Institute of City of Hope, Duarte, CA 91010, USA
    Free Radic Biol Med 52:1569-76. 2012
  6. ncbi request reprint Mutation accumulation in the intestine and colon of mice deficient in two intracellular glutathione peroxidases
    Dong Hyun Lee
    Department of Biology and Department of Radiation Biology, City of Hope Cancer Center, Duarte, California 91010, USA
    Cancer Res 66:9845-51. 2006
  7. pmc Colitis locus on chromosome 2 impacting the severity of early-onset disease in mice deficient in GPX1 and GPX2
    R Steven Esworthy
    Department of Cancer Biology, Beckman Research Institute of City of Hope, Duarte, California, USA
    Inflamm Bowel Dis 17:1373-86. 2011
  8. pmc Atherogenic diets exacerbate colitis in mice deficient in glutathione peroxidase
    Qiang Gao
    Department of Radiation Biology, Beckman Research Institute of City of Hope, Duarte, California, USA
    Inflamm Bowel Dis 16:2043-54. 2010
  9. ncbi request reprint Epithelium-specific glutathione peroxidase, Gpx2, is involved in the prevention of intestinal inflammation in selenium-deficient mice
    R Steven Esworthy
    Department of Medical Oncology and Therapeutics Research, City of Hope Comprehensive Cancer Center, Duarte, CA 91010 3000, USA
    J Nutr 135:740-5. 2005
  10. pmc Methylation of polycomb target genes in intestinal cancer is mediated by inflammation
    Maria A Hahn
    Division of Biology, Beckman Research Institute of the City of Hope, Duarte, California 91010, USA
    Cancer Res 68:10280-9. 2008

Collaborators

  • James H Doroshow
  • Thomas L Leto
  • David D Smith
  • Min Li
  • Binghui Shen
  • Paul H Frankel
  • Mark Huycke
  • GERD PFEIFER
  • R Steven Esworthy
  • Byung Wook Kim
  • Qiang Gao
  • Maria A Hahn
  • Dong Hyun Lee
  • Robert S Esworthy
  • Tamas Kriska
  • Jennifer Walshe
  • Joni Chow
  • Yufeng Wang
  • Guillermo E Rivas
  • Garrett P Larson
  • M L Richard Yip
  • Timothy W Synold
  • Vladislav V Levchenko
  • Torsten Hahn
  • Albert W Girotti
  • Arthur D Riggs
  • Philip C Burcham
  • Sarina Cameron
  • Magdalena M Serewko-Auret
  • Louise Smith
  • Geoffrey Strutton
  • Vivienne Reeve
  • Stephen Esworthy
  • Nicholas A Saunders
  • Anthony Griffin
  • Kelly Minto
  • Ngari Teakle
  • Terry Russell
  • Christy Chu
  • Lixin Yang
  • Scott W Binder

Detail Information

Publications15

  1. ncbi request reprint Bacteria-induced intestinal cancer in mice with disrupted Gpx1 and Gpx2 genes
    Fong Fong Chu
    Department of Medical Oncology and Therapeutics Research, City of Hope Comprehensive Cancer Center, Duarte, California, USA
    Cancer Res 64:962-8. 2004
    ..The sensitivity exhibited in these mice suggests that peroxidative stress plays an important role in ileal and colonic pathology and inflammation, which can lead to tumorigenesis...
  2. pmc Analysis of candidate colitis genes in the Gdac1 locus of mice deficient in glutathione peroxidase-1 and -2
    R Steven Esworthy
    Department of Radiation Biology, Beckman Research Institute of City of Hope, Duarte, California, United States of America
    PLoS ONE 7:e44262. 2012
    ..The aim of this study was to identify the best gene candidates within the Gdac1 locus contributing to the murine colitis phenotype...
  3. ncbi request reprint Role of Se-dependent glutathione peroxidases in gastrointestinal inflammation and cancer
    Fong Fong Chu
    Department of Medical Oncology and Therapeutics Research, Beckman Research Institute of City of Hope, Duarte, CA 91010 3000, USA
    Free Radic Biol Med 36:1481-95. 2004
    ..This review summarizes the current view of GPX in inflammation and cancer with emphasis on the GI tract...
  4. ncbi request reprint Microflora trigger colitis in mice deficient in selenium-dependent glutathione peroxidase and induce Gpx2 gene expression
    R Steven Esworthy
    Department of Medical Oncology and Experimental Therapeutics, City of Hope Comprehensive Cancer Center, Duarte, CA 91010, USA
    Biol Chem 384:597-607. 2003
    ..Our results suggest that ileal Gpx2 mRNA and GPX-2 activity levels are induced by luminal microflora. This response is consistent with a role for GPX as an anti-inflammatory activity...
  5. pmc Expression of lactoperoxidase in differentiated mouse colon epithelial cells
    Byung Wook Kim
    Department of Cancer Biology, Beckman Research Institute of City of Hope, Duarte, CA 91010, USA
    Free Radic Biol Med 52:1569-76. 2012
    ..Also, Lpo DNA methylation is not correlated with gene expression...
  6. ncbi request reprint Mutation accumulation in the intestine and colon of mice deficient in two intracellular glutathione peroxidases
    Dong Hyun Lee
    Department of Biology and Department of Radiation Biology, City of Hope Cancer Center, Duarte, California 91010, USA
    Cancer Res 66:9845-51. 2006
    ..0% versus 40.1%; P < 0.001). Our results suggest that inflammation drives gene mutations, which leads to neoplastic transformation of intestinal epithelium in the B6.129 Gpx1/2-DKO mice but rarely in the B6 Gpx1/2-DKO mice...
  7. pmc Colitis locus on chromosome 2 impacting the severity of early-onset disease in mice deficient in GPX1 and GPX2
    R Steven Esworthy
    Department of Cancer Biology, Beckman Research Institute of City of Hope, Duarte, California, USA
    Inflamm Bowel Dis 17:1373-86. 2011
    ..The DKO mice on a B6 background have mild ileocolitis. We characterized the 129 DKO mice to identify a genetic locus affecting disease severity...
  8. pmc Atherogenic diets exacerbate colitis in mice deficient in glutathione peroxidase
    Qiang Gao
    Department of Radiation Biology, Beckman Research Institute of City of Hope, Duarte, California, USA
    Inflamm Bowel Dis 16:2043-54. 2010
    ..GPx1/2-double-knockout (DKO) mice deficient in 2 intracellular glutathione peroxidases, GPx1 and GPx2, on a C57BL/6 (B6) background, have mild ileocolitis on a conventional chow...
  9. ncbi request reprint Epithelium-specific glutathione peroxidase, Gpx2, is involved in the prevention of intestinal inflammation in selenium-deficient mice
    R Steven Esworthy
    Department of Medical Oncology and Therapeutics Research, City of Hope Comprehensive Cancer Center, Duarte, CA 91010 3000, USA
    J Nutr 135:740-5. 2005
    ..The results show that a trace amount of Gpx2 is protective against ileocolitis, and Se-deficient young Gpx1(+/-)Gpx2(-/-) mice will develop pathology and symptoms similar to Se-adequate Gpx1(-/-)Gpx2(-/-) mice...
  10. pmc Methylation of polycomb target genes in intestinal cancer is mediated by inflammation
    Maria A Hahn
    Division of Biology, Beckman Research Institute of the City of Hope, Duarte, California 91010, USA
    Cancer Res 68:10280-9. 2008
    ..In summary, inflammation creates a signature of aberrant DNA methylation, which is observed later in the malignant tissue and is directed by the PcG complex...
  11. pmc The Gdac1 locus modifies spontaneous and Salmonella-induced colitis in mice deficient in either Gpx2 or Gpx1 gene
    R Steven Esworthy
    Department of Radiation Biology, Beckman Research Institute, City of Hope, Duarte, CA 91010, USA
    Free Radic Biol Med 65:1273-83. 2013
    ..We conclude that the Gdac1 locus affects both spontaneous and S. Tm-induced colitis in 129 non-DKO mice, although in opposite directions. ..
  12. pmc Nox1 causes ileocolitis in mice deficient in glutathione peroxidase-1 and -2
    Robert S Esworthy
    Department of Radiation Biology and Beckman Research Institute, City of Hope, Duarte, CA 91010, USA
    Free Radic Biol Med 68:315-25. 2014
    ..The milder disease in female het-TKO intestine is probably due to random or imprinted X-chromosome inactivation, which produces mosaic Nox1 expression. ..
  13. ncbi request reprint Inactivation of glutathione peroxidase activity contributes to UV-induced squamous cell carcinoma formation
    Jennifer Walshe
    Epithelial Pathobiology Group, Cancer Biology Programme, Diamantina Institute for Cancer, Immunology and Metabolic Medicine, University of Queensland, Queensland, Australia
    Cancer Res 67:4751-8. 2007
    ..These studies showed that Gpx2 deficiency predisposed mice to UV-induced CSCC formation. These results suggest that inactivation of GPX2 in human skin may be an early event in UV-induced SCC formation...
  14. pmc Novel enrichment of tumor cell transfectants expressing high levels of type 4 glutathione peroxidase using 7alpha-hydroperoxycholesterol as a selection agent
    Tamas Kriska
    Department of Biochemistry, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Free Radic Biol Med 45:700-7. 2008
    ..This approach should prove valuable for investigators interested in the peroxide regulatory properties of GPx4, in the context of both cytoprotection and redox signaling...

Research Grants7

  1. The mechanism for Se-afforded protection against athero*
    Fong Fong Chu; Fiscal Year: 2002
    ..The investigators will generate GpxS-knockout mice deficient in the plasma GPX isozyme, GPX-P, to study this activity as they have done for Gpx2-knockout mice. ..
  2. The role of glutathione peroxidase in the pathogenesis of intestinal cancer
    Fong Fong Chu; Fiscal Year: 2006
    ..About a million Americans suffer IBD, and have higher risks for cancer. Study of this novel mouse IBD model may provide new information on the etiology and treatment of IBD and IBD-related cancer. ..
  3. The role of glutathione peroxidase in the chemopreventi*
    Fong Fong Chu; Fiscal Year: 2006
    ..abstract_text> ..
  4. The role of glutathione peroxidase in the pathogenesis of intestinal cancer
    Fong Fong Chu; Fiscal Year: 2007
    ..About a million Americans suffer IBD, and have higher risks for cancer. Study of this novel mouse IBD model may provide new information on the etiology and treatment of IBD and IBD-related cancer. ..
  5. The role of glutathione peroxidase in the pathogenesis of intestinal cancer
    Fong Fong Chu; Fiscal Year: 2009
    ..About a million Americans suffer IBD, and have higher risks for cancer. Study of this novel mouse IBD model may provide new information on the etiology and treatment of IBD and IBD-related cancer. ..
  6. The role of glutathione peroxidase in the pathogenesis of intestinal cancer
    Fong Fong Chu; Fiscal Year: 2010
    ..About a million Americans suffer IBD, and have higher risks for cancer. Study of this novel mouse IBD model may provide new information on the etiology and treatment of IBD and IBD-related cancer. ..