Rochelle Buffenstein

Summary

Affiliation: City University of New York
Country: USA

Publications

  1. ncbi The naked mole rat--a new record for the oldest living rodent
    Rochelle Buffenstein
    Department of Biology, City College of the City University of New York, New York, NY 10031, USA
    Sci Aging Knowledge Environ 2002:pe7. 2002
  2. ncbi The naked mole-rat: a new long-living model for human aging research
    Rochelle Buffenstein
    Department of Biology, City College of CUNY, Convent Ave at 138th St, New York, NY 10031, USA
    J Gerontol A Biol Sci Med Sci 60:1369-77. 2005
  3. ncbi Disparate patterns of age-related changes in lipid peroxidation in long-lived naked mole-rats and shorter-lived mice
    Blazej Andziak
    Department of Biology, The City College of the City University of New York, New York, NY 10031, USA
    Aging Cell 5:525-32. 2006
  4. ncbi High oxidative damage levels in the longest-living rodent, the naked mole-rat
    Blazej Andziak
    Department of Biology, City College of the City University of New York, New York, NY 10031, USA
    Aging Cell 5:463-71. 2006
  5. ncbi Thermogenic changes with chronic cold exposure in the naked mole-rat (Heterocephalus glaber)
    Ryan Woodley
    Department of Anatomical Sciences, Medical School of the University of the Witwatersrand, 7 York Road, Park Town, 2193, South Africa
    Comp Biochem Physiol A Mol Integr Physiol 133:827-34. 2002
  6. ncbi Antioxidants do not explain the disparate longevity between mice and the longest-living rodent, the naked mole-rat
    Blazej Andziak
    Department of Biology, City College of New York, 138th St and Convent Avenue, New York, NY 10031, USA
    Mech Ageing Dev 126:1206-12. 2005
  7. ncbi Prolonged longevity in naked mole-rats: age-related changes in metabolism, body composition and gastrointestinal function
    Timothy P O'Connor
    Department of Biology, City College of City University of New York, 138th Street and Convent Avenue, New York, NY 10031, USA
    Comp Biochem Physiol A Mol Integr Physiol 133:835-42. 2002
  8. ncbi Oxidation-resistant membrane phospholipids can explain longevity differences among the longest-living rodents and similarly-sized mice
    A J Hulbert
    Department of Biology, City College of the City University of New York, Convent Ave at 138 St, New York, NY 10031, USA
    J Gerontol A Biol Sci Med Sci 61:1009-18. 2006
  9. doi Sustained high levels of neuregulin-1 in the longest-lived rodents; a key determinant of rodent longevity
    Yael H Edrey
    Department of Biology, The City College of New York, New York, NY 10031, USA
    Aging Cell 11:213-22. 2012
  10. ncbi The use of a novel and simple method of revealing neural fibers to show the regression of the lateral geniculate nucleus in the naked mole-rat (Heterocephalus glaber)
    Jun Xiao
    Biology Department, The City College of New York, 138th Street and Convent Avenue, New York, NY 10031, USA
    Brain Res 1077:81-9. 2006

Research Grants

  1. Mechanisms of Aging in the Long-lived Naked Mole-Rat
    Rochelle Buffenstein; Fiscal Year: 2007

Collaborators

Detail Information

Publications21

  1. ncbi The naked mole rat--a new record for the oldest living rodent
    Rochelle Buffenstein
    Department of Biology, City College of the City University of New York, New York, NY 10031, USA
    Sci Aging Knowledge Environ 2002:pe7. 2002
    ..He died in April 2002, indicating that he lived for more than 28 years. As such, his life-span surpassed the previous longevity record for a rodent, which was held by a porcupine (Hystrix brachyura) that lived for 27 years and 4 months...
  2. ncbi The naked mole-rat: a new long-living model for human aging research
    Rochelle Buffenstein
    Department of Biology, City College of CUNY, Convent Ave at 138th St, New York, NY 10031, USA
    J Gerontol A Biol Sci Med Sci 60:1369-77. 2005
    ..Young naked mole-rats surprisingly have high levels of accrued oxidative damage. With their similar longevity quotient to humans, these rodents may provide a novel opportunity to examine mechanisms modulating aging...
  3. ncbi Disparate patterns of age-related changes in lipid peroxidation in long-lived naked mole-rats and shorter-lived mice
    Blazej Andziak
    Department of Biology, The City College of the City University of New York, New York, NY 10031, USA
    Aging Cell 5:525-32. 2006
    ..These data suggest that the patterns of age-related changes in levels of markers of oxidative stress are species specific, and that the pronounced longevity of naked mole-rats is independent of oxidative stress parameters...
  4. ncbi High oxidative damage levels in the longest-living rodent, the naked mole-rat
    Blazej Andziak
    Department of Biology, City College of the City University of New York, New York, NY 10031, USA
    Aging Cell 5:463-71. 2006
    ..Given that NMRs live an order of magnitude longer than predicted based on their body size, our findings strongly suggest that mechanisms other than attenuated oxidative stress explain the impressive longevity of this species...
  5. ncbi Thermogenic changes with chronic cold exposure in the naked mole-rat (Heterocephalus glaber)
    Ryan Woodley
    Department of Anatomical Sciences, Medical School of the University of the Witwatersrand, 7 York Road, Park Town, 2193, South Africa
    Comp Biochem Physiol A Mol Integr Physiol 133:827-34. 2002
    ..05). Rapid heat loss across their uninsulated integument may necessitate continuous maximal stimulation of brown adipose tissue (BAT), and as such, prevent any further increase in thermogenic capacity following cold exposure...
  6. ncbi Antioxidants do not explain the disparate longevity between mice and the longest-living rodent, the naked mole-rat
    Blazej Andziak
    Department of Biology, City College of New York, 138th St and Convent Avenue, New York, NY 10031, USA
    Mech Ageing Dev 126:1206-12. 2005
    ..Maintenance of constant antioxidant defenses with age in NMRs concurs with previous physiological data, suggesting delayed aging in this species...
  7. ncbi Prolonged longevity in naked mole-rats: age-related changes in metabolism, body composition and gastrointestinal function
    Timothy P O'Connor
    Department of Biology, City College of City University of New York, 138th Street and Convent Avenue, New York, NY 10031, USA
    Comp Biochem Physiol A Mol Integr Physiol 133:835-42. 2002
    ..Since lifetime energy expenditure is an important index of potential exposure to oxidative damage, naked mole-rats may be valuable for studying mechanisms of aging...
  8. ncbi Oxidation-resistant membrane phospholipids can explain longevity differences among the longest-living rodents and similarly-sized mice
    A J Hulbert
    Department of Biology, City College of the City University of New York, Convent Ave at 138 St, New York, NY 10031, USA
    J Gerontol A Biol Sci Med Sci 61:1009-18. 2006
    ....
  9. doi Sustained high levels of neuregulin-1 in the longest-lived rodents; a key determinant of rodent longevity
    Yael H Edrey
    Department of Biology, The City College of New York, New York, NY 10031, USA
    Aging Cell 11:213-22. 2012
    ..These results suggest that NRG-1 is an important factor contributing to divergent species MLSP through its role in maintaining neuronal integrity...
  10. ncbi The use of a novel and simple method of revealing neural fibers to show the regression of the lateral geniculate nucleus in the naked mole-rat (Heterocephalus glaber)
    Jun Xiao
    Biology Department, The City College of New York, 138th Street and Convent Avenue, New York, NY 10031, USA
    Brain Res 1077:81-9. 2006
    ....
  11. ncbi Comparison of endothelial function, O2-* and H2O2 production, and vascular oxidative stress resistance between the longest-living rodent, the naked mole rat, and mice
    Nazar Labinskyy
    Dept of Physiology, New York Medical College, Valhalla, NY 10595, USA
    Am J Physiol Heart Circ Physiol 291:H2698-704. 2006
    ....
  12. ncbi The pancreas of the naked mole-rat (Heterocephalus glaber): an ultrastructural and immunocytochemical study of the endocrine component of thermoneutral and cold acclimated animals
    Beverley Kramer
    School of Anatomical Sciences, Faculty of Health Sciences, University of the Witwatersrand, 7 York Road, Parktown, Johannesburg 2193, South Africa
    Gen Comp Endocrinol 139:206-14. 2004
    ..Immunoreactivity of alpha and beta cells was more intense in cold-acclimated than in thermoneutral animals, possibly indicative of a change in hormonal production in animals housed at a lower temperature...
  13. ncbi Vascular aging in the longest-living rodent, the naked mole rat
    Anna Csiszar
    Department of Physiology, New York Medical College, Valhalla, NY 10595, USA
    Am J Physiol Heart Circ Physiol 293:H919-27. 2007
    ..Thus long-living NMRs can maintain a youthful vascular function and cellular oxidant-antioxidant phenotype relatively longer and are better protected against aging-induced oxidative stress than shorter-living rats...
  14. doi Negligible senescence in the longest living rodent, the naked mole-rat: insights from a successfully aging species
    Rochelle Buffenstein
    Department of Physiology and The Sam and Ann Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center at San Antonio, San Antonio, TX 78245, USA
    J Comp Physiol B 178:439-45. 2008
    ..Clearly physiological and biochemical processes in this species have evolved to dramatically extend healthy lifespan. The challenge that lies ahead is to understand what these mechanisms are...
  15. ncbi Oxidative stress in vascular senescence: lessons from successfully aging species
    Zoltan Ungvari
    Department of Physiology, New York Medical College, Valhalla, New York 10595, USA
    Front Biosci 13:5056-70. 2008
    ....
  16. pmc Fibroblasts from naked mole-rats are resistant to multiple forms of cell injury, but sensitive to peroxide, ultraviolet light, and endoplasmic reticulum stress
    Adam B Salmon
    Cellular and Molecular Biology Graduate Program, University of Michigan, Ann Arbor, MI, USA
    J Gerontol A Biol Sci Med Sci 63:232-41. 2008
    ..The sensitivity of both Snell dwarf and NMR cells to ER stress suggests that alterations in the unfolded protein response might modulate cell survival and aging rate...
  17. ncbi Membrane phospholipid composition may contribute to exceptional longevity of the naked mole-rat (Heterocephalus glaber): a comparative study using shotgun lipidomics
    Todd W Mitchell
    Metabolic Research Centre, University of Wollongong, NSW, Australia
    Exp Gerontol 42:1053-62. 2007
    ..Both characteristics possibly contribute to the exceptional longevity of naked mole-rats and may indicate a special role for peroxisomes in this extended longevity...
  18. ncbi Life and death: metabolic rate, membrane composition, and life span of animals
    A J Hulbert
    Metabolic Research Centre, Institute for Conservation Biology, School of Biological Sciences, University of Wollongong, Wollongong, New South Wales, Australia
    Physiol Rev 87:1175-213. 2007
    ..The more limited information for ectothermic animals and treatments that extend life span (e.g., caloric restriction) are also reviewed...
  19. ncbi Low rates of hydrogen peroxide production by isolated heart mitochondria associate with long maximum lifespan in vertebrate homeotherms
    Adrian J Lambert
    Medical Research Council, Dunn Human Nutrition Unit, Hills Road, Cambridge CB2 2XY, UK
    Aging Cell 6:607-18. 2007
    ..These findings indicate that enhanced longevity may be causally associated with low free radical production by mitochondria across species over two classes of vertebrate homeotherms...
  20. ncbi Hemoglobin-oxygen-affinity and acid-base properties of blood from the fossorial mole-rat, Cryptomys hottentotus pretoriae
    W J van Aardt
    School of Environmental Sciences and Development, North West University, Potchefstroom Campus, Potchefstroom, 2520, South Africa
    Comp Biochem Physiol A Mol Integr Physiol 147:50-6. 2007
    ..h. pretoriae to maintain an adequate oxygen supply to the tissues in a potentially hypoxic burrow atmospheres, but that the blood of this species shows no exceptional CO2 sensitivity or buffering capacity...
  21. pmc Extended longevity of wild-derived mice is associated with peroxidation-resistant membranes
    A J Hulbert
    Metabolic Research Centre, University of Wollongong, Wollongong, NSW 2522, Australia
    Mech Ageing Dev 127:653-7. 2006
    ..It is suggested that peroxidation-resistant membranes may be an important component of extended longevity...

Research Grants1

  1. Mechanisms of Aging in the Long-lived Naked Mole-Rat
    Rochelle Buffenstein; Fiscal Year: 2007
    ..These inter-species contrasts involving seven species with varying longevity will be used to test the ubiquity of proximate theories of aging. ..