Research Topics
Species | Smita BhatiaSummaryAffiliation: City of Hope National Medical Center Country: USA Publications
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Publications
Influence of race and socioeconomic status on outcome of children treated for childhood acute lymphoblastic leukemiaSmita Bhatia
Division of Peciatrics, City of Hope Cancer Center, Duarte, California 91010, USA
Curr Opin Pediatr 16:9-14. 2004..Black children historically have been reported to have a poorer survival rate compared with whites, but limited information is available for children from other racial/ethnic backgrounds...
Late morbidity after successful treatment of children with cancerSmita Bhatia
Department of Population Sciences, City of Hope National Medical Center, 1500 East Duarte Road, Duarte, CA 91010, USA
Cancer J 15:174-80. 2009....- Nonadherence to oral mercaptopurine and risk of relapse in Hispanic and non-Hispanic white children with acute lymphoblastic leukemia: a report from the children's oncology groupSmita Bhatia
City of Hope, Duarte, CA 91010 3000, USA
J Clin Oncol 30:2094-101. 2012..Nonadherence to oral MP could increase relapse risk and also contribute to inferior outcome in Hispanics. This study identified determinants of adherence and described impact of adherence on relapse, both overall and by ethnicity... 
Anthracycline-related cardiomyopathy after childhood cancer: role of polymorphisms in carbonyl reductase genes--a report from the Children's Oncology GroupJavier G Blanco
The State University of New York at Buffalo, Buffalo, NY, USA
J Clin Oncol 30:1415-21. 2012..We examined whether single nucleotide polymorphisms in CBR1 (CBR1 1096G>A) and/or CBR3 (CBR3 V244M) modified the dose-dependent risk of anthracycline-related cardiomyopathy in childhood cancer survivors...- High risk of subsequent neoplasms continues with extended follow-up of childhood Hodgkin's disease: report from the Late Effects Study GroupSmita Bhatia
City of Hope National Medical Center, 1500 E Duarte Rd, Duarte, CA 91010 3000, USA
J Clin Oncol 21:4386-94. 2003..We describe the pattern and incidence of subsequent neoplasms (SNs) occurring with extended follow-up... - Late mortality in survivors of autologous hematopoietic-cell transplantation: report from the Bone Marrow Transplant Survivor StudySmita Bhatia
City of Hope Cancer Center, 1500 E Duarte Rd, Duarte, CA 91010 3000, USA
Blood 105:4215-22. 2005..4) when compared with siblings. Although mortality rates approach that of the general population after 10 years in certain subgroups, long-term survivors of autologous HCT continue to face challenges affecting their health and well-being... - Role of genetic susceptibility in development of treatment-related adverse outcomes in cancer survivorsSmita Bhatia
Department of Population Sciences, City of Hope, Duarte, CA 91010 3000, USA
Cancer Epidemiol Biomarkers Prev 20:2048-67. 2011.... - Disparities in cancer outcomes: lessons learned from children with cancerSmita Bhatia
Department of Population Sciences, City of Hope, Duarte, CA 91010, USA
Pediatr Blood Cancer 56:994-1002. 2011..This review helps define areas of future research that could help develop targeted, disease-specific approaches to eliminate the disparities... - Evaluating survivors of pediatric cancerSmita Bhatia
Division of Pediatric Hematology Oncology and Hematopoietic Cell Transplantation, City of Hope Cancer Center, Duarte, California 91010, USA
Cancer J 11:340-54. 2005..We review the known late effects in survivors of childhood in order to suggest reasonable starting points for the evaluation of specific long-term problems in this unique but growing population... - What is the risk of second malignant neoplasms after childhood cancer?Smita Bhatia
City of Hope Cancer Center, Duarte, CA, USA
Nat Clin Pract Oncol 2:182-3. 2005 - Long-term follow-up of childhood cancer survivors: future directions for clinical care and researchSmita Bhatia
City of Hope Cancer Center, Duarte, California 91010, USA
Pediatr Blood Cancer 46:143-8. 2006..Several challenges remain in addressing these issues, and will be the focus of this article... - Therapy-related myelodysplasia and acute myeloid leukemia after Ewing sarcoma and primitive neuroectodermal tumor of bone: A report from the Children's Oncology GroupSmita Bhatia
Division of Pediatric Oncology, City of Hope National Medical Center, Duarte, CA, USA
Blood 109:46-51. 2007..Increasing exposure to ifosfamide from 90 to 140 g/m2, cyclophosphamide from 9.6 to 17.6 g/m2, and doxorubicin from 375 to 450 mg/m2 increased the risk of t-MDS/AML significantly... - Late mortality after allogeneic hematopoietic cell transplantation and functional status of long-term survivors: report from the Bone Marrow Transplant Survivor StudySmita Bhatia
Population Sciences, City of Hope National Medical Center, Duarte, CA 91010 3000, USA
Blood 110:3784-92. 2007..This study demonstrates that mortality rates remain twice as high as that of the general population among 15-year survivors of HCT, and that the survivors face challenges affecting their health and well-being... - The Minneapolis-Manchester Quality of Life instrument: Reliability and validity of the Youth FormSmita Bhatia
Division of Pediatric Oncology, City of Hope National Medical Center, Duarte, California, USA
J Pediatr 145:39-46. 2004..We developed the Minneapolis-Manchester Quality of Life-Youth Form (MMQL-YF) as a standardized patient self-report instrument designed to assess HRQoL in childhood cancer survivors between the ages of 8 and 12 years... - NCI, NHLBI first international consensus conference on late effects after pediatric hematopoietic cell transplantation: etiology and pathogenesis of late effects after HCT performed in childhood--methodologic challengesSmita Bhatia
Department of Population Sciences, City of Hope, Duarte, California 91010 3000, USA
Biol Blood Marrow Transplant 17:1428-35. 2011..However, several methodological challenges exist in achieving these goals; these issues are discussed in detail in this paper... - Racial and ethnic differences in survival of children with acute lymphoblastic leukemiaSmita Bhatia
Children s Oncology Group, City of Hope National Medical Center, PO Box 60012, Arcadia, CA 91006 6012, USA
Blood 100:1957-64. 2002..9% +/- 6.1%). Racial and ethnic differences in OS and EFS persist among children with ALL who receive contemporary risk-based therapy. Future studies should focus on reasons-perhaps compliance or pharmacogenetics-for those differences... - Late effects among survivors of leukemia during childhood and adolescenceSmita Bhatia
Division of Pediatrics, City of Hope National Medical Center, 1500 East Duarte Road, Duarte, CA 91019, USA
Blood Cells Mol Dis 31:84-92. 2003..This review summarizes some of the well-described long-term consequences of therapy among children and adolescents treated for ALL... - Long-term health impacts of hematopoietic stem cell transplantation inform recommendations for follow-upSmita Bhatia
Department of Population Sciences, City of Hope, 1500 E Duarte Road, Duarte, CA 91010, USA
Expert Rev Hematol 4:437-52; quiz 453-4. 2011..Future steps include wider dissemination and refinement of these guidelines... - Perspectives and attitudes on the use of adjuvant chemotherapy and trastuzumab in older adults with HER-2+ breast cancer: a survey of oncologistsArti Hurria
City of Hope, Duarte, California 91010, USA
Oncologist 14:883-90. 2009..The goal of the current study was to understand how patient age and health status impact oncologists' decisions to recommend adjuvant therapy in older women with HER-2(+) breast cancer... - An interaction of race and ethnicity with socioeconomic status in rectal cancer outcomesJoseph Kim
Division of Oncologic Surgery, Department of Surgery, City of Hope, Duarte, CA 91010, USA
Ann Surg 253:647-54. 2011..Because appropriate rectal cancer care and subsequent outcomes can be influenced by several variables, our objective was to investigate how race, ethnicity, and socioeconomic status (SES) may impact rectal cancer outcomes... - Cardiovascular risk factors in hematopoietic cell transplantation survivors: role in development of subsequent cardiovascular diseaseSaro H Armenian
Department of Population Sciences, City of Hope, 1500 E Duarte Rd, Duarte, CA 91010 3000, USA
Blood 120:4505-12. 2012..7% [none], 7.0% [1 CVRF], 11.2% [≥ 2 CVRFs], P < .01); the risk was especially high (15.0%) in patients with multiple CVRFs and pre-HCT exposure to anthracyclines or chest radiation... - Long-term recovery after hematopoietic cell transplantation: predictors of quality-of-life concernsF Lennie Wong
Population Sciences, City of Hope National Medical Center, Duarte, CA 91010 3000, USA
Blood 115:2508-19. 2010..05); allogeneic patients with chronic GVHD were less likely to work (P = .002). Multidisciplinary efforts to identify and support vulnerable subgroups after HCT need to be developed... - Incidence and predictors of delayed chronic kidney disease in long-term survivors of hematopoietic cell transplantationMichael Choi
Division of Population Sciences, City of Hope National Medical Center, Duarte, California, USA
Cancer 113:1580-7. 2008.... - Incidence and predictors of congestive heart failure after autologous hematopoietic cell transplantationSaro H Armenian
Department of Population Sciences, City of Hope, Duarte, CA 91010 3000, USA
Blood 118:6023-9. 2011.... - Long-term health-related outcomes in survivors of childhood cancer treated with HSCT versus conventional therapy: a report from the Bone Marrow Transplant Survivor Study (BMTSS) and Childhood Cancer Survivor Study (CCSS)Saro H Armenian
Population Sciences, City of Hope, Duarte, CA 91010 3000, USA
Blood 118:1413-20. 2011.... - Ethnic differences in chronic health conditions after hematopoietic cell transplantation: a report from the Bone Marrow Transplant Survivor StudySaro H Armenian
Department of Population Sciences, City of Hope National Medical Center, Duarte, CA 91010 3000, USA
Cancer 116:4152-9. 2010..Hispanics have a greater risk of early treatment failure after hematopoietic stem cell transplantation (HCT) compared with non-Hispanic whites. However, long-term morbidity among Hispanics has not been described... - Race, ethnicity, and socioeconomic status influence the survival of patients with hepatocellular carcinoma in the United StatesAvo Artinyan
Division of Oncologic Surgery, City of Hope, Duarte, CA, USA
Cancer 116:1367-77. 2010..The authors of this report hypothesized that these differences result from inequities in access to care and in response to therapy... - Evaluation of absolute serum α-fetoprotein levels in liver transplant for hepatocellular cancerBrian Mailey
Department of Oncologic Surgery, City of Hope, Duarte, CA, USA
Arch Surg 146:26-33. 2011..An elevated serum α-fetoprotein (AFP) level before orthotopic liver transplant (OLT) is predictive of mortality after OLT for hepatocellular carcinoma (HCC)... - Assessment of health-related quality of life of adolescent cancer patients using the Minneapolis-Manchester Quality of Life Adolescent QuestionnaireEric Wu
Division of Population Sciences, City of Hope National Medical Center, Duarte, California, USA
Pediatr Blood Cancer 48:678-86. 2007..Improved survival after childhood cancer has shifted the focus to health-related quality of life (HRQL)-an understudied problem, especially among adolescents... - Adverse psychological outcomes in long-term survivors of hematopoietic cell transplantation: a report from the Bone Marrow Transplant Survivor Study (BMTSS)Can Lan Sun
Population Sciences, City of Hope, Duarte, CA, USA
Blood 118:4723-31. 2011..These results identify vulnerable subpopulations and provide patients, families, and healthcare providers with necessary information to plan for post-HCT needs many years after HCT... - Accelerated telomere shortening precedes development of therapy-related myelodysplasia or acute myelogenous leukemia after autologous transplantation for lymphomaSujata Chakraborty
Department of Stem Cell and Leukemia Research, Division of Population Sciences, City of Hope National Medical Center, Duarte, CA 91010, USA
J Clin Oncol 27:791-8. 2009..Here, we investigated the hypothesis that accelerated telomere shortening after aHCT could contribute to the development of t-MDS/AML... - Prevalence and predictors of chronic health conditions after hematopoietic cell transplantation: a report from the Bone Marrow Transplant Survivor StudyCan Lan Sun
Population Sciences, City of Hope National Medical Center, 1500 E Duarte Road, Duarte, CA 91010 3000, USA
Blood 116:3129-39; quiz 3377. 2010..7 times as likely to develop severe/life-threatening conditions (95% CI, 3.0-7.2). The burden of long-term morbidity borne by HCT survivors is substantial, and long-term follow-up of patients who received transplantation is recommended... - Health-related quality of life in young survivors of childhood cancer using the Minneapolis-Manchester Quality of Life-Youth FormSadhna Shankar
Division of Pediatric Oncology, Vanderbilt University, Nashville, Tennessee, USA
Pediatrics 115:435-42. 2005..These results are reassuring, suggesting that this group of survivors may have been too young to encounter some of the negative psychosocial impacts of cancer and its treatment... - Predictors of avascular necrosis of bone in long-term survivors of hematopoietic cell transplantationStephanie Campbell
Department of Population Sciences, City of Hope National Medical Center, Duarte, California 91010 3000, USA
Cancer 115:4127-35. 2009.... - The Minneapolis-Manchester Quality of Life instrument: reliability and validity of the Adolescent FormSmita Bhatia
Division of Pediatric Oncology, City of Hope National Medical Center, Duarte, CA, USA
J Clin Oncol 20:4692-8. 2002..This report focuses on the development and testing of the MMQL-Adolescent Form... - Predictors of late cardiovascular complications in survivors of hematopoietic cell transplantationSaro H Armenian
Department of Population Sciences, City of Hope, Duarte, California 91010 3000, USA
Biol Blood Marrow Transplant 16:1138-44. 2010..These data form the basis for developing predictive models for identifying high-risk individuals for targeted surveillance and aggressive management of comorbidities... - Low incidence of second neoplasms among children diagnosed with acute lymphoblastic leukemia after 1983Smita Bhatia
City of Hope National Medical Center, Duarte, CA, USA. group.org
Blood 99:4257-64. 2002..Follow-up of this large cohort that was treated with contemporary risk-based therapy showed that the incidence of second neoplasms remains low after diagnosis of childhood ALL... - Metastatic gastrointestinal stromal tumors in the era of imatinib: improved survival and elimination of socioeconomic survival disparitiesAvo Artinyan
Department of General and Oncology Surgery, City of Hope National Medical Center, 1500 East Duarte Road, Duarte, CA 91010, USA
Cancer Epidemiol Biomarkers Prev 17:2194-201. 2008..Our objective was to determine if the introduction of imatinib coincided with improved survival from metastatic gastrointestinal stromal tumor in the U.S. population and in specific socioeconomic groups... - Chronic health conditions in childhood cancer survivors: is it all treatment-related--or do genetics play a role?Saro H Armenian
Department of Population Sciences, City of Hope National Medical Center, Duarte, CA, USA
J Gen Intern Med 24:S395-400. 2009..It is increasingly recognized that many of these complications result from complex interactions between therapeutic exposures and genetic susceptibility... - Predicting chemotherapy toxicity in older adults with cancer: a prospective multicenter studyArti Hurria
City of Hope Comprehensive Cancer Center and Beckman Research Institute, Duarte, CA 91010, USA
J Clin Oncol 29:3457-65. 2011..The goals of this study are to identify risk factors for chemotherapy toxicity in older adults and develop a risk stratification schema for chemotherapy toxicity... - Successful coordination and execution of nontherapeutic studies in a cooperative group setting: lessons learned from Children's Oncology Group studiesAndrea Carter
Population Sciences, City of Hope Cancer Center, Duarte, CA 91010 3000, USA
Cancer Epidemiol Biomarkers Prev 17:1665-73. 2008..The successful execution of these nontherapeutic studies shows the advantages of diverse study publicity techniques, detailed standardized operating procedures, and effective utilization of technological resources... - NMR-based metabolomic analysis of the molecular pathogenesis of therapy-related myelodysplasia/acute myeloid leukemiaKristin E Cano
Department of Molecular Medicine, Beckman Research Institute of the City of Hope, Duarte, California 91010, USA
J Proteome Res 10:2873-81. 2011..These observations suggest predisposing factors for the development of t-MDS... - Second solid malignancies among children, adolescents, and young adults diagnosed with malignant bone tumors after 1976: follow-up of a Children's Oncology Group cohortRobert Goldsby
Department of Pediatric Oncology, University of California San Francisco Children s Hospital, San Francisco, California, USA
Cancer 113:2597-604. 2008..The growing number of individuals surviving childhood cancer has increased the awareness of adverse long-term sequelae. One of the most worrisome complications after cancer therapy is the development of second malignant neoplasms (SMNs)... - Disparities in gastric cancer outcomes among Asian ethnicities in the USAJoseph Kim
Comprehensive Cancer Center, City of Hope, Duarte, CA, USA
Ann Surg Oncol 16:2433-41. 2009..It is unclear whether differences in outcome exist among Asian ethnicities. Our objective was to assess gastric cancer survival in Asian ethnic groups in a large heterogeneous population... - The impact of lymph node number on survival in patients with lymph node-negative pancreatic cancerMinia Hellan
Department of General Oncologic Surgery, City of Hope National Medical Center, Duarte, CA 91010, USA
Pancreas 37:19-24. 2008..The role of lymph node (LN) dissection for pancreatic cancer remains uncertain, and guidelines for a minimum LN number have not been established. We hypothesized that LN number in node-negative (N0) pancreatic cancer influences survival... - Development of risk-based guidelines for pediatric cancer survivors: the Children's Oncology Group Long-Term Follow-Up Guidelines from the Children's Oncology Group Late Effects Committee and Nursing DisciplineWendy Landier
Division of Pediatrics, City of Hope Comprehensive Cancer Center, Duarte, CA, USA
J Clin Oncol 22:4979-90. 2004..The Guidelines, and related Health Links, can be downloaded in their entirety at www.survivorshipguidelines.org... - Glutathione S-transferase genotypes, genetic susceptibility, and outcome of therapy in childhood acute lymphoblastic leukemiaStella M Davies
Children s Oncology Group, Arcadia, CA 91066 6012, USA
Blood 100:67-71. 2002..These data, representing a larger series than any reported previously, suggest that GST genotype does not affect etiology or outcome of childhood ALL... - A grounded theory of the process of adherence to oral chemotherapy in Hispanic and caucasian children and adolescents with acute lymphoblastic leukemiaWendy Landier
Department of Population Sciences, Center for Cancer Survivorship, City of Hope, 1500 E Duarte Rd, Duarte, CA 91010, USA
J Pediatr Oncol Nurs 28:203-23. 2011..Understanding the association between taking oral chemotherapy and control/cure of leukemia (Making the Connection) appeared to mediate adherence behaviors... - Longitudinal assessment of hematopoietic abnormalities after autologous hematopoietic cell transplantation for lymphomaRavi Bhatia
Division of Hematology and Hematopoietic Cell Transplantation, City of Hope National Medical Center, Duarte, CA 91010, USA
J Clin Oncol 23:6699-711. 2005..The phenomenon of hematopoietic reconstitution after autologous HCT and the role of proliferative stress in the pathogenesis of t-MDS/AML are poorly understood... - Altered hematopoietic cell gene expression precedes development of therapy-related myelodysplasia/acute myeloid leukemia and identifies patients at riskLiang Li
City of Hope National Medical Center, Duarte, CA 91010, USA
Cancer Cell 20:591-605. 2011..We conclude that genetic programs associated with t-MDS/AML are perturbed long before disease onset, and accurately identify patients at risk for this complication... - Chronic myelogenous leukemia stem and progenitor cells demonstrate chromosomal instability related to repeated breakage-fusion-bridge cycles mediated by increased nonhomologous end joiningSujata Chakraborty
Division of Hematopoietic Stem Cell and Leukemia Research, City of Hope National Medical Center, Duarte, CA 91010, USA
Blood 119:6187-97. 2012..These studies reveal a previously unrecognized mechanism of chromosomal instability in leukemia progenitors because of continued generation of unstable chromosomal lesions through repeated cycles of breakage and repair of such lesions... - Cancer survivorship: a pediatric perspectiveWendy Landier
Department of Population Sciences, City of Hope Cancer Center, Duarte, California 91010, USA
Oncologist 13:1181-92. 2008..This review describes some of the known late effects described in childhood cancer survivors in order to suggest reasonable starting points for evaluation of specific long-term problems in this unique and growing population... - Role of age and health in treatment recommendations for older adults with breast cancer: the perspective of oncologists and primary care providersArti Hurria
City of Hope National Medical Center, Duarte, CA 91010, USA
J Clin Oncol 26:5386-92. 2008..To determine the impact of age and health status on adjuvant treatment recommendations for older patients with breast cancer from the perspective of medical oncologists and primary care physicians with geriatric expertise... - Second malignancies after allogeneic hematopoietic cell transplantationThomas Lowe
City of Hope Comprehensive Cancer Center, Duarte, California 91010, USA
Biol Blood Marrow Transplant 13:1121-34. 2007..Most importantly, guidelines should be developed in regard to screening and prevention of second malignancies, so that physicians can provide state-of-the-art counsel and care for the benefit of our patients... - Male breast cancer 15 years after allogeneic hematopoietic cell transplantation including total body irradiation for recurrent acute lymphoblastic leukemiaThomas Lowe
City of Hope Comprehensive Cancer Center, Duarte, CA 91010 3000, USA
Onkologie 31:266-9. 2008..One of the most devastating long-term complications is the development of a second malignancy... - Second primary malignancies after autologous hematopoietic cell transplantation for multiple myelomaAmrita Y Krishnan
Department of Hematology and Hematopoietic Cell Transplantation, City of Hope, Duarte, California Electronic address
Biol Blood Marrow Transplant 19:260-5. 2013..The trend toward increased risk with thalidomide exposure suggests a class effect from immunomodulatory drugs that might not be restricted to lenalidomide... - Yield of screening for long-term complications using the children's oncology group long-term follow-up guidelinesWendy Landier
City of Hope, Duarte, CA 91010 3000, USA
J Clin Oncol 30:4401-8. 2012..However, the yield from these recommendations is not known... - Functional status and health-related quality of life among allogeneic transplant patients at hospital discharge: a comparison of sociodemographic, disease, and treatment characteristicsMarcia Grant
Division of Nursing Research and Education, City of Hope, 1500 East Duarte Road, Duarte, CA 91010, USA
Support Care Cancer 20:2697-704. 2012..The findings of this study are part of a larger mixed-methods study, representing one data time point of the larger study... - An interaction of race and ethnicity with socioeconomic status in rectal cancer outcomesJoseph Kim
Division of Oncologic Surgery, Department of Surgery, City of Hope, Duarte, CA Michael E DeBakey Department of Surgery and Houston Health Services and Research Center of Excellence, Michael E DeBakey Veterans Affairs Medical Center, Baylor College of Medicine Houston, TX Department of Surgery, University of California Davis, Sacramento, CA and Department of Population Sciences, City of Hope, Duarte, CA Department of Population Sciences, City of Hope, Duarte, CA
Ann Surg 253:647-54. 2011..Because appropriate rectal cancer care and subsequent outcomes can be influenced by several variables, our objective was to investigate how race, ethnicity, and socioeconomic status (SES) may impact rectal cancer outcomes... - Preparing professional staff to care for cancer survivorsMarcia Grant
Department of Nursing Research and Education, City of Hope National Medical Center, 1500 East Duarte Road, Duarte, CA 91010 3000, USA
J Cancer Surviv 1:98-106. 2007.... - Discharge and unscheduled readmissions of adult patients undergoing hematopoietic stem cell transplantation: implications for developing nursing interventionsMarcia Grant
City of Hope Comprehensive Cancer Center in Duarte, CA, USA
Oncol Nurs Forum 32:E1-8. 2005..To identify implications for nursing practice from survey results and the literature that may improve patient outcomes during and following initial hospital discharge... - Genetically mediated Nf1 loss in mice promotes diverse radiation-induced tumors modeling second malignant neoplasmsGrace Choi
Department of Radiation Oncology, University of California, San Francisco, San Francisco, California, USA
Cancer Res 72:6425-34. 2012..Nf1 heterozygosity confers broad susceptibility to genotoxin-induced tumorigenesis, and this paradigm serves as an experimental platform for future studies of SMNs... - Second cancers in survivors of childhood cancerSmita Bhatia
City of Hope National Medical Center, Duarte, California 91010, USA
Nat Rev Cancer 2:124-32. 2002..Of these, the most devastating is a second cancer... - A genome-wide meta-analysis of nodular sclerosing Hodgkin lymphoma identifies risk loci at 6p21.32Wendy Cozen
Department of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, CA, USA
Blood 119:469-75. 2012..In a separate analysis, the DRB1*0701 allele was associated with a decreased risk of NSHL (OR = 0.5, 95% confidence interval = 0.4, 0.7). These data support the importance of the HLA class II region in NSHL etiology... - Monitoring for cardiovascular disease in survivors of childhood cancer: report from the Cardiovascular Disease Task Force of the Children's Oncology GroupSadhna M Shankar
Division of Pediatric Hematology Oncology, Department of Pediatrics, Vanderbilt University, Nashville, Tennessee 37232 6310, USA
Pediatrics 121:e387-96. 2008.... - Myelodysplastic syndrome and acute myeloid leukemia after autotransplantation for lymphoma: a multicenter case-control studyCatherine Metayer
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA
Blood 101:2015-23. 2003..Transplantation-related factors may also modulate this risk; however, the apparent contribution of high-dose TBI requires confirmation... - Genetic polymorphisms in the carbonyl reductase 3 gene CBR3 and the NAD(P)H:quinone oxidoreductase 1 gene NQO1 in patients who developed anthracycline-related congestive heart failure after childhood cancerJavier G Blanco
Department of Pharmaceutical Sciences, State University of New York at Buffalo, Buffalo, New York, USA
Cancer 112:2789-95. 2008.... - Late-effects among survivors of leukaemia and lymphoma during childhood and adolescenceLeslie L Robison
Division of Pediatric Epidemiology and Clinical Research, University of Minnesota Cancer Center, Minneapolis, MN, USA
Br J Haematol 122:345-59. 2003 - Visual, auditory, sensory, and motor impairments in long-term survivors of hematopoietic stem cell transplantation performed in childhood: results from the Bone Marrow Transplant Survivor studyJames G Gurney
Department of Pediatrics, Division of General Pediatrics, 300 NIB 6E02 Box 0456, University of Michigan, 300 N Ingalls Street, Ann Arbor, MI 48109, USA
Cancer 106:1402-8. 2006..Because of treatment-related toxicity, research is increasingly being focused on long-term sequelae secondary to hematopoietic stem cell transplantation (HSCT) in survivor populations... - Late effects in survivors of Hodgkin and non-Hodgkin lymphoma treated with autologous hematopoietic cell transplantation: a report from the bone marrow transplant survivor studyNavneet S Majhail
Blood and Marrow Transplant Program, Departments of Medicine and Pediatrics, University of Minnesota, Minneapolis, Minnesota 55455, USA
Biol Blood Marrow Transplant 13:1153-9. 2007..4, 95% CI 1.0-5.5). HL and NHL survivors of autologous HCT have a high prevalence of long-term health-related complications and require continued monitoring for late effects of transplantation... - A methodological issue in the analysis of second-primary cancer incidence in long-term survivors of childhood cancersYutaka Yasui
Cancer Research Program, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
Am J Epidemiol 158:1108-13. 2003..These showed appreciable differences in the analytical results by not accounting for the natural age-associated increase of risk, illustrating a significant impact of this methodological issue on study conclusions... - Impact of chronic graft-versus-host disease on the health status of hematopoietic cell transplantation survivors: a report from the Bone Marrow Transplant Survivor StudyChristopher J Fraser
Pediatric Blood and Marrow Transplant Program, Department of Pediatrics, University of Minnesota, 420 Delaware Street SE, Minneapolis, MN 55455, USA
Blood 108:2867-73. 2006..We conclude that active cGVHD has a significant impact on many aspects of the overall health status of HCT survivors and that, most importantly, those successfully treated for cGVHD do not appear to have long-term impairments... - Late effects in survivors of chronic myeloid leukemia treated with hematopoietic cell transplantation: results from the Bone Marrow Transplant Survivor StudyK Scott Baker
University of Minnesota Cancer Center, Blood and Marrow Transplant Program, Department of Internal Medicine, University of Minnesota, Minneapolis, USA
Blood 104:1898-906. 2004..However, adverse medical late effects with significant morbidity were uncommon. Chronic GVHD is the most important predictor of adverse medical late effects and poor overall health... - Performance limitations and participation restrictions among childhood cancer survivors treated with hematopoietic stem cell transplantation: the bone marrow transplant survivor studyKirsten K Ness
Department of Pediatrics, University of Minnesota, Minneapolis, USA
Arch Pediatr Adolesc Med 159:706-13. 2005..9-4.2). CONCLUSION: This study demonstrated that persons treated with HCT as children were at increased risk for performance limitations that restricted participation in routine daily activities and interpersonal relationships... - Diabetes, hypertension, and cardiovascular events in survivors of hematopoietic cell transplantation: a report from the bone marrow transplantation survivor studyK Scott Baker
Department of Pediatrics, University of Minnesota, Minneapolis 55455, USA
Blood 109:1765-72. 2007..42; 95% CI, 1.55-7.52). Thus, HCT survivors have a higher age- and BMI-adjusted risk of diabetes and hypertension, potentially leading to a higher than expected risk of CV events with age... - Cardiovascular disease after hematopoietic cell transplantation--lessons learnedSaro H Armenian
Haematologica 93:1132-6. 2008 - Clinical characteristics and outcome of children with Down syndrome and acute lymphoblastic leukemia: a Children's Cancer Group studyJames A Whitlock
Department of Pediatric Hematology/Oncology, Vanderbilt University Medical Center, Nashville, TN, USA
Blood 106:4043-9. 2005..These results suggest that intensification of therapy for patients with ALL-DS is needed to maintain outcome comparable with those of ALL-NDS patients... - Health care utilization by adult long-term survivors of hematopoietic cell transplant: report from the Bone Marrow Transplant Survivor StudySadhna M Shankar
Vanderbilt Ingram Cancer Center, Nashville, Tennessee, USA
Cancer Epidemiol Biomarkers Prev 16:834-9. 2007..Primary care physicians provide health care for an increasing number of adult long-term survivors of HCT, emphasizing the need for increased awareness of the long-term follow-up needs of the HCT survivors by the health care providers... - Twenty years of follow-up among survivors of childhood and young adult acute myeloid leukemia: a report from the Childhood Cancer Survivor StudyDaniel A Mulrooney
Department of Pediatrics, University of Minnesota Medical School and Cancer Center, Minneapolis, MN 55455, USA
Cancer 112:2071-9. 2008..Limited data exist on the comprehensive assessment of late medical and social effects experienced by survivors of childhood and young adult acute myeloid leukemia (AML)... - Survival variability by race and ethnicity in childhood acute lymphoblastic leukemiaNina S Kadan-Lottick
Division of Pediatric Hematology/Oncology, Yale University, New Haven, Conn, USA
JAMA 290:2008-14. 2003..Future work must delineate the social and biological factors, including any differences in pharmacokinetics associated with chemotherapeutic agents, that account for disparities in outcome...
Research Grants
- Ethnic Differences in Survival after Childhood ALLSmita Bhatia; Fiscal Year: 2009..abstract_text> ..
- Role of Genetic Susceptibility in Therapy-related Subsequent MalignanciesSmita Bhatia; Fiscal Year: 2010....
- BONE MARROW TRANSPLANT (BMT) SURVIVORS STUDYSmita Bhatia; Fiscal Year: 2003..g., second cancers, births, cardiac complications, etc.) that may have occurred since the completion of the initial questionnaire. ..
- Role of Genetic Susceptibility in Therapy-related Subsequent MalignanciesSmita Bhatia; Fiscal Year: 2011....