Smita Bhatia

Summary

Affiliation: City of Hope National Medical Center
Country: USA

Publications

  1. ncbi request reprint Influence of race and socioeconomic status on outcome of children treated for childhood acute lymphoblastic leukemia
    Smita Bhatia
    Division of Peciatrics, City of Hope Cancer Center, Duarte, California 91010, USA
    Curr Opin Pediatr 16:9-14. 2004
  2. ncbi request reprint Late morbidity after successful treatment of children with cancer
    Smita Bhatia
    Department of Population Sciences, City of Hope National Medical Center, 1500 East Duarte Road, Duarte, CA 91010, USA
    Cancer J 15:174-80. 2009
  3. pmc Conditional survival and cause-specific mortality after autologous hematopoietic cell transplantation for hematological malignancies
    A M Vanderwalde
    Department of Hematology and Hematopoietic Cell Transplantation, City of Hope, Duarte, CA, USA
    Leukemia 27:1139-45. 2013
  4. pmc Health behaviors and cancer screening practices in long-term survivors of hematopoietic cell transplantation (HCT): a report from the BMT Survivor Study
    S H Armenian
    Department of Population Sciences, City of Hope, Duarte, CA 91010 3000, USA
    Bone Marrow Transplant 47:283-90. 2012
  5. pmc Therapy-related myelodysplasia and acute myeloid leukemia
    Smita Bhatia
    Department of Population Sciences, City of Hope Comprehensive Cancer Center, Duarte, CA Electronic address
    Semin Oncol 40:666-75. 2013
  6. pmc Nonadherence to oral mercaptopurine and risk of relapse in Hispanic and non-Hispanic white children with acute lymphoblastic leukemia: a report from the children's oncology group
    Smita Bhatia
    City of Hope, Duarte, CA 91010 3000, USA
    J Clin Oncol 30:2094-101. 2012
  7. pmc Anthracycline-related cardiomyopathy after childhood cancer: role of polymorphisms in carbonyl reductase genes--a report from the Children's Oncology Group
    Javier G Blanco
    The State University of New York at Buffalo, Buffalo, NY, USA
    J Clin Oncol 30:1415-21. 2012
  8. ncbi request reprint Evaluating survivors of pediatric cancer
    Smita Bhatia
    Division of Pediatric Hematology Oncology and Hematopoietic Cell Transplantation, City of Hope Cancer Center, Duarte, California 91010, USA
    Cancer J 11:340-54. 2005
  9. ncbi request reprint Long-term follow-up of childhood cancer survivors: future directions for clinical care and research
    Smita Bhatia
    City of Hope Cancer Center, Duarte, California 91010, USA
    Pediatr Blood Cancer 46:143-8. 2006
  10. pmc Therapy-related myelodysplasia and acute myeloid leukemia after Ewing sarcoma and primitive neuroectodermal tumor of bone: A report from the Children's Oncology Group
    Smita Bhatia
    Division of Pediatric Oncology, City of Hope National Medical Center, Duarte, CA, USA
    Blood 109:46-51. 2007

Detail Information

Publications89

  1. ncbi request reprint Influence of race and socioeconomic status on outcome of children treated for childhood acute lymphoblastic leukemia
    Smita Bhatia
    Division of Peciatrics, City of Hope Cancer Center, Duarte, California 91010, USA
    Curr Opin Pediatr 16:9-14. 2004
    ..Black children historically have been reported to have a poorer survival rate compared with whites, but limited information is available for children from other racial/ethnic backgrounds...
  2. ncbi request reprint Late morbidity after successful treatment of children with cancer
    Smita Bhatia
    Department of Population Sciences, City of Hope National Medical Center, 1500 East Duarte Road, Duarte, CA 91010, USA
    Cancer J 15:174-80. 2009
    ....
  3. pmc Conditional survival and cause-specific mortality after autologous hematopoietic cell transplantation for hematological malignancies
    A M Vanderwalde
    Department of Hematology and Hematopoietic Cell Transplantation, City of Hope, Duarte, CA, USA
    Leukemia 27:1139-45. 2013
    ..0). Among those who had survived 10 years, nonrelapse-related mortality rates exceeded relapse-related mortality rates. This study provides clinically relevant survival estimates after aHCT, and helps inform interventional strategies...
  4. pmc Health behaviors and cancer screening practices in long-term survivors of hematopoietic cell transplantation (HCT): a report from the BMT Survivor Study
    S H Armenian
    Department of Population Sciences, City of Hope, Duarte, CA 91010 3000, USA
    Bone Marrow Transplant 47:283-90. 2012
    ..Survivors were significantly less likely to report high-risk behavior (OR=0.5; P<0.01) and more likely to have had a screening mammogram (OR=2.8; P=0.05) when compared with gender-matched sibling controls (N=309)...
  5. pmc Therapy-related myelodysplasia and acute myeloid leukemia
    Smita Bhatia
    Department of Population Sciences, City of Hope Comprehensive Cancer Center, Duarte, CA Electronic address
    Semin Oncol 40:666-75. 2013
    ..Because of the poor response to conventional chemotherapy, allogeneic HCT is recommended. Current research is focused on developing risk prediction and risk reduction strategies. ..
  6. pmc Nonadherence to oral mercaptopurine and risk of relapse in Hispanic and non-Hispanic white children with acute lymphoblastic leukemia: a report from the children's oncology group
    Smita Bhatia
    City of Hope, Duarte, CA 91010 3000, USA
    J Clin Oncol 30:2094-101. 2012
    ..Nonadherence to oral MP could increase relapse risk and also contribute to inferior outcome in Hispanics. This study identified determinants of adherence and described impact of adherence on relapse, both overall and by ethnicity...
  7. pmc Anthracycline-related cardiomyopathy after childhood cancer: role of polymorphisms in carbonyl reductase genes--a report from the Children's Oncology Group
    Javier G Blanco
    The State University of New York at Buffalo, Buffalo, NY, USA
    J Clin Oncol 30:1415-21. 2012
    ..We examined whether single nucleotide polymorphisms in CBR1 (CBR1 1096G>A) and/or CBR3 (CBR3 V244M) modified the dose-dependent risk of anthracycline-related cardiomyopathy in childhood cancer survivors...
  8. ncbi request reprint Evaluating survivors of pediatric cancer
    Smita Bhatia
    Division of Pediatric Hematology Oncology and Hematopoietic Cell Transplantation, City of Hope Cancer Center, Duarte, California 91010, USA
    Cancer J 11:340-54. 2005
    ..We review the known late effects in survivors of childhood in order to suggest reasonable starting points for the evaluation of specific long-term problems in this unique but growing population...
  9. ncbi request reprint Long-term follow-up of childhood cancer survivors: future directions for clinical care and research
    Smita Bhatia
    City of Hope Cancer Center, Duarte, California 91010, USA
    Pediatr Blood Cancer 46:143-8. 2006
    ..Several challenges remain in addressing these issues, and will be the focus of this article...
  10. pmc Therapy-related myelodysplasia and acute myeloid leukemia after Ewing sarcoma and primitive neuroectodermal tumor of bone: A report from the Children's Oncology Group
    Smita Bhatia
    Division of Pediatric Oncology, City of Hope National Medical Center, Duarte, CA, USA
    Blood 109:46-51. 2007
    ..Increasing exposure to ifosfamide from 90 to 140 g/m2, cyclophosphamide from 9.6 to 17.6 g/m2, and doxorubicin from 375 to 450 mg/m2 increased the risk of t-MDS/AML significantly...
  11. pmc Late mortality after allogeneic hematopoietic cell transplantation and functional status of long-term survivors: report from the Bone Marrow Transplant Survivor Study
    Smita Bhatia
    Population Sciences, City of Hope National Medical Center, Duarte, CA 91010 3000, USA
    Blood 110:3784-92. 2007
    ..This study demonstrates that mortality rates remain twice as high as that of the general population among 15-year survivors of HCT, and that the survivors face challenges affecting their health and well-being...
  12. pmc Long-term health impacts of hematopoietic stem cell transplantation inform recommendations for follow-up
    Smita Bhatia
    Department of Population Sciences, City of Hope, 1500 E Duarte Road, Duarte, CA 91010, USA
    Expert Rev Hematol 4:437-52; quiz 453-4. 2011
    ..Future steps include wider dissemination and refinement of these guidelines...
  13. pmc Disparities in cancer outcomes: lessons learned from children with cancer
    Smita Bhatia
    Department of Population Sciences, City of Hope, Duarte, CA 91010, USA
    Pediatr Blood Cancer 56:994-1002. 2011
    ..This review helps define areas of future research that could help develop targeted, disease-specific approaches to eliminate the disparities...
  14. pmc NCI, NHLBI first international consensus conference on late effects after pediatric hematopoietic cell transplantation: etiology and pathogenesis of late effects after HCT performed in childhood--methodologic challenges
    Smita Bhatia
    Department of Population Sciences, City of Hope, Duarte, California 91010 3000, USA
    Biol Blood Marrow Transplant 17:1428-35. 2011
    ..However, several methodological challenges exist in achieving these goals; these issues are discussed in detail in this paper...
  15. pmc Role of genetic susceptibility in development of treatment-related adverse outcomes in cancer survivors
    Smita Bhatia
    Department of Population Sciences, City of Hope, Duarte, CA 91010 3000, USA
    Cancer Epidemiol Biomarkers Prev 20:2048-67. 2011
    ....
  16. pmc Late mortality in survivors of autologous hematopoietic-cell transplantation: report from the Bone Marrow Transplant Survivor Study
    Smita Bhatia
    City of Hope Cancer Center, 1500 E Duarte Rd, Duarte, CA 91010 3000, USA
    Blood 105:4215-22. 2005
    ..4) when compared with siblings. Although mortality rates approach that of the general population after 10 years in certain subgroups, long-term survivors of autologous HCT continue to face challenges affecting their health and well-being...
  17. ncbi request reprint Late effects among survivors of leukemia during childhood and adolescence
    Smita Bhatia
    Division of Pediatrics, City of Hope National Medical Center, 1500 East Duarte Road, Duarte, CA 91019, USA
    Blood Cells Mol Dis 31:84-92. 2003
    ..This review summarizes some of the well-described long-term consequences of therapy among children and adolescents treated for ALL...
  18. ncbi request reprint The Minneapolis-Manchester Quality of Life instrument: Reliability and validity of the Youth Form
    Smita Bhatia
    Division of Pediatric Oncology, City of Hope National Medical Center, Duarte, California, USA
    J Pediatr 145:39-46. 2004
    ..We developed the Minneapolis-Manchester Quality of Life-Youth Form (MMQL-YF) as a standardized patient self-report instrument designed to assess HRQoL in childhood cancer survivors between the ages of 8 and 12 years...
  19. ncbi request reprint High risk of subsequent neoplasms continues with extended follow-up of childhood Hodgkin's disease: report from the Late Effects Study Group
    Smita Bhatia
    City of Hope National Medical Center, 1500 E Duarte Rd, Duarte, CA 91010 3000, USA
    J Clin Oncol 21:4386-94. 2003
    ..We describe the pattern and incidence of subsequent neoplasms (SNs) occurring with extended follow-up...
  20. ncbi request reprint Racial and ethnic differences in survival of children with acute lymphoblastic leukemia
    Smita Bhatia
    Children s Oncology Group, City of Hope National Medical Center, PO Box 60012, Arcadia, CA 91006 6012, USA
    Blood 100:1957-64. 2002
    ..9% +/- 6.1%). Racial and ethnic differences in OS and EFS persist among children with ALL who receive contemporary risk-based therapy. Future studies should focus on reasons-perhaps compliance or pharmacogenetics-for those differences...
  21. ncbi request reprint What is the risk of second malignant neoplasms after childhood cancer?
    Smita Bhatia
    City of Hope Cancer Center, Duarte, CA, USA
    Nat Clin Pract Oncol 2:182-3. 2005
  22. doi request reprint Perspectives and attitudes on the use of adjuvant chemotherapy and trastuzumab in older adults with HER-2+ breast cancer: a survey of oncologists
    Arti Hurria
    City of Hope, Duarte, California 91010, USA
    Oncologist 14:883-90. 2009
    ..The goal of the current study was to understand how patient age and health status impact oncologists' decisions to recommend adjuvant therapy in older women with HER-2(+) breast cancer...
  23. doi request reprint An interaction of race and ethnicity with socioeconomic status in rectal cancer outcomes
    Joseph Kim
    Division of Oncologic Surgery, Department of Surgery, City of Hope, Duarte, CA 91010, USA
    Ann Surg 253:647-54. 2011
    ..Because appropriate rectal cancer care and subsequent outcomes can be influenced by several variables, our objective was to investigate how race, ethnicity, and socioeconomic status (SES) may impact rectal cancer outcomes...
  24. pmc Burden of morbidity in 10+ year survivors of hematopoietic cell transplantation: report from the bone marrow transplantation survivor study
    Can Lan Sun
    Department of Population Sciences, City of Hope National Medical Center, Duarte, CA, USA
    Biol Blood Marrow Transplant 19:1073-80. 2013
    ..Patients, families, and healthcare providers need to be made aware of the high burden, so they can plan for post-HCT care, even many years after HCT...
  25. pmc Cardiovascular risk factors in hematopoietic cell transplantation survivors: role in development of subsequent cardiovascular disease
    Saro H Armenian
    Department of Population Sciences, City of Hope, 1500 E Duarte Rd, Duarte, CA 91010 3000, USA
    Blood 120:4505-12. 2012
    ..7% [none], 7.0% [1 CVRF], 11.2% [≥ 2 CVRFs], P < .01); the risk was especially high (15.0%) in patients with multiple CVRFs and pre-HCT exposure to anthracyclines or chest radiation...
  26. pmc Long-term recovery after hematopoietic cell transplantation: predictors of quality-of-life concerns
    F Lennie Wong
    Population Sciences, City of Hope National Medical Center, Duarte, CA 91010 3000, USA
    Blood 115:2508-19. 2010
    ..05); allogeneic patients with chronic GVHD were less likely to work (P = .002). Multidisciplinary efforts to identify and support vulnerable subgroups after HCT need to be developed...
  27. pmc Incidence and predictors of delayed chronic kidney disease in long-term survivors of hematopoietic cell transplantation
    Michael Choi
    Division of Population Sciences, City of Hope National Medical Center, Duarte, California, USA
    Cancer 113:1580-7. 2008
    ....
  28. pmc Accelerated telomere shortening precedes development of therapy-related myelodysplasia or acute myelogenous leukemia after autologous transplantation for lymphoma
    Sujata Chakraborty
    Department of Stem Cell and Leukemia Research, Division of Population Sciences, City of Hope National Medical Center, Duarte, CA 91010, USA
    J Clin Oncol 27:791-8. 2009
    ..Here, we investigated the hypothesis that accelerated telomere shortening after aHCT could contribute to the development of t-MDS/AML...
  29. pmc Incidence and predictors of congestive heart failure after autologous hematopoietic cell transplantation
    Saro H Armenian
    Department of Population Sciences, City of Hope, Duarte, CA 91010 3000, USA
    Blood 118:6023-9. 2011
    ....
  30. pmc Ethnic differences in chronic health conditions after hematopoietic cell transplantation: a report from the Bone Marrow Transplant Survivor Study
    Saro H Armenian
    Department of Population Sciences, City of Hope National Medical Center, Duarte, CA 91010 3000, USA
    Cancer 116:4152-9. 2010
    ..Hispanics have a greater risk of early treatment failure after hematopoietic stem cell transplantation (HCT) compared with non-Hispanic whites. However, long-term morbidity among Hispanics has not been described...
  31. pmc Long-term health-related outcomes in survivors of childhood cancer treated with HSCT versus conventional therapy: a report from the Bone Marrow Transplant Survivor Study (BMTSS) and Childhood Cancer Survivor Study (CCSS)
    Saro H Armenian
    Population Sciences, City of Hope, Duarte, CA 91010 3000, USA
    Blood 118:1413-20. 2011
    ....
  32. doi request reprint Evaluation of absolute serum α-fetoprotein levels in liver transplant for hepatocellular cancer
    Brian Mailey
    Department of Oncologic Surgery, City of Hope, Duarte, CA, USA
    Arch Surg 146:26-33. 2011
    ..An elevated serum α-fetoprotein (AFP) level before orthotopic liver transplant (OLT) is predictive of mortality after OLT for hepatocellular carcinoma (HCC)...
  33. ncbi request reprint Assessment of health-related quality of life of adolescent cancer patients using the Minneapolis-Manchester Quality of Life Adolescent Questionnaire
    Eric Wu
    Division of Population Sciences, City of Hope National Medical Center, Duarte, California, USA
    Pediatr Blood Cancer 48:678-86. 2007
    ..Improved survival after childhood cancer has shifted the focus to health-related quality of life (HRQL)-an understudied problem, especially among adolescents...
  34. doi request reprint Race, ethnicity, and socioeconomic status influence the survival of patients with hepatocellular carcinoma in the United States
    Avo Artinyan
    Division of Oncologic Surgery, City of Hope, Duarte, CA, USA
    Cancer 116:1367-77. 2010
    ..The authors of this report hypothesized that these differences result from inequities in access to care and in response to therapy...
  35. pmc Genetic susceptibility to anthracycline-related congestive heart failure in survivors of haematopoietic cell transplantation
    Saro H Armenian
    Department of Population Sciences, Outcomes Research, City of Hope, Duarte, CA, USA
    Br J Haematol 163:205-13. 2013
    ..A combined (clinical and genetic) CHF predictive model performed better [area under the curve (AUC), 0·79] than the genetic (AUC = 0·67) or the clinical (AUC = 0·69) models alone...
  36. pmc Adverse psychological outcomes in long-term survivors of hematopoietic cell transplantation: a report from the Bone Marrow Transplant Survivor Study (BMTSS)
    Can Lan Sun
    Population Sciences, City of Hope, Duarte, CA, USA
    Blood 118:4723-31. 2011
    ..These results identify vulnerable subpopulations and provide patients, families, and healthcare providers with necessary information to plan for post-HCT needs many years after HCT...
  37. pmc Functional status and health-related quality of life among allogeneic transplant patients at hospital discharge: a comparison of sociodemographic, disease, and treatment characteristics
    Marcia Grant
    Division of Nursing Research and Education, City of Hope, 1500 East Duarte Road, Duarte, CA 91010, USA
    Support Care Cancer 20:2697-704. 2012
    ..The findings of this study are part of a larger mixed-methods study, representing one data time point of the larger study...
  38. pmc Prevalence and predictors of chronic health conditions after hematopoietic cell transplantation: a report from the Bone Marrow Transplant Survivor Study
    Can Lan Sun
    Population Sciences, City of Hope National Medical Center, 1500 E Duarte Road, Duarte, CA 91010 3000, USA
    Blood 116:3129-39; quiz 3377. 2010
    ..7 times as likely to develop severe/life-threatening conditions (95% CI, 3.0-7.2). The burden of long-term morbidity borne by HCT survivors is substantial, and long-term follow-up of patients who received transplantation is recommended...
  39. ncbi request reprint Health-related quality of life in young survivors of childhood cancer using the Minneapolis-Manchester Quality of Life-Youth Form
    Sadhna Shankar
    Division of Pediatric Oncology, Vanderbilt University, Nashville, Tennessee, USA
    Pediatrics 115:435-42. 2005
    ....
  40. pmc Predictors of avascular necrosis of bone in long-term survivors of hematopoietic cell transplantation
    Stephanie Campbell
    Department of Population Sciences, City of Hope National Medical Center, Duarte, California 91010 3000, USA
    Cancer 115:4127-35. 2009
    ....
  41. ncbi request reprint The Minneapolis-Manchester Quality of Life instrument: reliability and validity of the Adolescent Form
    Smita Bhatia
    Division of Pediatric Oncology, City of Hope National Medical Center, Duarte, CA, USA
    J Clin Oncol 20:4692-8. 2002
    ..This report focuses on the development and testing of the MMQL-Adolescent Form...
  42. pmc Altered hematopoietic cell gene expression precedes development of therapy-related myelodysplasia/acute myeloid leukemia and identifies patients at risk
    Liang Li
    City of Hope National Medical Center, Duarte, CA 91010, USA
    Cancer Cell 20:591-605. 2011
    ..We conclude that genetic programs associated with t-MDS/AML are perturbed long before disease onset, and accurately identify patients at risk for this complication...
  43. pmc Predictors of late cardiovascular complications in survivors of hematopoietic cell transplantation
    Saro H Armenian
    Department of Population Sciences, City of Hope, Duarte, California 91010 3000, USA
    Biol Blood Marrow Transplant 16:1138-44. 2010
    ..These data form the basis for developing predictive models for identifying high-risk individuals for targeted surveillance and aggressive management of comorbidities...
  44. ncbi request reprint Low incidence of second neoplasms among children diagnosed with acute lymphoblastic leukemia after 1983
    Smita Bhatia
    City of Hope National Medical Center, Duarte, CA, USA group org
    Blood 99:4257-64. 2002
    ..Follow-up of this large cohort that was treated with contemporary risk-based therapy showed that the incidence of second neoplasms remains low after diagnosis of childhood ALL...
  45. ncbi request reprint Metastatic gastrointestinal stromal tumors in the era of imatinib: improved survival and elimination of socioeconomic survival disparities
    Avo Artinyan
    Department of General and Oncology Surgery, City of Hope National Medical Center, 1500 East Duarte Road, Duarte, CA 91010, USA
    Cancer Epidemiol Biomarkers Prev 17:2194-201. 2008
    ..Our objective was to determine if the introduction of imatinib coincided with improved survival from metastatic gastrointestinal stromal tumor in the U.S. population and in specific socioeconomic groups...
  46. pmc Chronic health conditions in childhood cancer survivors: is it all treatment-related--or do genetics play a role?
    Saro H Armenian
    Department of Population Sciences, City of Hope National Medical Center, Duarte, CA, USA
    J Gen Intern Med 24:S395-400. 2009
    ..It is increasingly recognized that many of these complications result from complex interactions between therapeutic exposures and genetic susceptibility...
  47. pmc Predicting chemotherapy toxicity in older adults with cancer: a prospective multicenter study
    Arti Hurria
    City of Hope Comprehensive Cancer Center and Beckman Research Institute, Duarte, CA 91010, USA
    J Clin Oncol 29:3457-65. 2011
    ..The goals of this study are to identify risk factors for chemotherapy toxicity in older adults and develop a risk stratification schema for chemotherapy toxicity...
  48. ncbi request reprint Ototoxicity in Children With High-Risk Neuroblastoma: Prevalence, Risk Factors, and Concordance of Grading Scales--A Report From the Children's Oncology Group
    Wendy Landier
    Wendy Landier, F Lennie Wong, Jin Lee, Ola Thomas, Heeyoung Kim, and Smita Bhatia, City of Hope, Duarte Lu Chen, Children s Oncology Group, Monrovia, CA Kristin Knight, Oregon Health and Science University, Portland, OR Susan G Kreissman, Duke University Medical Center, Durham, NC Mary Lou Schmidt, University of Illinois at Chicago, Chicago, IL Wendy B London, Dana Farber Harvard Cancer Care, Children s Hospital Boston, Boston, MA and James G Gurney, University of Memphis School of Public Health, Memphis, TN
    J Clin Oncol 32:527-34. 2014
    ..There is no consensus regarding optimal ototoxicity grading. Furthermore, prevalence and predictors of hearing loss in a large uniformly treated high-risk neuroblastoma population are unknown. We address these gaps in our study...
  49. ncbi request reprint Longitudinal assessment of hematopoietic abnormalities after autologous hematopoietic cell transplantation for lymphoma
    Ravi Bhatia
    Division of Hematology and Hematopoietic Cell Transplantation, City of Hope National Medical Center, Duarte, CA 91010, USA
    J Clin Oncol 23:6699-711. 2005
    ..The phenomenon of hematopoietic reconstitution after autologous HCT and the role of proliferative stress in the pathogenesis of t-MDS/AML are poorly understood...
  50. pmc Children's Oncology Group's 2013 blueprint for research: survivorship and outcomes
    Saro H Armenian
    Department of Population Sciences, City of Hope, Duarte, CA 91010 3000, USA
    Pediatr Blood Cancer 60:1063-8. 2013
    ..Ongoing health education initiatives have helped standardize the follow-up care for childhood cancer survivors and facilitate the early transfer of health-related information to patients, families, and healthcare providers...
  51. pmc Successful coordination and execution of nontherapeutic studies in a cooperative group setting: lessons learned from Children's Oncology Group studies
    Andrea Carter
    Population Sciences, City of Hope Cancer Center, Duarte, CA 91010 3000, USA
    Cancer Epidemiol Biomarkers Prev 17:1665-73. 2008
    ..The successful execution of these nontherapeutic studies shows the advantages of diverse study publicity techniques, detailed standardized operating procedures, and effective utilization of technological resources...
  52. pmc NMR-based metabolomic analysis of the molecular pathogenesis of therapy-related myelodysplasia/acute myeloid leukemia
    Kristin E Cano
    Department of Molecular Medicine, Beckman Research Institute of the City of Hope, Duarte, California 91010, USA
    J Proteome Res 10:2873-81. 2011
    ..These observations suggest predisposing factors for the development of t-MDS...
  53. doi request reprint Disparities in gastric cancer outcomes among Asian ethnicities in the USA
    Joseph Kim
    Comprehensive Cancer Center, City of Hope, Duarte, CA, USA
    Ann Surg Oncol 16:2433-41. 2009
    ..It is unclear whether differences in outcome exist among Asian ethnicities. Our objective was to assess gastric cancer survival in Asian ethnic groups in a large heterogeneous population...
  54. pmc Second solid malignancies among children, adolescents, and young adults diagnosed with malignant bone tumors after 1976: follow-up of a Children's Oncology Group cohort
    Robert Goldsby
    Department of Pediatric Oncology, University of California San Francisco Children s Hospital, San Francisco, California, USA
    Cancer 113:2597-604. 2008
    ..The growing number of individuals surviving childhood cancer has increased the awareness of adverse long-term sequelae. One of the most worrisome complications after cancer therapy is the development of second malignant neoplasms (SMNs)...
  55. doi request reprint The impact of lymph node number on survival in patients with lymph node-negative pancreatic cancer
    Minia Hellan
    Department of General Oncologic Surgery, City of Hope National Medical Center, Duarte, CA 91010, USA
    Pancreas 37:19-24. 2008
    ..The role of lymph node (LN) dissection for pancreatic cancer remains uncertain, and guidelines for a minimum LN number have not been established. We hypothesized that LN number in node-negative (N0) pancreatic cancer influences survival...
  56. ncbi request reprint Development of risk-based guidelines for pediatric cancer survivors: the Children's Oncology Group Long-Term Follow-Up Guidelines from the Children's Oncology Group Late Effects Committee and Nursing Discipline
    Wendy Landier
    Division of Pediatrics, City of Hope Comprehensive Cancer Center, Duarte, CA, USA
    J Clin Oncol 22:4979-90. 2004
    ..The Guidelines, and related Health Links, can be downloaded in their entirety at www.survivorshipguidelines.org...
  57. ncbi request reprint Glutathione S-transferase genotypes, genetic susceptibility, and outcome of therapy in childhood acute lymphoblastic leukemia
    Stella M Davies
    Children s Oncology Group, Arcadia, CA 91066 6012, USA
    Blood 100:67-71. 2002
    ..These data, representing a larger series than any reported previously, suggest that GST genotype does not affect etiology or outcome of childhood ALL...
  58. pmc A grounded theory of the process of adherence to oral chemotherapy in Hispanic and caucasian children and adolescents with acute lymphoblastic leukemia
    Wendy Landier
    Department of Population Sciences, Center for Cancer Survivorship, City of Hope, 1500 E Duarte Rd, Duarte, CA 91010, USA
    J Pediatr Oncol Nurs 28:203-23. 2011
    ..Understanding the association between taking oral chemotherapy and control/cure of leukemia (Making the Connection) appeared to mediate adherence behaviors...
  59. pmc Second primary malignancies after autologous hematopoietic cell transplantation for multiple myeloma
    Amrita Y Krishnan
    Department of Hematology and Hematopoietic Cell Transplantation, City of Hope, Duarte, California 91010, USA
    Biol Blood Marrow Transplant 19:260-5. 2013
    ..The trend toward increased risk with thalidomide exposure suggests a class effect from immunomodulatory drugs that might not be restricted to lenalidomide...
  60. pmc Neurocognitive and behavioral outcomes in Latino childhood cancer survivors
    Sunita K Patel
    Department of Population Sciences, City of Hope Medical Center and Beckman Research Institute, Duarte, CA, USA
    Pediatr Blood Cancer 60:1696-702. 2013
    ..We evaluated the neurocognitive and behavioral outcomes and their impact on the health-related quality of life in survivors of childhood cancer drawn from Latino families in the Los Angeles region...
  61. pmc Yield of screening for long-term complications using the children's oncology group long-term follow-up guidelines
    Wendy Landier
    City of Hope, Duarte, CA 91010 3000, USA
    J Clin Oncol 30:4401-8. 2012
    ..However, the yield from these recommendations is not known...
  62. pmc Chronic myelogenous leukemia stem and progenitor cells demonstrate chromosomal instability related to repeated breakage-fusion-bridge cycles mediated by increased nonhomologous end joining
    Sujata Chakraborty
    Division of Hematopoietic Stem Cell and Leukemia Research, City of Hope National Medical Center, Duarte, CA 91010, USA
    Blood 119:6187-97. 2012
    ..These studies reveal a previously unrecognized mechanism of chromosomal instability in leukemia progenitors because of continued generation of unstable chromosomal lesions through repeated cycles of breakage and repair of such lesions...
  63. doi request reprint Cancer survivorship: a pediatric perspective
    Wendy Landier
    Department of Population Sciences, City of Hope Cancer Center, Duarte, California 91010, USA
    Oncologist 13:1181-92. 2008
    ..This review describes some of the known late effects described in childhood cancer survivors in order to suggest reasonable starting points for evaluation of specific long-term problems in this unique and growing population...
  64. ncbi request reprint Second malignancies after allogeneic hematopoietic cell transplantation
    Thomas Lowe
    City of Hope Comprehensive Cancer Center, Duarte, California 91010, USA
    Biol Blood Marrow Transplant 13:1121-34. 2007
    ..Most importantly, guidelines should be developed in regard to screening and prevention of second malignancies, so that physicians can provide state-of-the-art counsel and care for the benefit of our patients...
  65. doi request reprint Male breast cancer 15 years after allogeneic hematopoietic cell transplantation including total body irradiation for recurrent acute lymphoblastic leukemia
    Thomas Lowe
    City of Hope Comprehensive Cancer Center, Duarte, CA 91010 3000, USA
    Onkologie 31:266-9. 2008
    ..One of the most devastating long-term complications is the development of a second malignancy...
  66. pmc Role of age and health in treatment recommendations for older adults with breast cancer: the perspective of oncologists and primary care providers
    Arti Hurria
    City of Hope National Medical Center, Duarte, CA 91010, USA
    J Clin Oncol 26:5386-92. 2008
    ..To determine the impact of age and health status on adjuvant treatment recommendations for older patients with breast cancer from the perspective of medical oncologists and primary care physicians with geriatric expertise...
  67. pmc Preparing professional staff to care for cancer survivors
    Marcia Grant
    Department of Nursing Research and Education, City of Hope National Medical Center, 1500 East Duarte Road, Duarte, CA 91010 3000, USA
    J Cancer Surviv 1:98-106. 2007
    ....
  68. ncbi request reprint Discharge and unscheduled readmissions of adult patients undergoing hematopoietic stem cell transplantation: implications for developing nursing interventions
    Marcia Grant
    City of Hope Comprehensive Cancer Center in Duarte, CA, USA
    Oncol Nurs Forum 32:E1-8. 2005
    ..To identify implications for nursing practice from survey results and the literature that may improve patient outcomes during and following initial hospital discharge...
  69. ncbi request reprint An interaction of race and ethnicity with socioeconomic status in rectal cancer outcomes
    Joseph Kim
    Division of Oncologic Surgery, Department of Surgery, City of Hope, Duarte, CA Michael E DeBakey Department of Surgery and Houston Health Services and Research Center of Excellence, Michael E DeBakey Veterans Affairs Medical Center, Baylor College of Medicine Houston, TX Department of Surgery, University of California Davis, Sacramento, CA and Department of Population Sciences, City of Hope, Duarte, CA Department of Population Sciences, City of Hope, Duarte, CA
    Ann Surg 253:647-54. 2011
    ..Because appropriate rectal cancer care and subsequent outcomes can be influenced by several variables, our objective was to investigate how race, ethnicity, and socioeconomic status (SES) may impact rectal cancer outcomes...
  70. pmc Genetically mediated Nf1 loss in mice promotes diverse radiation-induced tumors modeling second malignant neoplasms
    Grace Choi
    Department of Radiation Oncology, University of California, San Francisco, San Francisco, California, USA
    Cancer Res 72:6425-34. 2012
    ..Nf1 heterozygosity confers broad susceptibility to genotoxin-induced tumorigenesis, and this paradigm serves as an experimental platform for future studies of SMNs...
  71. ncbi request reprint Second cancers in survivors of childhood cancer
    Smita Bhatia
    City of Hope National Medical Center, Duarte, California 91010, USA
    Nat Rev Cancer 2:124-32. 2002
    ..Of these, the most devastating is a second cancer...
  72. pmc A genome-wide meta-analysis of nodular sclerosing Hodgkin lymphoma identifies risk loci at 6p21.32
    Wendy Cozen
    Department of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, CA, USA
    Blood 119:469-75. 2012
    ..In a separate analysis, the DRB1*0701 allele was associated with a decreased risk of NSHL (OR = 0.5, 95% confidence interval = 0.4, 0.7). These data support the importance of the HLA class II region in NSHL etiology...
  73. ncbi request reprint Performance limitations and participation restrictions among childhood cancer survivors treated with hematopoietic stem cell transplantation: the bone marrow transplant survivor study
    Kirsten K Ness
    Department of Pediatrics, University of Minnesota, Minneapolis, USA
    Arch Pediatr Adolesc Med 159:706-13. 2005
    ....
  74. pmc Diabetes, hypertension, and cardiovascular events in survivors of hematopoietic cell transplantation: a report from the bone marrow transplantation survivor study
    K Scott Baker
    Department of Pediatrics, University of Minnesota, Minneapolis 55455, USA
    Blood 109:1765-72. 2007
    ..42; 95% CI, 1.55-7.52). Thus, HCT survivors have a higher age- and BMI-adjusted risk of diabetes and hypertension, potentially leading to a higher than expected risk of CV events with age...
  75. ncbi request reprint Myelodysplastic syndrome and acute myeloid leukemia after autotransplantation for lymphoma: a multicenter case-control study
    Catherine Metayer
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA
    Blood 101:2015-23. 2003
    ..Transplantation-related factors may also modulate this risk; however, the apparent contribution of high-dose TBI requires confirmation...
  76. ncbi request reprint Late-effects among survivors of leukaemia and lymphoma during childhood and adolescence
    Leslie L Robison
    Division of Pediatric Epidemiology and Clinical Research, University of Minnesota Cancer Center, Minneapolis, MN, USA
    Br J Haematol 122:345-59. 2003
  77. doi request reprint Monitoring for cardiovascular disease in survivors of childhood cancer: report from the Cardiovascular Disease Task Force of the Children's Oncology Group
    Sadhna M Shankar
    Division of Pediatric Hematology Oncology, Department of Pediatrics, Vanderbilt University, Nashville, Tennessee 37232 6310, USA
    Pediatrics 121:e387-96. 2008
    ....
  78. pmc Late effects in survivors of Hodgkin and non-Hodgkin lymphoma treated with autologous hematopoietic cell transplantation: a report from the bone marrow transplant survivor study
    Navneet S Majhail
    Blood and Marrow Transplant Program, Departments of Medicine and Pediatrics, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Biol Blood Marrow Transplant 13:1153-9. 2007
    ..4, 95% CI 1.0-5.5). HL and NHL survivors of autologous HCT have a high prevalence of long-term health-related complications and require continued monitoring for late effects of transplantation...
  79. ncbi request reprint Genetic polymorphisms in the carbonyl reductase 3 gene CBR3 and the NAD(P)H:quinone oxidoreductase 1 gene NQO1 in patients who developed anthracycline-related congestive heart failure after childhood cancer
    Javier G Blanco
    Department of Pharmaceutical Sciences, State University of New York at Buffalo, Buffalo, New York, USA
    Cancer 112:2789-95. 2008
    ....
  80. ncbi request reprint Late effects in survivors of chronic myeloid leukemia treated with hematopoietic cell transplantation: results from the Bone Marrow Transplant Survivor Study
    K Scott Baker
    University of Minnesota Cancer Center, Blood and Marrow Transplant Program, Department of Internal Medicine, University of Minnesota, Minneapolis, USA
    Blood 104:1898-906. 2004
    ..However, adverse medical late effects with significant morbidity were uncommon. Chronic GVHD is the most important predictor of adverse medical late effects and poor overall health...
  81. pmc Impact of chronic graft-versus-host disease on the health status of hematopoietic cell transplantation survivors: a report from the Bone Marrow Transplant Survivor Study
    Christopher J Fraser
    Pediatric Blood and Marrow Transplant Program, Department of Pediatrics, University of Minnesota, 420 Delaware Street SE, Minneapolis, MN 55455, USA
    Blood 108:2867-73. 2006
    ..We conclude that active cGVHD has a significant impact on many aspects of the overall health status of HCT survivors and that, most importantly, those successfully treated for cGVHD do not appear to have long-term impairments...
  82. ncbi request reprint Visual, auditory, sensory, and motor impairments in long-term survivors of hematopoietic stem cell transplantation performed in childhood: results from the Bone Marrow Transplant Survivor study
    James G Gurney
    Department of Pediatrics, Division of General Pediatrics, 300 NIB 6E02 Box 0456, University of Michigan, 300 N Ingalls Street, Ann Arbor, MI 48109, USA
    Cancer 106:1402-8. 2006
    ..Because of treatment-related toxicity, research is increasingly being focused on long-term sequelae secondary to hematopoietic stem cell transplantation (HSCT) in survivor populations...
  83. ncbi request reprint A methodological issue in the analysis of second-primary cancer incidence in long-term survivors of childhood cancers
    Yutaka Yasui
    Cancer Research Program, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Am J Epidemiol 158:1108-13. 2003
    ..These showed appreciable differences in the analytical results by not accounting for the natural age-associated increase of risk, illustrating a significant impact of this methodological issue on study conclusions...
  84. doi request reprint Cardiovascular disease after hematopoietic cell transplantation--lessons learned
    Saro H Armenian
    Haematologica 93:1132-6. 2008
  85. doi request reprint Twenty years of follow-up among survivors of childhood and young adult acute myeloid leukemia: a report from the Childhood Cancer Survivor Study
    Daniel A Mulrooney
    Department of Pediatrics, University of Minnesota Medical School and Cancer Center, Minneapolis, MN 55455, USA
    Cancer 112:2071-9. 2008
    ..Limited data exist on the comprehensive assessment of late medical and social effects experienced by survivors of childhood and young adult acute myeloid leukemia (AML)...
  86. ncbi request reprint Clinical characteristics and outcome of children with Down syndrome and acute lymphoblastic leukemia: a Children's Cancer Group study
    James A Whitlock
    Department of Pediatric Hematology Oncology, Vanderbilt University Medical Center, Nashville, TN, USA
    Blood 106:4043-9. 2005
    ..These results suggest that intensification of therapy for patients with ALL-DS is needed to maintain outcome comparable with those of ALL-NDS patients...
  87. ncbi request reprint Survival variability by race and ethnicity in childhood acute lymphoblastic leukemia
    Nina S Kadan-Lottick
    Division of Pediatric Hematology Oncology, Yale University, New Haven, Conn, USA
    JAMA 290:2008-14. 2003
    ....
  88. ncbi request reprint Health care utilization by adult long-term survivors of hematopoietic cell transplant: report from the Bone Marrow Transplant Survivor Study
    Sadhna M Shankar
    Vanderbilt Ingram Cancer Center, Nashville, Tennessee, USA
    Cancer Epidemiol Biomarkers Prev 16:834-9. 2007
    ..Primary care physicians provide health care for an increasing number of adult long-term survivors of HCT, emphasizing the need for increased awareness of the long-term follow-up needs of the HCT survivors by the health care providers...

Research Grants12

  1. Ethnic Differences in Survival after Childhood ALL
    Smita Bhatia; Fiscal Year: 2006
    ..abstract_text> ..
  2. BONE MARROW TRANSPLANT (BMT) SURVIVORS STUDY
    Smita Bhatia; Fiscal Year: 2001
    ..g., second cancers, births, cardiac complications, etc.) that may have occurred since the completion of the initial questionnaire. ..
  3. Ethnic Differences in Survival after Childhood ALL
    Smita Bhatia; Fiscal Year: 2005
    ..abstract_text> ..
  4. Ethnic Differences in Survival after Childhood ALL
    Smita Bhatia; Fiscal Year: 2009
    ..abstract_text> ..
  5. Role of Genetic Susceptibility in Therapy-related Subsequent Malignancies
    Smita Bhatia; Fiscal Year: 2010
    ....
  6. Ethnic Differences in Survival after Childhood ALL
    Smita Bhatia; Fiscal Year: 2007
    ..abstract_text> ..
  7. BONE MARROW TRANSPLANT (BMT) SURVIVORS STUDY
    Smita Bhatia; Fiscal Year: 2000
    ..g., second cancers, births, cardiac complications, etc.) that may have occurred since the completion of the initial questionnaire. ..
  8. Ethnic Differences in Survival after Childhood ALL
    Smita Bhatia; Fiscal Year: 2004
    ..abstract_text> ..
  9. BONE MARROW TRANSPLANT (BMT) SURVIVORS STUDY
    Smita Bhatia; Fiscal Year: 2003
    ..g., second cancers, births, cardiac complications, etc.) that may have occurred since the completion of the initial questionnaire. ..
  10. BONE MARROW TRANSPLANT (BMT) SURVIVORS STUDY
    Smita Bhatia; Fiscal Year: 2002
    ..g., second cancers, births, cardiac complications, etc.) that may have occurred since the completion of the initial questionnaire. ..
  11. Role of Genetic Susceptibility in Therapy-related Subsequent Malignancies
    Smita Bhatia; Fiscal Year: 2011
    ....