Ravi Bhatia

Summary

Affiliation: City of Hope National Medical Center
Country: USA

Publications

  1. ncbi request reprint Contact with fibronectin enhances preservation of normal but not chronic myelogenous leukemia primitive hematopoietic progenitors
    Ravi Bhatia
    Division of Hematology and Bone Marrow Transplantation, City of Hope National Medical Center, 1500 E Duarte Road, Duarte, CA 91010, USA
    Exp Hematol 30:324-32. 2002
  2. ncbi request reprint Longitudinal assessment of hematopoietic abnormalities after autologous hematopoietic cell transplantation for lymphoma
    Ravi Bhatia
    Division of Hematology and Hematopoietic Cell Transplantation, City of Hope National Medical Center, Duarte, CA 91010, USA
    J Clin Oncol 23:6699-711. 2005
  3. pmc Role of BCR-ABL-Y177-mediated p27kip1 phosphorylation and cytoplasmic localization in enhanced proliferation of chronic myeloid leukemia progenitors
    S Chu
    Division of Hematopoietic Stem Cell and Leukemia Research, Department of Hematology and Hematopoietic Cell Transplantation, City of Hope National Medical Center, Duarte, CA 91010, USA
    Leukemia 24:779-87. 2010
  4. pmc Inhibition of Grb2 expression demonstrates an important role in BCR-ABL-mediated MAPK activation and transformation of primary human hematopoietic cells
    H Modi
    Division of Hematopoietic Stem Cell and Leukemia Research, Department of Hematology and Hematopoietic Cell Transplantation, City of Hope National Medical Center, Duarte, CA 91010, USA
    Leukemia 25:305-12. 2011
  5. ncbi request reprint Persistence of malignant hematopoietic progenitors in chronic myelogenous leukemia patients in complete cytogenetic remission following imatinib mesylate treatment
    Ravi Bhatia
    Division of Hematology and Bone Marrow Transplantation, City of Hope National Medical Center, Duarte, CA 91010, USA
    Blood 101:4701-7. 2003
  6. ncbi request reprint Abnormal growth factor modulation of beta1-integrin-mediated adhesion in chronic myelogenous leukaemia haematopoietic progenitors
    R Bhatia
    Division of Hematology and Bone Marrow Transplantation, City of Hope National Medical Center, 1500 E Duarte Road, Duarte, CA 91010, USA
    Br J Haematol 115:845-53. 2001
  7. ncbi request reprint Chronic myelogenous leukemia primitive hematopoietic progenitors demonstrate increased sensitivity to growth factor-induced proliferation and maturation
    R Bhatia
    Division of Hematology and Bone Marrow Transplantation, City of Hope National Medical Center, Duarte, CA 91010, USA
    Exp Hematol 28:1401-12. 2000
  8. pmc Treatment-related myelodysplastic syndrome: molecular characteristics and therapy
    Ravi Bhatia
    Division of Hematopoietic Stem Cell and Leukemia Research, City of Hope Comprehensive Cancer Center, Duarte, California 91010, USA
    Curr Opin Hematol 18:77-82. 2011
  9. ncbi request reprint Autologous hematopoietic cell transplantation for chronic myelogenous leukemia
    Ravi Bhatia
    Stem Cell Biology Program, Division of Hematology and Bone Marrow Transplantation, Comprehensive Cancer Center, City of Hope National Medical Center, 1500 East Duarte Road, Duarte, CA 91010, USA
    Hematol Oncol Clin North Am 18:715-32, xi. 2004
  10. pmc Activation of stress response gene SIRT1 by BCR-ABL promotes leukemogenesis
    Hongfeng Yuan
    Department of Cancer Biology, Beckman Research Institute, City of Hope, Duarte, CA, USA
    Blood 119:1904-14. 2012

Collaborators

Detail Information

Publications62

  1. ncbi request reprint Contact with fibronectin enhances preservation of normal but not chronic myelogenous leukemia primitive hematopoietic progenitors
    Ravi Bhatia
    Division of Hematology and Bone Marrow Transplantation, City of Hope National Medical Center, 1500 E Duarte Road, Duarte, CA 91010, USA
    Exp Hematol 30:324-32. 2002
    ....
  2. ncbi request reprint Longitudinal assessment of hematopoietic abnormalities after autologous hematopoietic cell transplantation for lymphoma
    Ravi Bhatia
    Division of Hematology and Hematopoietic Cell Transplantation, City of Hope National Medical Center, Duarte, CA 91010, USA
    J Clin Oncol 23:6699-711. 2005
    ..The phenomenon of hematopoietic reconstitution after autologous HCT and the role of proliferative stress in the pathogenesis of t-MDS/AML are poorly understood...
  3. pmc Role of BCR-ABL-Y177-mediated p27kip1 phosphorylation and cytoplasmic localization in enhanced proliferation of chronic myeloid leukemia progenitors
    S Chu
    Division of Hematopoietic Stem Cell and Leukemia Research, Department of Hematology and Hematopoietic Cell Transplantation, City of Hope National Medical Center, Duarte, CA 91010, USA
    Leukemia 24:779-87. 2010
    ..These studies show the importance of BCR-ABL-Y177-AKT-mediated p27 phosphorylation in altered p27 localization and enhanced proliferation and expansion of primary CML progenitors...
  4. pmc Inhibition of Grb2 expression demonstrates an important role in BCR-ABL-mediated MAPK activation and transformation of primary human hematopoietic cells
    H Modi
    Division of Hematopoietic Stem Cell and Leukemia Research, Department of Hematology and Hematopoietic Cell Transplantation, City of Hope National Medical Center, Duarte, CA 91010, USA
    Leukemia 25:305-12. 2011
    ..These results support further investigation of downstream effectors of Grb2-mediated signals and targeting of Grb2 interactions in the treatment of CML...
  5. ncbi request reprint Persistence of malignant hematopoietic progenitors in chronic myelogenous leukemia patients in complete cytogenetic remission following imatinib mesylate treatment
    Ravi Bhatia
    Division of Hematology and Bone Marrow Transplantation, City of Hope National Medical Center, Duarte, CA 91010, USA
    Blood 101:4701-7. 2003
    ..Patients in CCR with imatinib mesylate treatment need to be followed carefully to assess for risk of relapse...
  6. ncbi request reprint Abnormal growth factor modulation of beta1-integrin-mediated adhesion in chronic myelogenous leukaemia haematopoietic progenitors
    R Bhatia
    Division of Hematology and Bone Marrow Transplantation, City of Hope National Medical Center, 1500 E Duarte Road, Duarte, CA 91010, USA
    Br J Haematol 115:845-53. 2001
    ..BCR-ABL induced abnormalities in GF-integrin interactions could contribute to abnormal circulation and microenvironmental localization of CML progenitors...
  7. ncbi request reprint Chronic myelogenous leukemia primitive hematopoietic progenitors demonstrate increased sensitivity to growth factor-induced proliferation and maturation
    R Bhatia
    Division of Hematology and Bone Marrow Transplantation, City of Hope National Medical Center, Duarte, CA 91010, USA
    Exp Hematol 28:1401-12. 2000
    ..Altered GF responsiveness may contribute to abnormal expansion of malignant myeloid cells in CML. These findings may also be applied toward the development of novel approaches to select benign stem cells in CML...
  8. pmc Treatment-related myelodysplastic syndrome: molecular characteristics and therapy
    Ravi Bhatia
    Division of Hematopoietic Stem Cell and Leukemia Research, City of Hope Comprehensive Cancer Center, Duarte, California 91010, USA
    Curr Opin Hematol 18:77-82. 2011
    ..Treatment-related myelodysplastic syndrome (t-MDS) is a serious complication of cancer treatment. Here we review recent advances in knowledge of the risk factors, pathogenesis, and treatment of t-MDS...
  9. ncbi request reprint Autologous hematopoietic cell transplantation for chronic myelogenous leukemia
    Ravi Bhatia
    Stem Cell Biology Program, Division of Hematology and Bone Marrow Transplantation, Comprehensive Cancer Center, City of Hope National Medical Center, 1500 East Duarte Road, Duarte, CA 91010, USA
    Hematol Oncol Clin North Am 18:715-32, xi. 2004
    ..Several promising methods to improve purging of the autograft and for more effective elimination of residual leukemia are being explored...
  10. pmc Activation of stress response gene SIRT1 by BCR-ABL promotes leukemogenesis
    Hongfeng Yuan
    Department of Cancer Biology, Beckman Research Institute, City of Hope, Duarte, CA, USA
    Blood 119:1904-14. 2012
    ..Our findings suggest further exploration of SIRT1 as a therapeutic target for CML treatment to overcome resistance...
  11. ncbi request reprint BCR-tyrosine 177 plays an essential role in Ras and Akt activation and in human hematopoietic progenitor transformation in chronic myelogenous leukemia
    Su Chu
    Department of Hematopoietic Stem Cell and Leukemia Research, Division of Hematology and Hematopoietic Cell Transplantation, City of Hope National Medical Center, 1500 East Duarte Road, Duarte, CA 91010, USA
    Cancer Res 67:7045-53. 2007
    ..Our studies indicate that BCR/ABL-Y177 plays an essential role in Ras and Akt activation and in human hematopoietic progenitor transformation in CML...
  12. pmc Activation of p53 by SIRT1 inhibition enhances elimination of CML leukemia stem cells in combination with imatinib
    Ling Li
    Division of Hematopoietic Stem Cell and Leukemia Research, City of Hope National Medical Center, Duarte, CA 91010, USA
    Cancer Cell 21:266-81. 2012
    ..Activation of p53 via SIRT1 inhibition represents a potential approach to target CML LSC...
  13. pmc Microenvironmental protection of CML stem and progenitor cells from tyrosine kinase inhibitors through N-cadherin and Wnt-β-catenin signaling
    Bin Zhang
    Division of Hematopoietic Stem Cell and Leukemia Research, Beckman Research Institute, Duarte, CA 91010, USA
    Blood 121:1824-38. 2013
    ..Importantly, these results reveal novel mechanisms of resistance of CML LSCs to TKI treatment and suggest new targets for treatment designed to eradicate residual LSCs in CML patients...
  14. pmc Role of BCR/ABL gene-expression levels in determining the phenotype and imatinib sensitivity of transformed human hematopoietic cells
    Hardik Modi
    Department of Hematopoietic Stem Cell and Leukemia Research, Division of Hematology and Hematopoietic Cell Transplantation HCT, City of Hope National Medical Center, Duarte, CA 91010, USA
    Blood 109:5411-21. 2007
    ....
  15. pmc BCR-ABL gene expression is required for its mutations in a novel KCL-22 cell culture model for acquired resistance of chronic myelogenous leukemia
    Hongfeng Yuan
    Department of Cancer Biology, City of Hope, Duarte, California 91010, USA
    J Biol Chem 285:5085-96. 2010
    ..Our study suggests important roles of BCR-ABL gene expression and its native chromosomal locus for acquisition of BCR-ABL mutations and provides a new tool for further studying resistance mechanisms...
  16. ncbi request reprint Effect of mutational inactivation of tyrosine kinase activity on BCR/ABL-induced abnormalities in cell growth and adhesion in human hematopoietic progenitors
    Pandurangan Ramaraj
    Division of Hematology and Bone Marrow Transplantation, City of Hope National Medical Center, Duarte, CA 91010, USA
    Cancer Res 64:5322-31. 2004
    ..We conclude that abnormal kinase activity is essential for abnormal proliferation and survival of CML progenitors but that abnormal adhesion and migration result from both kinase-dependent and -independent mechanisms...
  17. ncbi request reprint Detection of BCR-ABL kinase mutations in CD34+ cells from chronic myelogenous leukemia patients in complete cytogenetic remission on imatinib mesylate treatment
    Su Chu
    Division of Hematology and Hematopoietic Cell Transplantation, City of Hope National Medical Center, Duarte, CA 91010, USA
    Blood 105:2093-8. 2005
    ..We conclude that BCR-ABL kinase mutations can be detected in CD34+ cells from CML patients in CCR on imatinib, may contribute to persistence of small populations of malignant progenitors, and could be a potential source of relapse...
  18. pmc Effects of dasatinib on SRC kinase activity and downstream intracellular signaling in primitive chronic myelogenous leukemia hematopoietic cells
    Heiko Konig
    Department of Hematopoietic Stem Cell and Leukemia Research, City of Hope National Medical Center and Division of Molecular Medicine, Beckman Research Institute of the City of Hope, Duarte, California 91010, USA
    Cancer Res 68:9624-33. 2008
    ..These observations argue against a prominent role for Src kinases in persistence of primitive CML cells in TKI-treated patients...
  19. pmc Indirubin derivatives induce apoptosis of chronic myelogenous leukemia cells involving inhibition of Stat5 signaling
    Sangkil Nam
    Molecular Medicine, Beckman Research Institute, City of Hope Comprehensive Cancer Center, Duarte, CA 91010, USA
    Mol Oncol 6:276-83. 2012
    ..IRDs represent a promising structural class for development of new therapeutics for wild type or T315I mutant Bcr-Abl-positive CML patients...
  20. pmc Persistence of leukemia stem cells in chronic myelogenous leukemia patients in prolonged remission with imatinib treatment
    Su Chu
    Division of Hematopoietic Stem Cell and Leukemia Research, City of Hope National Medical Center, Duarte, CA, USA
    Blood 118:5565-72. 2011
    ..These results directly demonstrate that BCR-ABL(+) stem cells persist in CML patients despite prolonged treatment with imatinib, and support ongoing efforts to target this population...
  21. pmc Altered microenvironmental regulation of leukemic and normal stem cells in chronic myelogenous leukemia
    Bin Zhang
    Division of Hematopoietic Stem Cell and Leukemia Research, City of Hope National Medical Center, Duarte, CA 91010, USA
    Cancer Cell 21:577-92. 2012
    ..These results were validated using human CML samples and provide improved understanding of microenvironmental regulation of normal and leukemic LTHSC and their response to IM in CML...
  22. pmc Altered hematopoietic cell gene expression precedes development of therapy-related myelodysplasia/acute myeloid leukemia and identifies patients at risk
    Liang Li
    City of Hope National Medical Center, Duarte, CA 91010, USA
    Cancer Cell 20:591-605. 2011
    ..We conclude that genetic programs associated with t-MDS/AML are perturbed long before disease onset, and accurately identify patients at risk for this complication...
  23. pmc Accelerated telomere shortening precedes development of therapy-related myelodysplasia or acute myelogenous leukemia after autologous transplantation for lymphoma
    Sujata Chakraborty
    Department of Stem Cell and Leukemia Research, Division of Population Sciences, City of Hope National Medical Center, Duarte, CA 91010, USA
    J Clin Oncol 27:791-8. 2009
    ..Here, we investigated the hypothesis that accelerated telomere shortening after aHCT could contribute to the development of t-MDS/AML...
  24. doi request reprint Deferasirox exposure induces reactive oxygen species and reduces growth and viability of myelodysplastic hematopoietic progenitors
    Vinod Pullarkat
    Department of Hematology and Hematopoietic Cell Transplantation, City of Hope Medical Center, Duarte, CA, USA
    Leuk Res 36:966-73. 2012
    ..Reactive oxygen species levels were elevated above control at concentrations of DFX above 5 μM. We conclude that exposure to DFX results in dose-dependent inhibition of proliferation, and survival in MDS progenitors...
  25. ncbi request reprint Effect of imatinib mesylate on chronic myelogenous leukemia hematopoietic progenitor cells
    Melissa S Holtz
    Division of Hematology and Bone Marrow Transplantation, City of Hope National Medical Center, Duarte, CA 91010, USA
    Leuk Lymphoma 45:237-45. 2004
    ..Finally we discuss studies evaluating new approaches to overcome resistance of CML progenitor cells to imatinib...
  26. pmc Overcoming CML acquired resistance by specific inhibition of Aurora A kinase in the KCL-22 cell model
    Hongfeng Yuan
    Department of Cancer Biology, Beckman Research Institute, City of Hope, 1500 East Duarte Road, Duarte, CA 91010, USA
    Carcinogenesis 33:285-93. 2012
    ....
  27. pmc Chronic myelogenous leukemia stem and progenitor cells demonstrate chromosomal instability related to repeated breakage-fusion-bridge cycles mediated by increased nonhomologous end joining
    Sujata Chakraborty
    Division of Hematopoietic Stem Cell and Leukemia Research, City of Hope National Medical Center, Duarte, CA 91010, USA
    Blood 119:6187-97. 2012
    ..These studies reveal a previously unrecognized mechanism of chromosomal instability in leukemia progenitors because of continued generation of unstable chromosomal lesions through repeated cycles of breakage and repair of such lesions...
  28. pmc A critical role for SHP2 in STAT5 activation and growth factor-mediated proliferation, survival, and differentiation of human CD34+ cells
    Liang Li
    Division of Hematopoietic Stem Cell and Leukemia Research, City of Hope Nationa, Medical Center, Duarte, CA, USA
    Blood 118:1504-15. 2011
    ..These results indicate an important role for SHP2 in STAT5 activation and GF-mediated proliferation, survival, and differentiation of human progenitor cells...
  29. pmc Effective targeting of quiescent chronic myelogenous leukemia stem cells by histone deacetylase inhibitors in combination with imatinib mesylate
    Bin Zhang
    Division of Hematopoietic Stem Cell and Leukemia Research, City of Hope National Medical Center, Duarte, CA 91010, USA
    Cancer Cell 17:427-42. 2010
    ..The interaction of IM and HDACis inhibited genes regulating hematopoietic stem cell maintenance and survival. HDACi treatment represents an effective strategy to target LSCs in CML patients receiving tyrosine kinase inhibitors...
  30. ncbi request reprint Imatinib mesylate (STI571) inhibits growth of primitive malignant progenitors in chronic myelogenous leukemia through reversal of abnormally increased proliferation
    Melissa S Holtz
    Division of Hematology and Bone Marrow Transplantation and the Department of Cytogenetics, City of Hope National Medical Center, Duarte, CA 91010, USA
    Blood 99:3792-800. 2002
    ..These results suggest that inhibition of Bcr-Abl tyrosine kinase by imatinib mesylate restores normal hematopoiesis by removing the proliferative advantage of CML progenitors but that elimination of all CML progenitors may not occur...
  31. ncbi request reprint BCR/ABL kinase inhibition by imatinib mesylate enhances MAP kinase activity in chronic myelogenous leukemia CD34+ cells
    Su Chu
    Division of Hematology and Bone Marrow Transplantation, City of Hope National Medical Center, Duarte, CA 91010, USA
    Blood 103:3167-74. 2004
    ..These mechanisms may contribute to incomplete elimination of CML progenitors by imatinib...
  32. ncbi request reprint Peripheral blood hematopoietic stem cell mobilization and collection efficacy is not an independent prognostic factor for autologous stem cell transplantation
    Shirong Wang
    Department of Transfusion Medicine, Division of Pathology, City of Hope National Medical Center, Duarte, California 91010, USA
    Transfusion 47:2207-16. 2007
    ..The aim of this retrospective study was to determine whether the effectiveness of mobilization and collection is an independent prognostic factor for autologous stem cell transplantation outcome...
  33. pmc Reduced intensity allogeneic hematopoietic stem cell transplantation for MDS using tacrolimus/sirolimus-based GVHD prophylaxis
    Ryotaro Nakamura
    Department of Hematology Hematopoietic Cell Transplantation, City of Hope, Duarte, CA 91010, USA
    Leuk Res 36:1152-6. 2012
    ..This RI-HSCT protocol produces encouraging outcomes in MDS patients, and tacrolimus/sirolimus-based GVHD prophylaxis may contribute to that promising result...
  34. pmc NMR-based metabolomic analysis of the molecular pathogenesis of therapy-related myelodysplasia/acute myeloid leukemia
    Kristin E Cano
    Department of Molecular Medicine, Beckman Research Institute of the City of Hope, Duarte, California 91010, USA
    J Proteome Res 10:2873-81. 2011
    ..These observations suggest predisposing factors for the development of t-MDS...
  35. pmc Effective and selective inhibition of chronic myeloid leukemia primitive hematopoietic progenitors by the dual Src/Abl kinase inhibitor SKI-606
    Heiko Konig
    Department of Hematopoietic Stem Cell and Leukemia Research, City of Hope National Medical Center, Duarte, CA 91010, USA
    Blood 111:2329-38. 2008
    ....
  36. ncbi request reprint Growth factor stimulation reduces residual quiescent chronic myelogenous leukemia progenitors remaining after imatinib treatment
    Melissa Holtz
    Division of Hematology and Hematopoietic Cell Transplantation, Department of Hematopoietic Stem Cell and Leukemia Research, City of Hope National Medical Center, 1500 E Duarte Road, Duarte, CA 91010, USA
    Cancer Res 67:1113-20. 2007
    ..These results support the potential efficacy of growth factor stimulation in reducing the residual leukemia progenitor population in imatinib-treated patients...
  37. ncbi request reprint Comparative analysis of autografting in chronic myelogenous leukemia: effects of priming regimen and marrow or blood origin of stem cells
    C M Verfaillie
    Department of Medicine, Stem Cell Biology Program, Bone Marrow Transplantation Program, and Department of Laboratory Medicine at the University of Minnesota, Minneapolis, MN, USA
    Blood 92:1820-31. 1998
    ....
  38. pmc Reproducibility, fidelity, and discriminant validity of mRNA amplification for microarray analysis from primary hematopoietic cells
    Liang Li
    Division of Hematology and Bone Marrow Transplantation, City of Hope National Medical Center, 1500 East Duarte Rd, Duarte, CA 91010, USA
    J Mol Diagn 7:48-56. 2005
    ..However, it is possible to obtain reproducible and representative results using optimized protocols...
  39. ncbi request reprint Expression of DLK1 in hematopoietic cells results in inhibition of differentiation and proliferation
    Liang Li
    Division of Hematology and Hematopoietic Cell Transplantation, City of Hope National Medical Center, 1500 E Duarte Road, Duarte, CA 91010, USA
    Oncogene 24:4472-6. 2005
    ..Our studies identify novel molecular mechanisms and indicate that DLK1 has activity both as a soluble and a transmembrane expressed protein. Our results support further investigation of the role of DLK1 in abnormal hematopoiesis in MDS...
  40. pmc The novel histone deacetylase inhibitor, LBH589, induces expression of DNA damage response genes and apoptosis in Ph- acute lymphoblastic leukemia cells
    Anna Scuto
    Molecular Medicine, City of Hope Beckman Research Institute and National Medical Center, Duarte, CA, USA
    Blood 111:5093-100. 2008
    ..These findings provide a rationale for exploring the clinical activity of LBH589 in the treatment of patients with Ph(-) ALL...
  41. pmc TLR9-mediated siRNA delivery for targeting of normal and malignant human hematopoietic cells in vivo
    Qifang Zhang
    Department of Cancer Immunotherapeutics and Tumor Immunology, Beckman Research Institute at City of Hope, Duarte, CA 91010, USA
    Blood 121:1304-15. 2013
    ..The results of the present study show the potential of using tumoricidal/immunostimulatory CpG-siRNA oligonucleotides as a novel 2-pronged therapeutic strategy for hematologic malignancies...
  42. ncbi request reprint Nonproliferating CML CD34+ progenitors are resistant to apoptosis induced by a wide range of proapoptotic stimuli
    M S Holtz
    Division of Hematology and Hematopoietic Cell Transplantation, City of Hope National Medical Center, Duarte, CA 91010, USA
    Leukemia 19:1034-41. 2005
    ..Combination treatment with Ara-C or arsenic may not enhance targeting of nonproliferating CML progenitors. The assay described here may be useful for identifying agents targeting quiescent CML progenitors...
  43. ncbi request reprint Role of abnormal integrin-cytoskeletal interactions in impaired beta1 integrin function in chronic myelogenous leukemia hematopoietic progenitors
    R Bhatia
    Department of Hematology and Bone Marrow Transplantation, City of Hope National Medical Center, Duarte, CA 91010, USA
    Exp Hematol 27:1384-96. 1999
    ....
  44. ncbi request reprint Solid cancers after bone marrow transplantation
    S Bhatia
    Division of Hematology and Bone Marrow Transplantation, City of Hope National Medical Center, Duarte, CA 91010 3000, USA
    J Clin Oncol 19:464-71. 2001
    ..To evaluate the incidence and associated risk factors of solid cancers after bone marrow transplantation (BMT)...
  45. ncbi request reprint Reduced-intensity conditioning for allogeneic hematopoietic stem cell transplantation with fludarabine and melphalan is associated with durable disease control in myelodysplastic syndrome
    R Nakamura
    Division of Hematology Hematopoietic Cell Transplantation, City of Hope Comprehensive Cancer Center, Duarte, CA 91010, USA
    Bone Marrow Transplant 40:843-50. 2007
    ..5 versus 7%, P=0.02). RIC with fludarabine plus melphalan was associated with durable disease control and acceptable toxicity in this high-risk cohort...
  46. ncbi request reprint Autologous stem-cell transplantation for poor-risk and relapsed intermediate- and high-grade non-Hodgkin's lymphoma
    A Nademanee
    Division of Hematology and Bone Marrow Transplantation, City of Hope National Medical Center, Duarte, CA 91010, USA
    Clin Lymphoma 1:46-54. 2000
    ..The development of a second malignancy is a serious complication of high-dose therapy, which requires close surveillance...
  47. ncbi request reprint Reduced-intensity allogeneic stem cell transplantation for patients whose prior autologous stem cell transplantation for hematologic malignancy failed
    H C Fung
    Division of Hematology and Bone Marrow Transplantation, Kaiser Permanente City of Hope BMT Program, City of Hope Cancer Center, 1500 E Duarte Road, Duarte, CA 91010, USA
    Biol Blood Marrow Transplant 9:649-56. 2003
    ....
  48. ncbi request reprint The effect of interferon-alpha on beta-1 integrin mediated adhesion and growth regulation in chronic myelogenous leukemia
    R Bhatia
    Department of Hematology and Bone Marrow Transplantation, City of Hope National Medical Center, Duarte, California, USA
    Leuk Lymphoma 28:241-54. 1998
    ..The above studies offer some insights into the mechanisms of abnormal hematopoietic regulation in CML and the mechanisms by which interferon-alpha may restore normal hematopoiesis, in this disease...
  49. ncbi request reprint A long-term follow-up report on allogeneic stem cell transplantation for patients with primary refractory acute myelogenous leukemia: impact of cytogenetic characteristics on transplantation outcome
    H C Fung
    Division of Hematology and Bone Marrow Transplantation, City of Hope Comprehensive Cancer Center, Duarte, California 91010, USA
    Biol Blood Marrow Transplant 9:766-71. 2003
    ..0107 and.0038, respectively). Allogeneic SCT can cure approximately one third of patients with primary refractory AML. Cytogenetic characteristics before SCT correlate with transplantation outcome and posttransplantation relapse...
  50. pmc Roles of SIRT1 in leukemogenesis
    Wenyong Chen
    Department of Cancer Biology, Beckman Research Institute, City of Hope, Duarte, California 91010, USA
    Curr Opin Hematol 20:308-13. 2013
    ..SIRT1 is a multifunctional protein and recent studies demonstrate that SIRT1 plays a crucial role in myeloid leukemogenesis and drug resistance...
  51. pmc The controversial role of Sirtuins in tumorigenesis - SIRT7 joins the debate
    Ling Li
    Division of Hematopoietic Stem Cell and Leukemia Research, City of Hope National Medical Center, Duarte, CA 91010, USA
    Cell Res 23:10-2. 2013
    ..A new report sheds light on the function of SIRT7, the least understood member of the Sirtuin family by identifying its locus-specific H3K18 deacetylase activity, and linking it to maintenance of cellular transformation in malignancies...
  52. pmc Stem cell quiescence
    Ling Li
    Authors Affiliation Division of Hematopoietic Stem Cell and Leukemia Research, City of Hope National Medical Center, Duarte, California, USA
    Clin Cancer Res 17:4936-41. 2011
    ..In this article, we review current advances in understanding normal stem cell quiescence, their significance for CSC quiescence and drug resistance, and the potential clinical applications of these findings...
  53. ncbi request reprint Neoplastic mast cells in systemic mastocytosis associated with t(8;21) acute myeloid leukemia are derived from the leukemic clone
    Vinod Pullarkat
    Division of Hematology and Hematopoietic Cell Transplantation, Department of Cytogenetics, Division of Pathology, City of Hope Comprehensive Cancer Center, 1500 East Duarte Road, Duarte, CA 91010, United States
    Leuk Res 31:261-5. 2007
    ..We also show that after successful allogeneic hematopoietic stem cell transplantation, these neoplastic bone marrow mast cells can persist without adverse consequences and gradually decline with time...
  54. pmc The LRF transcription factor regulates mature B cell development and the germinal center response in mice
    Nagisa Sakurai
    Division of Hematopoietic Stem Cell and Leukemia Research, Beckman Research Institute of City of Hope, Duarte, California 91010, USA
    J Clin Invest 121:2583-98. 2011
    ..These studies identify what we believe to be a new key factor for mature B cell development and provide a rationale for targeting LRF dimers for the treatment of autoimmune diseases and B cell malignancies...
  55. ncbi request reprint Efficacy of mycophenolate mofetil in the treatment of chronic graft-versus-host disease
    Francisco Lopez
    Division of Hematology and Hematopoietic Cell Transplantation, City of Hope National Medical Center, Duarte, California 91010, USA
    Biol Blood Marrow Transplant 11:307-13. 2005
    ..These data suggest that MMF is an active, well-tolerated agent in the treatment of cGVHD and may have a beneficial effect on the survival of patients with this complication...
  56. doi request reprint Enhanced BCR-ABL kinase inhibition does not result in increased inhibition of downstream signaling pathways or increased growth suppression in CML progenitors
    H Konig
    Division of Hematology and HCT, Department of Hematopoietic Stem Cell and Leukemia Research, City of Hope National Medical Center, Duarte, CA 91010, USA
    Leukemia 22:748-55. 2008
    ....
  57. ncbi request reprint Nilotinib (formerly AMN107), a highly selective BCR-ABL tyrosine kinase inhibitor, is effective in patients with Philadelphia chromosome-positive chronic myelogenous leukemia in chronic phase following imatinib resistance and intolerance
    Hagop M Kantarjian
    Department of Leukemia, The University of Texas M D Anderson Cancer Center, Houston, TX 77230 1402, USA
    Blood 110:3540-6. 2007
    ..In summary, nilotinib is highly active and safe in patients with CML-CP after imatinib failure or intolerance. This clinical trial is registered at http://clinicaltrials.gov as ID no. NCT00109707...
  58. pmc The effects of imatinib mesylate treatment before allogeneic transplantation for chronic myeloid leukemia
    Vivian G Oehler
    Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Blood 109:1782-9. 2007
    ..However, patients with a suboptimal or loss of IM response before HCT do worse, suggesting a more aggressive disease course for these patients...
  59. pmc Experiences of refugees and asylum seekers in general practice: a qualitative study
    Ravi Bhatia
    Department of Primary Care and Population Sciences, Royal Free and University College Medical School, Holborn Union Building, Archway Campus, Highgate Hill, London, N19 5LW, UK
    BMC Fam Pract 8:48. 2007
    ..This study was established to determine the views of asylum seekers and refugees on their overall experiences in primary care and to suggest improvements to their care...
  60. ncbi request reprint Late effects in survivors of chronic myeloid leukemia treated with hematopoietic cell transplantation: results from the Bone Marrow Transplant Survivor Study
    K Scott Baker
    University of Minnesota Cancer Center, Blood and Marrow Transplant Program, Department of Internal Medicine, University of Minnesota, Minneapolis, USA
    Blood 104:1898-906. 2004
    ..However, adverse medical late effects with significant morbidity were uncommon. Chronic GVHD is the most important predictor of adverse medical late effects and poor overall health...
  61. pmc CREB is a critical regulator of normal hematopoiesis and leukemogenesis
    Jerry C Cheng
    Division of Hematology Oncology, Department of Pediatrics, Gwynne Hazen Cherry Memorial Laboratories and Mattel Children s Hospital, Jonsson Comprehensive Cancer Center, UCLA, Los Angeles, CA 90095 1752, USA
    Blood 111:1182-92. 2008
    ..Our results suggest that CREB is critical for normal myelopoiesis and leukemia cell proliferation...
  62. ncbi request reprint Growing cholesterol-dependent NS0 myeloma cell line in the wave bioreactor system: overcoming cholesterol-polymer interaction by using pretreated polymer or inert fluorinated ethylene propylene
    Judith Kadarusman
    Human Genome Sciences, Inc, Cell Culture Sciences, 14200 Shady Grove Rd, Rockville, MD 20850, USA
    Biotechnol Prog 21:1341-6. 2005
    ..Another material, fluorinated ethylene propylene (FEP) does not need to be pretreated and is found to be superior (negligible cholesterol adsorption) as a result of its inert characteristics...

Research Grants16

  1. Resistance of CML Stem Cells to Imatinib (Gleevec)
    Ravi Bhatia; Fiscal Year: 2010
    ..The results if these studies will have direct application to clinical approaches to eliminate leukemia stem cells and potentially achieve cure in CML patients. ..
  2. Resistance of CML stem cells to STI571 (Gleevec)
    Ravi Bhatia; Fiscal Year: 2003
    ..The long-term goal of these studies is to allow optimal use of STI, alone or in combination, in the treatment of CML and improve overall outcomes of treatment. ..
  3. Resistance of CML Stem Cells to Imatinib (Gleevec)
    Ravi Bhatia; Fiscal Year: 2009
    ..The results if these studies will have direct application to clinical approaches to eliminate leukemia stem cells and potentially achieve cure in CML patients. ..
  4. Resistance of CML stem cells to STI571 (Gleevec)
    Ravi Bhatia; Fiscal Year: 2006
    ..The long-term goal of these studies is to allow optimal use of STI, alone or in combination, in the treatment of CML and improve overall outcomes of treatment. ..
  5. Human Hematopoietic Cell Transformation by BCR/ABL
    Ravi Bhatia; Fiscal Year: 2006
    ..These studies are expected to result in improved understanding of mechanisms critical for human progenitor transformation in CML and guide rational development of additional mechanism-based therapies. ..
  6. Resistance of CML stem cells to STI571 (Gleevec)
    Ravi Bhatia; Fiscal Year: 2004
    ..The long-term goal of these studies is to allow optimal use of STI, alone or in combination, in the treatment of CML and improve overall outcomes of treatment. ..
  7. Human Hematopoietic Cell Transformation by BCR/ABL
    Ravi Bhatia; Fiscal Year: 2005
    ..These studies are expected to result in improved understanding of mechanisms critical for human progenitor transformation in CML and guide rational development of additional mechanism-based therapies. ..
  8. Resistance of CML Stem Cells to Imatinib (Gleevec)
    Ravi Bhatia; Fiscal Year: 2009
    ..The results if these studies will have direct application to clinical approaches to eliminate leukemia stem cells and potentially achieve cure in CML patients. ..
  9. Abnormalities in gene expression in therapy-related MDS
    Ravi Bhatia; Fiscal Year: 2005
    ..These studies may also allow identification of markers of susceptibility to t-MDS allowing early detection of patients at risk for this complication. ..
  10. Resistance of CML stem cells to STI571 (Gleevec)
    Ravi Bhatia; Fiscal Year: 2005
    ..The long-term goal of these studies is to allow optimal use of STI, alone or in combination, in the treatment of CML and improve overall outcomes of treatment. ..
  11. Abnormalities in gene expression in therapy-related MDS
    Ravi Bhatia; Fiscal Year: 2007
    ..These studies may also allow identification of markers of susceptibility to t-MDS allowing early detection of patients at risk for this complication. ..
  12. Abnormalities in gene expression in therapy-related MDS
    Ravi Bhatia; Fiscal Year: 2006
    ..These studies may also allow identification of markers of susceptibility to t-MDS allowing early detection of patients at risk for this complication. ..
  13. Human Hematopoietic Cell Transformation by BCR/ABL
    Ravi Bhatia; Fiscal Year: 2007
    ..These studies are expected to result in improved understanding of mechanisms critical for human progenitor transformation in CML and guide rational development of additional mechanism-based therapies. ..