Ganesaratnam K Balendiran

Summary

Affiliation: City of Hope National Medical Center
Country: USA

Publications

  1. ncbi request reprint Fibrates inhibit aldose reductase activity in the forward and reverse reactions
    Ganesaratnam K Balendiran
    Division of Immunology, Beckman Research Institute of the City of Hope National Medical Center, 1450 E Duarte Road, Duarte, CA 91010, USA
    Biochem Pharmacol 70:1653-63. 2005
  2. ncbi request reprint The role of glutathione in cancer
    Ganesaratnam K Balendiran
    Division of Immunology, Beckman Research Institute of the City of Hope, 1450 East Duarte Road, Duarte, CA 91010, USA
    Cell Biochem Funct 22:343-52. 2004
  3. doi request reprint Inhibiting wild-type and C299S mutant AKR1B10; a homologue of aldose reductase upregulated in cancers
    Malkhey Verma
    Division of Immunology, Beckman Research Institute, City of Hope National Medical Center, 1450 E Duarte Road, Duarte, CA 91010, USA
    Eur J Pharmacol 584:213-21. 2008
  4. ncbi request reprint WY 14,643 inhibits human aldose reductase activity
    Sara Klemin
    Division of Immunology, Beckman Research Institute and City of Hope National Medical Center, 1450 E Duarte Road, Duarte, CA 91010, USA
    J Enzyme Inhib Med Chem 21:569-73. 2006
  5. ncbi request reprint High-resolution crystal structure of AKR11C1 from Bacillus halodurans: an NADPH-dependent 4-hydroxy-2,3-trans-nonenal reductase
    Tobias Marquardt
    Biomolecular Research, Paul Scherrer Institut, 5232 Villigen, Switzerland
    J Mol Biol 354:304-16. 2005
  6. ncbi request reprint Crystal structure of the restriction-modification system control element C.Bcll and mapping of its binding site
    Michael R Sawaya
    UCLA DOE Laboratory of Structural Biology and Molecular Medicine, 205 Boyer Hall, Box 951570, Los Angeles, California 90095, USA
    Structure 13:1837-47. 2005

Collaborators

  • E Maser
  • Malkhey Verma
  • Sara Klemin
  • Tobias Marquardt
  • Michael R Sawaya
  • Hans Joerg Martin
  • TIMOTHY R O'CONNOR
  • Wahajul Haq
  • Rachel Perez
  • Stephanie Bond
  • Lucy Chow
  • Richard Y Calvo
  • Heather Dingess
  • Balakrishnan Rajkumar
  • Fana Mersha
  • Alberto Podjarny
  • Rajkumar Balakrishnan
  • Siu Hong Chan
  • Shuang yong Xu
  • Zhenyu Zhu
  • Dirk Kostrewa
  • Rajesh Dabur
  • Fritz K Winkler
  • Xiao Dan Li
  • Christian Kambach
  • Antonietta Gasperina

Detail Information

Publications6

  1. ncbi request reprint Fibrates inhibit aldose reductase activity in the forward and reverse reactions
    Ganesaratnam K Balendiran
    Division of Immunology, Beckman Research Institute of the City of Hope National Medical Center, 1450 E Duarte Road, Duarte, CA 91010, USA
    Biochem Pharmacol 70:1653-63. 2005
    ..Alternatively, these findings demonstrate that AR plays a significant role in the fibrate metabolism under various scenarios...
  2. ncbi request reprint The role of glutathione in cancer
    Ganesaratnam K Balendiran
    Division of Immunology, Beckman Research Institute of the City of Hope, 1450 East Duarte Road, Duarte, CA 91010, USA
    Cell Biochem Funct 22:343-52. 2004
    ..Here we present a number of studies investigating the role of glutathione in promoting cancer, impeding chemotherapy, and the use of glutathione modulation to enhance anti-neoplastic therapy...
  3. doi request reprint Inhibiting wild-type and C299S mutant AKR1B10; a homologue of aldose reductase upregulated in cancers
    Malkhey Verma
    Division of Immunology, Beckman Research Institute, City of Hope National Medical Center, 1450 E Duarte Road, Duarte, CA 91010, USA
    Eur J Pharmacol 584:213-21. 2008
    ..The reaction of the mutant AKR1B10 is inhibited by fenofibric acid, but manifests pure non-competitive inhibition kinetics that are different from those demonstrated for the wild-type enzyme...
  4. ncbi request reprint WY 14,643 inhibits human aldose reductase activity
    Sara Klemin
    Division of Immunology, Beckman Research Institute and City of Hope National Medical Center, 1450 E Duarte Road, Duarte, CA 91010, USA
    J Enzyme Inhib Med Chem 21:569-73. 2006
    ..In addition, this observation indicates that AR, AR-like proteins and aldo-keto reductase (AKR) members may be involved in the WY 14,643 mechanism of action when it is administered as PPAR agonist...
  5. ncbi request reprint High-resolution crystal structure of AKR11C1 from Bacillus halodurans: an NADPH-dependent 4-hydroxy-2,3-trans-nonenal reductase
    Tobias Marquardt
    Biomolecular Research, Paul Scherrer Institut, 5232 Villigen, Switzerland
    J Mol Biol 354:304-16. 2005
    ..We suggest that AKR11C1 is the first structurally characterized member of a new class of AKRs with specificity for substrates with long aliphatic tails...
  6. ncbi request reprint Crystal structure of the restriction-modification system control element C.Bcll and mapping of its binding site
    Michael R Sawaya
    UCLA DOE Laboratory of Structural Biology and Molecular Medicine, 205 Boyer Hall, Box 951570, Los Angeles, California 90095, USA
    Structure 13:1837-47. 2005
    ..The C.Bcll-DNA model proposed suggests that DNA bending might play an important role in gene regulation, and that Glu27 and Asp31 in C.Bcll might function critically in the regulation...