Research Topics
Genomes and Genes | Aaron M ZornSummaryAffiliation: Cincinnati Children's Hospital Medical Center Country: USA Publications
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Detail Information
Publications
Vertebrate endoderm development and organ formationAaron M Zorn
Division of Developmental Biology, Cincinnati Children s Research Foundation and Department of Pediatrics, College of Medicine, University of Cincinnati, Cincinnati, Ohio 45229, USA
Annu Rev Cell Dev Biol 25:221-51. 2009....- Prolonged FGF signaling is necessary for lung and liver induction in XenopusEmily T Shifley
Perinatal Institute, Divisions of Developmental Biology, University of Cincinnati, Cincinnati, OH 45229, USA
BMC Dev Biol 12:27. 2012..The mechanisms that regulate FGF dose in vivo are unknown. Here we use Xenopus embryos to examine the hypothesis that a prolonged duration of FGF signaling from the mesoderm is required to induce foregut organs... 
Sizzled-tolloid interactions maintain foregut progenitors by regulating fibronectin-dependent BMP signalingAlan P Kenny
Perinatal Institute, Cincinnati Children s Research Foundation, Cincinnati, OH 45229, USA
Dev Cell 23:292-304. 2012..These results have implications for BMP signaling in diverse contexts and the differentiation of foregut tissue from stem cells...- Directed differentiation of human pluripotent stem cells into intestinal tissue in vitroJason R Spence
Division of Developmental Biology, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, Ohio 45229 3039, USA
Nature 470:105-9. 2011..PSC-derived human intestinal tissue should allow for unprecedented studies of human intestinal development and disease... - Sfrp5 coordinates foregut specification and morphogenesis by antagonizing both canonical and noncanonical Wnt11 signalingYan Li
Cincinnati Children s Research Foundation and Department of Pediatrics, College of Medicine, University of Cincinnati, Cincinnati, Ohio 45229, USA
Genes Dev 22:3050-63. 2008..This novel mechanism coordinating canonical and noncanonical Wnt signaling may have broad implications for organogenesis and cancer... - CRIM1 complexes with ß-catenin and cadherins, stabilizes cell-cell junctions and is critical for neural morphogenesisVirgilio G Ponferrada
The Visual Systems Group, Cincinnati Children s Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio, United States of America
PLoS ONE 7:e32635. 2012..We conclude that CRIM1 is critical for cell-cell adhesion during neural development because it is required for the function of cadherin-dependent junctions... - New doxycycline-inducible transgenic lines in XenopusScott A Rankin
Division of Developmental Biology, Cincinnati Children s Research Foundation and Department of Pediatrics, College of Medicine, University of Cincinnati, Cincinnati, Ohio 45208, USA
Dev Dyn 240:1467-74. 2011..These transgenic lines will be made available through the new Xenopus Stock Center and will serve as valuable tools for genetic analysis of development and metamorphosis... - A gene regulatory network controlling hhex transcription in the anterior endoderm of the organizerScott A Rankin
Division of Developmental Biology, Cincinnati Children s Research Foundation and Department of Pediatrics, College of Medicine, University of Cincinnati, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
Dev Biol 351:297-310. 2011..This study reveals a complex network regulating anterior endoderm transcription in the early embryo... - Sox17 and Sox4 differentially regulate beta-catenin/T-cell factor activity and proliferation of colon carcinoma cellsDebora Sinner
Division of Developmental Biology, Cincinnati Children s Hospital Research Foundation, 3333 Burnet Avenue, Cincinnati, Ohio 45229 3039, USA
Mol Cell Biol 27:7802-15. 2007..These findings indicate that Sox proteins can act as both antagonists and agonists of beta-catenin/TCF activity, and this mechanism may regulate Wnt signaling responses in many developmental and disease contexts... - Suppression of Bmp4 signaling by the zinc-finger repressors Osr1 and Osr2 is required for Wnt/β-catenin-mediated lung specification in XenopusScott A Rankin
Division of Developmental Biology, Cincinnati Children s Hospital Research Foundation, and Department of Pediatrics, College of Medicine, University of Cincinnati, Cincinnati, OH 45229, USA
Development 139:3010-20. 2012..These results significantly advance our understanding of early lung development and may impact strategies to differentiate respiratory tissue from stem cells... - Improved cre reporter transgenic XenopusScott A Rankin
Division of Developmental Biology, Cincinnati Children s Research Foundation and Department of Pediatrics, College of Medicine, University of Cincinnati, Cincinnati, Ohio, USA
Dev Dyn 238:2401-8. 2009..Similarly, transgenically expressed Cre under control of tissue-specific promoters will allow detailed analysis of cell lineage relationships throughout embryogenesis, metamorphosis, and adulthood... - Members of the DAN family are BMP antagonists that form highly stable noncovalent dimersChandramohan Kattamuri
Department of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati Medical Sciences Building, Cincinnati, OH 45267, USA
J Mol Biol 424:313-27. 2012..These results demonstrate that certain DAN family members can form both monomers and noncovalent dimers, implying that biological activity of DAN family members might be linked to their oligomeric state... - Interactions between SOX factors and Wnt/beta-catenin signaling in development and diseaseJay D Kormish
Division of Developmental Biology, Cincinnati Children s Research Foundation and University of Cincinnati Department of Pediatrics, College of Medicine, Cincinnati, Ohio 45229, USA
Dev Dyn 239:56-68. 2010..In this review, we summarize the examples of Sox-Wnt interactions and examine the underlying mechanisms of this potentially widespread and underappreciated mode of Wnt-regulation... 
Repression of Wnt/beta-catenin signaling in the anterior endoderm is essential for liver and pancreas developmentValerie A McLin
Cincinnati Children s Research Foundation, Department of Pediatrics, College of Medicine, University of Cincinnati, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
Development 134:2207-17. 2007..These results illustrate that turning Wnt signaling off and on in the correct temporal sequence is essential for organ formation, a finding that might directly impact efforts to differentiate liver and pancreas tissue from stem cells...- Molecular basis of vertebrate endoderm developmentAaron M Zorn
Division of Developmental Biology, Cincinnati Children s Hospital Research, Foundation and University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA
Int Rev Cytol 259:49-111. 2007.... - Global analysis of the transcriptional network controlling Xenopus endoderm formationDebora Sinner
Division of Developmental Biology, Cincinnati Children s Hospital Research Foundation and Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45299, USA
Development 133:1955-66. 2006..These data provides new insight into the complexity of endoderm formation and will serve as valuable resource for establishing a complete endoderm gene regulatory network... - Sox17 and beta-catenin cooperate to regulate the transcription of endodermal genesDebora Sinner
Cincinnati Children s Hospital Medical Center, Division of Developmental Biology and The Department of Pediatrics, University of Cincinnati College of Medicine, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
Development 131:3069-80. 2004..These data suggest that in a mechanism analogous to Tcf/Lef interacting with beta-catenin, Sox17 and beta-catenin interact to transcribe endodermal target genes... - Molecular components of the endoderm specification pathway in Xenopus tropicalisAnjali D'Souza
Cincinnati Children s Hospital Medical Center, Division of Developmental Biology, Cincinnati, Ohio 45229 3039, USA
Dev Dyn 226:118-27. 2003....