Aaron M Zorn

Summary

Affiliation: Cincinnati Children's Hospital Medical Center
Country: USA

Publications

  1. pmc Vertebrate endoderm development and organ formation
    Aaron M Zorn
    Division of Developmental Biology, Cincinnati Children s Research Foundation and Department of Pediatrics, College of Medicine, University of Cincinnati, Cincinnati, Ohio 45229, USA
    Annu Rev Cell Dev Biol 25:221-51. 2009
  2. ncbi request reprint Global analysis of the transcriptional network controlling Xenopus endoderm formation
    Debora Sinner
    Division of Developmental Biology, Cincinnati Children s Hospital Research Foundation and Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45299, USA
    Development 133:1955-66. 2006
  3. doi request reprint Different thresholds of Wnt-Frizzled 7 signaling coordinate proliferation, morphogenesis and fate of endoderm progenitor cells
    Zheng Zhang
    Perinatal Institute, Division of Developmental Biology, Cincinnati Children s Hospital Medical Center and the College of Medicine, University of Cincinnati, Cincinnati OH 45229, USA
    Dev Biol 378:1-12. 2013
  4. pmc Prolonged FGF signaling is necessary for lung and liver induction in Xenopus
    Emily T Shifley
    Perinatal Institute, Divisions of Developmental Biology, University of Cincinnati, Cincinnati, OH 45229, USA
    BMC Dev Biol 12:27. 2012
  5. ncbi request reprint Sox17 influences the differentiation of respiratory epithelial cells
    Kwon Sik Park
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, OH 45229 3039, USA
    Dev Biol 294:192-202. 2006
  6. ncbi request reprint Sox17 and beta-catenin cooperate to regulate the transcription of endodermal genes
    Debora Sinner
    Cincinnati Children s Hospital Medical Center, Division of Developmental Biology and The Department of Pediatrics, University of Cincinnati College of Medicine, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
    Development 131:3069-80. 2004
  7. pmc Transdifferentiation of ciliated cells during repair of the respiratory epithelium
    Kwon Sik Park
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
    Am J Respir Cell Mol Biol 34:151-7. 2006
  8. pmc Sizzled-tolloid interactions maintain foregut progenitors by regulating fibronectin-dependent BMP signaling
    Alan P Kenny
    Perinatal Institute, Cincinnati Children s Research Foundation, Cincinnati, OH 45229, USA
    Dev Cell 23:292-304. 2012
  9. pmc Directed differentiation of human pluripotent stem cells into intestinal tissue in vitro
    Jason R Spence
    Division of Developmental Biology, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, Ohio 45229 3039, USA
    Nature 470:105-9. 2011
  10. ncbi request reprint FoxI1e activates ectoderm formation and controls cell position in the Xenopus blastula
    Adnan Mir
    Division of Developmental Biology, Cincinnati Children s Hospital Research Foundation, 3333 Burnett Avenue, Cincinnati, OH 45229, USA
    Development 134:779-88. 2007

Collaborators

Detail Information

Publications26

  1. pmc Vertebrate endoderm development and organ formation
    Aaron M Zorn
    Division of Developmental Biology, Cincinnati Children s Research Foundation and Department of Pediatrics, College of Medicine, University of Cincinnati, Cincinnati, Ohio 45229, USA
    Annu Rev Cell Dev Biol 25:221-51. 2009
    ....
  2. ncbi request reprint Global analysis of the transcriptional network controlling Xenopus endoderm formation
    Debora Sinner
    Division of Developmental Biology, Cincinnati Children s Hospital Research Foundation and Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45299, USA
    Development 133:1955-66. 2006
    ..These data provides new insight into the complexity of endoderm formation and will serve as valuable resource for establishing a complete endoderm gene regulatory network...
  3. doi request reprint Different thresholds of Wnt-Frizzled 7 signaling coordinate proliferation, morphogenesis and fate of endoderm progenitor cells
    Zheng Zhang
    Perinatal Institute, Division of Developmental Biology, Cincinnati Children s Hospital Medical Center and the College of Medicine, University of Cincinnati, Cincinnati OH 45229, USA
    Dev Biol 378:1-12. 2013
    ..We show that in the foregut Fzd7 signals via both the Wnt/β-catenin and Wnt/JNK pathways and that different thresholds of Wnt-Fzd7 activity coordinate progenitor cell fate, proliferation and morphogenesis...
  4. pmc Prolonged FGF signaling is necessary for lung and liver induction in Xenopus
    Emily T Shifley
    Perinatal Institute, Divisions of Developmental Biology, University of Cincinnati, Cincinnati, OH 45229, USA
    BMC Dev Biol 12:27. 2012
    ..The mechanisms that regulate FGF dose in vivo are unknown. Here we use Xenopus embryos to examine the hypothesis that a prolonged duration of FGF signaling from the mesoderm is required to induce foregut organs...
  5. ncbi request reprint Sox17 influences the differentiation of respiratory epithelial cells
    Kwon Sik Park
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, OH 45229 3039, USA
    Dev Biol 294:192-202. 2006
    ..Sites of expression and the effects of Sox17 in vivo and in vitro are consistent with a role for Sox17 or other members of the Sox family of transcription factors in differentiation of the conducting airway epithelium...
  6. ncbi request reprint Sox17 and beta-catenin cooperate to regulate the transcription of endodermal genes
    Debora Sinner
    Cincinnati Children s Hospital Medical Center, Division of Developmental Biology and The Department of Pediatrics, University of Cincinnati College of Medicine, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
    Development 131:3069-80. 2004
    ..These data suggest that in a mechanism analogous to Tcf/Lef interacting with beta-catenin, Sox17 and beta-catenin interact to transcribe endodermal target genes...
  7. pmc Transdifferentiation of ciliated cells during repair of the respiratory epithelium
    Kwon Sik Park
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
    Am J Respir Cell Mol Biol 34:151-7. 2006
    ..Taken together, these findings demonstrate that ciliated epithelial cells spread and transdifferentiate into distinct epithelial cell types to repair the airway epithelium...
  8. pmc Sizzled-tolloid interactions maintain foregut progenitors by regulating fibronectin-dependent BMP signaling
    Alan P Kenny
    Perinatal Institute, Cincinnati Children s Research Foundation, Cincinnati, OH 45229, USA
    Dev Cell 23:292-304. 2012
    ..These results have implications for BMP signaling in diverse contexts and the differentiation of foregut tissue from stem cells...
  9. pmc Directed differentiation of human pluripotent stem cells into intestinal tissue in vitro
    Jason R Spence
    Division of Developmental Biology, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, Ohio 45229 3039, USA
    Nature 470:105-9. 2011
    ..PSC-derived human intestinal tissue should allow for unprecedented studies of human intestinal development and disease...
  10. ncbi request reprint FoxI1e activates ectoderm formation and controls cell position in the Xenopus blastula
    Adnan Mir
    Division of Developmental Biology, Cincinnati Children s Hospital Research Foundation, 3333 Burnett Avenue, Cincinnati, OH 45229, USA
    Development 134:779-88. 2007
    ..The work also shows that FoxI1e plays a role in the embryo in the poorly understood process of differential adhesion, which limits cell mixing as primary germ layers become specified...
  11. pmc A gene regulatory network controlling hhex transcription in the anterior endoderm of the organizer
    Scott A Rankin
    Division of Developmental Biology, Cincinnati Children s Research Foundation and Department of Pediatrics, College of Medicine, University of Cincinnati, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
    Dev Biol 351:297-310. 2011
    ..This study reveals a complex network regulating anterior endoderm transcription in the early embryo...
  12. pmc Sfrp5 coordinates foregut specification and morphogenesis by antagonizing both canonical and noncanonical Wnt11 signaling
    Yan Li
    Cincinnati Children s Research Foundation and Department of Pediatrics, College of Medicine, University of Cincinnati, Cincinnati, Ohio 45229, USA
    Genes Dev 22:3050-63. 2008
    ..This novel mechanism coordinating canonical and noncanonical Wnt signaling may have broad implications for organogenesis and cancer...
  13. pmc Sox17 and Sox4 differentially regulate beta-catenin/T-cell factor activity and proliferation of colon carcinoma cells
    Debora Sinner
    Division of Developmental Biology, Cincinnati Children s Hospital Research Foundation, 3333 Burnet Avenue, Cincinnati, Ohio 45229 3039, USA
    Mol Cell Biol 27:7802-15. 2007
    ..These findings indicate that Sox proteins can act as both antagonists and agonists of beta-catenin/TCF activity, and this mechanism may regulate Wnt signaling responses in many developmental and disease contexts...
  14. pmc CRIM1 complexes with ß-catenin and cadherins, stabilizes cell-cell junctions and is critical for neural morphogenesis
    Virgilio G Ponferrada
    The Visual Systems Group, Cincinnati Children s Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio, United States of America
    PLoS ONE 7:e32635. 2012
    ..We conclude that CRIM1 is critical for cell-cell adhesion during neural development because it is required for the function of cadherin-dependent junctions...
  15. ncbi request reprint Organogenesis: making pancreas from liver
    Valerie A McLin
    Division of Gastroenterology, Hepatology and Nutrition, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
    Curr Biol 13:R96-8. 2003
    ..The experimentally induced conversion of hepatocytes into pancreatic cells, using a modified version of the transcription factor Pdx-1, may provide an alternative to stem cell approaches...
  16. pmc Structure of protein related to Dan and Cerberus: insights into the mechanism of bone morphogenetic protein antagonism
    Kristof Nolan
    Department of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati, Medical Sciences Building, Cincinnati, OH 45267, USA
    Structure 21:1417-29. 2013
    ..We also determined that PRDC binds heparin with high affinity and that heparin binding to PRDC interferes with BMP antagonism. These results offer insight for how DAN family antagonists functionally inhibit BMP ligands. ..
  17. pmc New doxycycline-inducible transgenic lines in Xenopus
    Scott A Rankin
    Division of Developmental Biology, Cincinnati Children s Research Foundation and Department of Pediatrics, College of Medicine, University of Cincinnati, Cincinnati, Ohio 45208, USA
    Dev Dyn 240:1467-74. 2011
    ..These transgenic lines will be made available through the new Xenopus Stock Center and will serve as valuable tools for genetic analysis of development and metamorphosis...
  18. pmc Suppression of Bmp4 signaling by the zinc-finger repressors Osr1 and Osr2 is required for Wnt/β-catenin-mediated lung specification in Xenopus
    Scott A Rankin
    Division of Developmental Biology, Cincinnati Children s Hospital Research Foundation, and Department of Pediatrics, College of Medicine, University of Cincinnati, Cincinnati, OH 45229, USA
    Development 139:3010-20. 2012
    ..These results significantly advance our understanding of early lung development and may impact strategies to differentiate respiratory tissue from stem cells...
  19. pmc A new method to remove hybridization bias for interspecies comparison of global gene expression profiles uncovers an association between mRNA sequence divergence and differential gene expression in Xenopus
    Maureen A Sartor
    University of Cincinnati, Department of Environmental Health Cincinnati, OH 45267 0056, USA
    Nucleic Acids Res 34:185-200. 2006
    ..laevis and X.tropicalis differences in mRNA expression levels also increase...
  20. pmc Improved cre reporter transgenic Xenopus
    Scott A Rankin
    Division of Developmental Biology, Cincinnati Children s Research Foundation and Department of Pediatrics, College of Medicine, University of Cincinnati, Cincinnati, Ohio, USA
    Dev Dyn 238:2401-8. 2009
    ..Similarly, transgenically expressed Cre under control of tissue-specific promoters will allow detailed analysis of cell lineage relationships throughout embryogenesis, metamorphosis, and adulthood...
  21. pmc Xenbase: expansion and updates of the Xenopus model organism database
    Christina James-Zorn
    Division of Developmental Biology, Cincinnati Children s Research Foundation, 3333 Burnet Avenue, S3 620, Cincinnati, OH 45229 3039, USA
    Nucleic Acids Res 41:D865-70. 2013
    ....
  22. pmc Members of the DAN family are BMP antagonists that form highly stable noncovalent dimers
    Chandramohan Kattamuri
    Department of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati Medical Sciences Building, Cincinnati, OH 45267, USA
    J Mol Biol 424:313-27. 2012
    ..These results demonstrate that certain DAN family members can form both monomers and noncovalent dimers, implying that biological activity of DAN family members might be linked to their oligomeric state...
  23. ncbi request reprint Molecular components of the endoderm specification pathway in Xenopus tropicalis
    Anjali D'Souza
    Cincinnati Children s Hospital Medical Center, Division of Developmental Biology, Cincinnati, Ohio 45229 3039, USA
    Dev Dyn 226:118-27. 2003
    ....
  24. pmc Interactions between SOX factors and Wnt/beta-catenin signaling in development and disease
    Jay D Kormish
    Division of Developmental Biology, Cincinnati Children s Research Foundation and University of Cincinnati Department of Pediatrics, College of Medicine, Cincinnati, Ohio 45229, USA
    Dev Dyn 239:56-68. 2010
    ..In this review, we summarize the examples of Sox-Wnt interactions and examine the underlying mechanisms of this potentially widespread and underappreciated mode of Wnt-regulation...
  25. ncbi request reprint Repression of Wnt/beta-catenin signaling in the anterior endoderm is essential for liver and pancreas development
    Valerie A McLin
    Cincinnati Children s Research Foundation, Department of Pediatrics, College of Medicine, University of Cincinnati, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
    Development 134:2207-17. 2007
    ..These results illustrate that turning Wnt signaling off and on in the correct temporal sequence is essential for organ formation, a finding that might directly impact efforts to differentiate liver and pancreas tissue from stem cells...
  26. ncbi request reprint Molecular basis of vertebrate endoderm development
    Aaron M Zorn
    Division of Developmental Biology, Cincinnati Children s Hospital Research, Foundation and University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA
    Int Rev Cytol 259:49-111. 2007
    ....