Basilia Zingarelli

Summary

Affiliation: Cincinnati Children's Hospital Medical Center
Country: USA

Publications

  1. ncbi Differential regulation of activator protein-1 and heat shock factor-1 in myocardial ischemia and reperfusion injury: role of poly(ADP-ribose) polymerase-1
    Basilia Zingarelli
    Division of Critical Care Medicine, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    Am J Physiol Heart Circ Physiol 286:H1408-15. 2004
  2. pmc Lung injury after hemorrhage is age dependent: role of peroxisome proliferator-activated receptor gamma
    Basilia Zingarelli
    Department of Pediatrics, Division of Critical Care Medicine, Cincinnati Children s Hospital Medical Center, Cincinnati, OH, USA
    Crit Care Med 37:1978-87. 2009
  3. ncbi Peroxisome proliferator activator receptor-gamma ligands, 15-deoxy-Delta(12,14)-prostaglandin J2 and ciglitazone, reduce systemic inflammation in polymicrobial sepsis by modulation of signal transduction pathways
    Basilia Zingarelli
    Division of Critical Care, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    J Immunol 171:6827-37. 2003
  4. pmc Absence of poly(ADP-ribose)polymerase-1 alters nuclear factor-kappa B activation and gene expression of apoptosis regulators after reperfusion injury
    Basilia Zingarelli
    Division of Critical Care Medicine, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Mol Med 9:143-53. 2003
  5. pmc Liver apoptosis is age dependent and is reduced by activation of peroxisome proliferator-activated receptor-gamma in hemorrhagic shock
    Basilia Zingarelli
    Division of Critical Care Medicine, Cincinnati Children s Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH 45229, USA
    Am J Physiol Gastrointest Liver Physiol 298:G133-41. 2010
  6. ncbi Inhibitors of poly (ADP-ribose) polymerase modulate signal transduction pathways in colitis
    Basilia Zingarelli
    Division of Critical Care Medicine, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
    Eur J Pharmacol 469:183-94. 2003
  7. pmc Activator protein-1 signalling pathway and apoptosis are modulated by poly(ADP-ribose) polymerase-1 in experimental colitis
    Basilia Zingarelli
    Division of Critical Care Medicine, Cincinnati Children s Hospital Medical Center and College of Medicine, University of Cincinnati, Cincinnati, OH 45229, USA
    Immunology 113:509-17. 2004
  8. pmc Peroxisome proliferator-activated receptor {delta} regulates inflammation via NF-{kappa}B signaling in polymicrobial sepsis
    Basilia Zingarelli
    Division of Critical Care Medicine, Cincinnati Children s Hospital Medical Center and College of Medicine, University of Cincinnati, Cincinnati, Ohio 45229, USA
    Am J Pathol 177:1834-47. 2010
  9. ncbi Peroxisome proliferator-activated receptor-gamma is a new therapeutic target in sepsis and inflammation
    Basilia Zingarelli
    Division of Critical Care Medicine, Cincinnati Children s Hospital Medical Center and the College of Medicine, University of Cincinnati, Cincinnati, Ohio 45229, USA
    Shock 23:393-9. 2005
  10. pmc Peroxisome proliferator activated receptor gamma is not necessary for the development of LPS-induced tolerance in macrophages
    Basilia Zingarelli
    Division of Critical Care Medicine, Cincinnati Children s Hospital Medical Center and the University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
    Immunology 124:51-7. 2008

Research Grants

Collaborators

Detail Information

Publications63

  1. ncbi Differential regulation of activator protein-1 and heat shock factor-1 in myocardial ischemia and reperfusion injury: role of poly(ADP-ribose) polymerase-1
    Basilia Zingarelli
    Division of Critical Care Medicine, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    Am J Physiol Heart Circ Physiol 286:H1408-15. 2004
    ..The data indicate that PARP-1 may exert a pathological role in reperfusion injury by functioning as an enhancing factor of AP-1 activation and as a repressing factor of HSF-1 activation and HSP70 expression...
  2. pmc Lung injury after hemorrhage is age dependent: role of peroxisome proliferator-activated receptor gamma
    Basilia Zingarelli
    Department of Pediatrics, Division of Critical Care Medicine, Cincinnati Children s Hospital Medical Center, Cincinnati, OH, USA
    Crit Care Med 37:1978-87. 2009
    ..We investigated whether the pathophysiologic characteristics of hemorrhage-induced lung injury may be age dependent and may be regulated by the peroxisome proliferator-activated receptor gamma (PPARgamma)...
  3. ncbi Peroxisome proliferator activator receptor-gamma ligands, 15-deoxy-Delta(12,14)-prostaglandin J2 and ciglitazone, reduce systemic inflammation in polymicrobial sepsis by modulation of signal transduction pathways
    Basilia Zingarelli
    Division of Critical Care, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    J Immunol 171:6827-37. 2003
    ..Our data suggest that PPARgamma ligands attenuate the inflammatory response in sepsis through regulation of the NF-kappaB and AP-1 pathways...
  4. pmc Absence of poly(ADP-ribose)polymerase-1 alters nuclear factor-kappa B activation and gene expression of apoptosis regulators after reperfusion injury
    Basilia Zingarelli
    Division of Critical Care Medicine, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Mol Med 9:143-53. 2003
    ..The data indicate that during reperfusion absence of PARP-1 leads to reduction of myocardial apoptosis, which is associated with reduced NF-kappa B activation and altered gene expression profiles...
  5. pmc Liver apoptosis is age dependent and is reduced by activation of peroxisome proliferator-activated receptor-gamma in hemorrhagic shock
    Basilia Zingarelli
    Division of Critical Care Medicine, Cincinnati Children s Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH 45229, USA
    Am J Physiol Gastrointest Liver Physiol 298:G133-41. 2010
    ..Our data suggest that liver injury after severe hemorrhage is age dependent and PPARgamma activation is a novel hepatoprotective mechanism...
  6. ncbi Inhibitors of poly (ADP-ribose) polymerase modulate signal transduction pathways in colitis
    Basilia Zingarelli
    Division of Critical Care Medicine, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
    Eur J Pharmacol 469:183-94. 2003
    ..These data demonstrate that pharmacological inhibition of PARP ameliorates colitis. Reduction of the inflammatory process is associated with modification of the activation of signal transduction pathways...
  7. pmc Activator protein-1 signalling pathway and apoptosis are modulated by poly(ADP-ribose) polymerase-1 in experimental colitis
    Basilia Zingarelli
    Division of Critical Care Medicine, Cincinnati Children s Hospital Medical Center and College of Medicine, University of Cincinnati, Cincinnati, OH 45229, USA
    Immunology 113:509-17. 2004
    ..The data indicate that PARP-1 exerts a pathological role in colitis possibly by regulating the early stress-related transcriptional response through a positive modulation of the AP-1 and JNK pathways...
  8. pmc Peroxisome proliferator-activated receptor {delta} regulates inflammation via NF-{kappa}B signaling in polymicrobial sepsis
    Basilia Zingarelli
    Division of Critical Care Medicine, Cincinnati Children s Hospital Medical Center and College of Medicine, University of Cincinnati, Cincinnati, Ohio 45229, USA
    Am J Pathol 177:1834-47. 2010
    ..These data suggest that PPARδ is a crucial anti-inflammatory regulator, providing a basis for novel sepsis therapies...
  9. ncbi Peroxisome proliferator-activated receptor-gamma is a new therapeutic target in sepsis and inflammation
    Basilia Zingarelli
    Division of Critical Care Medicine, Cincinnati Children s Hospital Medical Center and the College of Medicine, University of Cincinnati, Cincinnati, Ohio 45229, USA
    Shock 23:393-9. 2005
    ....
  10. pmc Peroxisome proliferator activated receptor gamma is not necessary for the development of LPS-induced tolerance in macrophages
    Basilia Zingarelli
    Division of Critical Care Medicine, Cincinnati Children s Hospital Medical Center and the University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
    Immunology 124:51-7. 2008
    ..These data demonstrate that PPARgamma does not play a role in the LPS-induced tolerant phenotype in macrophages...
  11. ncbi Diverse cardioprotective signaling mechanisms of peroxisome proliferator-activated receptor-gamma ligands, 15-deoxy-Delta12,14-prostaglandin J2 and ciglitazone, in reperfusion injury: role of nuclear factor-kappaB, heat shock factor 1, and Akt
    Basilia Zingarelli
    Division of Critical Care Medicine, Cincinnati Children s Hospital Medical Center, The University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA
    Shock 28:554-63. 2007
    ..In contrast, GW-9662 did not affect the beneficial effects afforded by 15d-PGJ2. Thus, our data suggest that treatment with these chemically unrelated PPAR-gamma ligands results in diverse anti-inflammatory mechanisms...
  12. pmc Ciglitazone ameliorates lung inflammation by modulating the inhibitor kappaB protein kinase/nuclear factor-kappaB pathway after hemorrhagic shock
    Ranjit S Chima
    Division of Critical Care Medicine, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH, USA
    Crit Care Med 36:2849-57. 2008
    ..We investigated the effects of ciglitazone on lung inflammation after severe hemorrhage...
  13. ncbi Synergistic effect of peroxisome proliferator activated receptor-gamma and liver X receptor-alpha in the regulation of inflammation in macrophages
    Giovanna Piraino
    Cincinnati Children s Hospital Medical Center, Division of Critical Care Medicine, Cincinnati, OH 45229, USA
    Shock 26:146-53. 2006
    ..Thus, our data suggest that PPARgamma and LXRalpha may interact in controlling the inflammatory response in macrophages...
  14. ncbi Therapeutic effect of epigallocatechin-3-gallate in a mouse model of colitis
    Patricia A Abboud
    Cincinnati Children s Hospital Medical Center, Division of Critical Care Medicine, College of Medicine, University of Cincinnati, 3333 Burnet Avenue, Cincinnati, Ohio 45229, USA
    Eur J Pharmacol 579:411-7. 2008
    ..Our data demonstrate that EGCG may be beneficial in colitis through selective immunomodulatory effects, which may be mediated, at least in part, by inhibition of NF-kappaB and AP-1...
  15. ncbi Poly(ADP-ribose) polymerase-1 regulates activation of activator protein-1 in murine fibroblasts
    Teresa L Andreone
    Division of Critical Care Medicine, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
    J Immunol 170:2113-20. 2003
    ..No DNA binding of heat shock factor-1 was observed in PARP-1-deficient cells. These data demonstrate that PARP-1 plays a pivotal role in the modulation of transcription...
  16. ncbi Absence of inducible nitric oxide synthase modulates early reperfusion-induced NF-kappaB and AP-1 activation and enhances myocardial damage
    Basilia Zingarelli
    Children s Hospital Medical Center, Division of Critical Care, Cincinnati, Ohio 45229, USA
    FASEB J 16:327-42. 2002
    ..Thus, we conclude that iNOS plays a beneficial role in modulating the early defensive inflammatory response against reperfusion injury through regulation of signal transduction...
  17. ncbi Peroxisome proliferator-activated receptor-gamma protects against hepatic ischemia/reperfusion injury in mice
    Satoshi Kuboki
    Laboratory of Trauma, Sepsis and Inflammation Research, Department of Surgery, University of Cincinnati, Cincinnati, OH 45267 0558, USA
    Hepatology 47:215-24. 2008
    ..Conclusion: These data suggest that PPARgamma is an important endogenous regulator of, and potential therapeutic target for, ischemic liver injury...
  18. ncbi Parthenolide, an inhibitor of the nuclear factor-kappaB pathway, ameliorates cardiovascular derangement and outcome in endotoxic shock in rodents
    Maeve Sheehan
    Children s Hospital Medical Center, Division of Critical Care Medicine, Cincinnati, Ohio 45229, USA
    Mol Pharmacol 61:953-63. 2002
    ..We conclude that parthenolide exerts beneficial effects during endotoxic shock through inhibition of NF-kappaB...
  19. ncbi 15-Deoxy-delta(12,14)-prostaglandin J(2) (15D-PGJ(2)), a peroxisome proliferator activated receptor gamma ligand, reduces tissue leukosequestration and mortality in endotoxic shock
    Jennifer M Kaplan
    Division of Critical Care Medicine, Cincinnati Children s Hospital Medical Center and the College of Medicine, University of Cincinnati, Cincinnati, Ohio 45229, USA
    Shock 24:59-65. 2005
    ..Our data demonstrate that 15d-PGJ2 ameliorates endotoxic shock most likely through repressing the proinflammatory pathway of NF-kappaB and enhancement of the cytoprotective heat shock response...
  20. ncbi The green tea polyphenol epigallocatechin-3-gallate improves systemic hemodynamics and survival in rodent models of polymicrobial sepsis
    Derek S Wheeler
    Division of Critical Care Medicine, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
    Shock 28:353-9. 2007
    ..Epigallocatechin-3-gallate may therefore represent a potential nutritional supplement or pharmacologic agent in patients with sepsis...
  21. ncbi Age-dependent responses to hepatic ischemia/reperfusion injury
    Tomohisa Okaya
    The Laboratory of Trauma, Sepsis, and Inflammation Research, Department of Surgery, University of Cincinnati, Cincinnati, Ohio 45267 0558, USA
    Shock 24:421-7. 2005
    ..These data suggest that there are multiple alterations at the cellular and molecular levels that contribute to enhanced postischemic liver injury in mature adult mice...
  22. pmc Induction of endotoxin tolerance enhances bacterial clearance and survival in murine polymicrobial sepsis
    Derek S Wheeler
    Division of Critical Care Medicine, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
    Shock 30:267-73. 2008
    ..Contrary to our original hypothesis, we conclude that endotoxin tolerance significantly attenuates the host inflammatory response, augments bacterial clearance, and improves survival in this murine model of polymicrobial sepsis...
  23. ncbi Inducible nitric oxide synthase is not required in the development of endotoxin tolerance in mice
    Basilia Zingarelli
    Division of Critical Care Medicine, Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    Shock 17:478-84. 2002
    ..Our data suggests that iNOS is not required for the development of endotoxin tolerance, and that other signal transduction pathways, rather than NF-kappaB, may regulate induction of endotoxin tolerance in the absence of iNOS...
  24. pmc Epigallocatechin, a green tea polyphenol, attenuates myocardial ischemia reperfusion injury in rats
    Rajesh Aneja
    Department of Pediatrics, Division of Critical Care Medicine OSB5, Cincinnati Children s Hospital Medical Center and College of Medicine, University of Cincinnati, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
    Mol Med 10:55-62. 2004
    ..The results of this study suggest that EGCG is beneficial for the treatment of reperfusion-induced myocardial damage by inhibition of the NF-kappaB and AP-1 pathway...
  25. ncbi Proinsulin c-peptide exerts beneficial effects in endotoxic shock in mice
    Michael G Vish
    Division of Critical Care Medicine, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, OH, USA
    Crit Care Med 35:1348-55. 2007
    ..This study was designed to investigate the biological effects of c-peptide during endotoxemia...
  26. pmc Phosphorylation of extracellular signal-regulated kinase (ERK)-1/2 Is associated with the downregulation of peroxisome proliferator-activated receptor (PPAR)-γ during polymicrobial sepsis
    Jennifer M Kaplan
    Division of Critical Care Medicine, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America
    Mol Med 16:491-7. 2010
    ..The inflammatory effects of sepsis cause changes in PPARγ expression and activation, in part, because of phosphorylation of PPARγ by ERK1/2. This phosphorylation can be reversed by ERK1/2 inhibition, thereby improving lung injury...
  27. ncbi Parthenolide improves systemic hemodynamics and decreases tissue leukosequestration in rats with polymicrobial sepsis
    Maeve Sheehan
    Cincinnati Children s Hospital, OH, USA
    Crit Care Med 31:2263-70. 2003
    ..This study was designed to investigate the biological effects of parthenolide, a specific inhibitor of NF-kappaB activation, in experimental sepsis and multiple organ failure...
  28. ncbi Inhibitors of poly (ADP-ribose) polymerase ameliorate myocardial reperfusion injury by modulation of activator protein-1 and neutrophil infiltration
    Jennifer Kaplan
    Division of Critical Care Medicine, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Shock 23:233-8. 2005
    ..Our data demonstrate that inhibition of catalytic activity of PARP-1 may provide cardioprotection by regulating stress-induced signal transduction pathways...
  29. pmc A novel role for matrix metalloproteinase-8 in sepsis
    Patrick D Solan
    Department of Surgery, University of Cincinnati College of Medicine, Cincinnati Children s Hospital Medical Center and Cincinnati Children s Research Foundation, Cincinnati, OH, USA
    Crit Care Med 40:379-87. 2012
    ..Here, we investigate the relationship between matrix metalloproteinase-8 and disease severity in children with septic shock. We further corroborate the role of matrix metalloproteinase-8 in sepsis in a murine model...
  30. pmc C-peptide, a novel inhibitor of lung inflammation following hemorrhagic shock
    Ranjit S Chima
    Division of Critical Care Medicine MLC 2005 Cincinnati Children s Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH 45229, USA
    Am J Physiol Lung Cell Mol Physiol 300:L730-9. 2011
    ..Our data suggest that C-peptide ameliorates the inflammatory response and lung inflammation following hemorrhagic shock. These effects may be modulated by altering the balance between pro- and anti-inflammatory signaling in the lung...
  31. ncbi Peroxisome proliferator-activated receptor gamma is required for the inhibitory effect of ciglitazone but not 15-deoxy-Delta 12,14-prostaglandin J2 on the NFkappaB pathway in human endothelial cells
    Jennifer Kaplan
    Cincinnati Children s Hospital Medical Center, 3229 Burnet Avenue, Cincinnati, OH 45229, USA
    Shock 28:722-726. 2007
    ..On the contrary, the inhibitory effect of ciglitazone on the NFkappaB pathway seems to require PPARgamma activation...
  32. ncbi Sesquiterpene lactone parthenolide, an inhibitor of IkappaB kinase complex and nuclear factor-kappaB, exerts beneficial effects in myocardial reperfusion injury
    Basilia Zingarelli
    Children s Hospital Medical Center, Division of Critical Care Medicine, Cincinnati, Ohio 45229, USA
    Shock 17:127-34. 2002
    ..The results of this study suggest that parthenolide may be beneficial for the treatment of reperfusion-induced myocardial damage by inhibition of the IKK/NF-kappaB pathway...
  33. pmc Short-term high fat feeding increases organ injury and mortality after polymicrobial sepsis
    Jennifer M Kaplan
    Division of Critical Care Medicine, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    Obesity (Silver Spring) 20:1995-2002. 2012
    ..CD-fed mice. Short duration high fat feeding increases mortality and organ injury following polymicrobial sepsis. These effects correspond to changes in NF-κB...
  34. ncbi Inhibition of nitric oxide restores surfactant gene expression following nickel-induced acute lung injury
    Susan A McDowell
    University of Cincinnati, and Children s Hospital Medical Center, Cincinnati, OH 45267 0056, USA
    Am J Respir Cell Mol Biol 28:188-98. 2003
    ..Rather, systemic L-NAME treatment appears to attenuate pulmonary endothelial NOS activity, subsequent cytokine expression, inflammation, and protein permeability, and thereby restores surfactant gene expression and increases survival...
  35. pmc Overexpression of Hsp20 prevents endotoxin-induced myocardial dysfunction and apoptosis via inhibition of NF-kappaB activation
    Xiaohong Wang
    Department of Pharmacology and Cell Biophysics, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0575, USA
    J Mol Cell Cardiol 47:382-90. 2009
    ..Thus, the increases in Hsp20 levels can protect against LPS-induced cardiac apoptosis and dysfunction, associated with inhibition of NF-kappaB activity, suggesting that Hsp20 may be a new therapeutic agent for the treatment of sepsis...
  36. ncbi Dexamethasone decreases neurological sequelae and caspase activity
    Jose Irazuzta
    Division of Critical Care Medicine, The Floating Hospital for Children, 750 Washington Street, NEMC 093, Boston, MA 02111, USA
    Intensive Care Med 31:146-50. 2005
    ..Changes in neurobehavioral performance were the primary outcome variables. Changes in caspase activation and markers of neuronal injury were the secondary outcome variables...
  37. doi Combined zinc supplementation with proinsulin C-Peptide treatment decreases the inflammatory response and mortality in murine polymicrobial sepsis
    Siarhei Slinko
    Division of Critical Care Medicine, Department of Pediatrics, Cincinnati Children s Hospital Medical Center and Department of Surgery, College of Medicine, University of Cincinnati, Cincinnati, Ohio
    Shock 41:292-300. 2014
    ..Our data demonstrate that short-term zinc prophylaxis before the infectious insult is a requisite for the anti-inflammatory properties of C-peptide by facilitating modulation of inflammatory pathways. ..
  38. pmc Reduced peroxisome proliferator-activated receptor α expression is associated with decreased survival and increased tissue bacterial load in sepsis
    Stephen W Standage
    Division of Critical Care Medicine, Cincinnati Children s Hospital Medical Center, Department of Surgery, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    Shock 37:164-9. 2012
    ..These data indicate that reduced or absent PPAR-α expression confers a survival disadvantage in sepsis and that PPAR-α plays a role in maintaining appropriate immune functions during the sepsis response...
  39. pmc Changes in peroxisome proliferator-activated receptor-gamma activity in children with septic shock
    Jennifer M Kaplan
    Cincinnati Children s Hospital Medical Center, The University of Cincinnati College of Medicine, 3333 Burnet Avenue, MLC 2005, Cincinnati, OH 45229 3039, USA
    Intensive Care Med 36:123-30. 2010
    ..Additionally, to investigate the effects of sepsis on the endogenous activator of PPARgamma, 15-deoxy-(12,14)-PGJ(2) (15d-PGJ(2)), and the downstream targets of PPARgamma activity, adiponectin and resistin...
  40. pmc C-peptide ameliorates kidney injury following hemorrhagic shock
    Ranjit S Chima
    Division of Critical Care Medicine, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio, USA
    Shock 35:524-9. 2011
    ..Thus, our data suggest that C-peptide may exert renoprotective effects after hemorrhagic shock by modulating activator protein 1 signaling...
  41. pmc Novel pharmacologic approaches to the management of sepsis: targeting the host inflammatory response
    Derek S Wheeler
    Division of Critical Care Medicine, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229 3039, USA
    Recent Pat Inflamm Allergy Drug Discov 3:96-112. 2009
    ..We will also reference some of the patents recently filed that pertain to the host innate immune response and sepsis...
  42. pmc Admission angiopoietin levels in children with septic shock
    John S Giuliano
    Division of Critical Care Medicine, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
    Shock 28:650-654. 2007
    ..Given the contrasting effects of angpt-2 and angpt-1 on the vascular endothelium, these two factors may play an important role in the pathophysiology of septic shock in children, and further studies are warranted...
  43. pmc The immunomodulatory effects of albumin in vitro and in vivo
    Derek S Wheeler
    Division of Critical Care Medicine, The Kindervelt Laboratory for Critical Care Medicine Research, Cincinnati Children s Research Foundation, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229 3039, USA
    Adv Pharmacol Sci 2011:691928. 2011
    ..Albumin preconditioning abrogated the LPS-mediated increase in NF-κB activation and TNF-α gene expression in vitro and in vivo. The clinical significance of these findings remains to be elucidated...
  44. ncbi Nitric oxide mediates increased P-glycoprotein activity in interferon-{gamma}-stimulated human intestinal cells
    Santosh G Dixit
    College of Pharmacy, University of Cincinnati, 3223 Eden Ave, Cincinnati, OH 45267 0004, USA
    Am J Physiol Gastrointest Liver Physiol 288:G533-40. 2005
    ....
  45. pmc Liver X receptor α activation with the synthetic ligand T0901317 reduces lung injury and inflammation after hemorrhage and resuscitation via inhibition of the nuclear factor κB pathway
    Patrick D Solan
    Department of Surgery, University of Cincinnati, Cincinnati, OH, USA
    Shock 35:367-74. 2011
    ..Thus, our data suggest that LXRα is an important modulator of the inflammatory response and lung injury after severe hemorrhagic shock, likely through the inhibition of the nuclear factor κB pathway...
  46. ncbi Nuclear factor-kappaB as a therapeutic target in critical care medicine
    Basilia Zingarelli
    Children s Hospital Medical Center, Division of Critical Care Medicine, 3333 Burnet Avenue, Cincinnati, Ohio 45229, USA
    Crit Care Med 31:S105-11. 2003
    ..The purpose of our review is to describe these novel therapeutic approaches and their potential efficacy...
  47. pmc Ciglitazone, a novel inhibitor of lung apoptosis following hemorrhagic shock
    Ranjit S Chima
    Division of Critical Care Medicine, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine Cincinnati, OH, USA
    Int J Clin Exp Med 3:1-9. 2010
    ..This was associated with increased phosphorylation of the pro-survival kinase Akt. Thus, our data suggest that ciglitazone, a PPARy ligand, promotes cell survival in the lung following hemorrhagic shock...
  48. doi Conditional deletion of cardiomyocyte peroxisome proliferator-activated receptor γ enhances myocardial ischemia-reperfusion injury in mice
    Michael J Hobson
    Division of Critical Care Medicine and Cardiovascular Imaging Core of the Heart Institute, Cincinnati Children s Hospital Medical Center, and the University of Cincinnati College of Medicine, Cincinnati, Ohio
    Shock 41:40-7. 2014
    ..Thus, our data suggest that cardiomyocyte PPARγ is a crucial protective receptor and may prevent reperfusion injury by modulating mechanisms of inflammation. ..
  49. ncbi Nuclear factor-kappaB
    Basilia Zingarelli
    Division of Critical Care Medicine, Cincinnati Children s Hospital Medical Center and the University of Cincinnati College of Medicine, Cincinnati, OH, USA
    Crit Care Med 33:S414-6. 2005
  50. ncbi Calpain inhibition decreases endothelin-1 levels and pulmonary hypertension after cardiopulmonary bypass with deep hypothermic circulatory arrest
    Jodie Y Duffy
    Pediatric Cardiothoracic Surgery, Cincinnati Children s Hospital Medical Center, and the University of Cincinnati College of Medicine, Cincinnati, OH, USA
    Crit Care Med 33:623-8. 2005
    ..The hypothesis is that calpain inhibition can alleviate the cardiopulmonary dysfunction seen in immature animals following ischemia and reperfusion with cardiopulmonary bypass...
  51. ncbi Modulation of nuclear factor-kappaB activation and decreased markers of neurological injury associated with hypothermic therapy in experimental bacterial meningitis
    Jose E Irazuzta
    Division of Critical Care Medicine, Tufts University, The Floating Hospital for Children, New England Medical Center, Boston, MA, USA
    Crit Care Med 30:2553-9. 2002
    ....
  52. pmc Role of biomarkers in sepsis care
    Ravi S Samraj
    Division of Critical Care Medicine, Cincinnati Children s Hospital Medical Center, and the University of Cincinnati College of Medicine, Cincinnati, Ohio
    Shock 40:358-65. 2013
    ..We will also discuss the new concept of combination biomarkers and biomarker risk models, their existing challenges, and their potential use in the daily management of patients with sepsis. ..
  53. ncbi Peroxisome proliferator-activated receptor-gamma agonists modulate macrophage activation by gram-negative and gram-positive bacterial stimuli
    Kelly Guyton
    Department of Microbiology, Medical University of South Carolina, 167 Ashley Avenue, Charleston, SC 29425, USA
    Shock 20:56-62. 2003
    ..PPARgamma-independent effects of 15-PGJ(2) may contribute to its more potent anti-inflammatory effects compared with troglitazone...
  54. pmc Lysophosphatidic acid inhibits bacterial endotoxin-induced pro-inflammatory response: potential anti-inflammatory signaling pathways
    Hongkuan Fan
    Department of Neurosciences, Medical University of South Carolina, Charleston, South Carolina, USA
    Mol Med 14:422-8. 2008
    ..These studies demonstrate that LPA has significant anti-inflammatory activities involving activation of ERK 1/2, serine/threonine phosphatases, and PI3 kinase signaling pathways...
  55. ncbi The phosphatidylinositol 3 kinase pathway regulates tolerance to lipopolysaccharide and priming responses to Staphylococcus aureus and lipopolysaccharide
    Octavia M Peck
    Department of Neurosciences, The Medical University of South Carolina, Charleston, SC 29425, USA
    Shock 26:31-6. 2006
    ..In contrast, mice pretreated with LPS and wortmannin demonstrated LPS tolerance reversal. These data suggest that PI3 kinase is essential for LPS induced homologous tolerance and reciprocal LPS and S. aureus induced priming responses...
  56. pmc Differential regulation of lipopolysaccharide and Gram-positive bacteria induced cytokine and chemokine production in macrophages by Galpha(i) proteins
    Hongkuan Fan
    Department of Neuroscience, Medical University of South Carolina, Charleston, SC, USA
    Immunology 122:116-23. 2007
    ..These data suggest that G(i2) and G(i1/3) proteins are both involved and differentially regulate murine inflammatory cytokine and chemokine production in response to both LPS and Gram-positive microbial stimuli...
  57. ncbi Lipopolysaccharide- and gram-positive bacteria-induced cellular inflammatory responses: role of heterotrimeric Galpha(i) proteins
    Hongkuan Fan
    Department of Physiology and Neuroscience, Medical University of South Carolina, 173 Ashley Ave, BSB Rm 403, Charleston, SC 29425, USA
    Am J Physiol Cell Physiol 289:C293-301. 2005
    ..These data suggest that G(i) proteins differentially regulate murine TLR-mediated inflammatory cytokine production in a cell-specific manner in response to both LPS and gram-positive microbial stimuli...
  58. ncbi Gi proteins regulate lipopolysaccharide and Staphylococcus aureus induced cytokine production but not (1--> 3)-beta-D-glucan induced cytokine suppression
    Hongkuan Fan
    Department of Neuroscience, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Front Biosci 11:2264-74. 2006
    ..In contrast, the effect of soluble glucan on inhibiting cellular activation by LPS and SA is Gi protein independent...
  59. ncbi Surfactant treatment of neonatal acute respiratory distress syndrome: is "fortification" the answer?
    Ranjit S Chima
    Crit Care Med 35:2442-3. 2007
  60. ncbi Ethyl pyruvate: a simple solution?
    Basilia Zingarelli
    Crit Care Med 32:1603-4. 2004
  61. ncbi Differential regulation of lipopolysaccharide and Gram-positive bacteria induced cytokine and chemokine production in splenocytes by Galphai proteins
    Hongkuan Fan
    Department of Neuroscience, 173 Ashley Ave, BSB Room 403, Charleston, SC 29425, USA
    Biochim Biophys Acta 1763:1051-8. 2006
    ....
  62. ncbi Peptidoglycan is an important pathogenic factor of the inflammatory response in sepsis
    Basilia Zingarelli
    Crit Care Med 32:613-4. 2004
  63. doi Caspases inhibition decreases neurological sequelae in meningitis
    Jose Irazuzta
    University of Florida at Jacksonville, Wolfson s Children Hospital, Jacksonville, FL, USA
    Crit Care Med 36:1603-6. 2008
    ..To evaluate the effects of sustained caspase inhibition during the acute phase of meningitis-induced brain injury. Changes in neurobehavioral performance were the primary outcome variables...

Research Grants15

  1. PPARgamma and PPARgamma agonists in septic shock
    Basilia Zingarelli; Fiscal Year: 2010
    ..This competitive renewal represents a logical extension of our previous application and will provide valuable information for the developing of novel experimental approaches to complement antibiotic therapy after sepsis. ..
  2. Mechanisms of age-related inflammatory response in hemorrhagic shock
    Basilia Zingarelli; Fiscal Year: 2007
    ....
  3. PPARgamma and PPARgamma agonists in septic shock
    Basilia Zingarelli; Fiscal Year: 2006
    ..The combination of in vivo and in vitro approaches will provide a strong test of the hypothesis that activation of PPARgamma is beneficial in sepsis. ..
  4. Poly (ADP-Ribose) synthetase in expression of endothelia
    Basilia Zingarelli; Fiscal Year: 2003
    ..abstract_text> ..
  5. Mechanisms of age-related inflammatory response in hemorrhagic shock
    Basilia Zingarelli; Fiscal Year: 2010
    ....