Research Topics
Genomes and Genes | Basilia ZingarelliSummaryAffiliation: Cincinnati Children's Hospital Medical Center Country: USA Publications
Research Grants
| Collaborators
|
Detail Information
Publications
Differential regulation of activator protein-1 and heat shock factor-1 in myocardial ischemia and reperfusion injury: role of poly(ADP-ribose) polymerase-1Basilia Zingarelli
Division of Critical Care Medicine, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
Am J Physiol Heart Circ Physiol 286:H1408-15. 2004..The data indicate that PARP-1 may exert a pathological role in reperfusion injury by functioning as an enhancing factor of AP-1 activation and as a repressing factor of HSF-1 activation and HSP70 expression...
Absence of poly(ADP-ribose)polymerase-1 alters nuclear factor-kappa B activation and gene expression of apoptosis regulators after reperfusion injuryBasilia Zingarelli
Division of Critical Care Medicine, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
Mol Med 9:143-53. 2003..The data indicate that during reperfusion absence of PARP-1 leads to reduction of myocardial apoptosis, which is associated with reduced NF-kappa B activation and altered gene expression profiles...- Inhibitors of poly (ADP-ribose) polymerase modulate signal transduction pathways in colitisBasilia Zingarelli
Division of Critical Care Medicine, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
Eur J Pharmacol 469:183-94. 2003..These data demonstrate that pharmacological inhibition of PARP ameliorates colitis. Reduction of the inflammatory process is associated with modification of the activation of signal transduction pathways... - Peroxisome proliferator activated receptor gamma is not necessary for the development of LPS-induced tolerance in macrophagesBasilia Zingarelli
Division of Critical Care Medicine, Cincinnati Children s Hospital Medical Center and the University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
Immunology 124:51-7. 2008..These data demonstrate that PPARgamma does not play a role in the LPS-induced tolerant phenotype in macrophages... - Lung injury after hemorrhage is age dependent: role of peroxisome proliferator-activated receptor gammaBasilia Zingarelli
Department of Pediatrics, Division of Critical Care Medicine, Cincinnati Children s Hospital Medical Center, Cincinnati, OH, USA
Crit Care Med 37:1978-87. 2009..We investigated whether the pathophysiologic characteristics of hemorrhage-induced lung injury may be age dependent and may be regulated by the peroxisome proliferator-activated receptor gamma (PPARgamma)... - Liver apoptosis is age dependent and is reduced by activation of peroxisome proliferator-activated receptor-gamma in hemorrhagic shockBasilia Zingarelli
Division of Critical Care Medicine, Cincinnati Children s Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH 45229, USA
Am J Physiol Gastrointest Liver Physiol 298:G133-41. 2010..Our data suggest that liver injury after severe hemorrhage is age dependent and PPARgamma activation is a novel hepatoprotective mechanism... - Peroxisome proliferator-activated receptor {delta} regulates inflammation via NF-{kappa}B signaling in polymicrobial sepsisBasilia Zingarelli
Division of Critical Care Medicine, Cincinnati Children s Hospital Medical Center and College of Medicine, University of Cincinnati, Cincinnati, Ohio 45229, USA
Am J Pathol 177:1834-47. 2010..These data suggest that PPARδ is a crucial anti-inflammatory regulator, providing a basis for novel sepsis therapies... - Diverse cardioprotective signaling mechanisms of peroxisome proliferator-activated receptor-gamma ligands, 15-deoxy-Delta12,14-prostaglandin J2 and ciglitazone, in reperfusion injury: role of nuclear factor-kappaB, heat shock factor 1, and AktBasilia Zingarelli
Division of Critical Care Medicine, Cincinnati Children s Hospital Medical Center, The University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA
Shock 28:554-63. 2007..In contrast, GW-9662 did not affect the beneficial effects afforded by 15d-PGJ2. Thus, our data suggest that treatment with these chemically unrelated PPAR-gamma ligands results in diverse anti-inflammatory mechanisms... - Activator protein-1 signalling pathway and apoptosis are modulated by poly(ADP-ribose) polymerase-1 in experimental colitisBasilia Zingarelli
Division of Critical Care Medicine, Cincinnati Children s Hospital Medical Center and College of Medicine, University of Cincinnati, Cincinnati, OH 45229, USA
Immunology 113:509-17. 2004..The data indicate that PARP-1 exerts a pathological role in colitis possibly by regulating the early stress-related transcriptional response through a positive modulation of the AP-1 and JNK pathways... - Peroxisome proliferator-activated receptor-gamma is a new therapeutic target in sepsis and inflammationBasilia Zingarelli
Division of Critical Care Medicine, Cincinnati Children s Hospital Medical Center and the College of Medicine, University of Cincinnati, Cincinnati, Ohio 45229, USA
Shock 23:393-9. 2005.... - Peroxisome proliferator activator receptor-gamma ligands, 15-deoxy-Delta(12,14)-prostaglandin J2 and ciglitazone, reduce systemic inflammation in polymicrobial sepsis by modulation of signal transduction pathwaysBasilia Zingarelli
Division of Critical Care, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
J Immunol 171:6827-37. 2003..Our data suggest that PPARgamma ligands attenuate the inflammatory response in sepsis through regulation of the NF-kappaB and AP-1 pathways... - Ciglitazone ameliorates lung inflammation by modulating the inhibitor kappaB protein kinase/nuclear factor-kappaB pathway after hemorrhagic shockRanjit S Chima
Division of Critical Care Medicine, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH, USA
Crit Care Med 36:2849-57. 2008..We investigated the effects of ciglitazone on lung inflammation after severe hemorrhage... - Poly(ADP-ribose) polymerase-1 regulates activation of activator protein-1 in murine fibroblastsTeresa L Andreone
Division of Critical Care Medicine, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
J Immunol 170:2113-20. 2003..No DNA binding of heat shock factor-1 was observed in PARP-1-deficient cells. These data demonstrate that PARP-1 plays a pivotal role in the modulation of transcription... - Therapeutic effect of epigallocatechin-3-gallate in a mouse model of colitisPatricia A Abboud
Cincinnati Children s Hospital Medical Center, Division of Critical Care Medicine, College of Medicine, University of Cincinnati, 3333 Burnet Avenue, Cincinnati, Ohio 45229, USA
Eur J Pharmacol 579:411-7. 2008..Our data demonstrate that EGCG may be beneficial in colitis through selective immunomodulatory effects, which may be mediated, at least in part, by inhibition of NF-kappaB and AP-1... - Absence of inducible nitric oxide synthase modulates early reperfusion-induced NF-kappaB and AP-1 activation and enhances myocardial damageBasilia Zingarelli
Children s Hospital Medical Center, Division of Critical Care, Cincinnati, Ohio 45229, USA
FASEB J 16:327-42. 2002..Thus, we conclude that iNOS plays a beneficial role in modulating the early defensive inflammatory response against reperfusion injury through regulation of signal transduction... - Peroxisome proliferator-activated receptor-gamma protects against hepatic ischemia/reperfusion injury in miceSatoshi Kuboki
Laboratory of Trauma, Sepsis and Inflammation Research, Department of Surgery, University of Cincinnati, Cincinnati, OH 45267 0558, USA
Hepatology 47:215-24. 2008..Conclusion: These data suggest that PPARgamma is an important endogenous regulator of, and potential therapeutic target for, ischemic liver injury... - Synergistic effect of peroxisome proliferator activated receptor-gamma and liver X receptor-alpha in the regulation of inflammation in macrophagesGiovanna Piraino
Cincinnati Children's Hospital Medical Center, Division of Critical Care Medicine, Cincinnati, OH 45229, USA
Shock 26:146-53. 2006..Thus, our data suggest that PPARgamma and LXRalpha may interact in controlling the inflammatory response in macrophages... - Age-dependent responses to hepatic ischemia/reperfusion injuryTomohisa Okaya
The Laboratory of Trauma, Sepsis, and Inflammation Research, Department of Surgery, University of Cincinnati, Cincinnati, Ohio 45267-0558, USA
Shock 24:421-7. 2005..These data suggest that there are multiple alterations at the cellular and molecular levels that contribute to enhanced postischemic liver injury in mature adult mice... - The green tea polyphenol epigallocatechin-3-gallate improves systemic hemodynamics and survival in rodent models of polymicrobial sepsisDerek S Wheeler
Division of Critical Care Medicine, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
Shock 28:353-9. 2007..Epigallocatechin-3-gallate may therefore represent a potential nutritional supplement or pharmacologic agent in patients with sepsis... - 15-Deoxy-delta(12,14)-prostaglandin J(2) (15D-PGJ(2)), a peroxisome proliferator activated receptor gamma ligand, reduces tissue leukosequestration and mortality in endotoxic shockJennifer M Kaplan
Division of Critical Care Medicine, Cincinnati Children's Hospital Medical Center and the College of Medicine, University of Cincinnati, Cincinnati, Ohio 45229, USA
Shock 24:59-65. 2005..Our data demonstrate that 15d-PGJ2 ameliorates endotoxic shock most likely through repressing the proinflammatory pathway of NF-kappaB and enhancement of the cytoprotective heat shock response... - Parthenolide, an inhibitor of the nuclear factor-kappaB pathway, ameliorates cardiovascular derangement and outcome in endotoxic shock in rodentsMaeve Sheehan
Children's Hospital Medical Center, Division of Critical Care Medicine, Cincinnati, Ohio 45229, USA
Mol Pharmacol 61:953-63. 2002..We conclude that parthenolide exerts beneficial effects during endotoxic shock through inhibition of NF-kappaB... - Inducible nitric oxide synthase is not required in the development of endotoxin tolerance in miceBasilia Zingarelli
Division of Critical Care Medicine, Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
Shock 17:478-84. 2002..Our data suggests that iNOS is not required for the development of endotoxin tolerance, and that other signal transduction pathways, rather than NF-kappaB, may regulate induction of endotoxin tolerance in the absence of iNOS... - Induction of endotoxin tolerance enhances bacterial clearance and survival in murine polymicrobial sepsisDerek S Wheeler
Division of Critical Care Medicine, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
Shock 30:267-73. 2008..Contrary to our original hypothesis, we conclude that endotoxin tolerance significantly attenuates the host inflammatory response, augments bacterial clearance, and improves survival in this murine model of polymicrobial sepsis... - Proinsulin c-peptide exerts beneficial effects in endotoxic shock in miceMichael G Vish
Division of Critical Care Medicine, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, OH, USA
Crit Care Med 35:1348-55. 2007..This study was designed to investigate the biological effects of c-peptide during endotoxemia... - Epigallocatechin, a green tea polyphenol, attenuates myocardial ischemia reperfusion injury in ratsRajesh Aneja
Department of Pediatrics, Division of Critical Care Medicine OSB5, Cincinnati Children s Hospital Medical Center and College of Medicine, University of Cincinnati, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
Mol Med 10:55-62. 2004..The results of this study suggest that EGCG is beneficial for the treatment of reperfusion-induced myocardial damage by inhibition of the NF-kappaB and AP-1 pathway... - Phosphorylation of extracellular signal-regulated kinase (ERK)-1/2 Is associated with the downregulation of peroxisome proliferator-activated receptor (PPAR)-γ during polymicrobial sepsisJennifer M Kaplan
Division of Critical Care Medicine, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America
Mol Med 16:491-7. 2010..The inflammatory effects of sepsis cause changes in PPARγ expression and activation, in part, because of phosphorylation of PPARγ by ERK1/2. This phosphorylation can be reversed by ERK1/2 inhibition, thereby improving lung injury... - Parthenolide improves systemic hemodynamics and decreases tissue leukosequestration in rats with polymicrobial sepsisMaeve Sheehan
Cincinnati Children's Hospital, OH, USA
Crit Care Med 31:2263-70. 2003..These beneficial effects of parthenolide were associated with reduction of NF-kappaB activity in the lung. CONCLUSIONS: Our data suggest that pharmacologic inhibition of NF-kappaB may represent a potential therapeutic approach in sepsis... - A novel role for matrix metalloproteinase-8 in sepsisPatrick D Solan
Department of Surgery, University of Cincinnati College of Medicine, Cincinnati Children s Hospital Medical Center and Cincinnati Children s Research Foundation, Cincinnati, OH, USA
Crit Care Med 40:379-87. 2012..Here, we investigate the relationship between matrix metalloproteinase-8 and disease severity in children with septic shock. We further corroborate the role of matrix metalloproteinase-8 in sepsis in a murine model... - C-peptide, a novel inhibitor of lung inflammation following hemorrhagic shockRanjit S Chima
Division of Critical Care Medicine MLC 2005 Cincinnati Children s Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH 45229, USA
Am J Physiol Lung Cell Mol Physiol 300:L730-9. 2011..Our data suggest that C-peptide ameliorates the inflammatory response and lung inflammation following hemorrhagic shock. These effects may be modulated by altering the balance between pro- and anti-inflammatory signaling in the lung... - Sesquiterpene lactone parthenolide, an inhibitor of IkappaB kinase complex and nuclear factor-kappaB, exerts beneficial effects in myocardial reperfusion injuryBasilia Zingarelli
Children's Hospital Medical Center, Division of Critical Care Medicine, Cincinnati, Ohio 45229, USA
Shock 17:127-34. 2002..The results of this study suggest that parthenolide may be beneficial for the treatment of reperfusion-induced myocardial damage by inhibition of the IKK/NF-kappaB pathway... - Inhibitors of poly (ADP-ribose) polymerase ameliorate myocardial reperfusion injury by modulation of activator protein-1 and neutrophil infiltrationJennifer Kaplan
Division of Critical Care Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA
Shock 23:233-8. 2005..Our data demonstrate that inhibition of catalytic activity of PARP-1 may provide cardioprotection by regulating stress-induced signal transduction pathways... - Peroxisome proliferator-activated receptor gamma is required for the inhibitory effect of ciglitazone but not 15-deoxy-Delta 12,14-prostaglandin J2 on the NFkappaB pathway in human endothelial cellsJennifer Kaplan
Cincinnati Children s Hospital Medical Center, 3229 Burnet Avenue, Cincinnati, OH 45229, USA
Shock 28:722-726. 2007..On the contrary, the inhibitory effect of ciglitazone on the NFkappaB pathway seems to require PPARgamma activation... - Inhibition of nitric oxide restores surfactant gene expression following nickel-induced acute lung injurySusan A McDowell
University of Cincinnati, and Children's Hospital Medical Center, Cincinnati, OH 45267-0056, USA
Am J Respir Cell Mol Biol 28:188-98. 2003..Rather, systemic L-NAME treatment appears to attenuate pulmonary endothelial NOS activity, subsequent cytokine expression, inflammation, and protein permeability, and thereby restores surfactant gene expression and increases survival... - Dexamethasone decreases neurological sequelae and caspase activityJose Irazuzta
Division of Critical Care Medicine, The Floating Hospital for Children, 750 Washington Street, NEMC 093, Boston, MA 02111, USA
Intensive Care Med 31:146-50. 2005..Changes in neurobehavioral performance were the primary outcome variables. Changes in caspase activation and markers of neuronal injury were the secondary outcome variables... - Overexpression of Hsp20 prevents endotoxin-induced myocardial dysfunction and apoptosis via inhibition of NF-kappaB activationXiaohong Wang
Department of Pharmacology and Cell Biophysics, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0575, USA
J Mol Cell Cardiol 47:382-90. 2009..Thus, the increases in Hsp20 levels can protect against LPS-induced cardiac apoptosis and dysfunction, associated with inhibition of NF-kappaB activity, suggesting that Hsp20 may be a new therapeutic agent for the treatment of sepsis... - Reduced peroxisome proliferator-activated receptor α expression is associated with decreased survival and increased tissue bacterial load in sepsisStephen W Standage
Division of Critical Care Medicine, Cincinnati Children s Hospital Medical Center, Department of Surgery, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
Shock 37:164-9. 2012..These data indicate that reduced or absent PPAR-α expression confers a survival disadvantage in sepsis and that PPAR-α plays a role in maintaining appropriate immune functions during the sepsis response... - Novel pharmacologic approaches to the management of sepsis: targeting the host inflammatory responseDerek S Wheeler
Division of Critical Care Medicine, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229 3039, USA
Recent Pat Inflamm Allergy Drug Discov 3:96-112. 2009..We will also reference some of the patents recently filed that pertain to the host innate immune response and sepsis... 
C-peptide ameliorates kidney injury following hemorrhagic shockRanjit S Chima
Division of Critical Care Medicine, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio, USA
Shock 35:524-9. 2011..Thus, our data suggest that C-peptide may exert renoprotective effects after hemorrhagic shock by modulating activator protein 1 signaling...- Changes in peroxisome proliferator-activated receptor-gamma activity in children with septic shockJennifer M Kaplan
Cincinnati Children s Hospital Medical Center, The University of Cincinnati College of Medicine, 3333 Burnet Avenue, MLC 2005, Cincinnati, OH 45229 3039, USA
Intensive Care Med 36:123-30. 2010..Additionally, to investigate the effects of sepsis on the endogenous activator of PPARgamma, 15-deoxy-(12,14)-PGJ(2) (15d-PGJ(2)), and the downstream targets of PPARgamma activity, adiponectin and resistin... - Nuclear factor-kappaB as a therapeutic target in critical care medicineBasilia Zingarelli
Children s Hospital Medical Center, Division of Critical Care Medicine, 3333 Burnet Avenue, Cincinnati, Ohio 45229, USA
Crit Care Med 31:S105-11. 2003..The purpose of our review is to describe these novel therapeutic approaches and their potential efficacy... - Admission angiopoietin levels in children with septic shockJohn S Giuliano
Division of Critical Care Medicine, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
Shock 28:650-654. 2007..Given the contrasting effects of angpt-2 and angpt-1 on the vascular endothelium, these two factors may play an important role in the pathophysiology of septic shock in children, and further studies are warranted... - Ciglitazone, a novel inhibitor of lung apoptosis following hemorrhagic shockRanjit S Chima
Division of Critical Care Medicine, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine Cincinnati, OH, USA
Int J Clin Exp Med 3:1-9. 2010..This was associated with increased phosphorylation of the pro-survival kinase Akt. Thus, our data suggest that ciglitazone, a PPARy ligand, promotes cell survival in the lung following hemorrhagic shock... - Liver X receptor α activation with the synthetic ligand T0901317 reduces lung injury and inflammation after hemorrhage and resuscitation via inhibition of the nuclear factor κB pathwayPatrick D Solan
Department of Surgery, University of Cincinnati, Cincinnati, OH, USA
Shock 35:367-74. 2011..Thus, our data suggest that LXRα is an important modulator of the inflammatory response and lung injury after severe hemorrhagic shock, likely through the inhibition of the nuclear factor κB pathway... - Nitric oxide mediates increased P-glycoprotein activity in interferon-{gamma}-stimulated human intestinal cellsSantosh G Dixit
College of Pharmacy, University of Cincinnati, 3223 Eden Ave, Cincinnati, OH 45267-0004, USA
Am J Physiol Gastrointest Liver Physiol 288:G533-40. 2005.... - The immunomodulatory effects of albumin in vitro and in vivoDerek S Wheeler
Division of Critical Care Medicine, The Kindervelt Laboratory for Critical Care Medicine Research, Cincinnati Children s Research Foundation, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229 3039, USA
Adv Pharmacol Sci 2011:691928. 2011..Albumin preconditioning abrogated the LPS-mediated increase in NF-κB activation and TNF-α gene expression in vitro and in vivo. The clinical significance of these findings remains to be elucidated... - Short-term high fat feeding increases organ injury and mortality after polymicrobial sepsisJennifer M Kaplan
Division of Critical Care Medicine, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
Obesity (Silver Spring) 20:1995-2002. 2012..CD-fed mice. Short duration high fat feeding increases mortality and organ injury following polymicrobial sepsis. These effects correspond to changes in NF-κB... - Nuclear factor-kappaBBasilia Zingarelli
Division of Critical Care Medicine, Cincinnati Children's Hospital Medical Center and the University of Cincinnati College of Medicine, Cincinnati, OH, USA
Crit Care Med 33:S414-6. 2005 - Calpain inhibition decreases endothelin-1 levels and pulmonary hypertension after cardiopulmonary bypass with deep hypothermic circulatory arrestJodie Y Duffy
Pediatric Cardiothoracic Surgery, Cincinnati Children's Hospital Medical Center, and the University of Cincinnati College of Medicine, Cincinnati, OH, USA
Crit Care Med 33:623-8. 2005.... - Modulation of nuclear factor-kappaB activation and decreased markers of neurological injury associated with hypothermic therapy in experimental bacterial meningitisJose E Irazuzta
Division of Critical Care Medicine, Tufts University, The Floating Hospital for Children, New England Medical Center, Boston, MA, USA
Crit Care Med 30:2553-9. 2002..The consequence of intermittent suppression of nuclear factor-kappaB activation by inducing specific periods of hypothermia requires further study... - Peroxisome proliferator-activated receptor-gamma agonists modulate macrophage activation by gram-negative and gram-positive bacterial stimuliKelly Guyton
Department of Microbiology, Medical University of South Carolina, 167 Ashley Avenue, Charleston, SC 29425, USA
Shock 20:56-62. 2003..PPARgamma-independent effects of 15-PGJ(2) may contribute to its more potent anti-inflammatory effects compared with troglitazone... - Lysophosphatidic acid inhibits bacterial endotoxin-induced pro-inflammatory response: potential anti-inflammatory signaling pathwaysHongkuan Fan
Department of Neurosciences, Medical University of South Carolina, Charleston, South Carolina, USA
Mol Med 14:422-8. 2008..These studies demonstrate that LPA has significant anti-inflammatory activities involving activation of ERK 1/2, serine/threonine phosphatases, and PI3 kinase signaling pathways... - The phosphatidylinositol 3 kinase pathway regulates tolerance to lipopolysaccharide and priming responses to Staphylococcus aureus and lipopolysaccharideOctavia M Peck
Department of Neurosciences, The Medical University of South Carolina, Charleston, SC 29425, USA
Shock 26:31-6. 2006..In contrast, mice pretreated with LPS and wortmannin demonstrated LPS tolerance reversal. These data suggest that PI3 kinase is essential for LPS induced homologous tolerance and reciprocal LPS and S. aureus induced priming responses... - Lipopolysaccharide- and gram-positive bacteria-induced cellular inflammatory responses: role of heterotrimeric Galpha(i) proteinsHongkuan Fan
Department of Physiology and Neuroscience, Medical University of South Carolina, 173 Ashley Ave, BSB Rm 403, Charleston, SC 29425, USA
Am J Physiol Cell Physiol 289:C293-301. 2005..These data suggest that G(i) proteins differentially regulate murine TLR-mediated inflammatory cytokine production in a cell-specific manner in response to both LPS and gram-positive microbial stimuli... - Differential regulation of lipopolysaccharide and Gram-positive bacteria induced cytokine and chemokine production in macrophages by Galpha(i) proteinsHongkuan Fan
Department of Neuroscience, Medical University of South Carolina, Charleston, SC, USA
Immunology 122:116-23. 2007..These data suggest that G(i2) and G(i1/3) proteins are both involved and differentially regulate murine inflammatory cytokine and chemokine production in response to both LPS and Gram-positive microbial stimuli... - Gi proteins regulate lipopolysaccharide and Staphylococcus aureus induced cytokine production but not (1--> 3)-beta-D-glucan induced cytokine suppressionHongkuan Fan
Department of Neuroscience, Medical University of South Carolina, Charleston, South Carolina 29425, USA
Front Biosci 11:2264-74. 2006..In contrast, the effect of soluble glucan on inhibiting cellular activation by LPS and SA is Gi protein independent... - Surfactant treatment of neonatal acute respiratory distress syndrome: is "fortification" the answer?Ranjit S Chima
Crit Care Med 35:2442-3. 2007 - Differential regulation of lipopolysaccharide and Gram-positive bacteria induced cytokine and chemokine production in splenocytes by Galphai proteinsHongkuan Fan
Department of Neuroscience, 173 Ashley Ave, BSB Room 403, Charleston, SC 29425, USA
Biochim Biophys Acta 1763:1051-8. 2006.... - Ethyl pyruvate: a simple solution?Basilia Zingarelli
Crit Care Med 32:1603-4. 2004 - Peptidoglycan is an important pathogenic factor of the inflammatory response in sepsisBasilia Zingarelli
Crit Care Med 32:613-4. 2004 - Caspases inhibition decreases neurological sequelae in meningitisJose Irazuzta
University of Florida at Jacksonville, Wolfson s Children Hospital, Jacksonville, FL, USA
Crit Care Med 36:1603-6. 2008..To evaluate the effects of sustained caspase inhibition during the acute phase of meningitis-induced brain injury. Changes in neurobehavioral performance were the primary outcome variables...
Research Grants
- PPARgamma and PPARgamma agonists in septic shockBasilia Zingarelli; Fiscal Year: 2010..This competitive renewal represents a logical extension of our previous application and will provide valuable information for the developing of novel experimental approaches to complement antibiotic therapy after sepsis. ..
- Mechanisms of age-related inflammatory response in hemorrhagic shockBasilia Zingarelli; Fiscal Year: 2007....
- PPARgamma and PPARgamma agonists in septic shockBasilia Zingarelli; Fiscal Year: 2006..The combination of in vivo and in vitro approaches will provide a strong test of the hypothesis that activation of PPARgamma is beneficial in sepsis. ..
- Poly (ADP-Ribose) synthetase in expression of endotheliaBasilia Zingarelli; Fiscal Year: 2003..abstract_text> ..
- Mechanisms of age-related inflammatory response in hemorrhagic shockBasilia Zingarelli; Fiscal Year: 2010....