Basilia Zingarelli

Summary

Affiliation: Cincinnati Children's Hospital Medical Center
Country: USA

Publications

  1. Zingarelli B, Hake P, O Connor M, Denenberg A, Wong H, Kong S, et al. Differential regulation of activator protein-1 and heat shock factor-1 in myocardial ischemia and reperfusion injury: role of poly(ADP-ribose) polymerase-1. Am J Physiol Heart Circ Physiol. 2004;286:H1408-15 pubmed
    ..The data indicate that PARP-1 may exert a pathological role in reperfusion injury by functioning as an enhancing factor of AP-1 activation and as a repressing factor of HSF-1 activation and HSP70 expression. ..
  2. Zingarelli B, Hake P, O Connor M, Burroughs T, Wong H, Solomkin J, et al. Lung injury after hemorrhage is age dependent: role of peroxisome proliferator-activated receptor gamma. Crit Care Med. 2009;37:1978-87 pubmed publisher
    ..Lung injury after severe hemorrhage is age dependent and may be secondary to a diverse regulation of PPARgamma. ..
  3. Zingarelli B, Cook J. Peroxisome proliferator-activated receptor-gamma is a new therapeutic target in sepsis and inflammation. Shock. 2005;23:393-9 pubmed
  4. Botez G, Piraino G, Hake P, Ledford J, O Connor M, Cook J, et al. Age-dependent therapeutic effects of liver X receptor-α activation in murine polymicrobial sepsis. Innate Immun. 2015;21:609-18 pubmed publisher
    ..This study suggests that the anti-inflammatory properties of LXRα in sepsis are age-dependent and severely compromised in mature adult animals. ..
  5. Matsiukevich D, Piraino G, Lahni P, Hake P, Wolfe V, O Connor M, et al. Metformin ameliorates gender-and age-dependent hemodynamic instability and myocardial injury in murine hemorrhagic shock. Biochim Biophys Acta Mol Basis Dis. 2017;1863:2680-2691 pubmed publisher
    ..Metformin did not affect hemodynamic or inflammatory responses in young animals. Thus, our data suggest that targeting metabolic recovery with metformin may be a potential treatment approach in severe hemorrhage in adult population. ..
  6. Inata Y, Kikuchi S, Samraj R, Hake P, O Connor M, Ledford J, et al. Autophagy and mitochondrial biogenesis impairment contributes to age-dependent liver injury in experimental sepsis: dysregulation of AMP-activated protein kinase pathway. FASEB J. 2017;: pubmed publisher
    ..O'Connor, J., Lahni, P., Wolfe, V., Piraino, G., Zingarelli, B. Autophagy and mitochondrial biogenesis impairment contributes to age-dependent liver injury in experimental sepsis: dysregulation of AMP-activated protein kinase pathway...
  7. Zingarelli B, Hake P, Mangeshkar P, O Connor M, Burroughs T, Piraino G, et al. Diverse cardioprotective signaling mechanisms of peroxisome proliferator-activated receptor-gamma ligands, 15-deoxy-Delta12,14-prostaglandin J2 and ciglitazone, in reperfusion injury: role of nuclear factor-kappaB, heat shock factor 1, and Akt. Shock. 2007;28:554-63 pubmed
    ..In contrast, GW-9662 did not affect the beneficial effects afforded by 15d-PGJ2. Thus, our data suggest that treatment with these chemically unrelated PPAR-gamma ligands results in diverse anti-inflammatory mechanisms. ..
  8. Zingarelli B, Chima R, O Connor M, Piraino G, Denenberg A, Hake P. Liver apoptosis is age dependent and is reduced by activation of peroxisome proliferator-activated receptor-gamma in hemorrhagic shock. Am J Physiol Gastrointest Liver Physiol. 2010;298:G133-41 pubmed publisher
    ..Our data suggest that liver injury after severe hemorrhage is age dependent and PPARgamma activation is a novel hepatoprotective mechanism. ..
  9. Zingarelli B, Piraino G, Hake P, O Connor M, Denenberg A, Fan H, et al. Peroxisome proliferator-activated receptor {delta} regulates inflammation via NF-{kappa}B signaling in polymicrobial sepsis. Am J Pathol. 2010;177:1834-47 pubmed publisher
    ..These data suggest that PPAR? is a crucial anti-inflammatory regulator, providing a basis for novel sepsis therapies...