Research Topics
Genomes and Genes
| Nives ZimmermannSummaryAffiliation: Cincinnati Children's Hospital Medical Center Country: USA Publications
| Collaborators
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Detail Information
Publications
Increased susceptibility of 129SvEvBrd mice to IgE-Mast cell mediated anaphylaxisMuthuvel Arumugam
Division of Biochemistry, National Institute of Siddha, Chennai, India
BMC Immunol 12:14. 2011..v infusion were assessed. Bone marrow mast cell (BMMC)s were examined for FcεRI, c-kit, degranulation efficiency, proliferation, apoptosis and cytokine profile...- Analysis of the CCR3 promoter reveals a regulatory region in exon 1 that binds GATA-1Nives Zimmermann
Division of Allergy and Immunology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio, USA
BMC Immunol 6:7. 2005..It is therefore important to elucidate the molecular mechanisms regulating receptor expression... 
Expression and regulation of a disintegrin and metalloproteinase (ADAM) 8 in experimental asthmaNina E King
Division of Allergy and Immunology, Cincinnati Children s Hospital Medical Center, University of Cincinatti College of Medicine, Cincinnati, OH 45229, USA
Am J Respir Cell Mol Biol 31:257-65. 2004..Taken together with the role of ADAM33 in asthma, these results suggest that allergic lung responses involve the interplay of diverse members of the ADAM family...- Expression and regulation of small proline-rich protein 2 in allergic inflammationNives Zimmermann
Division of Allergy and Immunology, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
Am J Respir Cell Mol Biol 32:428-35. 2005..Thus, SPRR2 is an allergen- and IL-13-induced gene in experimental allergic responses that may be involved in disease pathophysiology... - The cationic amino acid transporter 2 is induced in inflammatory lung models and regulates lung fibrosisKathryn A Niese
Division of Allergy and Immunology, Cincinnati Children s Hospital Medical Center, 3333 Burnet Ave, Cincinnati, Ohio 45229, USA
Respir Res 11:87. 2010..As such, arginine has the potential to influence diverse fundamental processes in the lung... - Negative regulation of eosinophil recruitment to the lung by the chemokine monokine induced by IFN-gamma (Mig, CXCL9)Patricia C Fulkerson
Department of Molecular Genetics, Biochemistry, and Microbiology, University of Cincinnati College of Medicine, 231 Bethesda Avenue, Cincinnati, OH 45257 0524, USA
Proc Natl Acad Sci U S A 101:1987-92. 2004..The identification of a naturally occurring eosinophil inhibitory chemokine pathway in vivo provides a strategic basis for future therapeutic consideration... - Transcript signatures in experimental asthma: identification of STAT6-dependent and -independent pathwaysNives Zimmermann
Division of Allergy and Immunology, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
J Immunol 172:1815-24. 2004..These results provide unprecedented insight into the complex steps involved in the pathogenesis of allergic airway responses; as such, these results have significant therapeutic and clinical implications... - Pulmonary chemokine expression is coordinately regulated by STAT1, STAT6, and IFN-gammaPatricia C Fulkerson
Department of Molecular Genetics, Biochemistry, and Microbiology, University of Cincinnati College of Medicine, Cincinnati, OH 45257, USA
J Immunol 173:7565-74. 2004..Collectively, we demonstrate that allergen-induced inflammation involves coordinate regulation by STAT1, STAT6, and IFN-gamma... - Identification of a cooperative mechanism involving interleukin-13 and eotaxin-2 in experimental allergic lung inflammationSamuel M Pope
Division of Allergy and Immunology, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA
J Biol Chem 280:13952-61. 2005..Taken together, these results demonstrate a cooperative mechanism between IL-13 and eotaxin-2. In particular, IL-13 mediates allergen-induced eotaxin-2 expression, and eotaxin-2 mediates IL-13-induced airway eosinophilia... - Dissection of experimental asthma with DNA microarray analysis identifies arginase in asthma pathogenesisNives Zimmermann
Division of Allergy and Immunology, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
J Clin Invest 111:1863-74. 2003..Based on the ability of arginase to regulate generation of NO, polyamines, and collagen, these results provide a basis for pharmacologically targeting arginine metabolism in allergic disorders... - The eotaxin chemokines and CCR3 are fundamental regulators of allergen-induced pulmonary eosinophiliaSamuel M Pope
Division of Allergy and Immunology, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
J Immunol 175:5341-50. 2005..These results imply that successful blockade of Ag-induced pulmonary eosinophilia will require antagonism of multiple CCR3 ligands... - Arginase I suppresses IL-12/IL-23p40-driven intestinal inflammation during acute schistosomiasisDe Broski R Herbert
Research Service, Cincinnati Veterans Administration Medical Center, Cincinnati, OH 45220, USA
J Immunol 184:6438-46. 2010..Thus, macrophage-derived Arg I protects hosts against excessive tissue injury caused by worm eggs during acute schistosomiasis by suppressing IL-12/IL-23p40 production and maintaining the Treg/Th17 balance within the intestinal mucosa... - The arginine-arginase balance in asthma and lung inflammationNives Zimmermann
Division of Allergy and Immunology, Cincinnati Children's Hospital Medical Center and Department of Pediatrics, University of Cincinnati College of Medicine, OH 45229, USA
Eur J Pharmacol 533:253-62. 2006..This review focuses on the current body of knowledge on l-arginine metabolism in asthma and lung inflammation... - Mast cells are required for experimental oral allergen-induced diarrheaEric B Brandt
Division of Allergy and Immunology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, Ohio 45229, USA
J Clin Invest 112:1666-77. 2003..These results demonstrate that oral allergen-induced diarrhea associated with experimental Th2 intestinal inflammation is largely mast cell, IgE, serotonin, and PAF dependent... - Bone marrow cell derived arginase I is the major source of allergen-induced lung arginase but is not required for airway hyperresponsiveness, remodeling and lung inflammatory responses in miceKathryn A Niese
Division of Allergy and Immunology, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
BMC Immunol 10:33. 2009..Arginase is significantly upregulated in the lungs in murine models of asthma, as well as in human asthma, but its role in allergic airway inflammation has not been fully elucidated in mice... - Cationic amino acid transporter 2 regulates inflammatory homeostasis in the lungMarc E Rothenberg
Division of Allergy and Immunology, Cincinnati Children s Hospital and University of Cincinnati College of Medicine, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
Proc Natl Acad Sci U S A 103:14895-900. 2006..This process was accompanied by an increase in the number of memory T cells. Thus, our data suggest that CAT2 regulates anti-inflammatory processes in the lungs via regulation of dendritic cell activation and subsequent T cell responses... - Eosinophil viability is increased by acidic pH in a cAMP- and GPR65-dependent mannerLeah C Kottyan
Cincinnati Children s Hospital Medical Center, OH, USA
Blood 114:2774-82. 2009..We conclude that eosinophil viability is increased in acidic microenvironments in a cAMP- and GPR65-dependent manner... - Arginine in asthma and lung inflammationNina E King
Division of Allergy and Immunology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA
J Nutr 134:2830S-2836S; discussion 2853S. 2004..This review focuses on the current body of knowledge on L-arginine metabolism in asthma... - Trefoil factor-2 is an allergen-induced gene regulated by Th2 cytokines and STAT6 in the lungNikolaos M Nikolaidis
Division of Allergy and Immunology, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, MLC 7028 Cincinnati, OH 45229, USA
Am J Respir Cell Mol Biol 29:458-64. 2003.... - Chemokines in asthma: cooperative interaction between chemokines and IL-13Nives Zimmermann
Divisions of Allergy and Immunology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229-3039, USA
J Allergy Clin Immunol 111:227-42; quiz 243. 2003.... - Receptor internalization is required for eotaxin-induced responses in human eosinophilsNives Zimmermann
Division of Allergy and Immunology, Department of Pediatrics, Children's Hospital Medical Center, Cincinnati, Ohio 45229, USA
J Allergy Clin Immunol 111:97-105. 2003..CONCLUSION: These results establish that CCR3 internalization is critically involved in select eosinophil functional responses (ie, cellular shape change and actin polymerization) but not desensitization and calcium mobilization...