Nives Zimmermann

Summary

Affiliation: Cincinnati Children's Hospital Medical Center
Country: USA

Publications

  1. pmc Increased susceptibility of 129SvEvBrd mice to IgE-Mast cell mediated anaphylaxis
    Muthuvel Arumugam
    Division of Biochemistry, National Institute of Siddha, Chennai, India
    BMC Immunol 12:14. 2011
  2. pmc Analysis of the CCR3 promoter reveals a regulatory region in exon 1 that binds GATA-1
    Nives Zimmermann
    Division of Allergy and Immunology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio, USA
    BMC Immunol 6:7. 2005
  3. ncbi request reprint Expression and regulation of a disintegrin and metalloproteinase (ADAM) 8 in experimental asthma
    Nina E King
    Division of Allergy and Immunology, Cincinnati Children s Hospital Medical Center, University of Cincinatti College of Medicine, Cincinnati, OH 45229, USA
    Am J Respir Cell Mol Biol 31:257-65. 2004
  4. ncbi request reprint Expression and regulation of small proline-rich protein 2 in allergic inflammation
    Nives Zimmermann
    Division of Allergy and Immunology, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
    Am J Respir Cell Mol Biol 32:428-35. 2005
  5. pmc The cationic amino acid transporter 2 is induced in inflammatory lung models and regulates lung fibrosis
    Kathryn A Niese
    Division of Allergy and Immunology, Cincinnati Children s Hospital Medical Center, 3333 Burnet Ave, Cincinnati, Ohio 45229, USA
    Respir Res 11:87. 2010
  6. pmc Negative regulation of eosinophil recruitment to the lung by the chemokine monokine induced by IFN-gamma (Mig, CXCL9)
    Patricia C Fulkerson
    Department of Molecular Genetics, Biochemistry, and Microbiology, University of Cincinnati College of Medicine, 231 Bethesda Avenue, Cincinnati, OH 45257 0524, USA
    Proc Natl Acad Sci U S A 101:1987-92. 2004
  7. ncbi request reprint Transcript signatures in experimental asthma: identification of STAT6-dependent and -independent pathways
    Nives Zimmermann
    Division of Allergy and Immunology, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
    J Immunol 172:1815-24. 2004
  8. ncbi request reprint Pulmonary chemokine expression is coordinately regulated by STAT1, STAT6, and IFN-gamma
    Patricia C Fulkerson
    Department of Molecular Genetics, Biochemistry, and Microbiology, University of Cincinnati College of Medicine, Cincinnati, OH 45257, USA
    J Immunol 173:7565-74. 2004
  9. ncbi request reprint Identification of a cooperative mechanism involving interleukin-13 and eotaxin-2 in experimental allergic lung inflammation
    Samuel M Pope
    Division of Allergy and Immunology, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA
    J Biol Chem 280:13952-61. 2005
  10. ncbi request reprint The eotaxin chemokines and CCR3 are fundamental regulators of allergen-induced pulmonary eosinophilia
    Samuel M Pope
    Division of Allergy and Immunology, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    J Immunol 175:5341-50. 2005

Collaborators

Detail Information

Publications26

  1. pmc Increased susceptibility of 129SvEvBrd mice to IgE-Mast cell mediated anaphylaxis
    Muthuvel Arumugam
    Division of Biochemistry, National Institute of Siddha, Chennai, India
    BMC Immunol 12:14. 2011
    ..v infusion were assessed. Bone marrow mast cell (BMMC)s were examined for FcεRI, c-kit, degranulation efficiency, proliferation, apoptosis and cytokine profile...
  2. pmc Analysis of the CCR3 promoter reveals a regulatory region in exon 1 that binds GATA-1
    Nives Zimmermann
    Division of Allergy and Immunology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio, USA
    BMC Immunol 6:7. 2005
    ..It is therefore important to elucidate the molecular mechanisms regulating receptor expression...
  3. ncbi request reprint Expression and regulation of a disintegrin and metalloproteinase (ADAM) 8 in experimental asthma
    Nina E King
    Division of Allergy and Immunology, Cincinnati Children s Hospital Medical Center, University of Cincinatti College of Medicine, Cincinnati, OH 45229, USA
    Am J Respir Cell Mol Biol 31:257-65. 2004
    ..Taken together with the role of ADAM33 in asthma, these results suggest that allergic lung responses involve the interplay of diverse members of the ADAM family...
  4. ncbi request reprint Expression and regulation of small proline-rich protein 2 in allergic inflammation
    Nives Zimmermann
    Division of Allergy and Immunology, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
    Am J Respir Cell Mol Biol 32:428-35. 2005
    ..Thus, SPRR2 is an allergen- and IL-13-induced gene in experimental allergic responses that may be involved in disease pathophysiology...
  5. pmc The cationic amino acid transporter 2 is induced in inflammatory lung models and regulates lung fibrosis
    Kathryn A Niese
    Division of Allergy and Immunology, Cincinnati Children s Hospital Medical Center, 3333 Burnet Ave, Cincinnati, Ohio 45229, USA
    Respir Res 11:87. 2010
    ..As such, arginine has the potential to influence diverse fundamental processes in the lung...
  6. pmc Negative regulation of eosinophil recruitment to the lung by the chemokine monokine induced by IFN-gamma (Mig, CXCL9)
    Patricia C Fulkerson
    Department of Molecular Genetics, Biochemistry, and Microbiology, University of Cincinnati College of Medicine, 231 Bethesda Avenue, Cincinnati, OH 45257 0524, USA
    Proc Natl Acad Sci U S A 101:1987-92. 2004
    ..The identification of a naturally occurring eosinophil inhibitory chemokine pathway in vivo provides a strategic basis for future therapeutic consideration...
  7. ncbi request reprint Transcript signatures in experimental asthma: identification of STAT6-dependent and -independent pathways
    Nives Zimmermann
    Division of Allergy and Immunology, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
    J Immunol 172:1815-24. 2004
    ..These results provide unprecedented insight into the complex steps involved in the pathogenesis of allergic airway responses; as such, these results have significant therapeutic and clinical implications...
  8. ncbi request reprint Pulmonary chemokine expression is coordinately regulated by STAT1, STAT6, and IFN-gamma
    Patricia C Fulkerson
    Department of Molecular Genetics, Biochemistry, and Microbiology, University of Cincinnati College of Medicine, Cincinnati, OH 45257, USA
    J Immunol 173:7565-74. 2004
    ..Collectively, we demonstrate that allergen-induced inflammation involves coordinate regulation by STAT1, STAT6, and IFN-gamma...
  9. ncbi request reprint Identification of a cooperative mechanism involving interleukin-13 and eotaxin-2 in experimental allergic lung inflammation
    Samuel M Pope
    Division of Allergy and Immunology, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA
    J Biol Chem 280:13952-61. 2005
    ..Taken together, these results demonstrate a cooperative mechanism between IL-13 and eotaxin-2. In particular, IL-13 mediates allergen-induced eotaxin-2 expression, and eotaxin-2 mediates IL-13-induced airway eosinophilia...
  10. ncbi request reprint The eotaxin chemokines and CCR3 are fundamental regulators of allergen-induced pulmonary eosinophilia
    Samuel M Pope
    Division of Allergy and Immunology, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    J Immunol 175:5341-50. 2005
    ..These results imply that successful blockade of Ag-induced pulmonary eosinophilia will require antagonism of multiple CCR3 ligands...
  11. pmc Dissection of experimental asthma with DNA microarray analysis identifies arginase in asthma pathogenesis
    Nives Zimmermann
    Division of Allergy and Immunology, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    J Clin Invest 111:1863-74. 2003
    ..Based on the ability of arginase to regulate generation of NO, polyamines, and collagen, these results provide a basis for pharmacologically targeting arginine metabolism in allergic disorders...
  12. pmc Arginase I suppresses IL-12/IL-23p40-driven intestinal inflammation during acute schistosomiasis
    De Broski R Herbert
    Research Service, Cincinnati Veterans Administration Medical Center, Cincinnati, OH 45220, USA
    J Immunol 184:6438-46. 2010
    ..Thus, macrophage-derived Arg I protects hosts against excessive tissue injury caused by worm eggs during acute schistosomiasis by suppressing IL-12/IL-23p40 production and maintaining the Treg/Th17 balance within the intestinal mucosa...
  13. ncbi request reprint The arginine-arginase balance in asthma and lung inflammation
    Nives Zimmermann
    Division of Allergy and Immunology, Cincinnati Children s Hospital Medical Center and Department of Pediatrics, University of Cincinnati College of Medicine, OH 45229, USA
    Eur J Pharmacol 533:253-62. 2006
    ..This review focuses on the current body of knowledge on l-arginine metabolism in asthma and lung inflammation...
  14. pmc Mast cells are required for experimental oral allergen-induced diarrhea
    Eric B Brandt
    Division of Allergy and Immunology, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, Ohio 45229, USA
    J Clin Invest 112:1666-77. 2003
    ..These results demonstrate that oral allergen-induced diarrhea associated with experimental Th2 intestinal inflammation is largely mast cell, IgE, serotonin, and PAF dependent...
  15. pmc Bone marrow cell derived arginase I is the major source of allergen-induced lung arginase but is not required for airway hyperresponsiveness, remodeling and lung inflammatory responses in mice
    Kathryn A Niese
    Division of Allergy and Immunology, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    BMC Immunol 10:33. 2009
    ..Arginase is significantly upregulated in the lungs in murine models of asthma, as well as in human asthma, but its role in allergic airway inflammation has not been fully elucidated in mice...
  16. pmc Eosinophil viability is increased by acidic pH in a cAMP- and GPR65-dependent manner
    Leah C Kottyan
    Cincinnati Children s Hospital Medical Center, OH, USA
    Blood 114:2774-82. 2009
    ..We conclude that eosinophil viability is increased in acidic microenvironments in a cAMP- and GPR65-dependent manner...
  17. pmc Cationic amino acid transporter 2 regulates inflammatory homeostasis in the lung
    Marc E Rothenberg
    Division of Allergy and Immunology, Cincinnati Children s Hospital and University of Cincinnati College of Medicine, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
    Proc Natl Acad Sci U S A 103:14895-900. 2006
    ..This process was accompanied by an increase in the number of memory T cells. Thus, our data suggest that CAT2 regulates anti-inflammatory processes in the lungs via regulation of dendritic cell activation and subsequent T cell responses...
  18. ncbi request reprint Arginine in asthma and lung inflammation
    Nina E King
    Division of Allergy and Immunology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    J Nutr 134:2830S-2836S; discussion 2853S. 2004
    ..This review focuses on the current body of knowledge on L-arginine metabolism in asthma...
  19. ncbi request reprint Trefoil factor-2 is an allergen-induced gene regulated by Th2 cytokines and STAT6 in the lung
    Nikolaos M Nikolaidis
    Division of Allergy and Immunology, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, MLC 7028 Cincinnati, OH 45229, USA
    Am J Respir Cell Mol Biol 29:458-64. 2003
    ....
  20. pmc Proton channel HVCN1 is required for effector functions of mouse eosinophils
    Xiang Zhu
    Division of Allergy and Immunology, Department of Pediatrics, Cincinnati Children s Hospital Medical Center and the University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
    BMC Immunol 14:24. 2013
    ..Although there are similarities between eosinophils and neutrophils regarding their mechanism for respiratory burst, the role of proton channels in eosinophil functions has not been fully understood...
  21. doi request reprint Chronic traffic pollution exposure is associated with eosinophilic, but not neutrophilic inflammation in older adult asthmatics
    Tolly G Epstein
    Department of Medicine, Division of Immunology, Allergy and Rheumatology, College of Medicine, University of Cincinnati, Cincinnati, OH, USA
    J Asthma 50:983-9. 2013
    ..In this study, we sought to define the relationship between exposure to traffic pollutants, biomarkers in induced sputum, and asthma control in older adults...
  22. pmc Mechanism of Siglec-8-mediated cell death in IL-5-activated eosinophils: role for reactive oxygen species-enhanced MEK/ERK activation
    Gen Kano
    Division of Allergy and Immunology, Cincinnati Children s Hospital, and the Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    J Allergy Clin Immunol 132:437-45. 2013
    ..Paradoxically, Siglec-8-mediated cell death is markedly enhanced by the presence of the activation and survival factor IL-5 and becomes independent of caspase activity...
  23. ncbi request reprint Chemokines in asthma: cooperative interaction between chemokines and IL-13
    Nives Zimmermann
    Divisions of Allergy and Immunology, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
    J Allergy Clin Immunol 111:227-42; quiz 243. 2003
    ....
  24. pmc Differential eosinophil and mast cell regulation: mast cell viability and accumulation in inflammatory tissue are independent of proton-sensing receptor GPR65
    Xiang Zhu
    Division of Allergy and Immunology, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio
    Am J Physiol Gastrointest Liver Physiol 306:G974-82. 2014
    ..In conclusion, our study demonstrates differential regulation of eosinophils and mast cells in inflammatory tissue, with mast cell viability and accumulation being independent of GPR65. ..
  25. ncbi request reprint Receptor internalization is required for eotaxin-induced responses in human eosinophils
    Nives Zimmermann
    Division of Allergy and Immunology, Department of Pediatrics, Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    J Allergy Clin Immunol 111:97-105. 2003
    ..We have previously demonstrated that CCR3 undergoes rapid and prolonged ligand-induced internalization...
  26. pmc Carbonic Anhydrase IV Is Expressed on IL-5-Activated Murine Eosinophils
    Ting Wen
    Division of Allergy and Immunology, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229 and
    J Immunol 192:5481-9. 2014
    ....