K Zhang

Summary

Affiliation: Cincinnati Children's Hospital Medical Center
Country: USA

Publications

  1. pmc Hypomorphic mutations in PRF1, MUNC13-4, and STXBP2 are associated with adult-onset familial HLH
    Kejian Zhang
    Division of Human Genetics, Children s Hospital Medical Center, University of Cincinnati College of Medicie, Cincinnati, OH 45229, USA
    Blood 118:5794-8. 2011
  2. ncbi request reprint Familial haemophagocytic lymphohistiocytosis in patients who are heterozygous for the A91V perforin variation is often associated with other genetic defects
    K Zhang
    Division of Human Genetics, Cincinnati Children s Hospital Medical Center, Department of Pediatrics, College of Medicine, University of Cincinnati, OH 45255, USA
    Int J Immunogenet 34:231-3. 2007
  3. ncbi request reprint Functional characterization of CD4+CD25+ regulatory T cells differentiated in vitro from bone marrow-derived haematopoietic cells of psoriasis patients with a family history of the disorder
    K Zhang
    Institute of Dermatology, Taiyuan City Centre Hospital, Affiliated to Shanxi Medical University, No 1 Dong San Dao Xiang, Taiyuan City, Shanxi Province 030009, China
    Br J Dermatol 158:298-305. 2008
  4. pmc A novel locus on 19q13 associated with autosomal-dominant macular dystrophy in a large Greek family
    Z Yang
    J Med Genet 43:e57. 2006
  5. pmc Characterisation of diverse PRF1 mutations leading to decreased natural killer cell activity in North American families with haemophagocytic lymphohistiocytosis
    S Molleran Lee
    J Med Genet 41:137-44. 2004
  6. ncbi request reprint Association between apolipoprotein CI HpaI polymorphism and sporadic Alzheimer's disease in Chinese
    J Shi
    Department of Medical Genetics, West China Hospital, Sichuan University, Chengdu, China
    Acta Neurol Scand 109:140-5. 2004
  7. ncbi request reprint Dopamine depletion abolishes apomorphine- and amphetamine-induced increases in extracellular serotonin levels in the striatum of conscious rats: a microdialysis study
    A Balcioglu
    Neuroregeneration Laboratories, McLean Hospital, Harvard Medical School, 115 Mill Street, Belmont, MA 02478, USA
    Neuroscience 119:1045-53. 2003
  8. ncbi request reprint The power of transmission disequilibrium tests for quantitative traits
    J Li
    Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, Connecticut, USA
    Genet Epidemiol 21:S632-7. 2001
  9. pmc Identification and functional consequences of a new mutation (E155G) in the gene for GCAP1 that causes autosomal dominant cone dystrophy
    S E Wilkie
    Division of Molecular Genetics, Institute of Ophthalmology, University College London, London EC1V 9EL, United Kingdom
    Am J Hum Genet 69:471-80. 2001
  10. ncbi request reprint A dominant Stargardt's macular dystrophy locus maps to chromosome 13q34
    K Zhang
    Department of Genetics, Brigham and Women s Hospital, Boston, Mass
    Arch Ophthalmol 112:759-64. 1994

Collaborators

  • Rebecca A Marsh
  • Yang Li
  • Ziheng Yang
  • David M Hunt
  • Zhao Yue Wang
  • S Molleran Lee
  • J Shi
  • A Balcioglu
  • S Zhang
  • J Li
  • S E Wilkie
  • J Villanueva
  • K Zheng
  • Y Guo
  • J Zhao
  • J Sumegi
  • K Kogawa
  • A H Filipovich
  • H Han
  • X Kong
  • C Ma
  • Z Zhao
  • X Liu
  • T Li
  • M Tang
  • J Davis
  • Z Su
  • F I Tarazi
  • M J Warren
  • D Garibaldi
  • R Jiang
  • S S Bhattacharya
  • H Zhang
  • E C Deery
  • J B Bateman
  • H Zhao
  • F Sun
  • D J Zack
  • W Lin
  • J Dong
  • D Wang
  • R J Newbold
  • D Diaz-Sanchez
  • A Saxon
  • S Chegini

Detail Information

Publications11

  1. pmc Hypomorphic mutations in PRF1, MUNC13-4, and STXBP2 are associated with adult-onset familial HLH
    Kejian Zhang
    Division of Human Genetics, Children s Hospital Medical Center, University of Cincinnati College of Medicie, Cincinnati, OH 45229, USA
    Blood 118:5794-8. 2011
    ..We conclude that late-onset familial HLH occurs more commonly than was suspected previously...
  2. ncbi request reprint Familial haemophagocytic lymphohistiocytosis in patients who are heterozygous for the A91V perforin variation is often associated with other genetic defects
    K Zhang
    Division of Human Genetics, Cincinnati Children s Hospital Medical Center, Department of Pediatrics, College of Medicine, University of Cincinnati, OH 45255, USA
    Int J Immunogenet 34:231-3. 2007
  3. ncbi request reprint Functional characterization of CD4+CD25+ regulatory T cells differentiated in vitro from bone marrow-derived haematopoietic cells of psoriasis patients with a family history of the disorder
    K Zhang
    Institute of Dermatology, Taiyuan City Centre Hospital, Affiliated to Shanxi Medical University, No 1 Dong San Dao Xiang, Taiyuan City, Shanxi Province 030009, China
    Br J Dermatol 158:298-305. 2008
    ..It is reasonable to speculate that the dysfunctional activity of CD4+CD25+ regulatory cells may originate partly from the abnormal haematopoietic cells determined mainly by genetic background...
  4. pmc A novel locus on 19q13 associated with autosomal-dominant macular dystrophy in a large Greek family
    Z Yang
    J Med Genet 43:e57. 2006
    ..To describe the clinical features of and genetic locus associated with autosomal-dominant macular dystrophy (MCDR5) in a large Greek family...
  5. pmc Characterisation of diverse PRF1 mutations leading to decreased natural killer cell activity in North American families with haemophagocytic lymphohistiocytosis
    S Molleran Lee
    J Med Genet 41:137-44. 2004
  6. ncbi request reprint Association between apolipoprotein CI HpaI polymorphism and sporadic Alzheimer's disease in Chinese
    J Shi
    Department of Medical Genetics, West China Hospital, Sichuan University, Chengdu, China
    Acta Neurol Scand 109:140-5. 2004
    ..To investigate into the relationship of apolipoprotein CI (ApoCI) polymorphism with sporadic Alzheimer's disease (AD) in Chinese...
  7. ncbi request reprint Dopamine depletion abolishes apomorphine- and amphetamine-induced increases in extracellular serotonin levels in the striatum of conscious rats: a microdialysis study
    A Balcioglu
    Neuroregeneration Laboratories, McLean Hospital, Harvard Medical School, 115 Mill Street, Belmont, MA 02478, USA
    Neuroscience 119:1045-53. 2003
    ..Addressing whether this impairment has significance in the onset of PD might lead to development of new strategies to manage parkinsonian symptoms...
  8. ncbi request reprint The power of transmission disequilibrium tests for quantitative traits
    J Li
    Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, Connecticut, USA
    Genet Epidemiol 21:S632-7. 2001
    ..Finally, we apply these methods to the Genetic Analysis Workshop 12 simulated data and compare their power...
  9. pmc Identification and functional consequences of a new mutation (E155G) in the gene for GCAP1 that causes autosomal dominant cone dystrophy
    S E Wilkie
    Division of Molecular Genetics, Institute of Ophthalmology, University College London, London EC1V 9EL, United Kingdom
    Am J Hum Genet 69:471-80. 2001
    ..The overall effect of this would be the constitutive activation of guanylate cyclase in photoreceptors, even at the high Ca2+ concentrations of the dark-adapted state, which may explain the dominant disease phenotype...
  10. ncbi request reprint A dominant Stargardt's macular dystrophy locus maps to chromosome 13q34
    K Zhang
    Department of Genetics, Brigham and Women s Hospital, Boston, Mass
    Arch Ophthalmol 112:759-64. 1994
    ..To identify the chromosomal location of a mutated gene that causes an autosomal dominant Stargardt's macular dystrophy...
  11. ncbi request reprint CD58 (LFA-3) stimulation provides a signal for human isotype switching and IgE production distinct from CD40
    D Diaz-Sanchez
    Hart and Louise Lyon Laboratory, Department of Medicine, UCLA School of Medicine 90024 1680
    J Immunol 153:10-20. 1994
    ..Given the relative importance of CD2 triggering on mucosal T cells and the mucosal location of IgE production, this may be especially true on mucosal surfaces...