Katherine E Yutzey


Affiliation: Cincinnati Children's Hospital Medical Center
Country: USA


  1. Hulin A, Hortells L, Gomez Stallons M, O Donnell A, Chetal K, Adam M, et al. Maturation of heart valve cell populations during postnatal remodeling. Development. 2019;: pubmed publisher
  2. Yutzey K. Cardiomyocyte Proliferation: Teaching an Old Dogma New Tricks. Circ Res. 2017;120:627-629 pubmed publisher
  3. Fang M, Alfieri C, Hulin A, Conway S, Yutzey K. Loss of β-catenin promotes chondrogenic differentiation of aortic valve interstitial cells. Arterioscler Thromb Vasc Biol. 2014;34:2601-8 pubmed publisher
    ..Catenin limits Sox9 nuclear localization and inhibits chondrogenic differentiation during valve development and in adult aortic valve homeostasis. ..
  4. Fang M, Xiang F, Braitsch C, Yutzey K. Epicardium-derived fibroblasts in heart development and disease. J Mol Cell Cardiol. 2016;91:23-7 pubmed publisher
    ..This article is part of a special issue entitled "Fibrosis and Myocardial Remodeling". ..
  5. Gomez Stallons M, Wirrig Schwendeman E, Hassel K, Conway S, Yutzey K. Bone Morphogenetic Protein Signaling Is Required for Aortic Valve Calcification. Arterioscler Thromb Vasc Biol. 2016;36:1398-405 pubmed publisher
    ..Importantly, BMP signaling is required for the development of AoV calcification in vitro and in vivo. ..
  6. Amofa D, Hulin A, Nakada Y, Sadek H, Yutzey K. Hypoxia promotes primitive glycosaminoglycan-rich extracellular matrix composition in developing heart valves. Am J Physiol Heart Circ Physiol. 2017;313:H1143-H1154 pubmed publisher
    ..Thus, hypoxia maintains a primitive extracellular matrix during heart valve development and promotes extracellular matrix remodeling in adult mice, as occurs in myxomatous disease. ..
  7. Hulin A, Anstine L, Kim A, Potter S, DeFalco T, Lincoln J, et al. Macrophage Transitions in Heart Valve Development and Myxomatous Valve Disease. Arterioscler Thromb Vasc Biol. 2018;38:636-644 pubmed publisher
  8. Lee M, Ratner N, Yutzey K. Genome-wide Twist1 occupancy in endocardial cushion cells, embryonic limb buds, and peripheral nerve sheath tumor cells. BMC Genomics. 2014;15:821 pubmed publisher
    ..In addition, there is a small subset of genes occupied by Twist1 in all three tissues that may represent a core group of Twist1 target genes in multiple cell types. ..
  9. Wirrig E, Gomez M, Hinton R, Yutzey K. COX2 inhibition reduces aortic valve calcification in vivo. Arterioscler Thromb Vasc Biol. 2015;35:938-47 pubmed publisher
    ..COX2 expression is upregulated in CAVD, and its activity contributes to osteogenic gene induction and valve calcification in vitro and in vivo. ..

More Information


  1. Xiang F, Guo M, Yutzey K. Overexpression of Tbx20 in Adult Cardiomyocytes Promotes Proliferation and Improves Cardiac Function After Myocardial Infarction. Circulation. 2016;133:1081-92 pubmed publisher
    ..Tbx20(OE), specifically in adult CM, activates multiple cardiac proliferative pathways, directly represses cell-cycle inhibitory genes p21, Meis1, and Btg2, promotes adult CM proliferation; and preserves cardiac performance after MI. ..
  2. Wu B, Wang Y, Xiao F, Butcher J, Yutzey K, Zhou B. Developmental Mechanisms of Aortic Valve Malformation and Disease. Annu Rev Physiol. 2017;79:21-41 pubmed publisher
  3. Hulin A, Moore V, JAMES J, Yutzey K. Loss of Axin2 results in impaired heart valve maturation and subsequent myxomatous valve disease. Cardiovasc Res. 2017;113:40-51 pubmed publisher
    ..Altogether, these data indicate that Axin2 limits Wnt/?-catenin signalling after birth and allows proper heart valve maturation. Moreover, dysregulation of Wnt/?-catenin signalling resulting from loss of Axin2 leads to progressive MVD. ..
  4. Xiang F, Fang M, Yutzey K. Loss of ?-catenin in resident cardiac fibroblasts attenuates fibrosis induced by pressure overload in mice. Nat Commun. 2017;8:712 pubmed publisher
    ..Here, the authors show that Wnt/?-catenin signaling in resident cardiac fibroblasts is required for deposition of fibrotic extracellular matrix and the regulation of cardiomyocyte hypertrophy in a mouse model of heart fibrosis. ..