Yan Xu

Summary

Affiliation: Cincinnati Children's Hospital Medical Center
Country: USA

Publications

  1. pmc Transcriptional programs controlling perinatal lung maturation
    Yan Xu
    The Perinatal Institute and Section of Neonatology, Perinatal and Pulmonary Biology, University of Cincinnati, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio, USA
    PLoS ONE 7:e37046. 2012
  2. pmc Gene expression and biological processes influenced by deletion of Stat3 in pulmonary type II epithelial cells
    Yan Xu
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, 3333 Burnet Avenue, Cincinnati, OH, USA
    BMC Genomics 8:455. 2007
  3. ncbi request reprint Functional genomic responses to cystic fibrosis transmembrane conductance regulator (CFTR) and CFTR(delta508) in the lung
    Yan Xu
    Division of Pulmonary Biology, Department of Pediatrics, Cincinnati Children s Hospital Medical Center and the University of Cincinnati College of Medicine, Cincinnati, Ohio 45229 3039, USA
    J Biol Chem 281:11279-91. 2006
  4. pmc A systems approach to mapping transcriptional networks controlling surfactant homeostasis
    Yan Xu
    Division of Pulmonary Biology, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH, USA
    BMC Genomics 11:451. 2010
  5. ncbi request reprint Compensatory roles of Foxa1 and Foxa2 during lung morphogenesis
    Huajing Wan
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center and the University of Cincinnati College of Medicine, Cincinnati, Ohio 45229 3039, USA
    J Biol Chem 280:13809-16. 2005
  6. doi request reprint Kruppel-like factor 5 is required for perinatal lung morphogenesis and function
    Huajing Wan
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center and the University of Cincinnati College of Medicine, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
    Development 135:2563-72. 2008
  7. pmc Calcineurin/Nfat signaling is required for perinatal lung maturation and function
    Vrushank Dave
    Section of Neonatology, Perinatal and Pulmonary Biology, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA
    J Clin Invest 116:2597-609. 2006
  8. pmc STAT3 regulates ABCA3 expression and influences lamellar body formation in alveolar type II cells
    Yohei Matsuzaki
    Cincinnati Children s Hospital Medical Center, Section of Neonatology, Perinatal and Pulmonary Biology, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
    Am J Respir Cell Mol Biol 38:551-8. 2008
  9. pmc Meckel-Gruber syndrome protein MKS3 is required for endoplasmic reticulum-associated degradation of surfactant protein C
    Mei Wang
    Division of Pulmonary Biology, Cincinnati Children s Research Foundation, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229 3039, USA
    J Biol Chem 284:33377-83. 2009
  10. ncbi request reprint Foxa2 programs Th2 cell-mediated innate immunity in the developing lung
    Gang Chen
    Section of Neonatology, Perinatal and Pulmonary Biology, Perinatal Institute, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229 3039, USA
    J Immunol 184:6133-41. 2010

Collaborators

Detail Information

Publications89

  1. pmc Transcriptional programs controlling perinatal lung maturation
    Yan Xu
    The Perinatal Institute and Section of Neonatology, Perinatal and Pulmonary Biology, University of Cincinnati, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio, USA
    PLoS ONE 7:e37046. 2012
    ..The present study systemically mapped key regulators, bioprocesses, and transcriptional networks controlling lung maturation, providing the basis for new therapeutic strategies to enhance lung function in preterm infants...
  2. pmc Gene expression and biological processes influenced by deletion of Stat3 in pulmonary type II epithelial cells
    Yan Xu
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, 3333 Burnet Avenue, Cincinnati, OH, USA
    BMC Genomics 8:455. 2007
    ..Differentially expressed genes were identified from Affymetrix Murine GeneChips analysis and subjected to gene ontology classification, promoter analysis, pathway mapping and literature mining...
  3. ncbi request reprint Functional genomic responses to cystic fibrosis transmembrane conductance regulator (CFTR) and CFTR(delta508) in the lung
    Yan Xu
    Division of Pulmonary Biology, Department of Pediatrics, Cincinnati Children s Hospital Medical Center and the University of Cincinnati College of Medicine, Cincinnati, Ohio 45229 3039, USA
    J Biol Chem 281:11279-91. 2006
    ..Genes and pathways involved in the response to CFTR may be of interest as modifiers of CF...
  4. pmc A systems approach to mapping transcriptional networks controlling surfactant homeostasis
    Yan Xu
    Division of Pulmonary Biology, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH, USA
    BMC Genomics 11:451. 2010
    ..The mechanisms regulating these interrelated processes are largely unknown...
  5. ncbi request reprint Compensatory roles of Foxa1 and Foxa2 during lung morphogenesis
    Huajing Wan
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center and the University of Cincinnati College of Medicine, Cincinnati, Ohio 45229 3039, USA
    J Biol Chem 280:13809-16. 2005
    ..Foxa family members regulate signaling and transcriptional programs required for morphogenesis and cell differentiation during formation of the lung...
  6. doi request reprint Kruppel-like factor 5 is required for perinatal lung morphogenesis and function
    Huajing Wan
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center and the University of Cincinnati College of Medicine, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
    Development 135:2563-72. 2008
    ..KLF5 regulates genes controlling paracrine interactions during lung morphogenesis, as well as those regulating the maturation of the respiratory epithelium that is required for lung function after birth...
  7. pmc Calcineurin/Nfat signaling is required for perinatal lung maturation and function
    Vrushank Dave
    Section of Neonatology, Perinatal and Pulmonary Biology, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA
    J Clin Invest 116:2597-609. 2006
    ..The calcineurin/Nfat pathway controls the morphologic maturation of lungs prior to birth and regulates expression of genes involved in surfactant homeostasis that are critical for adaptation to air breathing...
  8. pmc STAT3 regulates ABCA3 expression and influences lamellar body formation in alveolar type II cells
    Yohei Matsuzaki
    Cincinnati Children s Hospital Medical Center, Section of Neonatology, Perinatal and Pulmonary Biology, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
    Am J Respir Cell Mol Biol 38:551-8. 2008
    ..ABCA3 expression is regulated by IL-6 in a pathway that includes STAT3, PI3K, AKT, SCAP, and SREBP. Activation of STAT3 after exposure to IL-6 enhances ABCA3 expression, which, in turn, influences pulmonary surfactant homeostasis...
  9. pmc Meckel-Gruber syndrome protein MKS3 is required for endoplasmic reticulum-associated degradation of surfactant protein C
    Mei Wang
    Division of Pulmonary Biology, Cincinnati Children s Research Foundation, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229 3039, USA
    J Biol Chem 284:33377-83. 2009
    ..These results support a model in which MKS3 links the ER lumenal quality control machinery with the cytosolic degradation apparatus...
  10. ncbi request reprint Foxa2 programs Th2 cell-mediated innate immunity in the developing lung
    Gang Chen
    Section of Neonatology, Perinatal and Pulmonary Biology, Perinatal Institute, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229 3039, USA
    J Immunol 184:6133-41. 2010
    ..The respiratory epithelium plays a central role in the regulation of Th2-mediated inflammation and innate immunity in the developing lung in a process regulated by Foxa2...
  11. ncbi request reprint C/EBPalpha is required for lung maturation at birth
    Prithy C Martis
    Division of Pulmonary Biology and Neonatology, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
    Development 133:1155-64. 2006
    ..C/EBPalpha participates in a transcriptional network that is required for the regulation of genes mediating perinatal lung maturation and surfactant homeostasis that is necessary for adaptation to air breathing at birth...
  12. pmc Kruppel-like factor 5 is required for formation and differentiation of the bladder urothelium
    Sheila M Bell
    Perinatal Institute of Cincinnati Children s Hospital Medical Center, Division of Neonatology Perinatal Pulmonary Biology, University of Cincinnati College of Medicine, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
    Dev Biol 358:79-90. 2011
    ..Deletion of Klf5 from the developing bladder urothelium blocked epithelial cell differentiation, impaired bladder morphogenesis and function causing hydroureter and hydronephrosis at birth...
  13. ncbi request reprint Stat3 is required for cytoprotection of the respiratory epithelium during adenoviral infection
    Yohei Matsuzaki
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
    J Immunol 177:527-37. 2006
    ..Thus, Stat3 plays a critical cytoprotective role that is required for epithelial cell survival and maintenance of alveolar structures during the early phases of pulmonary adenoviral infection...
  14. pmc SPDEF is required for mouse pulmonary goblet cell differentiation and regulates a network of genes associated with mucus production
    Gang Chen
    The Perinatal Institute, Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center and the University of Cincinnati School of Medicine, 3333 Burnet Avenue, Cincinnati, Ohio 45229, USA
    J Clin Invest 119:2914-24. 2009
    ..These data show that SPDEF plays a critical role in regulating a transcriptional network mediating the goblet cell differentiation and mucus hyperproduction associated with chronic pulmonary disorders...
  15. pmc C/EBP{alpha} is required for pulmonary cytoprotection during hyperoxia
    Yan Xu
    Cincinnati Children s Hospital Medical Center, University of Cincinnati, Ohio 45229 3039, USA
    Am J Physiol Lung Cell Mol Physiol 297:L286-98. 2009
    ..While C/EBPalpha did not play a critical role in postnatal pulmonary function under normal conditions, C/EBPalpha mediated protection of the lung during acute lung injury induced by hyperoxia...
  16. ncbi request reprint Transcriptional adaptation to cystic fibrosis transmembrane conductance regulator deficiency
    Yan Xu
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
    J Biol Chem 278:7674-82. 2003
    ..Absence of CFTR influenced the expression of genes modulating diverse pulmonary cell functions that may ameliorate or contribute to the pathogenesis of CF...
  17. ncbi request reprint Beta-catenin regulates differentiation of respiratory epithelial cells in vivo
    Michael L Mucenski
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH 45229 3039, USA
    Am J Physiol Lung Cell Mol Physiol 289:L971-9. 2005
    ....
  18. pmc Kruppel-like factor 5 is not required for K-RasG12D lung tumorigenesis, but represses ABCG2 expression and is associated with better disease-specific survival
    Sara E Meyer
    Division of Immunobiology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio, USA
    Am J Pathol 177:1503-13. 2010
    ..In summary, while KLF5 is not required for oncogenic mutant K-Ras-induced lung tumorigenesis, KLF5 regulation of ABCG2 expression may be important for chemotherapeutic resistance and patient survival...
  19. pmc Kras(G12D) and Nkx2-1 haploinsufficiency induce mucinous adenocarcinoma of the lung
    Yutaka Maeda
    Perinatal Institute, Section of Neonatology, Perinatal and Pulmonary Biology, Cincinnati Children s Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, Ohio 45229 3039, USA
    J Clin Invest 122:4388-400. 2012
    ..NKX2-1 inhibited both AP-1 activity and tumor colony formation in vitro. These data demonstrate that NKX2-1 functions in a context-dependent manner in lung tumorigenesis and inhibits Kras(G12D)-driven mucinous pulmonary adenocarcinoma...
  20. pmc Foxa2 is required for transition to air breathing at birth
    Huajing Wan
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center and University of Cincinnati College of Medicine, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
    Proc Natl Acad Sci U S A 101:14449-54. 2004
    ..Foxa2 regulates a complex pulmonary program of epithelial cell maturation required for transition to air breathing at birth...
  21. pmc Activation of sterol-response element-binding proteins (SREBP) in alveolar type II cells enhances lipogenesis causing pulmonary lipotoxicity
    Laurent Plantier
    Section of Neonatology, Perinatal and Pulmonary Biology, Perinatal Institute, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    J Biol Chem 287:10099-114. 2012
    ..Deletion of Insig1/2 activated SREBP-enhancing lipogenesis in respiratory epithelial cells resulting in lipotoxicity-related lung inflammation and tissue remodeling...
  22. pmc ERdj4 and ERdj5 are required for endoplasmic reticulum-associated protein degradation of misfolded surfactant protein C
    Mei Dong
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, and the University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
    Mol Biol Cell 19:2620-30. 2008
    ..ERdj4 and ERdj5 promote turnover of misfolded SP-C and this activity is dependent on their ability to stimulate BiP ATPase activity...
  23. pmc Deletion of Scap in alveolar type II cells influences lung lipid homeostasis and identifies a compensatory role for pulmonary lipofibroblasts
    Valérie Besnard
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, Department of Pediatrics, The University of Cincinnati College of Medicine, Cincinnati, Ohio 45229 3039, USA
    J Biol Chem 284:4018-30. 2009
    ..Deletion of the SCAP/SREBP pathway in respiratory epithelial cells altered lung lipid homeostasis and induced compensatory lipid accumulation and synthesis in lung lipofibroblasts...
  24. pmc Persistence of LPS-induced lung inflammation in surfactant protein-C-deficient mice
    Stephan W Glasser
    1 Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio
    Am J Respir Cell Mol Biol 49:845-54. 2013
    ..Phospholipid vesicles alone did not modify the TLR4 response. In vivo deficiency of SP-C leads to inflammation, increased cytokine production by type II cells, and persistent inflammation after repetitive LPS stimulation...
  25. pmc Orphan G protein-coupled receptor GPR116 regulates pulmonary surfactant pool size
    James P Bridges
    Perinatal Institute, Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Am J Respir Cell Mol Biol 49:348-57. 2013
    ..Collectively, these data support the concept that GPR116 functions as a molecular sensor of alveolar surfactant lipid pool sizes by regulating surfactant secretion. ..
  26. pmc Kruppel-like factor 5 controls villus formation and initiation of cytodifferentiation in the embryonic intestinal epithelium
    Sheila M Bell
    Perinatal Institute, Divisions of Neonatology Perinatal Pulmonary Biology, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
    Dev Biol 375:128-39. 2013
    ..These studies indicate a novel requirement for KLF5 to initiate morphogenesis of the early endoderm into a compartmentalized intestinal epithelium comprised of villi and terminally differentiated cells...
  27. ncbi request reprint Sterol response element binding protein and thyroid transcription factor-1 (Nkx2.1) regulate Abca3 gene expression
    Valérie Besnard
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center and the University of Cincinnati College of Medicine, Cincinnati, OH 45229 3039, USA
    Am J Physiol Lung Cell Mol Physiol 293:L1395-405. 2007
    ..Abca3 gene expression is mediated by discrete cis-acting cassettes that mediate pulmonary cell- and lipid-sensitive pathways regulating surfactant homeostasis...
  28. pmc Airway epithelial transcription factor NK2 homeobox 1 inhibits mucous cell metaplasia and Th2 inflammation
    Yutaka Maeda
    Perinatal Institute, Divisions of Neonatology, Perinatal, and Pulmonary Biology, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
    Am J Respir Crit Care Med 184:421-9. 2011
    ..Elucidation of the molecular mechanisms regulating mucous metaplasia and hypersecretion provides the scientific basis for diagnostic and therapeutic opportunities to improve the care of chronic pulmonary diseases...
  29. pmc Forkhead box M1 transcriptional factor is required for smooth muscle cells during embryonic development of blood vessels and esophagus
    Vladimir Ustiyan
    Divisions of Pulmonary Biology, Perinatal Institute of the Cincinnati Children s Hospital Research Foundation, 3333 Burnet Ave, Cincinnati, OH 45229, USA
    Dev Biol 336:266-79. 2009
    ..Foxm1 is critical for proliferation of smooth muscle cells and is required for proper embryonic development of blood vessels and esophagus...
  30. pmc Adaptation and increased susceptibility to infection associated with constitutive expression of misfolded SP-C
    James P Bridges
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, The University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
    J Cell Biol 172:395-407. 2006
    ..The wide variability in the age of onset of ILD in patients with SFTPC mutations may be related to environmental insults that ultimately overwhelm the homeostatic cytoprotective response...
  31. ncbi request reprint Expression of ABCA3 in developing lung and other tissues
    Mildred T Stahlman
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229 3039, USA
    J Histochem Cytochem 55:71-83. 2007
    ..The role of ABCA3 in extrapulmonary tissues and organs remains to be elucidated. This manuscript contains online supplemental material at (www.jhc.org). Please visit this article online to view these materials...
  32. pmc Conditional deletion of Abca3 in alveolar type II cells alters surfactant homeostasis in newborn and adult mice
    Valérie Besnard
    The Perinatal Institute and Section of Neonatology, Perinatal and Pulmonary Biology, Cincinnati Children s Hospital Medical Center, Department of Pediatrics and University of Cincinnati College of Medicine, Ohio
    Am J Physiol Lung Cell Mol Physiol 298:L646-59. 2010
    ..Compensatory surfactant synthesis was initiated in ABCA3-sufficient type II cells, indicating that surfactant homeostasis is a highly regulated process that includes sensing and coregulation among alveolar type II cells...
  33. pmc Misexpression of MIA disrupts lung morphogenesis and causes neonatal death
    Sui Lin
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
    Dev Biol 316:441-55. 2008
    ..These results suggest that the silencing of Mia1 that occurs in late gestation may be required for maturation of the surfactant system...
  34. pmc CCAAT/enhancer binding protein-α regulates the protease/antiprotease balance required for bronchiolar epithelium regeneration
    Atsuyasu Sato
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229 3039, USA
    Am J Respir Cell Mol Biol 47:454-63. 2012
    ..Treatment with serine protease inhibitor may aid in the recovery of injured bronchiolar epithelial cells, and prevent common chronic lung diseases...
  35. pmc Maternal synchronization of gestational length and lung maturation
    Valérie Besnard
    The Perinatal Institute and Section of Neonatology, Perinatal and Pulmonary Biology, Cincinnati Children s Hospital Medical Center, the Department of Pediatrics and The University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America
    PLoS ONE 6:e26682. 2011
    ..Ovarian transfer experiments demonstrated that maternal genotype determines the timing of birth and can influence fetal lung growth and maturation to ensure perinatal survival...
  36. ncbi request reprint Sox17 is required for normal pulmonary vascular morphogenesis
    Alexander W Lange
    Perinatal Institute, Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, The University of Cincinnati College of Medicine, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, United States
    Dev Biol 387:109-20. 2014
    ..The severity of the postnatal cardiac phenotype was correlated with the severity of pulmonary vasculature abnormalities. Sox17 is required for normal formation of the pulmonary vasculature and postnatal cardiovascular homeostasis...
  37. ncbi request reprint Genetic disorders of surfactant homeostasis
    Jeffrey A Whitsett
    Section of Neonatology, Perinatal and Pulmonary Biology, Cincinnati Children s Hospital Medical Center, The University of Cincinnati College of Medicine, Cincinnati, OH 45229 3039, USA
    Biol Neonate 87:283-7. 2005
    ....
  38. ncbi request reprint Elf5 is an epithelium-specific, fibroblast growth factor-sensitive transcription factor in the embryonic lung
    David E Metzger
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
    Dev Dyn 236:1175-92. 2007
    ..5 lungs. These results demonstrate that Elf5 is an FGF-sensitive transcription factor in the lung with a dynamic pattern of expression and that FGF regulation of Elf5 by means of FGFR2b occurs through the PI3-Kinase/Akt pathway...
  39. pmc Epithelial SCAP/INSIG/SREBP signaling regulates multiple biological processes during perinatal lung maturation
    James P Bridges
    Perinatal Institute, Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio, United States of America
    PLoS ONE 9:e91376. 2014
    ..SREBP regulates perinatal lung lipogenesis and maturation through multiple mechanisms by interactions with distinct sets of regulatory partners...
  40. ncbi request reprint Role of Sonic hedgehog in patterning of tracheal-bronchial cartilage and the peripheral lung
    Leigh Anne D Miller
    Department of Pediatrics, Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    Dev Dyn 231:57-71. 2004
    ..SHH regulates branching morphogenesis and influences differentiation of the peripheral lung mesenchyme required for formation of bronchial and vascular smooth muscle...
  41. ncbi request reprint Macrophage dysfunction and susceptibility to pulmonary Pseudomonas aeruginosa infection in surfactant protein C-deficient mice
    Stephan W Glasser
    Division of Pulmonary Biology, Department of Pediatrics, Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229 3039, USA
    J Immunol 181:621-8. 2008
    ..SP-C plays an important role in innate host defense of the lung, enhancing macrophage-mediated Pseudomonas phagocytosis, clearance and limiting pulmonary inflammatory responses...
  42. pmc Comparative proteomic analysis of lung lamellar bodies and lysosome-related organelles
    Ross Ridsdale
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, and Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America
    PLoS ONE 6:e16482. 2011
    ..The lung LB proteome will facilitate identification of molecular pathways involved in LB biogenesis, surfactant homeostasis and disease pathogenesis...
  43. pmc 4-Phenylbutyric acid treatment rescues trafficking and processing of a mutant surfactant protein-C
    Gareth A Stewart
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, 3333 Burnet Ave, MLC7029, Cincinnati, OH 45229 3039, USA
    Am J Respir Cell Mol Biol 47:324-31. 2012
    ..This study provides proof of the principle that a chemical chaperone can correct the mistrafficking and processing of a disease-associated mutant SP-C proprotein...
  44. ncbi request reprint Hypoxia enhances lysophosphatidic acid responsiveness in ovarian cancer cells and lysophosphatidic acid induces ovarian tumor metastasis in vivo
    Kwan Sik Kim
    Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA
    Cancer Res 66:7983-90. 2006
    ..HIF1 alpha plays a critical role in enhancing and/or sensitizing the role of LPA on cell migration and invasion under hypoxic conditions, where cPLA(2) is required for LPA-induced cell migration...
  45. ncbi request reprint Lysosomal acid lipase deficiency causes respiratory inflammation and destruction in the lung
    Xuemei Lian
    Div of Human Genetics, Cincinnati Children s Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH 45229 3039, USA
    Am J Physiol Lung Cell Mol Physiol 286:L801-7. 2004
    ..The studies support the concept that neutral lipid metabolites play essential roles in pulmonary homeostasis, inflammatory responses, remodeling, and injury repair...
  46. ncbi request reprint Lysophosphatidic acid is constitutively produced by human peritoneal mesothelial cells and enhances adhesion, migration, and invasion of ovarian cancer cells
    Juan Ren
    Department of Cancer Biology, Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, Ohio, USA
    Cancer Res 66:3006-14. 2006
    ..Conditioned medium from peritoneal mesothelial cells stimulate migration, adhesion, and invasion of ovarian cancer cells, and may play similar roles in vivo...
  47. ncbi request reprint Plasma lysophosphatidylcholine levels: potential biomarkers for colorectal cancer
    Zhenwen Zhao
    Department of Cancer Biology, Lerner Research Institute, Taussig Cancer Center, Cleveland Clinic, Cleveland, OH, USA
    J Clin Oncol 25:2696-701. 2007
    ..Plasma levels of lysophospholipids were evaluated as potential biomarkers for colorectal cancer (CRC), where a highly reliable and minimally invasive blood test is lacking...
  48. ncbi request reprint Defective lipoxin-mediated anti-inflammatory activity in the cystic fibrosis airway
    Christopher L Karp
    Division of Molecular Immunology, Cincinnati Children s Hospital Medical Center, and University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA
    Nat Immunol 5:388-92. 2004
    ..These findings suggest that there is a pathophysiologically important defect in lipoxin-mediated anti-inflammatory activity in the cystic fibrosis lung and that lipoxins have therapeutic potential in this lethal autosomal disease...
  49. ncbi request reprint Expression of cyclooxygenase isoforms in developing rat placenta, human term placenta, and BeWo human trophoblast model
    Yan Xu
    Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854 8020, USA
    Mol Pharm 2:481-90. 2005
    ....
  50. ncbi request reprint Identification of genes uniquely involved in frequent microsatellite instability colon carcinogenesis by expression profiling combined with epigenetic scanning
    Yuriko Mori
    Department of Medicine, Division of Gastroenterology, University of Maryland School of Medicine and Greenebaum Cancer Center and Baltimore Veterans Affairs Hospital, Baltimore, Maryland, USA
    Cancer Res 64:2434-8. 2004
    ..This methylation screening strategy should identify additional genes inactivated by epigenetic silencing in colorectal and other cancers...
  51. ncbi request reprint Activation of the esophagin promoter during esophageal epithelial cell differentiation
    Kara N Smolinski
    Department of Medicine, Gastroenterology Division and Greenebaum Cancer Center, University of Maryland School of Medicine, 22 S Greene Street, Baltimore, MD 21201, USA
    Genomics 79:875-80. 2002
    ....
  52. ncbi request reprint Blocking of N-acetylglucosaminyltransferase V induces cellular endoplasmic reticulum stress in human hepatocarcinoma 7,721 cells
    Huan Fang
    State Key Laboratory of Genetic Engineering, Department of Biochemistry, Shanghai Medical College, Fudan University, 138 Yi Xue Yuan Road, Shanghai 200032, China
    Cell Res 16:82-92. 2006
    ..These results supported the mechanism that blocking of GnT-V expression impaired functions of chaperones and N-glycan-synthesizing enzymes, which caused UPR in vivo...
  53. ncbi request reprint TTF-1 phosphorylation is required for peripheral lung morphogenesis, perinatal survival, and tissue-specific gene expression
    Mario DeFelice
    Stazione Zoologica A Dohrn, Villa Comunale, 80121 Naples, Italy
    J Biol Chem 278:35574-83. 2003
    ..Direct and indirect transcriptional targets of TTF-1 were identified that are likely to play important roles in lung formation and function...
  54. ncbi request reprint Exogenous IL-7 induces Fas-mediated human neuronal apoptosis: potential effects during human immunodeficiency virus type 1 infection
    Giuseppe Nunnari
    Center for Human Virology and Biodefense, Division of Infectious Diseases and Environmental Medicine, Department of Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    J Neurovirol 11:319-28. 2005
    ....
  55. ncbi request reprint Application of cDNA microarrays to generate a molecular taxonomy capable of distinguishing between colon cancer and normal colon
    Tong Tong Zou
    Department of Medicine, Division of Gastroenterology and Greenebaum Cancer Center, University of Maryland School of Medicine and Baltimore VA Hospital, Baltimore, Maryland, MD 21201, USA
    Oncogene 21:4855-62. 2002
    ..Our data suggests that a large-scale approach may be undertaken with the purpose of identifying biomarkers relevant to cancer progression...
  56. ncbi request reprint Palmitoyl-protein thioesterase-1 deficiency mediates the activation of the unfolded protein response and neuronal apoptosis in INCL
    Zhongjian Zhang
    Section on Developmental Genetics, Heritable Disorders Branch, National Institute of Child Health and Human Development, The National Institutes of Health, Bethesda, MD 20892 1830, USA
    Hum Mol Genet 15:337-46. 2006
    ..Our results, for the first time, link PPT1 deficiency with the activation of UPR, apoptosis and neurodegeneration in INCL and identify potential targets for therapeutic intervention in this uniformly fatal disease...
  57. pmc Upregulation of a tonoplast-localized cytochrome P450 during petal senescence in Petunia inflata
    Yan Xu
    Department of Molecular Biology and Genetics, Biotechnology Building, Cornell University, Ithaca, NY 14853, USA
    BMC Plant Biol 6:8. 2006
    ..Expression of a number of genes and various enzyme activities involved in the degradation and remobilization of macromolecules have been found to be upregulated during the early stages of petal senescence...
  58. ncbi request reprint Artificial neural networks and gene filtering distinguish between global gene expression profiles of Barrett's esophagus and esophageal cancer
    Yan Xu
    Department of Medicine, Division of Gastroenterology, Greenebaum Cancer Center, University of Maryland School of Medicine, Baltimore VA Hospital, 21201, USA
    Cancer Res 62:3493-7. 2002
    ..Finally, the 160 genes selected by SAM may merit further study as biomarkers of neoplastic progression in the esophagus, as well as in elucidating pathological mechanisms underlying BA and CA...
  59. ncbi request reprint Potential treatment of cerebral global ischemia with Oct-4+ umbilical cord matrix cells
    Sachiko Jomura
    Department of Anesthesiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15260, USA
    Stem Cells 25:98-106. 2007
    ..The Oct-4(+) RUCM cells might repair nonfocal tissue damage by an extracellular signaling mechanism. Treating cerebral global ischemia with umbilical cord matrix cells seems promising and worthy of further investigation...
  60. ncbi request reprint The lysophosphatidic acid receptor LPA1 links pulmonary fibrosis to lung injury by mediating fibroblast recruitment and vascular leak
    Andrew M Tager
    Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Harvard Medical School, CNY149 8301, 149 13th Street, Charlestown, Massachusetts 02129 USA
    Nat Med 14:45-54. 2008
    ..LPA1 therefore represents a new therapeutic target for diseases in which aberrant responses to injury contribute to fibrosis, such as idiopathic pulmonary fibrosis...
  61. ncbi request reprint Production of lysophosphatidylcholine by cPLA2 in the brain of mice lacking PPT1 is a signal for phagocyte infiltration
    Zhongjian Zhang
    Section on Developmental Genetics, Heritable Disorders Branch, National Institute of Child Health and Human Developement, The National Institutes of Health, Bethesda, MD 20892 1830, USA
    Hum Mol Genet 16:837-47. 2007
    ..We propose that increased cPLA(2)-catalyzed LPC production in the brain is at least one of the mechanisms that mediate phagocyte infiltration contributing to INCL neuropathology...
  62. ncbi request reprint Inactivation of p16, RUNX3, and HPP1 occurs early in Barrett's-associated neoplastic progression and predicts progression risk
    Karsten Schulmann
    Division of Gastroenterology, School of Medicine, University of Maryland, Baltimore, MD 21201, USA
    Oncogene 24:4138-48. 2005
    ..These findings have implications regarding risk stratification, early EAC detection, and the appropriate endoscopic surveillance interval for patients with BE...
  63. ncbi request reprint Effects of brominated flame retardants and brominated dioxins on steroidogenesis in H295R human adrenocortical carcinoma cell line
    Ling Ding
    State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan 430072, People s Republic of China
    Environ Toxicol Chem 26:764-72. 2007
    ..6- to 20-fold. The results demonstrate that bromophenol, bromobiphenyls, and bromodibenzo-p-dioxin/furan are able to modulate steroidogenic gene expression, which may lead to endocrine disruption...
  64. ncbi request reprint Hypermethylation of HPP1 is associated with hMLH1 hypermethylation in gastric adenocarcinomas
    David M Shibata
    Division of Surgical Oncology, Department of Surgery, University of Maryland School of Medicine, Baltimore 21201, USA
    Cancer Res 62:5637-40. 2002
    ..Moreover, hMLH1 hypermethylation occurs predominantly in the setting of HPP1 hypermethylation. HPP1 hypermethylation may represent an early event in mismatch repair-deficient gastric tumorigenesis...
  65. ncbi request reprint [Construction of eukaryote expression vector carrying human soluble interleukin-1 receptor gene]
    Peng Li
    Department of Oral and Maxillofacial Surgery, West China College of Stomatology, Sichuan University, Chengdu 610041, China
    Hua Xi Kou Qiang Yi Xue Za Zhi 21:140-3. 2003
    ..The purpose of this study was to construct a eukaryote expression vector carrying human sIL-1R gene...
  66. ncbi request reprint Production of galacto-oligosaccharides by immobilized recombinant beta-galactosidase from Aspergillus candidus
    Pu Zheng
    Key Laboratory of Industry Biotechnology, Ministry of Education, Southern Yangtze University, Wuxi, PR China
    Biotechnol J 1:1464-70. 2006
    ..The average yield of GOSs was 32%, corresponding to the average productivity of 64 g/L.h, which implied that the immobilized recombinant beta-galactosidase has potential application for GOS production...
  67. ncbi request reprint [Expression changes of Notch-related genes during the differentiation of human mesenchymal stem cells into neurons]
    Ying Xing
    The Stem Cells Research Center, China
    Sheng Li Xue Bao 59:267-72. 2007
    ..Based on these findings, we propose that low level of Notch signaling activation may contribute to neural cell differentiation...
  68. ncbi request reprint [HPV DNA vaccines expressing recombinant CRT/HPV6bE7 fusion protein inhibit tumor growth and angiogenic activity]
    Yan Xu
    Sir Run Run Shaw Hospital, Zhejiang University Medical School, Hangzhou 310016, China
    Bing Du Xue Bao 23:466-70. 2007
    ..The antiangiogenic activity of CRT were suggested residing in a domain between CRT 120-180 aa...
  69. ncbi request reprint Efficient and erroneous incorporation of oxidized DNA precursors by human DNA polymerase eta
    Masatomi Shimizu
    Division of Genetics and Mutagenesis, National Institute of Health Sciences, Tokyo, Japan
    Biochemistry 46:5515-22. 2007
    ..We propose that human DNA polymerase eta may participate in oxidative mutagenesis through the efficient and erroneous incorporation of oxidized dNTPs during DNA synthesis...
  70. ncbi request reprint An unsupervised approach to identify molecular phenotypic components influencing breast cancer features
    Florin M Selaru
    Department of Medicine, Division of Gastroenterology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Cancer Res 64:1584-8. 2004
    ..Moreover, these findings illustrate the potential of PCs analysis to detect molecular phenotypic bases for relevant clinical or biological features of human tumors in general...
  71. ncbi request reprint Dependence of early cerebral reperfusion and long-term outcome on resuscitation efficiency after cardiac arrest in rats
    Yan Xu
    Department of Anesthesiology and Critical Care Medicine, University of Pittsburgh School of Medicine, PA 15261, USA
    Stroke 33:837-43. 2002
    ....
  72. ncbi request reprint Hypermethylation of the p14(ARF) gene in ulcerative colitis-associated colorectal carcinogenesis
    Fumiaki Sato
    Gastroenterology Division, Department of Medicine, University of Maryland School of Medicine and Gastroenterology Service, Baltimore, Maryland 21201, USA
    Cancer Res 62:1148-51. 2002
    ..p14(ARF) offers potential as a biomarker for the early detection of cancer or dysplasia in UC. Finally, analyses of p14(ARF) methylation in other organs should explore not only frank cancers but other premalignant lesions...
  73. ncbi request reprint Photodynamic therapy with hypericin induces vascular damage and apoptosis in the RIF-1 mouse tumor model
    Bin Chen
    Laboratorium voor Farmaceutische Biologie en Fytofarmacologie, Faculteit Farmaceutische Wetenschappen, K U Leuven, Belgium
    Int J Cancer 98:284-90. 2002
    ..In conclusion, our results demonstrate that apoptosis, likely occurring as a result of vascular damage, is responsible for the tumor eradication by PDT with hypericin in this tumor model...
  74. ncbi request reprint Molecular phenotype of inflammatory bowel disease-associated neoplasms with microsatellite instability
    Karsten Schulmann
    Division of Gastroenterology, Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Gastroenterology 129:74-85. 2005
    ..We sought to determine the frequency of high-level microsatellite instability (MSI-H) and the mutational and methylation profile of MSI-H IBD-related neoplasms (IBDNs)...
  75. ncbi request reprint Linkage disequilibrium and haplotype analysis of two single nucleotide polymorphisms in STK15 in Chinese
    Li Chen
    The Research Center for Medical Genomics and MOH Key Laboratory of Cell Biology, China Medical University, Shenyang 110001, China
    Yi Chuan Xue Bao 32:331-6. 2005
    ..11%), 91T-169G/91T-169A (4.15%), 91T-169A/91T-169A (1.55%). Whereas no 91A-169A haplotype was detected in all individuals examined in the current study, linkage disequilibrium (LD) between the two SNPs was found...
  76. ncbi request reprint Apoptotic cells induce migration of phagocytes via caspase-3-mediated release of a lipid attraction signal
    Kirsten Lauber
    Department of Internal Medicine I, University of Tubingen, Tubingen, Germany
    Cell 113:717-30. 2003
    ..These data suggest that in addition to eat-me signals, apoptotic cells display attraction signals to ensure the efficient removal of apoptotic cells and prevent postapoptotic necrosis...
  77. ncbi request reprint GPR4 plays a critical role in endothelial cell function and mediates the effects of sphingosylphosphorylcholine
    Kwan Sik Kim
    Department of Cancer Biology, Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    FASEB J 19:819-21. 2005
    ..Moreover, the effects of SPC on EC require SPC induced trans-phosphorylation and activation of the VEGF receptor 2. These results identify SPC and its receptor, GPR4, as critical regulators of the angiogenic potential of EC...
  78. doi request reprint Mapping of cytotoxic T lymphocytes epitopes in E7 antigen of human papillomavirus type 11
    Yan Xu
    Department of Dermatology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, PR China
    Arch Dermatol Res 300:235-42. 2008
    ..We propose that this epitope could be more helpful in the characterization of HPV control mechanism and be useful for the development of immunotherapeutic approaches for low-risk HPV infectious diseases such as CA...
  79. ncbi request reprint Therapeutic effect of cisapride on gastric injury following hemorrhagic shock resuscitation in rats
    Lian yang Zhang
    General Surgery Department, Daping Hospital, Research Institute of Field Surgery, Third Military Medical University, Chongqing 400042, China
    Chin J Traumatol 8:101-4. 2005
    ..To investigate the therapeutic effect of cisapride on gastric injury following hemorrhagic shock resuscitation...
  80. ncbi request reprint Esophagin and proliferating cell nuclear antigen (PCNA) are biomarkers of human esophageal neoplastic progression
    Martha C Kimos
    Department of Medicine Gastroenterology Division, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Int J Cancer 111:415-7. 2004
    ..Moreover, this combined staining approach also offers promise for detecting esophageal cancer in early, precancerous stages...
  81. pmc Simultaneous amplification and screening of whole plasmids using the T7 bacteriophage replisome
    Yan Xu
    BioHelix Corporation, 32 Tozer Road, Beverly, MA 01915, USA
    Nucleic Acids Res 34:e98. 2006
    ..By utilizing the helicase enzyme, circular DNA samples can be simultaneously screened and amplified at one constant temperature in one easy step...
  82. ncbi request reprint Tendon healing in vitro: activation of NIK, IKKalpha, IKKbeta, and NF- kappaB genes in signal pathway and proliferation of tenocytes
    Jin Bo Tang
    Hand Surgery Research Center, Department of Hand Surgery, Affiliated Hospital of Nantong Medical College, Nantong, Jiangsu, China
    Plast Reconstr Surg 113:1703-11. 2004
    ....
  83. ncbi request reprint LPA3 receptor mediates chemotaxis of immature murine dendritic cells to unsaturated lysophosphatidic acid (LPA)
    Liana C Chan
    Gladstone Institute of Cardiovascular Disease, San Francisco, CA 94158, USA
    J Leukoc Biol 82:1193-200. 2007
    ..In summary, our results indicate that immature mouse DCs migrate preferentially in response to unsaturated LPA and that LPA(3) is important in this response...
  84. ncbi request reprint Effects of EGF and bFGF on expression of microtubule-associated protein tau and MAP-2 mRNA in human umbilical cord mononuclear cells
    Wen Hai Yan
    Department of Pathophysiology, Medical College of Zhengzhou University, Zhengzhou 450052, PR China
    Cell Biol Int 29:153-7. 2005
    ..The same upregulatory tendency was noted for tau mRNA expression. It is concluded that MNCs derived from human UCB cells may express some neural specific molecules that can be upregulated by cytokines, especially EGF and bFGF together...
  85. ncbi request reprint Recombined DNA vaccines encoding calreticulin linked to HPV6bE7 enhance immune response and inhibit angiogenic activity in B16 melanoma mouse model expressing HPV 6bE7 antigen
    Ke Jia Zhao
    Department of Dermatology and Venereology, Sir Run Run Shaw Hospital, Zhejiang University Medical School, 3 East Qing Chun Road, Hangzhou, 310016, People s Republic of China
    Arch Dermatol Res 298:64-72. 2006
    ..This construct may be useful in preventing HPV-associated dermatosis and may be developed as a promising strategy to control CA...
  86. ncbi request reprint IL-10 mediates suppression of the CD8 T cell IFN-gamma response to a novel viral epitope in a primed host
    Xiao Song Liu
    Centre for Immunology and Cancer Research, Princess Alexandra Hospital, University of Queensland, Woolloongabba, Brisbane, Australia
    J Immunol 171:4765-72. 2003
    ..Induction of virus- or tumor Ag-specific CD8 effector T cells in the partially Ag-primed host may thus be facilitated by local neutralization of IL-10...
  87. ncbi request reprint Ovarian cancer G protein-coupled receptor 1, a new metastasis suppressor gene in prostate cancer
    Lisam Shanjukumar Singh
    Department of Obstetrics and Gynecology, Indiana University School of Medicine, 975 W Walnut St, Indianapolis, IN 46202, USA
    J Natl Cancer Inst 99:1313-27. 2007
    ..The ovarian cancer G protein-coupled receptor 1 (OGR1) gene has been shown to be expressed at lower levels in metastatic compared with primary prostate cancer tissues...
  88. ncbi request reprint Pathological TDP-43 in parkinsonism-dementia complex and amyotrophic lateral sclerosis of Guam
    Felix Geser
    Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, Alzheimer s Disease Core Center, Institute on Aging, University of Pennsylvania School of Medicine, Philadelphia, PA, 19104 4283, USA
    Acta Neuropathol 115:133-45. 2008
    ..Finally, we conclude that the spectrum of TDP-43 proteinopathies should be expanded to include neurodegenerative cognitive and motor diseases, affecting the Chamorro population of Guam...
  89. ncbi request reprint Tendon healing in vitro: promotion of collagen gene expression by bFGF with NF-kappaB gene activation
    Jin Bo Tang
    Hand Surgery Research Center, Department of Hand Surgery, Affiliated Hospital of Nantong Medical College, Nantong, Jiangsu, China
    J Hand Surg Am 28:215-20. 2003
    ..We investigated the effects of basic fibroblast growth factor (bFGF) on synthesis of type I collagen and activation of nuclear transcription factor kappaB (NF-kappaB) in an in vitro culture model of intrasynovial tenocytes...