Marsha Wills-Karp

Summary

Affiliation: Cincinnati Children's Hospital Medical Center
Country: USA

Publications

  1. ncbi request reprint Differences in expression, affinity, and function of soluble (s)IL-4Ralpha and sIL-13Ralpha2 suggest opposite effects on allergic responses
    Marat Khodoun
    Cincinnati Veterans Affairs Medical Center, Cincinnati, OH 45220, USA
    J Immunol 179:6429-38. 2007
  2. pmc Unique and overlapping gene expression patterns driven by IL-4 and IL-13 in the mouse lung
    Christina C Lewis
    Division of Immunobiology, Cincinnati Children s Hospital Medical Center, Department of Pediatrics, University of Cincinnati, Cincinnati, Ohio 45229, USA
    J Allergy Clin Immunol 123:795-804.e8. 2009
  3. ncbi request reprint Interleukin-13 in asthma
    Marsha Wills-Karp
    Division of Immunobiology, Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    Curr Opin Pulm Med 9:21-7. 2003
  4. pmc Complement activation pathways: a bridge between innate and adaptive immune responses in asthma
    Marsha Wills-Karp
    Division of Immunobiology, Center for Immunological Research, Cincinnati Children s Hospital Medical Center, Department of Pediatrics, University of Cincinnati, Cincinnati, Ohio 45229, USA
    Proc Am Thorac Soc 4:247-51. 2007
  5. pmc Allergen-specific pattern recognition receptor pathways
    Marsha Wills-Karp
    Division of Immunobiology, Cincinnati Children s Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, 3333 Burnet Avenue, MLC 7038, Cincinnati, OH 45229, United States
    Curr Opin Immunol 22:777-82. 2010
  6. doi request reprint Untangling the complex web of IL-4- and IL-13-mediated signaling pathways
    Marsha Wills-Karp
    Division of Immunobiology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Sci Signal 1:pe55. 2008
  7. ncbi request reprint Biomedicine. Eosinophils in asthma: remodeling a tangled tale
    Marsha Wills-Karp
    Division of Immunobiology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Science 305:1726-9. 2004
  8. pmc New insights into innate immune mechanisms underlying allergenicity
    M Wills-Karp
    Division of Immunobiology, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio, USA
    Mucosal Immunol 3:104-10. 2010
  9. pmc Complement-mediated regulation of the IL-17A axis is a central genetic determinant of the severity of experimental allergic asthma
    Stephane Lajoie
    Division of Immunobiology, Cincinnati Children s Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    Nat Immunol 11:928-35. 2010
  10. ncbi request reprint Suppressive effect of IL-4 on IL-13-induced genes in mouse lung
    Fred D Finkelman
    Division of Immunology, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
    J Immunol 174:4630-8. 2005

Collaborators

Detail Information

Publications60

  1. ncbi request reprint Differences in expression, affinity, and function of soluble (s)IL-4Ralpha and sIL-13Ralpha2 suggest opposite effects on allergic responses
    Marat Khodoun
    Cincinnati Veterans Affairs Medical Center, Cincinnati, OH 45220, USA
    J Immunol 179:6429-38. 2007
    ....
  2. pmc Unique and overlapping gene expression patterns driven by IL-4 and IL-13 in the mouse lung
    Christina C Lewis
    Division of Immunobiology, Cincinnati Children s Hospital Medical Center, Department of Pediatrics, University of Cincinnati, Cincinnati, Ohio 45229, USA
    J Allergy Clin Immunol 123:795-804.e8. 2009
    ..Although these 2 cytokines share signaling components, the molecular mechanisms by which they mediate different phases of the allergic asthmatic response remain elusive...
  3. ncbi request reprint Interleukin-13 in asthma
    Marsha Wills-Karp
    Division of Immunobiology, Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    Curr Opin Pulm Med 9:21-7. 2003
    ....
  4. pmc Complement activation pathways: a bridge between innate and adaptive immune responses in asthma
    Marsha Wills-Karp
    Division of Immunobiology, Center for Immunological Research, Cincinnati Children s Hospital Medical Center, Department of Pediatrics, University of Cincinnati, Cincinnati, Ohio 45229, USA
    Proc Am Thorac Soc 4:247-51. 2007
    ....
  5. pmc Allergen-specific pattern recognition receptor pathways
    Marsha Wills-Karp
    Division of Immunobiology, Cincinnati Children s Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, 3333 Burnet Avenue, MLC 7038, Cincinnati, OH 45229, United States
    Curr Opin Immunol 22:777-82. 2010
    ..Elucidation of the specific innate immune pathways activated by allergens holds great promise in defining new therapeutic targets for the treatment of allergic diseases...
  6. doi request reprint Untangling the complex web of IL-4- and IL-13-mediated signaling pathways
    Marsha Wills-Karp
    Division of Immunobiology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Sci Signal 1:pe55. 2008
    ..A better understanding of the interactions of IL-4 and IL-13 with their cognate receptors may facilitate the development of therapies without unintended side effects...
  7. ncbi request reprint Biomedicine. Eosinophils in asthma: remodeling a tangled tale
    Marsha Wills-Karp
    Division of Immunobiology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Science 305:1726-9. 2004
  8. pmc New insights into innate immune mechanisms underlying allergenicity
    M Wills-Karp
    Division of Immunobiology, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio, USA
    Mucosal Immunol 3:104-10. 2010
    ..A greater understanding of the fundamental origins of allergenicity should help define new preventive and therapeutic targets in allergic disease...
  9. pmc Complement-mediated regulation of the IL-17A axis is a central genetic determinant of the severity of experimental allergic asthma
    Stephane Lajoie
    Division of Immunobiology, Cincinnati Children s Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    Nat Immunol 11:928-35. 2010
    ..The opposing effects of C3a and C5a were mediated through their reciprocal regulation of IL-23 production. These data demonstrate a critical role for complement-mediated regulation of the IL-23-T(H)17 axis in severe asthma...
  10. ncbi request reprint Suppressive effect of IL-4 on IL-13-induced genes in mouse lung
    Fred D Finkelman
    Division of Immunology, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
    J Immunol 174:4630-8. 2005
    ..These results provide a potential explanation for the dominant role of IL-13 in induction of goblet cell hyperplasia and airway hyperresponsiveness in asthma...
  11. pmc Mucosal sensitization to German cockroach involves protease-activated receptor-2
    Kristen Page
    Department of Pediatrics, Cincinnati Children s Hospital Medical Center, University of Cincinnati, Cincinnati, OH, USA
    Respir Res 11:62. 2010
    ..The role for PAR-2 in mediating allergic airway inflammation has not been assessed using a real world allergen...
  12. pmc A regulatory role for the C5a anaphylatoxin in type 2 immunity in asthma
    Jörg Köhl
    Division of Molecular Immunology, Cincinnati Children s Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA
    J Clin Invest 116:783-96. 2006
    ..e., protection from the development of maladaptive type 2 immune responses during allergen sensitization at the DC/T cell interface but enhancement of airway inflammation and AHR in an established inflammatory environment...
  13. pmc IL-13 receptor α2 contributes to development of experimental allergic asthma
    Weiguo Chen
    Division of Asthma Research, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio
    J Allergy Clin Immunol 132:951-8.e1-6. 2013
    ..There are soluble and membrane forms of IL-13Rα2 generated by alternative splicing in mice, but human subjects express only the membrane form of IL-13Rα2 (memIL-13Rα2)...
  14. pmc A nonredundant role for mouse Serpinb3a in the induction of mucus production in asthma
    Umasundari Sivaprasad
    Division of Asthma Research, Cincinnati Children s Hospital Medical Center, Department of Pediatrics, University of Cincinnati, Cincinnati, Ohio 45229, USA
    J Allergy Clin Immunol 127:254-61, 261.e1-6. 2011
    ..Asthma is a major public health burden worldwide. Studies from our group and others have demonstrated that SERPINB3 and SERPINB4 are induced in patients with asthma; however, their mechanistic role in asthma has yet to be determined...
  15. pmc TLR2-mediated activation of neutrophils in response to German cockroach frass
    Kristen Page
    Division of Critical Care Medicine, Cincinnati Children s Hospital Medical Center and Research Foundation, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
    J Immunol 180:6317-24. 2008
    ....
  16. pmc Protease-activated receptor 2 activation of myeloid dendritic cells regulates allergic airway inflammation
    Ian P Lewkowich
    Department of Pediatrics, Cincinnati Children s Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio, USA
    Respir Res 12:122. 2011
    ..A common characteristic of allergens is that they contain proteases that can activate protease-activated receptor (PAR-2); however the mechanism by which PAR-2 regulates allergic airway inflammation is unclear...
  17. doi request reprint A critical role for C5L2 in the pathogenesis of experimental allergic asthma
    Xun Zhang
    Division of Molecular Immunology, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
    J Immunol 185:6741-52. 2010
    ..Furthermore, it drives Th2 immune responses independent of mDCs, suggesting a complex role for C5L2 in the development of experimental allergic asthma...
  18. pmc Trefoil factor 2 rapidly induces interleukin 33 to promote type 2 immunity during allergic asthma and hookworm infection
    Marsha Wills-Karp
    Division of Immunobiology and 2 Division of Asthma Research, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    J Exp Med 209:607-22. 2012
    ..These experiments extend the biological functions of TFF2 from tissue repair to the initiation and maintenance of mucosal T(H)2 responses...
  19. pmc Allergen uptake, activation, and IL-23 production by pulmonary myeloid DCs drives airway hyperresponsiveness in asthma-susceptible mice
    Ian P Lewkowich
    Division of Immunobiology, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America
    PLoS ONE 3:e3879. 2008
    ....
  20. doi request reprint Foxa2 programs Th2 cell-mediated innate immunity in the developing lung
    Gang Chen
    Section of Neonatology, Perinatal and Pulmonary Biology, Perinatal Institute, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229 3039, USA
    J Immunol 184:6133-41. 2010
    ..The respiratory epithelium plays a central role in the regulation of Th2-mediated inflammation and innate immunity in the developing lung in a process regulated by Foxa2...
  21. pmc Particulate matter-induced airway hyperresponsiveness is lymphocyte dependent
    Vanessa Saunders
    Division of Immunobiology, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA
    Environ Health Perspect 118:640-6. 2010
    ..However, the mechanism(s) by which it induces these features of asthma remains unknown...
  22. pmc Differences in susceptibility to German cockroach frass and its associated proteases in induced allergic inflammation in mice
    Kristen Page
    Division of Critical Care Medicine, Cincinnati Children s Hospital Medical Center, Cincinnati, OH, USA
    Respir Res 8:91. 2007
    ..Cockroach exposure is a major risk factor for the development of asthma. Inhalation of fecal remnants (frass) is the likely sensitizing agent; however isolated frass has not been tested for its ability to induce experimental asthma in mice...
  23. pmc Matrix metalloproteinase 8 contributes to solubilization of IL-13 receptor alpha2 in vivo
    Weiguo Chen
    Division of Allergy and Immunology, Institute for Personalized and Predictive Medicine, Children s Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH 45229, USA
    J Allergy Clin Immunol 122:625-32. 2008
    ..IL-13R alpha 2 exists in soluble and membrane forms, which can both bind IL-13 and modulate its activity. Yet the proteolytic processes that contribute to the generation of soluble IL-13R alpha 2 are largely unknown...
  24. doi request reprint Importance of cytokines in murine allergic airway disease and human asthma
    Fred D Finkelman
    Department of Medicine, Cincinnati Veterans Affairs Medical Center, Cincinnati, OH 45220, USA
    J Immunol 184:1663-74. 2010
    ..Results of these analyses establish the importance of specific cytokines in MAAD and human asthma and have therapeutic implications...
  25. ncbi request reprint IL-4 induces IL-13-independent allergic airway inflammation
    Charles Perkins
    Division of Immunology, University of Cincinnati College of Medicine, 231 Albert Sabin Way, Cincinnati, OH 45267, USA
    J Allergy Clin Immunol 118:410-9. 2006
    ..The nonredundant role of IL-13 could reflect unique IL-13 activation of a signaling pathway, inhibitory effects induced by IL-4 but not IL-13, or greater production-potency of IL-13 than IL-4...
  26. pmc Selective stimulation of IL-4 receptor on smooth muscle induces airway hyperresponsiveness in mice
    Charles Perkins
    Department of Medicine, Cincinnati Veterans Affairs Medical Center, Cincinnati, OH 45220, USA
    J Exp Med 208:853-67. 2011
    ..These observations demonstrate that IL-4Rα promotes AHR through multiple mechanisms and provide a model for testing smooth muscle-directed asthma therapeutics...
  27. ncbi request reprint Complement regulates inhalation tolerance at the dendritic cell/T cell interface
    Jörg Köhl
    Division of Molecular Immunology, Cincinnati Children s Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
    Mol Immunol 44:44-56. 2007
    ..The emerging paradigm is that constitutive local generation of C5a and C5aR signaling in airway DCs controls inhalation tolerance directly as well as indirectly through sensitization of airway DCs for T(Reg)-mediated immunosuppression...
  28. pmc A protective role for C5a in the development of allergic asthma associated with altered levels of B7-H1 and B7-DC on plasmacytoid dendritic cells
    Xun Zhang
    Division of Molecular Immunology, Cincinnati Children s Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
    J Immunol 182:5123-30. 2009
    ..Ex vivo targeting of B7-H1 and B7-DC increased Th2 cytokine production from T cells of wild-type but not of C5aR-targeted mice, suggesting a protective role for C5a through regulation of B7 molecule expression on plasmacytoid DCs...
  29. pmc Partial restoration of T-cell function in aged mice by in vitro blockade of the PD-1/ PD-L1 pathway
    Celine S Lages
    Cincinnati Children s Hospital Research Foundation, Department of Pediatrics, University of Cincinnati College of Medicine, OH 45229, USA
    Aging Cell 9:785-98. 2010
    ....
  30. pmc Downregulation of glutathione S-transferase pi in asthma contributes to enhanced oxidative stress
    Kathy T Schroer
    Department of Pediatrics, Cincinnati Children s Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio, USA
    J Allergy Clin Immunol 128:539-48. 2011
    ..Glutathione S-transferase pi (GSTPi) is the predominant redox regulator in the lung. Although evidence implicates an important role for GSTPi in asthma, the mechanism for this has remained elusive...
  31. ncbi request reprint Expression and regulation of small proline-rich protein 2 in allergic inflammation
    Nives Zimmermann
    Division of Allergy and Immunology, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
    Am J Respir Cell Mol Biol 32:428-35. 2005
    ..Thus, SPRR2 is an allergen- and IL-13-induced gene in experimental allergic responses that may be involved in disease pathophysiology...
  32. pmc CD4+CD25+ T cells protect against experimentally induced asthma and alter pulmonary dendritic cell phenotype and function
    Ian P Lewkowich
    Division of Immunobiology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    J Exp Med 202:1549-61. 2005
    ..These data suggest that resistance to allergen-driven AHR is mediated in part by CD4+CD25+ T reg cell suppression of DC activation and that the absence of this regulatory pathway contributes to susceptibility...
  33. pmc Allergenicity resulting from functional mimicry of a Toll-like receptor complex protein
    Aurelien Trompette
    Division of Molecular Immunology, Cincinnati Children s Hospital Medical Center and the University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA
    Nature 457:585-8. 2009
    ....
  34. doi request reprint Correlation between serum caffeine levels and changes in cytokine profile in a cohort of preterm infants
    Raul Chavez Valdez
    Department of Pediatrics, Division of Neonatology, Johns Hopkins Hospital, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    J Pediatr 158:57-64, 64.e1. 2011
    ..To determine changes in cytokine levels associated with caffeine treatment in a cohort of preterm infants...
  35. ncbi request reprint Interleukin-13 in asthma pathogenesis
    Marsha Wills-Karp
    Division of Immunobiology, Children s Hospital Medical Center, 3333 Burnett Avenue, MLC 7038, Cincinnati, OH 45208, USA
    Curr Allergy Asthma Rep 4:123-31. 2004
    ....
  36. ncbi request reprint Interleukin-13 in asthma pathogenesis
    Marsha Wills-Karp
    Division of Immunobiology, Children s Hospital Medical Center, Cincinnati, OH 45208, USA
    Immunol Rev 202:175-90. 2004
    ....
  37. ncbi request reprint Chitin checking--novel insights into asthma
    Marsha Wills-Karp
    Division of Immunobiology, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, USA
    N Engl J Med 351:1455-7. 2004
  38. pmc Distinct roles of Cdc42 in thymopoiesis and effector and memory T cell differentiation
    Fukun Guo
    Division of Experimental Hematology and Cancer Biology, Children s Hospital Research Foundation, Cincinnati, Ohio, United States of America
    PLoS ONE 6:e18002. 2011
    ..Collectively, these data establish that Cdc42 is critically involved in thymopoiesis and plays a restrictive role in effector and memory T cell differentiation and autoimmunity...
  39. ncbi request reprint Elevated cytokine levels in children with autism spectrum disorder
    Cynthia A Molloy
    Center for Epidemiology and Biostatistics, Cincinnati Children s Hospital Medical Center, and Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45229 3039, United States
    J Neuroimmunol 172:198-205. 2006
    ..Conclusion: Children with ASD had increased activation of both Th2 and Th1 arms of the adaptive immune response, with a Th2 predominance, and without the compensatory increase in the regulatory cytokine IL-10...
  40. doi request reprint The potential role of interleukin-17 in severe asthma
    Yui Hsi Wang
    Division of Allergy and Immunology, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
    Curr Allergy Asthma Rep 11:388-94. 2011
    ..Understanding the biology of IL-17 in the context of allergic inflammation may be informative in the development of novel approaches to the diagnosis and treatment of asthma...
  41. ncbi request reprint A dual role for complement in allergic asthma
    Jörg Köhl
    Division of Molecular Immunology, Cincinnati Children s Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
    Curr Opin Pharmacol 7:283-9. 2007
    ..As such, selective targeting of pro-allergic complement pathways appears an attractive therapeutic option in allergic asthma...
  42. ncbi request reprint Atorvastatin affects interleukin-2 signaling by altering the lipid raft enrichment of the interleukin-2 receptor beta chain
    Jens Goebel
    Division of Nephrology and Hypertension, Cincinnati Children s Hospital, Cincinnati, OH 45229, USA
    J Investig Med 53:322-8. 2005
    ..We conclude that AS affects IL-2R signaling by altering the raft enrichment of the IL-2R beta chain and propose that this effect is one mechanism underlying the immunomodulatory properties of statins...
  43. pmc A role for immune complexes in enhanced respiratory syncytial virus disease
    Fernando P Polack
    Department of Pediatrics, School of Medicine, Bloomberg School of Public Health at Johns Hopkins University, Baltimore, MD 21205, USA
    J Exp Med 196:859-65. 2002
    ..Further, we show correlation with the enhanced disease observed in children by providing evidence of complement activation in postmortem lung sections from children with enhanced RSV disease...
  44. pmc Differences in candidate gene association between European ancestry and African American asthmatic children
    Tesfaye M Baye
    Department of Pediatrics, Cincinnati Children s Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio, United States of America
    PLoS ONE 6:e16522. 2011
    ..Our aim was to compare association patterns of asthma candidate genes between children of European and African ancestry...
  45. ncbi request reprint New insights into the role of the complement pathway in allergy and asthma
    Marsha Wills-Karp
    Division of Immunobiology, Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
    Curr Allergy Asthma Rep 5:362-9. 2005
    ..Herein, we explore our current understanding of the role of complement activation in asthma pathogenesis and highlight the potential of targeting complement pathways for therapeutic drug development...
  46. pmc Innate immune responses of airway epithelium to house dust mite are mediated through beta-glucan-dependent pathways
    Amy T Nathan
    Division of Neonatology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    J Allergy Clin Immunol 123:612-8. 2009
    ....
  47. pmc Identification of IFRD1 as a modifier gene for cystic fibrosis lung disease
    YuanYuan Gu
    Division of Molecular Immunology, Cincinnati Children s Hospital Research Foundation and the University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA
    Nature 458:1039-42. 2009
    ..These data indicate that IFRD1 modulates the pathogenesis of cystic fibrosis lung disease through the regulation of neutrophil effector function...
  48. ncbi request reprint Time to draw breath: asthma-susceptibility genes are identified
    Marsha Wills-Karp
    Division of Immunobiology, Cincinnati Children s Hospital Research Foundation, 3333 Burnet Avenue, Cincinnati, Ohio 45229, USA
    Nat Rev Genet 5:376-87. 2004
  49. pmc Bone marrow cell derived arginase I is the major source of allergen-induced lung arginase but is not required for airway hyperresponsiveness, remodeling and lung inflammatory responses in mice
    Kathryn A Niese
    Division of Allergy and Immunology, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    BMC Immunol 10:33. 2009
    ..Arginase is significantly upregulated in the lungs in murine models of asthma, as well as in human asthma, but its role in allergic airway inflammation has not been fully elucidated in mice...
  50. pmc A TLR2 agonist in German cockroach frass activates MMP-9 release and is protective against allergic inflammation in mice
    Kristen Page
    Division of Critical Care Medicine, Cincinnati Children s Research Foundation, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    J Immunol 183:3400-8. 2009
    ..This suggests a protective role for TLR2 activation and MMP-9 release in the context of experimentally induced asthma in mice...
  51. ncbi request reprint Understanding the origin of asthma and its relationship to breastfeeding
    Marsha Wills-Karp
    Division of Immunobiology, Human Milk Research Program, Cincinnati Children s Hospital Research Foundation, Cincinnati, OH 45229, USA
    Adv Exp Med Biol 554:171-91. 2004
    ....
  52. pmc Regulation of angiogenesis by a non-canonical Wnt-Flt1 pathway in myeloid cells
    James A Stefater
    The Visual Systems Group, Division of Pediatric Ophthalmology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    Nature 474:511-5. 2011
    ..These findings indicate that resident myeloid cells can use a non-canonical, Wnt-Flt1 pathway to suppress angiogenic branching...
  53. ncbi request reprint The anaphylatoxins bridge innate and adaptive immune responses in allergic asthma
    Heiko Hawlisch
    Division of Molecular Immunology, Cincinnati Children s Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
    Mol Immunol 41:123-31. 2004
    ..During the effector phase, both anaphylatoxins trigger the inflammatory response and contribute to bronchoconstriction...
  54. ncbi request reprint Defective lipoxin-mediated anti-inflammatory activity in the cystic fibrosis airway
    Christopher L Karp
    Division of Molecular Immunology, Cincinnati Children s Hospital Medical Center, and University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA
    Nat Immunol 5:388-92. 2004
    ..These findings suggest that there is a pathophysiologically important defect in lipoxin-mediated anti-inflammatory activity in the cystic fibrosis lung and that lipoxins have therapeutic potential in this lethal autosomal disease...
  55. pmc Plasminogen activator inhibitor-1 mitigates brain injury in a rat model of infection-sensitized neonatal hypoxia-ischemia
    Dianer Yang
    Division of Developmental Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Cereb Cortex 23:1218-29. 2013
    ..Together, because CPAI blocks both proteolytic and nonproteolytic tPA neurotoxicity, it is a promising therapeutics of neonatal HI injury either with or without infection...
  56. pmc Identification of Cd101 as a susceptibility gene for Novosphingobium aromaticivorans-induced liver autoimmunity
    Javid P Mohammed
    Division of Immunobiology, Cincinnati Children s Hospital, Cincinnati, OH 45229, USA
    J Immunol 187:337-49. 2011
    ..These data strongly support the hypothesis that allelic variation of the Cd101 gene, located in the Idd10 region, alters the severity of liver autoimmunity induced by N. aromaticivorans...
  57. ncbi request reprint Altered gene expression profiles in nasal respiratory epithelium reflect stable versus acute childhood asthma
    Jesus R Guajardo
    Division of Allergy and Immunology, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    J Allergy Clin Immunol 115:243-51. 2005
    ..Asthma is the most common chronic disease of childhood and has a strong genetic component...
  58. ncbi request reprint Tubulin polymerization modulates interleukin-2 receptor signal transduction in human T cells
    Jens Goebel
    Department of Pediatrics, University of Kentucky, Lexington, Kentucky, USA
    J Recept Signal Transduct Res 26:87-106. 2006
    ..10 mice stimulated with their nominal antigen. We conclude that altered polymerization of cytoskeletal components, especially tubulin, is accompanied by modulation of IL-2 signaling at the receptor level...
  59. doi request reprint Caffeine modulates TNF-alpha production by cord blood monocytes: the role of adenosine receptors
    Raul Chavez-Valdez
    Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Pediatr Res 65:203-8. 2009
    ..Our findings also suggest that caffeine, via A1R blockade, increases cAMP production and inhibits pretranscriptional TNF-alpha production by CBM...
  60. pmc Cerebral ischemia-hypoxia induces intravascular coagulation and autophagy
    Faisal Adhami
    Division of Developmental Biology, Cincinnati Children s Hospital Research Foundation, Room 3464, 3333 Burnet Ave, Cincinnati, OH 45229, USA
    Am J Pathol 169:566-83. 2006
    ..Together, these results suggest that ischemia-hypoxia is a powerful stimulus for spontaneous coagulation leading to reperfusion deficits and autophagic/lysosomal cell death in brain...