Research Topics
Genomes and Genes
| Marsha Wills-KarpSummaryAffiliation: Cincinnati Children's Hospital Medical Center Country: USA Publications
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Detail Information
Publications
Differences in expression, affinity, and function of soluble (s)IL-4Ralpha and sIL-13Ralpha2 suggest opposite effects on allergic responsesMarat Khodoun
Cincinnati Veterans Affairs Medical Center, Cincinnati, OH 45220, USA
J Immunol 179:6429-38. 2007....
Unique and overlapping gene expression patterns driven by IL-4 and IL-13 in the mouse lungChristina C Lewis
Division of Immunobiology, Cincinnati Children s Hospital Medical Center, Department of Pediatrics, University of Cincinnati, Cincinnati, Ohio 45229, USA
J Allergy Clin Immunol 123:795-804.e8. 2009..Although these 2 cytokines share signaling components, the molecular mechanisms by which they mediate different phases of the allergic asthmatic response remain elusive...- New insights into innate immune mechanisms underlying allergenicityM Wills-Karp
Division of Immunobiology, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio, USA
Mucosal Immunol 3:104-10. 2010..A greater understanding of the fundamental origins of allergenicity should help define new preventive and therapeutic targets in allergic disease... 
Allergen-specific pattern recognition receptor pathwaysMarsha Wills-Karp
Division of Immunobiology, Cincinnati Children s Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, 3333 Burnet Avenue, MLC 7038, Cincinnati, OH 45229, United States
Curr Opin Immunol 22:777-82. 2010..Elucidation of the specific innate immune pathways activated by allergens holds great promise in defining new therapeutic targets for the treatment of allergic diseases...- Untangling the complex web of IL-4- and IL-13-mediated signaling pathwaysMarsha Wills-Karp
Division of Immunobiology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
Sci Signal 1:pe55. 2008..A better understanding of the interactions of IL-4 and IL-13 with their cognate receptors may facilitate the development of therapies without unintended side effects... - Complement activation pathways: a bridge between innate and adaptive immune responses in asthmaMarsha Wills-Karp
Division of Immunobiology, Center for Immunological Research, Cincinnati Children s Hospital Medical Center, Department of Pediatrics, University of Cincinnati, Cincinnati, Ohio 45229, USA
Proc Am Thorac Soc 4:247-51. 2007.... - Biomedicine. Eosinophils in asthma: remodeling a tangled taleMarsha Wills-Karp
Division of Immunobiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA
Science 305:1726-9. 2004 - Interleukin-13 in asthmaMarsha Wills-Karp
Division of Immunobiology, Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
Curr Opin Pulm Med 9:21-7. 2003.... - Complement-mediated regulation of the IL-17A axis is a central genetic determinant of the severity of experimental allergic asthmaStephane Lajoie
Division of Immunobiology, Cincinnati Children s Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
Nat Immunol 11:928-35. 2010..The opposing effects of C3a and C5a were mediated through their reciprocal regulation of IL-23 production. These data demonstrate a critical role for complement-mediated regulation of the IL-23-T(H)17 axis in severe asthma... - Suppressive effect of IL-4 on IL-13-induced genes in mouse lungFred D Finkelman
Division of Immunology, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
J Immunol 174:4630-8. 2005..These results provide a potential explanation for the dominant role of IL-13 in induction of goblet cell hyperplasia and airway hyperresponsiveness in asthma... - Mucosal sensitization to German cockroach involves protease-activated receptor-2Kristen Page
Department of Pediatrics, Cincinnati Children s Hospital Medical Center, University of Cincinnati, Cincinnati, OH, USA
Respir Res 11:62. 2010..The role for PAR-2 in mediating allergic airway inflammation has not been assessed using a real world allergen... - A regulatory role for the C5a anaphylatoxin in type 2 immunity in asthmaJörg Köhl
Division of Molecular Immunology, Cincinnati Children s Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA
J Clin Invest 116:783-96. 2006..e., protection from the development of maladaptive type 2 immune responses during allergen sensitization at the DC/T cell interface but enhancement of airway inflammation and AHR in an established inflammatory environment... - A nonredundant role for mouse Serpinb3a in the induction of mucus production in asthmaUmasundari Sivaprasad
Division of Asthma Research, Cincinnati Children s Hospital Medical Center, Department of Pediatrics, University of Cincinnati, Cincinnati, Ohio 45229, USA
J Allergy Clin Immunol 127:254-61, 261.e1-6. 2011..Asthma is a major public health burden worldwide. Studies from our group and others have demonstrated that SERPINB3 and SERPINB4 are induced in patients with asthma; however, their mechanistic role in asthma has yet to be determined... - TLR2-mediated activation of neutrophils in response to German cockroach frassKristen Page
Division of Critical Care Medicine, Cincinnati Children s Hospital Medical Center and Research Foundation, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
J Immunol 180:6317-24. 2008.... - Protease-activated receptor 2 activation of myeloid dendritic cells regulates allergic airway inflammationIan P Lewkowich
Department of Pediatrics, Cincinnati Children s Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio, USA
Respir Res 12:122. 2011..A common characteristic of allergens is that they contain proteases that can activate protease-activated receptor (PAR-2); however the mechanism by which PAR-2 regulates allergic airway inflammation is unclear... - A critical role for C5L2 in the pathogenesis of experimental allergic asthmaXun Zhang
Division of Molecular Immunology, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
J Immunol 185:6741-52. 2010..Furthermore, it drives Th2 immune responses independent of mDCs, suggesting a complex role for C5L2 in the development of experimental allergic asthma... - Trefoil factor 2 rapidly induces interleukin 33 to promote type 2 immunity during allergic asthma and hookworm infectionMarsha Wills-Karp
Division of Immunobiology and 2 Division of Asthma Research, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
J Exp Med 209:607-22. 2012..These experiments extend the biological functions of TFF2 from tissue repair to the initiation and maintenance of mucosal T(H)2 responses... - Allergen uptake, activation, and IL-23 production by pulmonary myeloid DCs drives airway hyperresponsiveness in asthma-susceptible miceIan P Lewkowich
Division of Immunobiology, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America
PLoS ONE 3:e3879. 2008.... - Differences in susceptibility to German cockroach frass and its associated proteases in induced allergic inflammation in miceKristen Page
Division of Critical Care Medicine, Cincinnati Children s Hospital Medical Center, Cincinnati, OH, USA
Respir Res 8:91. 2007..Cockroach exposure is a major risk factor for the development of asthma. Inhalation of fecal remnants (frass) is the likely sensitizing agent; however isolated frass has not been tested for its ability to induce experimental asthma in mice... - Particulate matter-induced airway hyperresponsiveness is lymphocyte dependentVanessa Saunders
Division of Immunobiology, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA
Environ Health Perspect 118:640-6. 2010..However, the mechanism(s) by which it induces these features of asthma remains unknown... - Foxa2 programs Th2 cell-mediated innate immunity in the developing lungGang Chen
Section of Neonatology, Perinatal and Pulmonary Biology, Perinatal Institute, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229 3039, USA
J Immunol 184:6133-41. 2010..The respiratory epithelium plays a central role in the regulation of Th2-mediated inflammation and innate immunity in the developing lung in a process regulated by Foxa2... - Matrix metalloproteinase 8 contributes to solubilization of IL-13 receptor alpha2 in vivoWeiguo Chen
Division of Allergy and Immunology, Institute for Personalized and Predictive Medicine, Children s Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH 45229, USA
J Allergy Clin Immunol 122:625-32. 2008..IL-13R alpha 2 exists in soluble and membrane forms, which can both bind IL-13 and modulate its activity. Yet the proteolytic processes that contribute to the generation of soluble IL-13R alpha 2 are largely unknown... - Importance of cytokines in murine allergic airway disease and human asthmaFred D Finkelman
Department of Medicine, Cincinnati Veterans Affairs Medical Center, Cincinnati, OH 45220, USA
J Immunol 184:1663-74. 2010..Results of these analyses establish the importance of specific cytokines in MAAD and human asthma and have therapeutic implications... - Selective stimulation of IL-4 receptor on smooth muscle induces airway hyperresponsiveness in miceCharles Perkins
Department of Medicine, Cincinnati Veterans Affairs Medical Center, Cincinnati, OH 45220, USA
J Exp Med 208:853-67. 2011..These observations demonstrate that IL-4Rα promotes AHR through multiple mechanisms and provide a model for testing smooth muscle-directed asthma therapeutics... - IL-4 induces IL-13-independent allergic airway inflammationCharles Perkins
Division of Immunology, University of Cincinnati College of Medicine, 231 Albert Sabin Way, Cincinnati, OH 45267, USA
J Allergy Clin Immunol 118:410-9. 2006..The nonredundant role of IL-13 could reflect unique IL-13 activation of a signaling pathway, inhibitory effects induced by IL-4 but not IL-13, or greater production-potency of IL-13 than IL-4... - A protective role for C5a in the development of allergic asthma associated with altered levels of B7-H1 and B7-DC on plasmacytoid dendritic cellsXun Zhang
Division of Molecular Immunology, Cincinnati Children s Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
J Immunol 182:5123-30. 2009..Ex vivo targeting of B7-H1 and B7-DC increased Th2 cytokine production from T cells of wild-type but not of C5aR-targeted mice, suggesting a protective role for C5a through regulation of B7 molecule expression on plasmacytoid DCs... - Downregulation of glutathione S-transferase pi in asthma contributes to enhanced oxidative stressKathy T Schroer
Department of Pediatrics, Cincinnati Children s Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio, USA
J Allergy Clin Immunol 128:539-48. 2011..Glutathione S-transferase pi (GSTPi) is the predominant redox regulator in the lung. Although evidence implicates an important role for GSTPi in asthma, the mechanism for this has remained elusive... - Partial restoration of T-cell function in aged mice by in vitro blockade of the PD-1/ PD-L1 pathwayCeline S Lages
Cincinnati Children s Hospital Research Foundation, Department of Pediatrics, University of Cincinnati College of Medicine, OH 45229, USA
Aging Cell 9:785-98. 2010.... - Complement regulates inhalation tolerance at the dendritic cell/T cell interfaceJörg Köhl
Division of Molecular Immunology, Cincinnati Children s Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
Mol Immunol 44:44-56. 2007..The emerging paradigm is that constitutive local generation of C5a and C5aR signaling in airway DCs controls inhalation tolerance directly as well as indirectly through sensitization of airway DCs for T(Reg)-mediated immunosuppression... - Expression and regulation of small proline-rich protein 2 in allergic inflammationNives Zimmermann
Division of Allergy and Immunology, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
Am J Respir Cell Mol Biol 32:428-35. 2005..Thus, SPRR2 is an allergen- and IL-13-induced gene in experimental allergic responses that may be involved in disease pathophysiology... - CD4+CD25+ T cells protect against experimentally induced asthma and alter pulmonary dendritic cell phenotype and functionIan P Lewkowich
Division of Immunobiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA
J Exp Med 202:1549-61. 2005..These data suggest that resistance to allergen-driven AHR is mediated in part by CD4+CD25+ T reg cell suppression of DC activation and that the absence of this regulatory pathway contributes to susceptibility... - Allergenicity resulting from functional mimicry of a Toll-like receptor complex proteinAurelien Trompette
Division of Molecular Immunology, Cincinnati Children s Hospital Medical Center and the University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA
Nature 457:585-8. 2009.... - Correlation between serum caffeine levels and changes in cytokine profile in a cohort of preterm infantsRaul Chavez Valdez
Department of Pediatrics, Division of Neonatology, Johns Hopkins Hospital, Johns Hopkins University School of Medicine, Baltimore, MD, USA
J Pediatr 158:57-64, 64.e1. 2011..To determine changes in cytokine levels associated with caffeine treatment in a cohort of preterm infants... - Interleukin-13 in asthma pathogenesisMarsha Wills-Karp
Division of Immunobiology, Children s Hospital Medical Center, Cincinnati, OH 45208, USA
Immunol Rev 202:175-90. 2004.... - Interleukin-13 in asthma pathogenesisMarsha Wills-Karp
Division of Immunobiology, Children s Hospital Medical Center, 3333 Burnett Avenue, MLC 7038, Cincinnati, OH 45208, USA
Curr Allergy Asthma Rep 4:123-31. 2004.... - The potential role of interleukin-17 in severe asthmaYui Hsi Wang
Division of Allergy and Immunology, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
Curr Allergy Asthma Rep 11:388-94. 2011..Understanding the biology of IL-17 in the context of allergic inflammation may be informative in the development of novel approaches to the diagnosis and treatment of asthma... - Distinct roles of Cdc42 in thymopoiesis and effector and memory T cell differentiationFukun Guo
Division of Experimental Hematology and Cancer Biology, Children s Hospital Research Foundation, Cincinnati, Ohio, United States of America
PLoS ONE 6:e18002. 2011..Collectively, these data establish that Cdc42 is critically involved in thymopoiesis and plays a restrictive role in effector and memory T cell differentiation and autoimmunity... - Atorvastatin affects interleukin-2 signaling by altering the lipid raft enrichment of the interleukin-2 receptor beta chainJens Goebel
Division of Nephrology and Hypertension, Cincinnati Children s Hospital, Cincinnati, OH 45229, USA
J Investig Med 53:322-8. 2005..We conclude that AS affects IL-2R signaling by altering the raft enrichment of the IL-2R beta chain and propose that this effect is one mechanism underlying the immunomodulatory properties of statins... - Chitin checking--novel insights into asthmaMarsha Wills-Karp
Division of Immunobiology, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, USA
N Engl J Med 351:1455-7. 2004 - A dual role for complement in allergic asthmaJörg Köhl
Division of Molecular Immunology, Cincinnati Children s Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
Curr Opin Pharmacol 7:283-9. 2007..As such, selective targeting of pro-allergic complement pathways appears an attractive therapeutic option in allergic asthma... - Elevated cytokine levels in children with autism spectrum disorderCynthia A Molloy
Center for Epidemiology and Biostatistics, Cincinnati Children s Hospital Medical Center, and Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45229 3039, United States
J Neuroimmunol 172:198-205. 2006..Conclusion: Children with ASD had increased activation of both Th2 and Th1 arms of the adaptive immune response, with a Th2 predominance, and without the compensatory increase in the regulatory cytokine IL-10... 
A role for immune complexes in enhanced respiratory syncytial virus diseaseFernando P Polack
Department of Pediatrics, School of Medicine, Bloomberg School of Public Health at Johns Hopkins University, Baltimore, MD 21205, USA
J Exp Med 196:859-65. 2002..Further, we show correlation with the enhanced disease observed in children by providing evidence of complement activation in postmortem lung sections from children with enhanced RSV disease...- Differences in candidate gene association between European ancestry and African American asthmatic childrenTesfaye M Baye
Department of Pediatrics, Cincinnati Children s Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio, United States of America
PLoS ONE 6:e16522. 2011..Our aim was to compare association patterns of asthma candidate genes between children of European and African ancestry... - New insights into the role of the complement pathway in allergy and asthmaMarsha Wills-Karp
Division of Immunobiology, Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
Curr Allergy Asthma Rep 5:362-9. 2005..Herein, we explore our current understanding of the role of complement activation in asthma pathogenesis and highlight the potential of targeting complement pathways for therapeutic drug development... - Identification of IFRD1 as a modifier gene for cystic fibrosis lung diseaseYuanYuan Gu
Division of Molecular Immunology, Cincinnati Children s Hospital Research Foundation and the University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA
Nature 458:1039-42. 2009..These data indicate that IFRD1 modulates the pathogenesis of cystic fibrosis lung disease through the regulation of neutrophil effector function... - Innate immune responses of airway epithelium to house dust mite are mediated through beta-glucan-dependent pathwaysAmy T Nathan
Division of Neonatology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
J Allergy Clin Immunol 123:612-8. 2009.... - Time to draw breath: asthma-susceptibility genes are identifiedMarsha Wills-Karp
Division of Immunobiology, Cincinnati Children's Hospital Research Foundation, 3333 Burnet Avenue, Cincinnati, Ohio 45229, USA
Nat Rev Genet 5:376-87. 2004 - A TLR2 agonist in German cockroach frass activates MMP-9 release and is protective against allergic inflammation in miceKristen Page
Division of Critical Care Medicine, Cincinnati Children s Research Foundation, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
J Immunol 183:3400-8. 2009..This suggests a protective role for TLR2 activation and MMP-9 release in the context of experimentally induced asthma in mice... - Bone marrow cell derived arginase I is the major source of allergen-induced lung arginase but is not required for airway hyperresponsiveness, remodeling and lung inflammatory responses in miceKathryn A Niese
Division of Allergy and Immunology, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
BMC Immunol 10:33. 2009..Arginase is significantly upregulated in the lungs in murine models of asthma, as well as in human asthma, but its role in allergic airway inflammation has not been fully elucidated in mice... - Understanding the origin of asthma and its relationship to breastfeedingMarsha Wills-Karp
Division of Immunobiology, Human Milk Research Program, Cincinnati Children s Hospital Research Foundation, Cincinnati, OH 45229, USA
Adv Exp Med Biol 554:171-91. 2004.... - The anaphylatoxins bridge innate and adaptive immune responses in allergic asthmaHeiko Hawlisch
Division of Molecular Immunology, Cincinnati Children's Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
Mol Immunol 41:123-31. 2004..During the effector phase, both anaphylatoxins trigger the inflammatory response and contribute to bronchoconstriction... - Regulation of angiogenesis by a non-canonical Wnt-Flt1 pathway in myeloid cellsJames A Stefater
The Visual Systems Group, Division of Pediatric Ophthalmology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
Nature 474:511-5. 2011..These findings indicate that resident myeloid cells can use a non-canonical, Wnt-Flt1 pathway to suppress angiogenic branching... - Defective lipoxin-mediated anti-inflammatory activity in the cystic fibrosis airwayChristopher L Karp
Division of Molecular Immunology, Cincinnati Children s Hospital Medical Center, and University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA
Nat Immunol 5:388-92. 2004..These findings suggest that there is a pathophysiologically important defect in lipoxin-mediated anti-inflammatory activity in the cystic fibrosis lung and that lipoxins have therapeutic potential in this lethal autosomal disease... - Identification of Cd101 as a susceptibility gene for Novosphingobium aromaticivorans-induced liver autoimmunityJavid P Mohammed
Division of Immunobiology, Cincinnati Children s Hospital, Cincinnati, OH 45229, USA
J Immunol 187:337-49. 2011..These data strongly support the hypothesis that allelic variation of the Cd101 gene, located in the Idd10 region, alters the severity of liver autoimmunity induced by N. aromaticivorans... - Altered gene expression profiles in nasal respiratory epithelium reflect stable versus acute childhood asthmaJesus R Guajardo
Division of Allergy and Immunology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA
J Allergy Clin Immunol 115:243-51. 2005..Stable asthma status also exhibits differential signatures. The results suggest that there are independent gene expression signatures reflective of cells and genes poised or committed to activation by an asthma attack... - Caffeine modulates TNF-alpha production by cord blood monocytes: the role of adenosine receptorsRaul Chavez-Valdez
Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
Pediatr Res 65:203-8. 2009..Our findings also suggest that caffeine, via A1R blockade, increases cAMP production and inhibits pretranscriptional TNF-alpha production by CBM... - Cerebral ischemia-hypoxia induces intravascular coagulation and autophagyFaisal Adhami
Division of Developmental Biology, Cincinnati Children's Hospital Research Foundation, Room 3464, 3333 Burnet Ave, Cincinnati, OH 45229, USA
Am J Pathol 169:566-83. 2006..Together, these results suggest that ischemia-hypoxia is a powerful stimulus for spontaneous coagulation leading to reperfusion deficits and autophagic/lysosomal cell death in brain... - Tubulin polymerization modulates interleukin-2 receptor signal transduction in human T cellsJens Goebel
Department of Pediatrics, University of Kentucky, Lexington, Kentucky, USA
J Recept Signal Transduct Res 26:87-106. 2006..10 mice stimulated with their nominal antigen. We conclude that altered polymerization of cytoskeletal components, especially tubulin, is accompanied by modulation of IL-2 signaling at the receptor level...