Research Topics
Genomes and Genes
| Jeffrey WhitsettSummaryAffiliation: Cincinnati Children's Hospital Medical Center Country: USA Publications
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Detail Information
Publications
Gene expression and biological processes influenced by deletion of Stat3 in pulmonary type II epithelial cellsYan Xu
Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, 3333 Burnet Avenue, Cincinnati, OH, USA
BMC Genomics 8:455. 2007..Differentially expressed genes were identified from Affymetrix Murine GeneChips analysis and subjected to gene ontology classification, promoter analysis, pathway mapping and literature mining...
Genetic disorders influencing lung formation and function at birthJeffrey A Whitsett
Department of Pediatrics, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
Hum Mol Genet 13:R207-15. 2004..Inherited disorders of the surfactant system that affect neonatal respiratory adaptation at birth include hereditary surfactant protein B deficiency, mutations in surfactant protein C and the ABCA3 transporter...- Transcriptional regulation of perinatal lung maturationJeffrey A Whitsett
Department of Pediatrics, Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center and the University of Cincinnati College of Medicine, 3333 Burnet Avenue Cincinnati, OH 45229 3039, USA
Pediatr Clin North Am 53:873-87, viii. 2006.... - Genetic disorders of surfactant homeostasisJeffrey A Whitsett
Division of Pulmonary Biology, MLC 7029, Department of Pediatrics, Cincinnati Children s Hospital Medical Center and the University of Cincinnati College of Medicine, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
Paediatr Respir Rev 7:S240-2. 2006..Mutations in the genes encoding these proteins cause lethal respiratory distress in newborn infants. This review discusses the clinical and pathological findings associated with these inherited disorders of alveolar homeostasis... 
Review: The intersection of surfactant homeostasis and innate host defense of the lung: lessons from newborn infantsJeffrey A Whitsett
Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Ohio 45229 3039, USA
Innate Immun 16:138-42. 2010....- Alveolar surfactant homeostasis and the pathogenesis of pulmonary diseaseJeffrey A Whitsett
Perinatal Institute, Section of Neonatology, Perinatal and Pulmonary Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
Annu Rev Med 61:105-19. 2010.... - Disorders of lung morphogenesisJeffrey A Whitsett
Division of Pulmonary Biology, Department of Pediatrics, Cincinnati Children s Hospital Medical Center and the University of Cincinnati College of Medicine, MLC 7029, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
Paediatr Respir Rev 7:S248. 2006..Perinatal lung function depends upon formation of the conducting and gas exchange regions of the lung. The precise expression of transcription factors and signaling molecules is required for normal lung morphogenesis... - Genetic disorders of surfactant homeostasisJeffrey A Whitsett
Section of Neonatology, Perinatal and Pulmonary Biology, Cincinnati Children s Hospital Medical Center, The University of Cincinnati College of Medicine, Cincinnati, OH 45229 3039, USA
Biol Neonate 87:283-7. 2005.... - Integrin α6β4 defines a novel lung epithelial progenitor cell: a step forward for cell-based therapies for pulmonary diseaseJeffrey A Whitsett
Perinatal Institute, Division of Neonatology, Perinatal, and Pulmonary Biology, Cincinnati Children s Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
J Clin Invest 121:2543-5. 2011.... - Surfactant proteins in innate host defense of the lungJeffrey A Whitsett
Cincinnati Children s Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, Ohio 45229 3039, USA
Biol Neonate 88:175-80. 2005..Pulmonary surfactant proteins A and D play dual roles in pulmonary homeostasis, determining the structure of alveolar lipids and mediating the innate host defense system of the lung... - Notch and basal cells take center stage during airway epithelial regenerationJeffrey A Whitsett
Perinatal Institute, Section of Neonatology, Perinatal and Pulmonary Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229 3039, USA
Cell Stem Cell 8:597-8. 2011..In this issue of Cell Stem Cell, Rock et al. (2011) show that Notch signals regulate differentiation, but not self-renewal of basal cells after injury, and that this role appears conserved in mouse and human lung... - Intersections between pulmonary development and diseaseJeffrey A Whitsett
Perinatal Institute, Divisions of Neonatology, Perinatal, and Pulmonary Biology, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
Am J Respir Crit Care Med 184:401-6. 2011.... - CTGF disrupts alveolarization and induces pulmonary hypertension in neonatal mice: implication in the pathogenesis of severe bronchopulmonary dysplasiaShaoyi Chen
Department of Pediatrics, Division of Neonatology, Univ of Miami Miller School of Medicine, FL 33101, USA
Am J Physiol Lung Cell Mol Physiol 300:L330-40. 2011.... - Conditional overexpression of connective tissue growth factor disrupts postnatal lung developmentShu Wu
Department of Pediatrics, Division of Neonatology, University of Miami Miller School of Medicine, Miami, Florida 33101, USA
Am J Respir Cell Mol Biol 42:552-63. 2010..These histologic changes are similar to those observed in lungs of infants with bronchopulmonary dysplasia... - Inhaled nitric oxide for oligohydramnios-induced pulmonary hypoplasia: a report of two cases and review of the literatureCara Geary
Divisions of Neonatology and Pulmonary Biology, Children's Hospital Medical Center and Good Samaritan Hospital, Cincinnati, OH 45229-3039, USA
J Perinatol 22:82-5. 2002.... - Absence of SP-A modulates innate and adaptive defense responses to pulmonary influenza infectionAnn Marie LeVine
Division of Pulmonary Biology, Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
Am J Physiol Lung Cell Mol Physiol 282:L563-72. 2002..Because the airway is the usual portal of entry for IAV and other respiratory pathogens, SP-A is likely to play a role in innate defense and adaptive immune responses to IAV... - SAM pointed domain ETS factor (SPDEF) regulates terminal differentiation and maturation of intestinal goblet cellsTaeko K Noah
Division of Gastroenterology, Cincinnati Children s Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, OH, USA
Exp Cell Res 316:452-65. 2010..These data support a model in which Spdef promotes terminal differentiation into goblet cells of a common goblet/Paneth progenitor... - Surfactant replacement for ventilator-associated pneumonia: a preliminary reportRobert P Baughman
Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Cincinnati Medical Center, Cincinnati, Ohio 45267 0564, USA
Respiration 69:57-62. 2002..Surfactant abnormalities have been described in bacterial pneumonia... - Cell-specific conditional deletion of Pten in the uterus results in differential phenotypesTakiko Daikoku
Division of Reproductive Sciences, The Perinatal Institute, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229 3039, USA
Gynecol Oncol 122:424-9. 2011..Our objective was to determine whether deletion of Pten specifically in the uterine stroma and myometrium induces cancer or manifests different phenotypes... - TAZ interacts with TTF-1 and regulates expression of surfactant protein-CKwon Sik Park
Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
J Biol Chem 279:17384-90. 2004..TAZ binds to TTF-1, increasing the transcriptional activity of TTF-1 on the SP-C promoter. Developmental and cell-selective regulation of TAZ provides a mechanism by which the activity of TTF-1 on target genes is modulated... - Sox2 activates cell proliferation and differentiation in the respiratory epitheliumDavid H Tompkins
Cincinnati Children s Hospital Medical Center, Division of Pulmonary Biology, MLC 7029, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
Am J Respir Cell Mol Biol 45:101-10. 2011..Sox2 induces proliferation of respiratory epithelial cells and, subsequently, partially reprograms alveolar epithelial cells into cells with characteristics of the conducting airways... - Ectopic respiratory epithelial cell differentiation in bronchiolised distal airspaces in idiopathic pulmonary fibrosisLaurent Plantier
Section of Neonatology, Perinatal and Pulmonary Biology, Cincinnati Children s Hospital Medical Center, Perinatal Institute, MLC7029, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
Thorax 66:651-7. 2011..Bronchiolisation of distal airspaces is an unexplained feature of idiopathic pulmonary fibrosis (IPF). The authors sought to identify mechanisms driving the differentiation of mucus cells during the bronchiolisation process... - Conditional deletion of Abca3 in alveolar type II cells alters surfactant homeostasis in newborn and adult miceValérie Besnard
The Perinatal Institute and Section of Neonatology, Perinatal and Pulmonary Biology, Cincinnati Children s Hospital Medical Center, Department of Pediatrics and University of Cincinnati College of Medicine, Ohio
Am J Physiol Lung Cell Mol Physiol 298:L646-59. 2010..Compensatory surfactant synthesis was initiated in ABCA3-sufficient type II cells, indicating that surfactant homeostasis is a highly regulated process that includes sensing and coregulation among alveolar type II cells... - Correction of pulmonary abnormalities in Sftpd-/- mice requires the collagenous domain of surfactant protein DPaul S Kingma
Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
J Biol Chem 281:24496-505. 2006..The collagen domain of SP-D is required for the regulation of pulmonary macrophage activation, airspace remodeling, and surfactant lipid homeostasis... - Alveolar epithelial STAT3, IL-6 family cytokines, and host defense during Escherichia coli pneumoniaLee J Quinton
Molecular and Integrative Physiological Sciences Program, Harvard School of Public Health, 665 Huntington Ave, Boston, MA 02115, USA
Am J Respir Cell Mol Biol 38:699-706. 2008..Together, these results indicate that during E. coli pneumonia, select IL-6 family members activate alveolar epithelial STAT3, which functions to promote neutrophil recruitment and to limit both infection and lung injury... - Stat3 is required for cytoprotection of the respiratory epithelium during adenoviral infectionYohei Matsuzaki
Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
J Immunol 177:527-37. 2006..Thus, Stat3 plays a critical cytoprotective role that is required for epithelial cell survival and maintenance of alveolar structures during the early phases of pulmonary adenoviral infection... - Sox17 influences the differentiation of respiratory epithelial cellsKwon Sik Park
Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, OH 45229 3039, USA
Dev Biol 294:192-202. 2006..Sites of expression and the effects of Sox17 in vivo and in vitro are consistent with a role for Sox17 or other members of the Sox family of transcription factors in differentiation of the conducting airway epithelium... - R-spondin 2 is required for normal laryngeal-tracheal, lung and limb morphogenesisSheila M Bell
Section of Neonatology, Perinatal and Pulmonary Biology, Cincinnati Children s Hospital Medical Center and the University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
Development 135:1049-58. 2008..Interbreeding the Rspo2(Tg) and Lrp6(-) alleles resulted in more severe defects consisting of marked lung hypoplasia and absence of tracheal-bronchial rings, laryngeal structures and all limb skeletal elements... - C/EBPalpha is required for lung maturation at birthPrithy C Martis
Division of Pulmonary Biology and Neonatology, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
Development 133:1155-64. 2006..C/EBPalpha participates in a transcriptional network that is required for the regulation of genes mediating perinatal lung maturation and surfactant homeostasis that is necessary for adaptation to air breathing at birth... - PARP-2 interacts with TTF-1 and regulates expression of surfactant protein-BYutaka Maeda
Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
J Biol Chem 281:9600-6. 2006..PARP-2 and PARP-1 interact with TTF-1 and regulate the expression of surfactant protein B, a protein required for lung function... - Transdifferentiation of ciliated cells during repair of the respiratory epitheliumKwon-Sik Park
Division of Pulmonary Biology, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229-3039, USA
Am J Respir Cell Mol Biol 34:151-7. 2006..Taken together, these findings demonstrate that ciliated epithelial cells spread and transdifferentiate into distinct epithelial cell types to repair the airway epithelium... - Prenatal lung epithelial cell-specific abrogation of Alk3-bone morphogenetic protein signaling causes neonatal respiratory distress by disrupting distal airway formationJianping Sun
Developmental Biology Program, Childrens Hospital Los Angeles, 4650 Sunset Blvd, MS 35, Los Angeles, CA 90027, USA
Am J Pathol 172:571-82. 2008..Therefore, our data suggest that deficiency of appropriate BMP signaling in lung epithelial cells results in prenatal lung malformation, neonatal atelectasis, and respiratory failure... - Complementation of pulmonary abnormalities in SP-D(-/-) mice with an SP-D/conglutinin fusion proteinLiqian Zhang
Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
J Biol Chem 277:22453-9. 2002..Our findings also strongly suggest that the molecular mechanisms underlying impaired pulmonary host defense and abnormal lipid metabolism are distinct from those that promote ongoing inflammation and the development of emphysema... - Surfactant protein D alters allergic lung responses in mice and human subjectsEric B Brandt
Division of Allergy and Immunology, Cincinnati Children s Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA
J Allergy Clin Immunol 121:1140-1147.e2. 2008..Surfactant protein (SP) D has been proposed to be protective in allergic airway responses... - STAT3 regulates ABCA3 expression and influences lamellar body formation in alveolar type II cellsYohei Matsuzaki
Cincinnati Children s Hospital Medical Center, Section of Neonatology, Perinatal and Pulmonary Biology, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
Am J Respir Cell Mol Biol 38:551-8. 2008..ABCA3 expression is regulated by IL-6 in a pathway that includes STAT3, PI3K, AKT, SCAP, and SREBP. Activation of STAT3 after exposure to IL-6 enhances ABCA3 expression, which, in turn, influences pulmonary surfactant homeostasis... - GP130-STAT3 regulates epithelial cell migration and is required for repair of the bronchiolar epitheliumHiroshi Kida
Section of Neonatology, Perinatal and Pulmonary Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229 3039, USA
Am J Pathol 172:1542-54. 2008..In the present study, we show that GP130-STAT3 signaling functions in a cell-autonomous manner to restore cell shape and numbers required for repair of the bronchiolar epithelium following injury... - Pten controls lung morphogenesis, bronchioalveolar stem cells, and onset of lung adenocarcinomas in miceShigehisa Yanagi
Department of Molecular Biology, Akita University School of Medicine, Akita, Japan
J Clin Invest 117:2929-40. 2007..These results indicate that Pten is essential for both normal lung morphogenesis and the prevention of lung carcinogenesis, possibly because this tumor suppressor is required for BASC homeostasis... - Sterol response element binding protein and thyroid transcription factor-1 (Nkx2.1) regulate Abca3 gene expressionValérie Besnard
Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center and the University of Cincinnati College of Medicine, Cincinnati, OH 45229 3039, USA
Am J Physiol Lung Cell Mol Physiol 293:L1395-405. 2007..Abca3 gene expression is mediated by discrete cis-acting cassettes that mediate pulmonary cell- and lipid-sensitive pathways regulating surfactant homeostasis... - Epithelial-vascular cross talk mediated by VEGF-A and HGF signaling directs primary septae formation during distal lung morphogenesisHiroaki Yamamoto
Department of Medicine and Lung Biology Center, University of California, San Francisco, CA 94143, USA
Dev Biol 308:44-53. 2007.... - SPDEF regulates goblet cell hyperplasia in the airway epitheliumKwon Sik Park
Division of Pulmonary Biology, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
J Clin Invest 117:978-88. 2007..SPDEF was induced following intratracheal allergen exposure and after Th2 cytokine stimulation and was sufficient to cause goblet cell differentiation of Clara cells in vivo... - A Gata6-Wnt pathway required for epithelial stem cell development and airway regenerationYuzhen Zhang
Department of Medicine, University of Pennsylvania, 956 BRB II III, 421 Curie Boulevard, Philadelphia, Pennsylvania 19104, USA
Nat Genet 40:862-70. 2008..Together, these data demonstrate that Gata6-regulated Wnt signaling controls the balance between progenitor expansion and epithelial differentiation required for both lung development and regeneration... - Kruppel-like factor 5 is required for perinatal lung morphogenesis and functionHuajing Wan
Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center and the University of Cincinnati College of Medicine, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
Development 135:2563-72. 2008..KLF5 regulates genes controlling paracrine interactions during lung morphogenesis, as well as those regulating the maturation of the respiratory epithelium that is required for lung function after birth... - Neither SP-A nor NH2-terminal domains of SP-A can substitute for SP-D in regulation of alveolar homeostasisLiqian Zhang
Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, OH 45229, USA
Am J Physiol Lung Cell Mol Physiol 291:L181-90. 2006.... - Identification of the surfactant protein A receptor 210 as the unconventional myosin 18AChing Hui Yang
Center of Biomedical Research, University of Texas Health Center, Tyler, Texas 75708 3154, USA
J Biol Chem 280:34447-57. 2005..Antibodies raised against the neck domain of MyoXVIIIA blocked the binding of SP-A to macrophages. Together, these findings indicate that MyoXVIIIA constitutes a novel receptor for SP-A... - Surfactant protein B inhibits endotoxin-induced lung inflammationRalph Epaud
Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
Am J Respir Cell Mol Biol 28:373-8. 2003.... - Pneumonitis and emphysema in sp-C gene targeted miceStephan W Glasser
Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, Ohio 45229 3039, USA
J Biol Chem 278:14291-8. 2003..Absence of SP-C caused a severe progressive pulmonary disorder with histologic features consistent with interstitial pneumonitis... - Transcriptional adaptation to cystic fibrosis transmembrane conductance regulator deficiencyYan Xu
Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
J Biol Chem 278:7674-82. 2003..Absence of CFTR influenced the expression of genes modulating diverse pulmonary cell functions that may ameliorate or contribute to the pathogenesis of CF... - Prenatal, but not postnatal, inhibition of fibroblast growth factor receptor signaling causes emphysemaIsamu Hokuto
Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
J Biol Chem 278:415-21. 2003..5 but did not alter alveolarization when expressed after birth. Although FGF signaling was required for branching morphogenesis early in lung development, postnatal alveolarization was not influenced by FGFR-HFc... - Aminoglycoside suppression of a premature stop mutation in a Cftr-/- mouse carrying a human CFTR-G542X transgeneMing Du
Department of Microbiology, The University of Alabama at Birmingham, Birmingham, AL 35294 2170, USA
J Mol Med (Berl) 80:595-604. 2002..052). When taken together, these results indicate that gentamicin, and to a lesser extent tobramycin, can restore the synthesis of functional hCFTR protein by suppressing the hCFTR-G542X premature stop mutation in vivo... - Reversibility of pulmonary abnormalities by conditional replacement of surfactant protein D (SP-D) in vivoLiqian Zhang
Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
J Biol Chem 277:38709-13. 2002..However, once established, emphysema was not reversed by SP-D. SP-D-dependent processes regulating surfactant lipid homeostasis were disassociated from those mediating emphysema... - Early restriction of peripheral and proximal cell lineages during formation of the lungAnne-Karina T Perl
Cincinnati Children's Hospital Medical Center, Division of Pulmonary Biology, Cincinnati, OH 45229-3039, USA
Proc Natl Acad Sci U S A 99:10482-7. 2002.... - The role of pulmonary collectin N-terminal domains in surfactant structure, function, and homeostasis in vivoNades Palaniyar
Division of Pulmonary Critical Care Medicine, Department of Medicine, Children s Hospital Research Foundation, University of Cincinnati School of Medicine, Cincinnati, OH 45267 0564, USA
J Biol Chem 277:26971-9. 2002.... - Wild-type levels of the mouse Forkhead Box f1 gene are essential for lung repairVladimir V Kalinichenko
Department of Molecular Genetics, College of Medicine, University of Illinois at Chicago, 60607 7170, USA
Am J Physiol Lung Cell Mol Physiol 282:L1253-65. 2002..Collectively, our data suggest that sustained expression of Foxf1 is essential for normal lung repair and endothelial cell survival in response to pulmonary cell injury... - GATA6 regulates differentiation of distal lung epitheliumHonghua Yang
Department of Medicine, Molecular Cardiology Research Center, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Development 129:2233-46. 2002..Together, these data implicate GATA6 as an important regulator of distal epithelial cell differentiation and proximal airway development in the mouse... - Fusion of lung lobes and vessels in mouse embryos heterozygous for the forkhead box f1 targeted alleleLorena Lim
Department of Molecular Genetics, College of Medicine, University of Illinois at Chicago, Chicago, Illinois 60607 7170, USA
Am J Physiol Lung Cell Mol Physiol 282:L1012-22. 2002.... - Fibroblast growth factor 18 influences proximal programming during lung morphogenesisJeffrey A Whitsett
Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
J Biol Chem 277:22743-9. 2002..Effects were unique to FGF-18 because expression of other members of the FGF family had different consequences. These data show that FGF-18 is capable of enhancing proximal and inhibiting peripheral programs during lung morphogenesis... - Conditional gene expression in the respiratory epithelium of the mouseAnne-Karina T Perl
Children's Hospital Medical Center, Division of Pulmonary Biology, Cincinnati, Ohio, USA
Transgenic Res 11:21-9. 2002..The SP-C-rtTA and CCSP-rtTA activator mice control the expression of transgenes in the developing and mature respiratory epithelium, and will be useful for the study of gene function in the lung... - Increased expression of thyroid transcription factor-1 (TTF-1) in respiratory epithelial cells inhibits alveolarization and causes pulmonary inflammationSusan E Wert
Division of Pulmonary Biology, Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
Dev Biol 242:75-87. 2002..Increased expression of TTF-1 altered alveolarization and caused chronic pulmonary inflammation, demonstrating that precise regulation of TTF-1 is critical for homeostasis in the postnatal lung... - Deficiency of SP-B reveals protective role of SP-C during oxygen lung injuryMachiko Ikegami
Children s Hospital Medical Center, Division of Pulmonary Biology, Cincinnati, Ohio 45229 3039, USA
J Appl Physiol 92:519-26. 2002..Genetically decreased levels of SP-B combined with superimposed O(2)-induced injury reveals the distinct contribution of SP-C to pulmonary function in vivo... - In vivo measurements of changes in respiratory mechanics with age in mice deficient in surfactant protein DRachel A Collins
Division of Clinical Sciences, Telethon Institute for Child Health Research, Perth, Western Australia
Pediatr Res 53:463-7. 2003..These data demonstrate that the changes in lung structure in SP-D (-/-) mice are reflected in the mechanical properties of both airway and lung parenchyma measured in vivo... - SP-B deficiency causes respiratory failure in adult miceKristin R Melton
Cincinnati Children s Hospital Medical Center, Division of Pulmonary Biology, 3333 Burnet Ave, Cincinnati, OH 45229 3039, USA
Am J Physiol Lung Cell Mol Physiol 285:L543-9. 2003..Reduction of alveolar SP-B content causes surfactant dysfunction and respiratory failure, indicating that SP-B is required for postnatal lung function... - Thyroid transcription factor (TTF) -1 regulates the expression of midkine (MK) during lung morphogenesisPaul R Reynolds
Cincinnati Children s Hospital Medical Center, Division of Pulmonary Biology, Cincinnati, Ohio 45229 3039, USA
Dev Dyn 227:227-37. 2003..TTF-1 regulates expression of MK in the lung. The temporal/spatial distribution of midkine is consistent with a potential role in paracrine signaling during lung morphogenesis... - Wnt/beta-catenin signaling acts upstream of N-myc, BMP4, and FGF signaling to regulate proximal-distal patterning in the lungWeiguo Shu
Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
Dev Biol 283:226-39. 2005..Thus, Wnt/beta-catenin signaling is a critical upstream regulator of proximal-distal patterning in the lung, in part, through regulation of N-myc, BMP4, and FGF signaling... - Surfactant protein-D regulates soluble CD14 through matrix metalloproteinase-12Albert P Senft
Division of Neonatology and Pulmonary Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
J Immunol 174:4953-9. 2005..Supporting this observation, MMP-12 caused the release of sCD14 from RAW 264.7 cells in vitro. In conclusion, SP-D influences innate host defense, in part, by regulating sCD14 in a process mediated by MMP-9 and MMP-12... - Interleukin-1beta causes pulmonary inflammation, emphysema, and airway remodeling in the adult murine lungUrpo Lappalainen
Goteborg University, Department of Pediatrics, The Queen Silvia Children's Hospital, 41685 Goteborg, Sweden
Am J Respir Cell Mol Biol 32:311-8. 2005..Chronic production of IL-1beta in respiratory epithelial cells of adult mice causes lung inflammation, enlargement of distal airspaces, mucus metaplasia, and airway fibrosis in the adult mouse... - Compensatory roles of Foxa1 and Foxa2 during lung morphogenesisHuajing Wan
Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center and the University of Cincinnati College of Medicine, Cincinnati, Ohio 45229 3039, USA
J Biol Chem 280:13809-16. 2005..Foxa family members regulate signaling and transcriptional programs required for morphogenesis and cell differentiation during formation of the lung... - Foxa2 is required for transition to air breathing at birthHuajing Wan
Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center and University of Cincinnati College of Medicine, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
Proc Natl Acad Sci U S A 101:14449-54. 2004..Foxa2 regulates a complex pulmonary program of epithelial cell maturation required for transition to air breathing at birth... - Role of Sonic hedgehog in patterning of tracheal-bronchial cartilage and the peripheral lungLeigh Anne D Miller
Department of Pediatrics, Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
Dev Dyn 231:57-71. 2004..SHH regulates branching morphogenesis and influences differentiation of the peripheral lung mesenchyme required for formation of bronchial and vascular smooth muscle... - Midkine is regulated by hypoxia and causes pulmonary vascular remodelingPaul R Reynolds
Divisions of Pulmonary Biology and Human Genetics, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
J Biol Chem 279:37124-32. 2004..These data provide a model wherein the respiratory epithelium responds to hypoxia via HIF-1alpha-dependent regulation of MK, enhancing myocardin expression to influence pulmonary vascular gene expression... - Foxa2 regulates alveolarization and goblet cell hyperplasiaHuajing Wan
Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
Development 131:953-64. 2004..FOXA2 is required for alveolarization and regulates airway epithelial cell differentiation in the postnatal lung... - Stat-3 is required for pulmonary homeostasis during hyperoxiaIsamu Hokuto
Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
J Clin Invest 113:28-37. 2004..Expression of Stat-3 in respiratory epithelial cells is not required for lung formation, but plays a critical role in maintenance of surfactant homeostasis and lung function during oxygen injury... - Foxf1 haploinsufficiency reduces Notch-2 signaling during mouse lung developmentVladimir V Kalinichenko
Department of Biochemistry and Molecular Genetics, College of Medicine, University of Illinois, Chicago, IL 60607 7170, USA
Am J Physiol Lung Cell Mol Physiol 286:L521-30. 2004..Foxf1 haploinsufficiency disrupted pulmonary expression of genes in the Notch-2-signaling pathway and resulted in abnormal development of lung microvasculature... - Inhibition of alveolarization and altered pulmonary mechanics in mice expressing GATA-6Cong Liu
Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
Am J Physiol Lung Cell Mol Physiol 285:L1246-54. 2003..Normal postnatal morphogenesis of the lung depends upon precise temporal-spatial regulation of GATA-6... - Disrupted pulmonary vascular development and pulmonary hypertension in transgenic mice overexpressing transforming growth factor-alphaTimothy D Le Cras
Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
Am J Physiol Lung Cell Mol Physiol 285:L1046-54. 2003..Reductions in VEGF may contribute to the pathogenesis of pulmonary vascular disease in TGF-alpha mice... - Inhibitory effects of surfactant protein A on surfactant phospholipid hydrolysis by secreted phospholipases A2Sophie Chabot
Unité de Défense Innée et Inflammation, Institut Pasteur, Institut National de la Santé et de la Recherche Médicale E 336, Paris, France
J Immunol 171:995-1000. 2003..We conclude that SP-A inhibits sPLA(2) activity, which may play a protective role by maintaining surfactant integrity during lung injury... - TTF-1 phosphorylation is required for peripheral lung morphogenesis, perinatal survival, and tissue-specific gene expressionMario DeFelice
Stazione Zoologica A Dohrn, Villa Comunale, 80121 Naples, Italy
J Biol Chem 278:35574-83. 2003..Direct and indirect transcriptional targets of TTF-1 were identified that are likely to play important roles in lung formation and function... - Temporal effects of Sprouty on lung morphogenesisAnne Karina T Perl
Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229 3039, USA
Dev Biol 258:154-68. 2003..These findings demonstrate that the embryonic-pseudoglandular stage is a critical time period during which Spry-sensitive pathways are required for branching morphogenesis, lobulation, and formation of the peripheral lung parenchyma... - GATA-6 and thyroid transcription factor-1 directly interact and regulate surfactant protein-C gene expressionCong Liu
Division of Pulmonary Biology, Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
J Biol Chem 277:4519-25. 2002..GATA-6 influenced the activity of the sp-C promoter, binding and acting synergistically with TTF-1...
Research Grants
- PULMONARY AND CARDIOVASCULAR DEVELOPMENT TRAINING GRANTJeffrey Whitsett; Fiscal Year: 2007..Regular research meetings and several pertinent seminar series further enhance the program. Progress of each trainee will be reviewed annually by the Executive Committee. ..
- ABCA3 and Alveolar HomeostasisJeffrey Whitsett; Fiscal Year: 2007....
- Transcriptional Control of Respiratory Epithelial Progenitor CellsJeffrey Whitsett; Fiscal Year: 2007..A Stem Cell Consortium will be established at CCHMC, Univ. of Cincinnati College of Medicine to develop education, training, and research bridging hematopoietic stem cell and pulmonary stem cell biology on our campus. ..
- Transcriptional Programming of Asthma Related Pathology in Respiratory EpitheliaJeffrey A Whitsett; Fiscal Year: 2010..The work will identify mechanisms regulating airway epithelial homeostasis that will provide novel targets to diagnose and influence the pathogenesis of chronic pulmonary diseases affecting the airways. ..
- ABCA3 and Alveolar HomeostasisJeffrey A Whitsett; Fiscal Year: 2010....
- Transcriptional Control of Respiratory Epithelial Progenitor CellsJeffrey Whitsett; Fiscal Year: 2009..A Stem Cell Consortium will be established at CCHMC, Univ. of Cincinnati College of Medicine to develop education, training, and research bridging hematopoietic stem cell and pulmonary stem cell biology on our campus. ..
- PERINATAL EXPRESSION OF SURFACTANT PROTEIN GENE SP-BJeffrey Whitsett; Fiscal Year: 2007..Transcriptional responses to decreased SP-B will be determined using RNA microarray, to identify the molecular pathways mediating or compensating for reduced SP-B/surfactant function in vivo. ..
- PERINATAL EXPRESSION OF SURFACTANT PROTEIN GENEJeffrey Whitsett; Fiscal Year: 1991..Knowledge of the role of SAP-6-Phe in surfactant biology and control of SAP-6-Phe synthesis will be important in developing new strategies for therapy of hyaline membrane disease in newborn infants...
- PERINATAL EXPRESSION OF SURFACTANT PROTEIN GENE SP-BJeffrey Whitsett; Fiscal Year: 1993..Further understanding of the role of SP-B in lung function and the mechanisms regulating SP-B may provide insights critical to developing new therapeutic strategies for prevention of lung disease in premature infants...
- SHH and Alveolar FormationJeffrey Whitsett; Fiscal Year: 2006..abstract_text> ..
- Transcriptional Control of Respiratory Epithelial Progenitor CellsJeffrey A Whitsett; Fiscal Year: 2010..A Stem Cell Consortium will be established at CCHMC, Univ. of Cincinnati College of Medicine to develop education, training, and research bridging hematopoietic stem cell and pulmonary stem cell biology on our campus. ..