Research Topics
Species | D S WheelerSummaryAffiliation: Cincinnati Children's Hospital Medical Center Country: USA Publications
Research Grants
| Collaborators
|
Detail Information
Publications
Identification of candidate serum biomarkers for severe septic shock-associated kidney injury via microarrayRajit K Basu
Cincinnati Children s Hospital Medical Center and Cincinnati Children s Research Foundation, Department of Pediatrics, University of Cincinnati College of Medicine, 3333 Burnet Avenue, Cincinnati, OH 45223, USA
Crit Care 15:R273. 2011..The objective of our study was to determine whether microarray data from children with septic shock could be used to derive a panel of candidate biomarkers for predicting SSAKI...
An unexpected increase in catheter-associated bloodstream infections at a children's hospital following introduction of the Spiros closed male connectorDerek S Wheeler
James M Anderson Center for Health Systems Excellence, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229 3039, USA
Am J Infect Control 40:48-50. 2012..Previous investigations have reported outbreaks of CA-BSI temporally associated with the use of needleless connector valves or similar devices...- Excess circulating angiopoietin-2 levels in sepsis: harbinger of death in the intensive care unit?John S Giuliano
Department of Pediatrics, Division of Critical Care Medicine, Yale University School of Medicine, Yale New Haven Children s Hospital, New Haven, CT 06510, USA
Crit Care 13:114. 2009..It remains to be seen whether angpt-2 levels will function solely as an early marker of sepsis or whether the manipulation of the angpt/Tie-2 system will become a rational therapeutic target for the management of sepsis... - A hospital-wide quality-improvement collaborative to reduce catheter-associated bloodstream infectionsDerek S Wheeler
Division of Critical Care Medicine, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
Pediatrics 128:e995-e1004; quiz e1004-7. 2011..Quality-improvement collaboratives (QICs) are frequently used to improve health care quality. Our PICU was previously involved in a successful national QIC to reduce the incidence of CA BSI in critically ill children... 
Pentalogy of Cantrell associated with hypoplastic left heart syndromeD S Wheeler
Division of Critical Care Medicine, Cincinnati Children s Hospital Medical Center, and Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati Children s Research Foundation, OH 45229 3039, USA
Pediatr Cardiol 28:311-3. 2007..We describe the previously unreported association of pentalogy of Cantrell with hypoplastic left heart syndrome...- Extracellular heat shock protein 60 (Hsp60) levels in children with septic shockD S Wheeler
Division of Critical Care Medicine, Cincinnati Children s Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, 45229 3039, USA
Inflamm Res 56:216-9. 2007..Recent data suggest that extracellular Hsp60 modulates the host innate immune response. We analyzed plasma Hsp60 levels in children admitted to a level III tertiary care PICU with septic shock... - Serum neutrophil gelatinase-associated lipocalin (NGAL) as a marker of acute kidney injury in critically ill children with septic shockDerek S Wheeler
Division of Critical Care Medicine, Cincinnati Children s Hospital Medical Center, Cincinnati, OH, USA
Crit Care Med 36:1297-303. 2008..To validate serum neutrophil gelatinase-associated lipocalin (NGAL) as an early biomarker for acute kidney injury in critically ill children with septic shock... - Induction of endotoxin tolerance enhances bacterial clearance and survival in murine polymicrobial sepsisDerek S Wheeler
Division of Critical Care Medicine, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
Shock 30:267-73. 2008..Contrary to our original hypothesis, we conclude that endotoxin tolerance significantly attenuates the host inflammatory response, augments bacterial clearance, and improves survival in this murine model of polymicrobial sepsis... - An infant with fever and stridorDerek S Wheeler
Division of Critical Care Medicine, Cincinnati Children s Hospital Medical Center and Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45229 3039, USA
Pediatr Emerg Care 24:46-9. 2008..As illustrated in the following case, these children may not always present with classic features of supraglottitis... - Novel pharmacologic approaches to the management of sepsis: targeting the host inflammatory responseDerek S Wheeler
Division of Critical Care Medicine, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229 3039, USA
Recent Pat Inflamm Allergy Drug Discov 3:96-112. 2009..We will also reference some of the patents recently filed that pertain to the host innate immune response and sepsis... - Death to sepsis: targeting apoptosis pathways in sepsisDerek S Wheeler
Pediatric Intensive Care Unit, Division of Critical Care Medicine, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229 3039, USA
Crit Care 13:1010. 2009..Herein, the role of apoptosis in sepsis is briefly discussed, highlighting studies with one potential therapeutic agent targeting the apoptosis pathway... - The green tea polyphenol epigallocatechin-3-gallate improves systemic hemodynamics and survival in rodent models of polymicrobial sepsisDerek S Wheeler
Division of Critical Care Medicine, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
Shock 28:353-9. 2007..Epigallocatechin-3-gallate may therefore represent a potential nutritional supplement or pharmacologic agent in patients with sepsis... - Extracellular Hsp72, an endogenous DAMP, is released by virally infected airway epithelial cells and activates neutrophils via Toll-like receptor (TLR)-4Derek S Wheeler
Division of Critical Care Medicine, Cincinnati Children s Hospital Medical Center, Cincinnati Children s Research Foundation, Cincinnati, OH, USA
Respir Res 10:31. 2009..Heat shock proteins (HSPs) are generally regarded as intracellular proteins acting as molecular chaperones; however, HSP72 can also be released from cells, and the implications of this release are not fully understood... - Theophylline versus terbutaline in treating critically ill children with status asthmaticus: a prospective, randomized, controlled trialDerek S Wheeler
Department of Pediatrics, University of Cincinnati College of Medicine, Division of Critical Care Medicine, OH 45229, USA
Pediatr Crit Care Med 6:142-7. 2005.... - Clinical decision support systems in the pediatric intensive care unitElizabeth H Mack
Division of Critical Care Medicine, Cincinnati Children s Hospital Medical Center, Cincinnati, OH, USA
Pediatr Crit Care Med 10:23-8. 2009..To review the use of clinical decision support systems (CDSS) available in the pediatric intensive care unit (PICU)... - Interleukin-8 as a stratification tool for interventional trials involving pediatric septic shockHector R Wong
Division of Critical Care Medicine, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
Am J Respir Crit Care Med 178:276-82. 2008..Interventional clinical trials involving children with septic shock would benefit from an efficient preenrollment stratification strategy... - Admission chemokine (C-C motif) ligand 4 levels predict survival in pediatric septic shockJeffrey E Nowak
Division of Critical Care Medicine, Cincinnati Children s Hospital Medical Center, Cincinnati, OH, USA
Pediatr Crit Care Med 11:213-6. 2010..The objective of this study was to test the usefulness of chemokine (C-C motif) ligand 4 as an outcome biomarker for mortality in pediatric septic shock... - A green tea-derived polyphenol, epigallocatechin-3-gallate, inhibits IkappaB kinase activation and IL-8 gene expression in respiratory epitheliumPhilip C Chen
Division of Critical Care Medicine, Children's Hospital Medical Center and Children's Hospital Research Foundation, Cincinnati, OH 45244, USA
Inflammation 26:233-41. 2002..We conclude that EGCG is a potent inhibitor of IL-8 gene expression in vitro. The proximal mechanism of this effect involves, in part, inhibition of IkappaB kinase activation... - Toward a clinically feasible gene expression-based subclassification strategy for septic shock: proof of conceptHector R Wong
Division of Critical Care Medicine, Cincinnati Children s Hospital Medical Center and Cincinnati Children s Research Foundation, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA
Crit Care Med 38:1955-61. 2010..To develop a clinically feasible stratification strategy for pediatric septic shock, using gene expression mosaics and a 100-gene signature representing the first 24 hrs of admission to the pediatric intensive care unit... - The role of endogenously produced extracellular hsp72 in mononuclear cell reprogrammingPatricia A Abboud
Division of Critical Care Medicine, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio, USA
Shock 30:285-92. 2008..These data demonstrate that endogenously produced and released extracellular Hsp72 has the ability to reprogram the in vitro response to endotoxin in cultured human mononuclear cells... - Helium/oxygen-driven albuterol nebulization in the management of children with status asthmaticus: a randomized, placebo-controlled trialMichael T Bigham
Division of Critical Care Medicine, Akron Children s Hospital, Akron, OH, USA
Pediatr Crit Care Med 11:356-61. 2010..We investigated the effect of heliox-powered albuterol therapy on hospital length of stay and clinical status in children with moderate to severe status asthmaticus... - Transport of the mechanically ventilated pediatric patientDerek S Wheeler
Division of Critical Care Medicine, Children's Hospital Medical Center, Cincinnati, OH 45229-3039, USA
Respir Care Clin N Am 8:83-104. 2002..It is likely, then, that the field of pediatric transport medicine will assume greater importance in the coming decade... - Extracellular hsp70 levels in children with septic shockDerek S Wheeler
Department of Pediatrics, University of Cincinnati College of Medicine and Children's Hospital Research Foundation, Cincinnati, OH, USA
Pediatr Crit Care Med 6:308-11. 2005..Given the newly described cell signaling properties of hsp70, these data suggest that extracellular hsp70 may play a role in the host response during septic shock... - Mechanisms and regulation of the gene-expression response to sepsisTimothy T Cornell
Division of Critical Care Medicine, C S Mott Children s Hospital, University of Michigan, Ann Arbor, MI, USA
Pediatrics 125:1248-58. 2010..We anticipate that emerging data from genetic, genomic, and other translation studies in pediatric sepsis will advance our biological understanding of this response and undoubtedly identify targets for newer therapies... - Admission angiopoietin levels in children with septic shockJohn S Giuliano
Division of Critical Care Medicine, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
Shock 28:650-654. 2007..Given the contrasting effects of angpt-2 and angpt-1 on the vascular endothelium, these two factors may play an important role in the pathophysiology of septic shock in children, and further studies are warranted... - Hsp72 induces inflammation and regulates cytokine production in airway epithelium through a TLR4- and NF-kappaB-dependent mechanismMargaret A Chase
Division of Critical Care Medicine, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
J Immunol 179:6318-24. 2007..Taken together, these data suggest that Hsp72 is released and biologically active in the BALF and can regulate airway epithelial cell cytokine expression in a TLR4 and NF-kappaB-dependent mechanism... - Plasma angiopoietin-2 levels increase in children following cardiopulmonary bypassJohn S Giuliano
Division of Critical Care Medicine, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
Intensive Care Med 34:1851-7. 2008..The aim was to investigate the effects of cardiopulmonary bypass (CPB) on plasma levels of the vascular growth factors, angiopoietin (angpt)-1, angpt-2, and vascular endothelial growth factor (VEGF)... - Prehospital evaluation and care of the special needs and technology-dependent childDerek S Wheeler
Division of Critical Care Medicine, Ciincinnati Children's Hospital Medical Center, OH, USA
Emerg Med Serv 31:45-50, 52, 54 passim; quiz 97. 2002..Remember, the child's care provider is a valuable resource and should be used to the fullest extent whenever possible... - A formidable challenge: the diagnosis and treatment of viral myocarditis in childrenDerek S Wheeler
Division of Critical Care Medicine, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
Crit Care Clin 19:365-91. 2003..Viral myocarditis, however, will remain a significant diagnosticand therapeutic challenge to both physicians and scientists alike... - Heat shock response and acute lung injuryDerek S Wheeler
Division of Critical Care Medicine, Cincinnati Children s Hospital Medical Center, Kindervelt Laboratory for Critical Care Medicine Research, Childrens Hospital Research Foundation, Cincinnati, OH 45229, USA
Free Radic Biol Med 42:1-14. 2007.... - Unilateral pulmonary edema and acute rheumatic feverJohn S Giuliano
Division of Critical Care Medicine, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229 3039, USA
Eur J Pediatr 167:465-7. 2008..We present a case of an 8-year-old child who presented with unilateral pulmonary edema secondary to acute mitral insufficiency due to ARF. ARF should be considered in the differential diagnosis of unilateral pulmonary edema in children... - Therapeutic application of helium-oxygen and mechanical ventilation in a child with acute myelogenous leukemia and airway obstructionMichael T Bigham
Division of Critical Care Medicine, Akron Children s Hospital, Akron, OH 44308, USA
Pediatr Emerg Care 25:469-72. 2009..We then review mediastinal masses and the biophysical rationale for use of heliox in airway narrowing... - Training in pediatric critical care medicine: A survey of pediatric residency training programsDerek S Wheeler
Division of Critical Care Medicine, Children s Hospital Medical Center, Cincinnati, Ohio, USA
Pediatr Emerg Care 19:1-5. 2003..We sought to determine how individual programs have structured their critical care training experience in light of these changes... - Late-onset respiratory distress after inhalation of laundry detergentDerek S Wheeler
Division of Critical Care Medicine, Department of Pediatrics, Children s Hospital Medical Center, Cincinnati, Ohio 45244, USA
Pediatr Pulmonol 35:323-5. 2003..Parents, primary care providers, and emergency department physicians need to be aware of the potential toxicity of these widely used household products... - Factors prolonging length of stay in the cardiac intensive care unit following the arterial switch operationDerek S Wheeler
Divisions of Critical Care Medicine, Cardiology, and Cardiothoracic Surgery, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
Cardiol Young 18:41-50. 2008..In addition, based on these results, our practice has evolved to initiate enteral feedings in the preoperative period if feasible, with such enteral feedings resumed as soon as possible following surgery... - The safe and effective use of propofol sedation in children undergoing diagnostic and therapeutic procedures: experience in a pediatric ICU and a review of the literatureDerek S Wheeler
Department of Pediatrics, Naval Medical Center, San Diego, CA, USA
Pediatr Emerg Care 19:385-92. 2003..To describe our experience using propofol sedation to facilitate elective diagnostic and therapeutic procedures, and to document the safety profile of propofol in this setting... - Epigallocatechin-3-gallate, a green tea-derived polyphenol, inhibits IL-1 beta-dependent proinflammatory signal transduction in cultured respiratory epithelial cellsDerek S Wheeler
Section of Critical Care Medicine, Children s Medical Center, Medical College of Georgia, Augusta, GA 30912, USA
J Nutr 134:1039-44. 2004..Therefore, the green tea polyphenol EGCG is a potent inhibitor of IL-1 beta signal transduction in vitro. The proximal mechanisms of this effect involve inhibition of IRAK-dependent signaling and phosphorylation of p65... - Phospholipase A2 and acute lung injury: it's just not that simpleDerek S Wheeler
Crit Care Med 33:904-5. 2005 - Understanding the role of stress proteins in acute lung injury: Closer to the answer, but not there yetDerek S Wheeler
Crit Care Med 35:2226-7. 2007 - Acute rhabdomyolysis complicating status asthmaticus in children: case series and reviewRenuka Mehta
Section of Critical Care Medicine, MCG Children's Medical Center, Augusta, GA, USA
Pediatr Emerg Care 22:587-91. 2006..Further clinical study of the incidence and causative factors of rhabdomyolysis in this population is warranted... - Stress proteins and acute lung injury: dreams can come true... eventuallyDerek S Wheeler
Crit Care Med 36:360-2. 2008
Research Grants
- The immunomodulatory effects of extracellular Hsp70Derek Wheeler; Fiscal Year: 2007....