D S Wheeler

Summary

Affiliation: Cincinnati Children's Hospital Medical Center
Country: USA

Publications

  1. doi request reprint High-reliability emergency response teams in the hospital: improving quality and safety using in situ simulation training
    Derek S Wheeler
    Division of Critical Care Medicine, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    BMJ Qual Saf 22:507-14. 2013
  2. pmc Identification of candidate serum biomarkers for severe septic shock-associated kidney injury via microarray
    Rajit K Basu
    Cincinnati Children s Hospital Medical Center and Cincinnati Children s Research Foundation, Department of Pediatrics, University of Cincinnati College of Medicine, 3333 Burnet Avenue, Cincinnati, OH 45223, USA
    Crit Care 15:R273. 2011
  3. doi request reprint An unexpected increase in catheter-associated bloodstream infections at a children's hospital following introduction of the Spiros closed male connector
    Derek S Wheeler
    James M Anderson Center for Health Systems Excellence, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229 3039, USA
    Am J Infect Control 40:48-50. 2012
  4. pmc Excess circulating angiopoietin-2 levels in sepsis: harbinger of death in the intensive care unit?
    John S Giuliano
    Department of Pediatrics, Division of Critical Care Medicine, Yale University School of Medicine, Yale New Haven Children s Hospital, New Haven, CT 06510, USA
    Crit Care 13:114. 2009
  5. pmc Death to sepsis: targeting apoptosis pathways in sepsis
    Derek S Wheeler
    Pediatric Intensive Care Unit, Division of Critical Care Medicine, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229 3039, USA
    Crit Care 13:1010. 2009
  6. pmc Induction of endotoxin tolerance enhances bacterial clearance and survival in murine polymicrobial sepsis
    Derek S Wheeler
    Division of Critical Care Medicine, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
    Shock 30:267-73. 2008
  7. doi request reprint An infant with fever and stridor
    Derek S Wheeler
    Division of Critical Care Medicine, Cincinnati Children s Hospital Medical Center and Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45229 3039, USA
    Pediatr Emerg Care 24:46-9. 2008
  8. ncbi request reprint Extracellular heat shock protein 60 (Hsp60) levels in children with septic shock
    D S Wheeler
    Division of Critical Care Medicine, Cincinnati Children s Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, 45229 3039, USA
    Inflamm Res 56:216-9. 2007
  9. ncbi request reprint Pentalogy of Cantrell associated with hypoplastic left heart syndrome
    D S Wheeler
    Division of Critical Care Medicine, Cincinnati Children s Hospital Medical Center, and Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati Children s Research Foundation, OH 45229 3039, USA
    Pediatr Cardiol 28:311-3. 2007
  10. ncbi request reprint The green tea polyphenol epigallocatechin-3-gallate improves systemic hemodynamics and survival in rodent models of polymicrobial sepsis
    Derek S Wheeler
    Division of Critical Care Medicine, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
    Shock 28:353-9. 2007

Research Grants

Collaborators

Detail Information

Publications42

  1. doi request reprint High-reliability emergency response teams in the hospital: improving quality and safety using in situ simulation training
    Derek S Wheeler
    Division of Critical Care Medicine, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    BMJ Qual Saf 22:507-14. 2013
    ..We describe our experience with in situ simulation training in a major children's medical centre...
  2. pmc Identification of candidate serum biomarkers for severe septic shock-associated kidney injury via microarray
    Rajit K Basu
    Cincinnati Children s Hospital Medical Center and Cincinnati Children s Research Foundation, Department of Pediatrics, University of Cincinnati College of Medicine, 3333 Burnet Avenue, Cincinnati, OH 45223, USA
    Crit Care 15:R273. 2011
    ..The objective of our study was to determine whether microarray data from children with septic shock could be used to derive a panel of candidate biomarkers for predicting SSAKI...
  3. doi request reprint An unexpected increase in catheter-associated bloodstream infections at a children's hospital following introduction of the Spiros closed male connector
    Derek S Wheeler
    James M Anderson Center for Health Systems Excellence, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229 3039, USA
    Am J Infect Control 40:48-50. 2012
    ..Previous investigations have reported outbreaks of CA-BSI temporally associated with the use of needleless connector valves or similar devices...
  4. pmc Excess circulating angiopoietin-2 levels in sepsis: harbinger of death in the intensive care unit?
    John S Giuliano
    Department of Pediatrics, Division of Critical Care Medicine, Yale University School of Medicine, Yale New Haven Children s Hospital, New Haven, CT 06510, USA
    Crit Care 13:114. 2009
    ..It remains to be seen whether angpt-2 levels will function solely as an early marker of sepsis or whether the manipulation of the angpt/Tie-2 system will become a rational therapeutic target for the management of sepsis...
  5. pmc Death to sepsis: targeting apoptosis pathways in sepsis
    Derek S Wheeler
    Pediatric Intensive Care Unit, Division of Critical Care Medicine, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229 3039, USA
    Crit Care 13:1010. 2009
    ..Herein, the role of apoptosis in sepsis is briefly discussed, highlighting studies with one potential therapeutic agent targeting the apoptosis pathway...
  6. pmc Induction of endotoxin tolerance enhances bacterial clearance and survival in murine polymicrobial sepsis
    Derek S Wheeler
    Division of Critical Care Medicine, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
    Shock 30:267-73. 2008
    ..Contrary to our original hypothesis, we conclude that endotoxin tolerance significantly attenuates the host inflammatory response, augments bacterial clearance, and improves survival in this murine model of polymicrobial sepsis...
  7. doi request reprint An infant with fever and stridor
    Derek S Wheeler
    Division of Critical Care Medicine, Cincinnati Children s Hospital Medical Center and Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45229 3039, USA
    Pediatr Emerg Care 24:46-9. 2008
    ..As illustrated in the following case, these children may not always present with classic features of supraglottitis...
  8. ncbi request reprint Extracellular heat shock protein 60 (Hsp60) levels in children with septic shock
    D S Wheeler
    Division of Critical Care Medicine, Cincinnati Children s Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, 45229 3039, USA
    Inflamm Res 56:216-9. 2007
    ..Recent data suggest that extracellular Hsp60 modulates the host innate immune response. We analyzed plasma Hsp60 levels in children admitted to a level III tertiary care PICU with septic shock...
  9. ncbi request reprint Pentalogy of Cantrell associated with hypoplastic left heart syndrome
    D S Wheeler
    Division of Critical Care Medicine, Cincinnati Children s Hospital Medical Center, and Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati Children s Research Foundation, OH 45229 3039, USA
    Pediatr Cardiol 28:311-3. 2007
    ..We describe the previously unreported association of pentalogy of Cantrell with hypoplastic left heart syndrome...
  10. ncbi request reprint The green tea polyphenol epigallocatechin-3-gallate improves systemic hemodynamics and survival in rodent models of polymicrobial sepsis
    Derek S Wheeler
    Division of Critical Care Medicine, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
    Shock 28:353-9. 2007
    ..Epigallocatechin-3-gallate may therefore represent a potential nutritional supplement or pharmacologic agent in patients with sepsis...
  11. pmc Serum neutrophil gelatinase-associated lipocalin (NGAL) as a marker of acute kidney injury in critically ill children with septic shock
    Derek S Wheeler
    Division of Critical Care Medicine, Cincinnati Children s Hospital Medical Center, Cincinnati, OH, USA
    Crit Care Med 36:1297-303. 2008
    ..To validate serum neutrophil gelatinase-associated lipocalin (NGAL) as an early biomarker for acute kidney injury in critically ill children with septic shock...
  12. doi request reprint A hospital-wide quality-improvement collaborative to reduce catheter-associated bloodstream infections
    Derek S Wheeler
    Division of Critical Care Medicine, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
    Pediatrics 128:e995-e1004; quiz e1004-7. 2011
    ..Quality-improvement collaboratives (QICs) are frequently used to improve health care quality. Our PICU was previously involved in a successful national QIC to reduce the incidence of CA BSI in critically ill children...
  13. pmc Extracellular Hsp72, an endogenous DAMP, is released by virally infected airway epithelial cells and activates neutrophils via Toll-like receptor (TLR)-4
    Derek S Wheeler
    Division of Critical Care Medicine, Cincinnati Children s Hospital Medical Center, Cincinnati Children s Research Foundation, Cincinnati, OH, USA
    Respir Res 10:31. 2009
    ..Heat shock proteins (HSPs) are generally regarded as intracellular proteins acting as molecular chaperones; however, HSP72 can also be released from cells, and the implications of this release are not fully understood...
  14. ncbi request reprint Theophylline versus terbutaline in treating critically ill children with status asthmaticus: a prospective, randomized, controlled trial
    Derek S Wheeler
    Department of Pediatrics, University of Cincinnati College of Medicine, Division of Critical Care Medicine, OH 45229, USA
    Pediatr Crit Care Med 6:142-7. 2005
    ....
  15. pmc Novel pharmacologic approaches to the management of sepsis: targeting the host inflammatory response
    Derek S Wheeler
    Division of Critical Care Medicine, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229 3039, USA
    Recent Pat Inflamm Allergy Drug Discov 3:96-112. 2009
    ..We will also reference some of the patents recently filed that pertain to the host innate immune response and sepsis...
  16. doi request reprint Clinical decision support systems in the pediatric intensive care unit
    Elizabeth H Mack
    Division of Critical Care Medicine, Cincinnati Children s Hospital Medical Center, Cincinnati, OH, USA
    Pediatr Crit Care Med 10:23-8. 2009
    ..To review the use of clinical decision support systems (CDSS) available in the pediatric intensive care unit (PICU)...
  17. pmc The role of endogenously produced extracellular hsp72 in mononuclear cell reprogramming
    Patricia A Abboud
    Division of Critical Care Medicine, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio, USA
    Shock 30:285-92. 2008
    ..These data demonstrate that endogenously produced and released extracellular Hsp72 has the ability to reprogram the in vitro response to endotoxin in cultured human mononuclear cells...
  18. pmc Toward a clinically feasible gene expression-based subclassification strategy for septic shock: proof of concept
    Hector R Wong
    Division of Critical Care Medicine, Cincinnati Children s Hospital Medical Center and Cincinnati Children s Research Foundation, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA
    Crit Care Med 38:1955-61. 2010
    ..To develop a clinically feasible stratification strategy for pediatric septic shock, using gene expression mosaics and a 100-gene signature representing the first 24 hrs of admission to the pediatric intensive care unit...
  19. pmc Admission chemokine (C-C motif) ligand 4 levels predict survival in pediatric septic shock
    Jeffrey E Nowak
    Division of Critical Care Medicine, Cincinnati Children s Hospital Medical Center, Cincinnati, OH, USA
    Pediatr Crit Care Med 11:213-6. 2010
    ..The objective of this study was to test the usefulness of chemokine (C-C motif) ligand 4 as an outcome biomarker for mortality in pediatric septic shock...
  20. pmc Interleukin-8 as a stratification tool for interventional trials involving pediatric septic shock
    Hector R Wong
    Division of Critical Care Medicine, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
    Am J Respir Crit Care Med 178:276-82. 2008
    ..Interventional clinical trials involving children with septic shock would benefit from an efficient preenrollment stratification strategy...
  21. ncbi request reprint A green tea-derived polyphenol, epigallocatechin-3-gallate, inhibits IkappaB kinase activation and IL-8 gene expression in respiratory epithelium
    Philip C Chen
    Division of Critical Care Medicine, Children s Hospital Medical Center and Children s Hospital Research Foundation, Cincinnati, OH 45244, USA
    Inflammation 26:233-41. 2002
    ..We conclude that EGCG is a potent inhibitor of IL-8 gene expression in vitro. The proximal mechanism of this effect involves, in part, inhibition of IkappaB kinase activation...
  22. ncbi request reprint Helium/oxygen-driven albuterol nebulization in the management of children with status asthmaticus: a randomized, placebo-controlled trial
    Michael T Bigham
    Division of Critical Care Medicine, Akron Children s Hospital, Akron, OH, USA
    Pediatr Crit Care Med 11:356-61. 2010
    ..We investigated the effect of heliox-powered albuterol therapy on hospital length of stay and clinical status in children with moderate to severe status asthmaticus...
  23. ncbi request reprint Transport of the mechanically ventilated pediatric patient
    Derek S Wheeler
    Division of Critical Care Medicine, Children s Hospital Medical Center, Cincinnati, OH 45229 3039, USA
    Respir Care Clin N Am 8:83-104. 2002
    ..It is likely, then, that the field of pediatric transport medicine will assume greater importance in the coming decade...
  24. ncbi request reprint Extracellular hsp70 levels in children with septic shock
    Derek S Wheeler
    Department of Pediatrics, University of Cincinnati College of Medicine and Children s Hospital Research Foundation, Cincinnati, OH, USA
    Pediatr Crit Care Med 6:308-11. 2005
    ..To determine whether hsp70 is elevated in the plasma of children with septic shock...
  25. pmc Hsp72 induces inflammation and regulates cytokine production in airway epithelium through a TLR4- and NF-kappaB-dependent mechanism
    Margaret A Chase
    Division of Critical Care Medicine, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    J Immunol 179:6318-24. 2007
    ..Taken together, these data suggest that Hsp72 is released and biologically active in the BALF and can regulate airway epithelial cell cytokine expression in a TLR4 and NF-kappaB-dependent mechanism...
  26. pmc Admission angiopoietin levels in children with septic shock
    John S Giuliano
    Division of Critical Care Medicine, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
    Shock 28:650-654. 2007
    ..Given the contrasting effects of angpt-2 and angpt-1 on the vascular endothelium, these two factors may play an important role in the pathophysiology of septic shock in children, and further studies are warranted...
  27. pmc Mechanisms and regulation of the gene-expression response to sepsis
    Timothy T Cornell
    Division of Critical Care Medicine, C S Mott Children s Hospital, University of Michigan, Ann Arbor, MI, USA
    Pediatrics 125:1248-58. 2010
    ..We anticipate that emerging data from genetic, genomic, and other translation studies in pediatric sepsis will advance our biological understanding of this response and undoubtedly identify targets for newer therapies...
  28. pmc Plasma angiopoietin-2 levels increase in children following cardiopulmonary bypass
    John S Giuliano
    Division of Critical Care Medicine, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
    Intensive Care Med 34:1851-7. 2008
    ..The aim was to investigate the effects of cardiopulmonary bypass (CPB) on plasma levels of the vascular growth factors, angiopoietin (angpt)-1, angpt-2, and vascular endothelial growth factor (VEGF)...
  29. ncbi request reprint Prehospital evaluation and care of the special needs and technology-dependent child
    Derek S Wheeler
    Division of Critical Care Medicine, Ciincinnati Children s Hospital Medical Center, OH, USA
    Emerg Med Serv 31:45-50, 52, 54 passim; quiz 97. 2002
    ..Remember, the child's care provider is a valuable resource and should be used to the fullest extent whenever possible...
  30. ncbi request reprint Late-onset respiratory distress after inhalation of laundry detergent
    Derek S Wheeler
    Division of Critical Care Medicine, Department of Pediatrics, Children s Hospital Medical Center, Cincinnati, Ohio 45244, USA
    Pediatr Pulmonol 35:323-5. 2003
    ..Parents, primary care providers, and emergency department physicians need to be aware of the potential toxicity of these widely used household products...
  31. ncbi request reprint Training in pediatric critical care medicine: A survey of pediatric residency training programs
    Derek S Wheeler
    Division of Critical Care Medicine, Children s Hospital Medical Center, Cincinnati, Ohio, USA
    Pediatr Emerg Care 19:1-5. 2003
    ..We sought to determine how individual programs have structured their critical care training experience in light of these changes...
  32. ncbi request reprint The safe and effective use of propofol sedation in children undergoing diagnostic and therapeutic procedures: experience in a pediatric ICU and a review of the literature
    Derek S Wheeler
    Department of Pediatrics, Naval Medical Center, San Diego, CA, USA
    Pediatr Emerg Care 19:385-92. 2003
    ..To describe our experience using propofol sedation to facilitate elective diagnostic and therapeutic procedures, and to document the safety profile of propofol in this setting...
  33. doi request reprint Therapeutic application of helium-oxygen and mechanical ventilation in a child with acute myelogenous leukemia and airway obstruction
    Michael T Bigham
    Division of Critical Care Medicine, Akron Children s Hospital, Akron, OH 44308, USA
    Pediatr Emerg Care 25:469-72. 2009
    ..We then review mediastinal masses and the biophysical rationale for use of heliox in airway narrowing...
  34. pmc Factors prolonging length of stay in the cardiac intensive care unit following the arterial switch operation
    Derek S Wheeler
    Divisions of Critical Care Medicine, Cardiology, and Cardiothoracic Surgery, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
    Cardiol Young 18:41-50. 2008
    ..In addition, based on these results, our practice has evolved to initiate enteral feedings in the preoperative period if feasible, with such enteral feedings resumed as soon as possible following surgery...
  35. ncbi request reprint A formidable challenge: the diagnosis and treatment of viral myocarditis in children
    Derek S Wheeler
    Division of Critical Care Medicine, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
    Crit Care Clin 19:365-91. 2003
    ..Viral myocarditis, however, will remain a significant diagnosticand therapeutic challenge to both physicians and scientists alike...
  36. pmc Heat shock response and acute lung injury
    Derek S Wheeler
    Division of Critical Care Medicine, Cincinnati Children s Hospital Medical Center, Kindervelt Laboratory for Critical Care Medicine Research, Childrens Hospital Research Foundation, Cincinnati, OH 45229, USA
    Free Radic Biol Med 42:1-14. 2007
    ....
  37. ncbi request reprint Unilateral pulmonary edema and acute rheumatic fever
    John S Giuliano
    Division of Critical Care Medicine, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229 3039, USA
    Eur J Pediatr 167:465-7. 2008
    ..We present a case of an 8-year-old child who presented with unilateral pulmonary edema secondary to acute mitral insufficiency due to ARF. ARF should be considered in the differential diagnosis of unilateral pulmonary edema in children...
  38. ncbi request reprint Epigallocatechin-3-gallate, a green tea-derived polyphenol, inhibits IL-1 beta-dependent proinflammatory signal transduction in cultured respiratory epithelial cells
    Derek S Wheeler
    Section of Critical Care Medicine, Children s Medical Center, Medical College of Georgia, Augusta, GA 30912, USA
    J Nutr 134:1039-44. 2004
    ..Therefore, the green tea polyphenol EGCG is a potent inhibitor of IL-1 beta signal transduction in vitro. The proximal mechanisms of this effect involve inhibition of IRAK-dependent signaling and phosphorylation of p65...
  39. ncbi request reprint Phospholipase A2 and acute lung injury: it's just not that simple
    Derek S Wheeler
    Crit Care Med 33:904-5. 2005
  40. ncbi request reprint Acute rhabdomyolysis complicating status asthmaticus in children: case series and review
    Renuka Mehta
    Section of Critical Care Medicine, MCG Children s Medical Center, Augusta, GA, USA
    Pediatr Emerg Care 22:587-91. 2006
    ..To describe a case series of 4 children who developed acute rhabdomyolysis as a complication of acute respiratory failure secondary to status asthmaticus...
  41. ncbi request reprint Stress proteins and acute lung injury: dreams can come true... eventually
    Derek S Wheeler
    Crit Care Med 36:360-2. 2008
  42. ncbi request reprint Understanding the role of stress proteins in acute lung injury: Closer to the answer, but not there yet
    Derek S Wheeler
    Crit Care Med 35:2226-7. 2007

Research Grants3

  1. The immunomodulatory effects of extracellular Hsp70
    Derek Wheeler; Fiscal Year: 2007
    ....