Yui Hsi Wang

Summary

Affiliation: Cincinnati Children's Hospital Medical Center
Country: USA

Publications

  1. pmc Thymic stromal lymphopoietin, OX40-ligand, and interleukin-25 in allergic responses
    Y H Wang
    Department of Immunology and Center of Cancer Immunology Research, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Clin Exp Allergy 39:798-806. 2009
  2. pmc A novel subset of CD4(+) T(H)2 memory/effector cells that produce inflammatory IL-17 cytokine and promote the exacerbation of chronic allergic asthma
    Yui Hsi Wang
    Division of Allergy and Immunology, University of Cincinnati, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    J Exp Med 207:2479-91. 2010
  3. doi request reprint The potential role of interleukin-17 in severe asthma
    Yui Hsi Wang
    Division of Allergy and Immunology, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
    Curr Allergy Asthma Rep 11:388-94. 2011
  4. pmc The IL-17 cytokine family and their role in allergic inflammation
    Yui Hsi Wang
    Division of Allergy and Immunology, University of Cincinnati, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Curr Opin Immunol 20:697-702. 2008
  5. ncbi request reprint Hassall's corpuscles instruct dendritic cells to induce CD4+CD25+ regulatory T cells in human thymus
    Norihiko Watanabe
    Department of Immunology and Center for Cancer Immunology Research, The University of Texas, M D Anderson Cancer Center, 7455 Fannin Street, Houston, Texas 77054, USA
    Nature 436:1181-5. 2005
  6. pmc TSLP-activated dendritic cells induce an inflammatory T helper type 2 cell response through OX40 ligand
    Tomoki Ito
    Center for Cancer Immunology Research, Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, 77030, USA
    J Exp Med 202:1213-23. 2005
  7. pmc IL-25 augments type 2 immune responses by enhancing the expansion and functions of TSLP-DC-activated Th2 memory cells
    Yui Hsi Wang
    Department of Immunology and Center of Cancer Immunology Research, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    J Exp Med 204:1837-47. 2007
  8. pmc OX40 ligand shuts down IL-10-producing regulatory T cells
    Tomoki Ito
    Department of Immunology and Center for Cancer Immunology Research, University of Texas M D Anderson Cancer Center, Houston, 77030 1903, USA
    Proc Natl Acad Sci U S A 103:13138-43. 2006
  9. pmc Thymic stromal lymphopoietin-activated plasmacytoid dendritic cells induce the generation of FOXP3+ regulatory T cells in human thymus
    Shino Hanabuchi
    Department of Immunology and Center for Cancer Immunology Research, University of Texas MD Anderson Cancer Center, Houston, TX 77030 1903, USA
    J Immunol 184:2999-3007. 2010
  10. pmc Plasmacytoid dendritic cells regulate B-cell growth and differentiation via CD70
    Joanne Shaw
    Department of Immunology, University of Texas, M D Anderson Cancer Center, Houston, TX 77030 1903, USA
    Blood 115:3051-7. 2010

Collaborators

Detail Information

Publications26

  1. pmc Thymic stromal lymphopoietin, OX40-ligand, and interleukin-25 in allergic responses
    Y H Wang
    Department of Immunology and Center of Cancer Immunology Research, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Clin Exp Allergy 39:798-806. 2009
    ..These exciting findings expand our knowledge of the complex immunological cascades that result in allergic inflammation and may provide novel therapeutic approaches for the treatment of allergic diseases...
  2. pmc A novel subset of CD4(+) T(H)2 memory/effector cells that produce inflammatory IL-17 cytokine and promote the exacerbation of chronic allergic asthma
    Yui Hsi Wang
    Division of Allergy and Immunology, University of Cincinnati, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    J Exp Med 207:2479-91. 2010
    ..Our findings highlight the plasticity of T(H)2 memory cells and suggest that IL-17-producing T(H)2 cells may represent the key pathogenic T(H)2 cells promoting the exacerbation of allergic asthma...
  3. doi request reprint The potential role of interleukin-17 in severe asthma
    Yui Hsi Wang
    Division of Allergy and Immunology, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
    Curr Allergy Asthma Rep 11:388-94. 2011
    ..Understanding the biology of IL-17 in the context of allergic inflammation may be informative in the development of novel approaches to the diagnosis and treatment of asthma...
  4. pmc The IL-17 cytokine family and their role in allergic inflammation
    Yui Hsi Wang
    Division of Allergy and Immunology, University of Cincinnati, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Curr Opin Immunol 20:697-702. 2008
    ..Understanding the cellular source and targeting cells of IL-17 cytokine family member will provide the basis to elucidate the cellular mechanism underlying allergic inflammation and improve our therapeutic approaches for allergy...
  5. ncbi request reprint Hassall's corpuscles instruct dendritic cells to induce CD4+CD25+ regulatory T cells in human thymus
    Norihiko Watanabe
    Department of Immunology and Center for Cancer Immunology Research, The University of Texas, M D Anderson Cancer Center, 7455 Fannin Street, Houston, Texas 77054, USA
    Nature 436:1181-5. 2005
    ....
  6. pmc TSLP-activated dendritic cells induce an inflammatory T helper type 2 cell response through OX40 ligand
    Tomoki Ito
    Center for Cancer Immunology Research, Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, 77030, USA
    J Exp Med 202:1213-23. 2005
    ..We conclude that OX40L on TSLP-activated DCs triggers Th2 cell polarization in the absence of IL-12, and propose that OX40L can switch IL-10-producing regulatory Th cell responses into TNF-alpha-producing inflammatory Th cell responses...
  7. pmc IL-25 augments type 2 immune responses by enhancing the expansion and functions of TSLP-DC-activated Th2 memory cells
    Yui Hsi Wang
    Department of Immunology and Center of Cancer Immunology Research, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    J Exp Med 204:1837-47. 2007
    ..Our results provide a plausible explanation that IL-25 produced by innate effector eosinophils and basophils may augment the allergic inflammation by enhancing the maintenance and functions of adaptive Th2 memory cells...
  8. pmc OX40 ligand shuts down IL-10-producing regulatory T cells
    Tomoki Ito
    Department of Immunology and Center for Cancer Immunology Research, University of Texas M D Anderson Cancer Center, Houston, 77030 1903, USA
    Proc Natl Acad Sci U S A 103:13138-43. 2006
    ..These two novel functions of OX40L shed light on the mechanism by which OX40/OX40L regulates immunity and tolerance...
  9. pmc Thymic stromal lymphopoietin-activated plasmacytoid dendritic cells induce the generation of FOXP3+ regulatory T cells in human thymus
    Shino Hanabuchi
    Department of Immunology and Center for Cancer Immunology Research, University of Texas MD Anderson Cancer Center, Houston, TX 77030 1903, USA
    J Immunol 184:2999-3007. 2010
    ..The inability of TSLP to induce DC maturation without producing Th1- or Th2-polarizing cytokines may provide a thymic niche for T(R) development...
  10. pmc Plasmacytoid dendritic cells regulate B-cell growth and differentiation via CD70
    Joanne Shaw
    Department of Immunology, University of Texas, M D Anderson Cancer Center, Houston, TX 77030 1903, USA
    Blood 115:3051-7. 2010
    ..We have therefore identified CD70 as an important factor in the regulation of B-cell growth and differentiation by pDCs...
  11. pmc Interleukin 25 promotes the initiation of proallergic type 2 responses
    Pornpimon Angkasekwinai
    University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    J Exp Med 204:1509-17. 2007
    ..Thus, IL-25 is a critical factor regulating the initiation of innate and adaptive proallergic responses...
  12. ncbi request reprint Human plasmacytoid predendritic cells activate NK cells through glucocorticoid-induced tumor necrosis factor receptor-ligand (GITRL)
    Shino Hanabuchi
    Department of Immunology and Center for Cancer Immunology Research, The University of Texas M D Anderson Cancer Center, 7455 Fannin, Unit 910, Houston, 77030 1903, USA
    Blood 107:3617-23. 2006
    ..This study reveals a novel function of GITR/GITRL in pDC-mediated coactivation of NK cells...
  13. ncbi request reprint TSLP: an epithelial cell cytokine that regulates T cell differentiation by conditioning dendritic cell maturation
    Yong Jun Liu
    Department of Immunology, Center of Cancer Immunology Research, University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    Annu Rev Immunol 25:193-219. 2007
    ..We review recent progress on how TSLP expressed within thymus and peripheral lymphoid and nonlymphoid tissues regulates DC-mediated central tolerance, peripheral T cell homeostasis, and inflammatory Th2 responses...
  14. ncbi request reprint Dendritic cell apoptosis in the maintenance of immune tolerance
    Min Chen
    Department of Immunology, Baylor College of Medicine, Houston, TX 77030, USA
    Science 311:1160-4. 2006
    ..The observation that a defect in DC apoptosis can independently lead to autoimmunity is consistent with a central role for these cells in maintaining immune self-tolerance...
  15. pmc TSLP and IL-7 use two different mechanisms to regulate human CD4+ T cell homeostasis
    Ning Lu
    Department of Immunology, Center for Cancer Immunology Research, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    J Exp Med 206:2111-9. 2009
    ..5%. TSLP could only induce naive CD4(+) T cells to differentiate into Th2 cells in the presence of allogeneic mDCs. These results demonstrate that IL-7 and TSLP use different mechanisms to regulate human CD4(+) T cell homeostasis...
  16. pmc Plasmacytoid dendritic cells prime IL-10-producing T regulatory cells by inducible costimulator ligand
    Tomoki Ito
    Department of Immunology, M D Anderson Cancer Center, Graduate School of Biomedical Sciences at Houston, The University of Texas, Houston, TX 77030, USA
    J Exp Med 204:105-15. 2007
    ..Our findings demonstrate that mDC and pDCs are intrinsically different in the expression of costimulatory molecules that drive distinct types of T cell responses...
  17. pmc Food-induced anaphylaxis: mast cells as modulators of anaphylactic severity
    Simon P Hogan
    Division of Allergy and Immunology, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
    Semin Immunopathol 34:643-53. 2012
    ....
  18. pmc TSLP production by epithelial cells exposed to immunodeficiency virus triggers DC-mediated mucosal infection of CD4+ T cells
    Danielle Fontenot
    Departments of Immunology and Veterinary Sciences, The University of Texas M D Anderson Cancer Center, Houston, TX 77054, USA
    Proc Natl Acad Sci U S A 106:16776-81. 2009
    ..The cross talk between mucosal epithelial cells and DC, mediated by HIV-induced TSLP, may be an important mechanism for the high rate of HIV infection in women through the vaginal mucosa...
  19. pmc OX40-OX40L interactions: a promising therapeutic target for allergic diseases?
    Yui Hsi Wang
    Department of Immunology and Center of Cancer Immunology Research, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    J Clin Invest 117:3655-7. 2007
    ..The results point to potential therapeutic approaches to targeting the cellular and molecular mechanism underlying TSLP-mediated allergic inflammation...
  20. ncbi request reprint Plasmacytoid dendritic cell precursors/type I interferon-producing cells sense viral infection by Toll-like receptor (TLR) 7 and TLR9
    Tomoki Ito
    Department of Immunology and CCIR, The University of Texas, M D Anderson Cancer Center, Houston, TX, 77030, USA
    Springer Semin Immunopathol 26:221-9. 2005
    ..Stimulation of TLR7 or TLR9 leads to type I IFN responses through the MyD88 pathway. Thus, pDC/IPCs may play a central role in host defense against viral infection through the TLR7 and TLR9 system...
  21. pmc Identification of IL-17-producing FOXP3+ regulatory T cells in humans
    Kui Shin Voo
    Department of Immunology, Center for Cancer Immunology Research, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 106:4793-8. 2009
    ..IL-17-producing Treg cells may play critical roles in antimicrobial defense, while controlling autoimmunity and inflammation...
  22. ncbi request reprint Maintenance and polarization of human TH2 central memory T cells by thymic stromal lymphopoietin-activated dendritic cells
    Yui Hsi Wang
    Department of Immunology, Center of Cancer Immunology Research, Graduate School of Biomedical Science, Houston, Texas 77030, USA
    Immunity 24:827-38. 2006
    ....
  23. ncbi request reprint Metastasis-associated protein 1 transgenic mice: a new model of spontaneous B-cell lymphomas
    Rozita Bagheri-Yarmand
    Department of Molecular and Cellular Oncology, M D Anderson Cancer Center, Houston, TX 77030, USA
    Cancer Res 67:7062-7. 2007
    ..These observations suggest that MTA1-TG mice represent a new model of spontaneous DLBCL associated with high tumor incidence and could be used for therapeutic intervention studies...
  24. pmc Intestinal mast cell levels control severity of oral antigen-induced anaphylaxis in mice
    Richard Ahrens
    Division of Allergy and Immunology, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA
    Am J Pathol 180:1535-46. 2012
    ..Thus, an awareness of intestinal mast cell levels in patients with food allergies may aid in determining their susceptibility to life-threatening anaphylaxis and may eventually aid in the treatment of food-triggered anaphylaxis...
  25. ncbi request reprint Plasmacytoid dendritic cells sense self-DNA coupled with antimicrobial peptide
    Roberto Lande
    Department of Immunology, M D Anderson Cancer Center, University of Texas, Houston, Texas 77030, USA
    Nature 449:564-9. 2007
    ..Thus, our data uncover a fundamental role of an endogenous antimicrobial peptide in breaking innate tolerance to self-DNA and suggest that this pathway may drive autoimmunity in psoriasis...
  26. pmc The signal transducer STAT5 inhibits plasmacytoid dendritic cell development by suppressing transcription factor IRF8
    Eiji Esashi
    Department of Immunology and Center for Cancer Immunology Research, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Immunity 28:509-20. 2008
    ..Our results therefore show that GM-CSF controls the production of pDCs by employing STAT5 to suppress IRF8 and the pDC transcriptional network in lin- Flt3+ progenitors...