Research Topics
Genomes and Genes | Yui Hsi WangSummaryAffiliation: Cincinnati Children's Hospital Medical Center Country: USA Publications
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Publications
Thymic stromal lymphopoietin, OX40-ligand, and interleukin-25 in allergic responsesY H Wang
Department of Immunology and Center of Cancer Immunology Research, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
Clin Exp Allergy 39:798-806. 2009..These exciting findings expand our knowledge of the complex immunological cascades that result in allergic inflammation and may provide novel therapeutic approaches for the treatment of allergic diseases...
The IL-17 cytokine family and their role in allergic inflammationYui Hsi Wang
Division of Allergy and Immunology, University of Cincinnati, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
Curr Opin Immunol 20:697-702. 2008..Understanding the cellular source and targeting cells of IL-17 cytokine family member will provide the basis to elucidate the cellular mechanism underlying allergic inflammation and improve our therapeutic approaches for allergy...- A novel subset of CD4(+) T(H)2 memory/effector cells that produce inflammatory IL-17 cytokine and promote the exacerbation of chronic allergic asthmaYui Hsi Wang
Division of Allergy and Immunology, University of Cincinnati, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
J Exp Med 207:2479-91. 2010..Our findings highlight the plasticity of T(H)2 memory cells and suggest that IL-17-producing T(H)2 cells may represent the key pathogenic T(H)2 cells promoting the exacerbation of allergic asthma... - The potential role of interleukin-17 in severe asthmaYui Hsi Wang
Division of Allergy and Immunology, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
Curr Allergy Asthma Rep 11:388-94. 2011..Understanding the biology of IL-17 in the context of allergic inflammation may be informative in the development of novel approaches to the diagnosis and treatment of asthma... - TSLP-activated dendritic cells induce an inflammatory T helper type 2 cell response through OX40 ligandTomoki Ito
Center for Cancer Immunology Research, Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, 77030, USA
J Exp Med 202:1213-23. 2005..We conclude that OX40L on TSLP-activated DCs triggers Th2 cell polarization in the absence of IL-12, and propose that OX40L can switch IL-10-producing regulatory Th cell responses into TNF-alpha-producing inflammatory Th cell responses... - IL-25 augments type 2 immune responses by enhancing the expansion and functions of TSLP-DC-activated Th2 memory cellsYui Hsi Wang
Department of Immunology and Center of Cancer Immunology Research, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
J Exp Med 204:1837-47. 2007..Our results provide a plausible explanation that IL-25 produced by innate effector eosinophils and basophils may augment the allergic inflammation by enhancing the maintenance and functions of adaptive Th2 memory cells... - Interleukin 25 promotes the initiation of proallergic type 2 responsesPornpimon Angkasekwinai
University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
J Exp Med 204:1509-17. 2007..Thus, IL-25 is a critical factor regulating the initiation of innate and adaptive proallergic responses... - OX40 ligand shuts down IL-10-producing regulatory T cellsTomoki Ito
Department of Immunology and Center for Cancer Immunology Research, University of Texas M D Anderson Cancer Center, Houston, 77030 1903, USA
Proc Natl Acad Sci U S A 103:13138-43. 2006..These two novel functions of OX40L shed light on the mechanism by which OX40/OX40L regulates immunity and tolerance... 
Dendritic cell apoptosis in the maintenance of immune toleranceMin Chen
Department of Immunology, Baylor College of Medicine, Houston, TX 77030, USA
Science 311:1160-4. 2006..The observation that a defect in DC apoptosis can independently lead to autoimmunity is consistent with a central role for these cells in maintaining immune self-tolerance...- Human plasmacytoid predendritic cells activate NK cells through glucocorticoid-induced tumor necrosis factor receptor-ligand (GITRL)Shino Hanabuchi
Department of Immunology and Center for Cancer Immunology Research, The University of Texas M D Anderson Cancer Center, 7455 Fannin, Unit 910, Houston, 77030 1903, USA
Blood 107:3617-23. 2006..This study reveals a novel function of GITR/GITRL in pDC-mediated coactivation of NK cells... - Plasmacytoid dendritic cells regulate B-cell growth and differentiation via CD70Joanne Shaw
Department of Immunology, University of Texas, M D Anderson Cancer Center, Houston, TX 77030 1903, USA
Blood 115:3051-7. 2010..We have therefore identified CD70 as an important factor in the regulation of B-cell growth and differentiation by pDCs... - TSLP: an epithelial cell cytokine that regulates T cell differentiation by conditioning dendritic cell maturationYong Jun Liu
Department of Immunology, Center of Cancer Immunology Research, University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
Annu Rev Immunol 25:193-219. 2007..We review recent progress on how TSLP expressed within thymus and peripheral lymphoid and nonlymphoid tissues regulates DC-mediated central tolerance, peripheral T cell homeostasis, and inflammatory Th2 responses... - Thymic stromal lymphopoietin-activated plasmacytoid dendritic cells induce the generation of FOXP3+ regulatory T cells in human thymusShino Hanabuchi
Department of Immunology and Center for Cancer Immunology Research, University of Texas MD Anderson Cancer Center, Houston, TX 77030 1903, USA
J Immunol 184:2999-3007. 2010..The inability of TSLP to induce DC maturation without producing Th1- or Th2-polarizing cytokines may provide a thymic niche for T(R) development... - Plasmacytoid dendritic cells prime IL-10-producing T regulatory cells by inducible costimulator ligandTomoki Ito
Department of Immunology, M D Anderson Cancer Center, Graduate School of Biomedical Sciences at Houston, The University of Texas, Houston, TX 77030, USA
J Exp Med 204:105-15. 2007..Our findings demonstrate that mDC and pDCs are intrinsically different in the expression of costimulatory molecules that drive distinct types of T cell responses... - TSLP and IL-7 use two different mechanisms to regulate human CD4+ T cell homeostasisNing Lu
Department of Immunology, Center for Cancer Immunology Research, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
J Exp Med 206:2111-9. 2009..5%. TSLP could only induce naive CD4(+) T cells to differentiate into Th2 cells in the presence of allogeneic mDCs. These results demonstrate that IL-7 and TSLP use different mechanisms to regulate human CD4(+) T cell homeostasis... - Plasmacytoid dendritic cell precursors/type I interferon-producing cells sense viral infection by Toll-like receptor (TLR) 7 and TLR9Tomoki Ito
Department of Immunology and CCIR, The University of Texas, M D Anderson Cancer Center, Houston, TX, 77030, USA
Springer Semin Immunopathol 26:221-9. 2005..Stimulation of TLR7 or TLR9 leads to type I IFN responses through the MyD88 pathway. Thus, pDC/IPCs may play a central role in host defense against viral infection through the TLR7 and TLR9 system... - Food-induced anaphylaxis: mast cells as modulators of anaphylactic severitySimon P Hogan
Division of Allergy and Immunology, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
Semin Immunopathol 34:643-53. 2012.... - TSLP production by epithelial cells exposed to immunodeficiency virus triggers DC-mediated mucosal infection of CD4+ T cellsDanielle Fontenot
Departments of Immunology and Veterinary Sciences, The University of Texas M D Anderson Cancer Center, Houston, TX 77054, USA
Proc Natl Acad Sci U S A 106:16776-81. 2009..The cross talk between mucosal epithelial cells and DC, mediated by HIV-induced TSLP, may be an important mechanism for the high rate of HIV infection in women through the vaginal mucosa... - OX40-OX40L interactions: a promising therapeutic target for allergic diseases?Yui Hsi Wang
Department of Immunology and Center of Cancer Immunology Research, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
J Clin Invest 117:3655-7. 2007..The results point to potential therapeutic approaches to targeting the cellular and molecular mechanism underlying TSLP-mediated allergic inflammation... - Metastasis-associated protein 1 transgenic mice: a new model of spontaneous B-cell lymphomasRozita Bagheri Yarmand
Department of Molecular and Cellular Oncology, M D Anderson Cancer Center, Houston, TX 77030, USA
Cancer Res 67:7062-7. 2007..These observations suggest that MTA1-TG mice represent a new model of spontaneous DLBCL associated with high tumor incidence and could be used for therapeutic intervention studies... - Intestinal mast cell levels control severity of oral antigen-induced anaphylaxis in miceRichard Ahrens
Division of Allergy and Immunology, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA
Am J Pathol 180:1535-46. 2012..Thus, an awareness of intestinal mast cell levels in patients with food allergies may aid in determining their susceptibility to life-threatening anaphylaxis and may eventually aid in the treatment of food-triggered anaphylaxis... - Plasmacytoid dendritic cells sense self-DNA coupled with antimicrobial peptideRoberto Lande
Department of Immunology, M D Anderson Cancer Center, University of Texas, Houston, Texas 77030, USA
Nature 449:564-9. 2007..Thus, our data uncover a fundamental role of an endogenous antimicrobial peptide in breaking innate tolerance to self-DNA and suggest that this pathway may drive autoimmunity in psoriasis... - Identification of IL-17-producing FOXP3+ regulatory T cells in humansKui Shin Voo
Department of Immunology, Center for Cancer Immunology Research, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
Proc Natl Acad Sci U S A 106:4793-8. 2009..IL-17-producing Treg cells may play critical roles in antimicrobial defense, while controlling autoimmunity and inflammation... - The signal transducer STAT5 inhibits plasmacytoid dendritic cell development by suppressing transcription factor IRF8Eiji Esashi
Department of Immunology and Center for Cancer Immunology Research, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
Immunity 28:509-20. 2008..Our results therefore show that GM-CSF controls the production of pDCs by employing STAT5 to suppress IRF8 and the pDC transcriptional network in lin- Flt3+ progenitors...