Charles Vorhees

Summary

Affiliation: Cincinnati Children's Hospital Medical Center
Country: USA

Publications

  1. pmc Prenatal immune challenge in rats: altered responses to dopaminergic and glutamatergic agents, prepulse inhibition of acoustic startle, and reduced route-based learning as a function of maternal body weight gain after prenatal exposure to poly IC
    Charles V Vorhees
    Division of Neurology, Cincinnati Children s Research Foundation, Cincinnati, Ohio 45229, USA
    Synapse 66:725-37. 2012
  2. pmc Temporal gene expression profiling reveals CEBPD as a candidate regulator of brain disease in prosaposin deficient mice
    Ying Sun
    Division of Human Genetics, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, MLC 4006, Cincinnati, OH, USA
    BMC Neurosci 9:76. 2008
  3. pmc Comparison of time-dependent effects of (+)-methamphetamine or forced swim on monoamines, corticosterone, glucose, creatine, and creatinine in rats
    Nicole R Herring
    Division of Neurology, Cincinnati Children s Research Foundation and University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    BMC Neurosci 9:49. 2008
  4. pmc (+/-)3,4-Methylenedioxymethamphetamine (MDMA) dose-dependently impairs spatial learning in the morris water maze after exposure of rats to different five-day intervals from birth to postnatal day twenty
    Charles V Vorhees
    Division of Neurology, Department of Pediatrics and Cincinnati Children s Research Foundation, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229 3039, USA
    Dev Neurosci 31:107-20. 2009
  5. ncbi request reprint Exposure to 3,4-methylenedioxymethamphetamine (MDMA) on postnatal days 11-20 induces reference but not working memory deficits in the Morris water maze in rats: implications of prior learning
    Charles V Vorhees
    Division of Developmental Biology MLC 7007, Cincinnati Children s Research Foundation and University of Cincinnati College of Medicine, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
    Int J Dev Neurosci 22:247-59. 2004
  6. pmc Comparison of (+)-methamphetamine, ±-methylenedioxymethamphetamine, (+)-amphetamine and ±-fenfluramine in rats on egocentric learning in the Cincinnati water maze
    Charles V Vorhees
    Division of Neurology, Department of Pediatrics, Cincinnati Children s Research Foundation and University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA
    Synapse 65:368-78. 2011
  7. pmc Effects of (+)-methamphetamine on path integration and spatial learning, but not locomotor activity or acoustic startle, align with the stress hyporesponsive period in rats
    Charles V Vorhees
    Division of Neurology, Department of Pediatrics, Cincinnati Children s Research Foundation and University of Cincinnati College of Medicine, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
    Int J Dev Neurosci 27:289-98. 2009
  8. pmc Developmental effects of +/-3,4-methylenedioxymethamphetamine on spatial versus path integration learning: effects of dose distribution
    Charles V Vorhees
    Division of Neurology, Cincinnati Children s Research Foundation and University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA
    Synapse 61:488-99. 2007
  9. pmc Effects of neonatal (+)-methamphetamine on path integration and spatial learning in rats: effects of dose and rearing conditions
    Charles V Vorhees
    Division of Neurology, Department of Pediatrics, Cincinnati Children s Research Foundation and University of Cincinnati College of Medicine, 3333 Burnet Avenue, Cincinnati, OH 45229, United States
    Int J Dev Neurosci 26:599-610. 2008
  10. pmc Effects of periadolescent fluoxetine and paroxetine on elevated plus-maze, acoustic startle, and swimming immobility in rats while on and off-drug
    Charles V Vorhees
    Division of Neurology, Department of Pediatrics, Cincinnati Children s Research Foundation and University of Cincinnati College of Medicine, 3333 Burnet Ave, Cincinnati, OH 45229, USA
    Behav Brain Funct 7:41. 2011

Research Grants

  1. Effects of Neonatal MDMA on Brain and Behavior
    Charles Vorhees; Fiscal Year: 2007
  2. DEVELOPMENTAL EFFECTS OF METHAMPHETAMINE-LIKE STIMULANTS
    Charles Vorhees; Fiscal Year: 2007
  3. TRAINING GRANT IN TERATOLOGY
    Charles Vorhees; Fiscal Year: 2007
  4. DEVELOPMENTAL EFFECTS OF METHAMPHETAMINE-LIKE STIMULANTS
    Charles Vorhees; Fiscal Year: 2009
  5. DEVELOPMENTAL EFFECTS OF METHAMPHETAMINE LIKE STIMULANTS
    Charles Vorhees; Fiscal Year: 2003
  6. DEVELOPMENTAL EFFECTS OF METHLENEDIOXYMETHAMPHETAMINE
    Charles Vorhees; Fiscal Year: 2002
  7. DEVELOPMENTAL EFFECTS OF METHAMPHETAMINE-LIKE STIMULANTS
    Charles Vorhees; Fiscal Year: 1993
  8. Effects of Neonatal MDMA on Brain and Behavior
    Charles V Vorhees; Fiscal Year: 2010

Collaborators

Detail Information

Publications69

  1. pmc Prenatal immune challenge in rats: altered responses to dopaminergic and glutamatergic agents, prepulse inhibition of acoustic startle, and reduced route-based learning as a function of maternal body weight gain after prenatal exposure to poly IC
    Charles V Vorhees
    Division of Neurology, Cincinnati Children s Research Foundation, Cincinnati, Ohio 45229, USA
    Synapse 66:725-37. 2012
    ....
  2. pmc Temporal gene expression profiling reveals CEBPD as a candidate regulator of brain disease in prosaposin deficient mice
    Ying Sun
    Division of Human Genetics, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, MLC 4006, Cincinnati, OH, USA
    BMC Neurosci 9:76. 2008
    ..Extensive GSL storage occurs in various central nervous system regions in mammalian prosaposin deficiencies...
  3. pmc Comparison of time-dependent effects of (+)-methamphetamine or forced swim on monoamines, corticosterone, glucose, creatine, and creatinine in rats
    Nicole R Herring
    Division of Neurology, Cincinnati Children s Research Foundation and University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    BMC Neurosci 9:49. 2008
    ..In order to compare MA's effects with stress, animals were subjected to a forced swim test in a temporal pattern similar to MA administration [i.e., (30 min/session) 4 times at 2 h intervals]...
  4. pmc (+/-)3,4-Methylenedioxymethamphetamine (MDMA) dose-dependently impairs spatial learning in the morris water maze after exposure of rats to different five-day intervals from birth to postnatal day twenty
    Charles V Vorhees
    Division of Neurology, Department of Pediatrics and Cincinnati Children s Research Foundation, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229 3039, USA
    Dev Neurosci 31:107-20. 2009
    ..However, since no effects on egocentric learning were found, but were apparent after PD 11-20 treatment, the results show that these 2 forms of learning have different exposure-duration sensitivities...
  5. ncbi request reprint Exposure to 3,4-methylenedioxymethamphetamine (MDMA) on postnatal days 11-20 induces reference but not working memory deficits in the Morris water maze in rats: implications of prior learning
    Charles V Vorhees
    Division of Developmental Biology MLC 7007, Cincinnati Children s Research Foundation and University of Cincinnati College of Medicine, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
    Int J Dev Neurosci 22:247-59. 2004
    ..No MDMA effects on the Barnes maze were found regardless of test order, however, the interpretation of this finding was compromised by the poor performance of the animals on this task...
  6. pmc Comparison of (+)-methamphetamine, ±-methylenedioxymethamphetamine, (+)-amphetamine and ±-fenfluramine in rats on egocentric learning in the Cincinnati water maze
    Charles V Vorhees
    Division of Neurology, Department of Pediatrics, Cincinnati Children s Research Foundation and University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA
    Synapse 65:368-78. 2011
    ..Given that FEN selectively and MDMA preferentially affect serotonin whereas AMPH selectively and MA preferentially affect DA, the data suggest that egocentric learning may be predominantly dopaminergically mediated...
  7. pmc Effects of (+)-methamphetamine on path integration and spatial learning, but not locomotor activity or acoustic startle, align with the stress hyporesponsive period in rats
    Charles V Vorhees
    Division of Neurology, Department of Pediatrics, Cincinnati Children s Research Foundation and University of Cincinnati College of Medicine, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
    Int J Dev Neurosci 27:289-98. 2009
    ..Cognitive deficits from neonatal MA treatment are associated with the SHRP and may be the product of hypothalamic-pituitary-adrenal (HPA) axis dysregulation during critical periods of brain development...
  8. pmc Developmental effects of +/-3,4-methylenedioxymethamphetamine on spatial versus path integration learning: effects of dose distribution
    Charles V Vorhees
    Division of Neurology, Cincinnati Children s Research Foundation and University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA
    Synapse 61:488-99. 2007
    ..Dose distribution warrants greater attention in the design of developmental drug studies along with the standard considerations of dose and age...
  9. pmc Effects of neonatal (+)-methamphetamine on path integration and spatial learning in rats: effects of dose and rearing conditions
    Charles V Vorhees
    Division of Neurology, Department of Pediatrics, Cincinnati Children s Research Foundation and University of Cincinnati College of Medicine, 3333 Burnet Avenue, Cincinnati, OH 45229, United States
    Int J Dev Neurosci 26:599-610. 2008
    ..The results demonstrate that a narrower exposure window (5 days) changes the long-term effects of MA treatment compared to longer exposures (10 days)...
  10. pmc Effects of periadolescent fluoxetine and paroxetine on elevated plus-maze, acoustic startle, and swimming immobility in rats while on and off-drug
    Charles V Vorhees
    Division of Neurology, Department of Pediatrics, Cincinnati Children s Research Foundation and University of Cincinnati College of Medicine, 3333 Burnet Ave, Cincinnati, OH 45229, USA
    Behav Brain Funct 7:41. 2011
    ..Whether selective serotonin reuptake inhibitors (SSRIs) exposure during adolescent brain development causes lasting effects remains unresolved...
  11. pmc Morris water maze: procedures for assessing spatial and related forms of learning and memory
    Charles V Vorhees
    Division of Neurology MLC 7044, Cincinnati Children s Research Foundation and Department of Pediatrics, University of Cincinnati College of Medicine, 3333 Burnet Ave, Cincinnati, OH 45229 3039, USA
    Nat Protoc 1:848-58. 2006
    ..We present protocols for performing variants of the MWM test, from which results can be obtained from individual animals in as few as 6 days...
  12. doi request reprint Developmental treatment with the dopamine D2/3 agonist quinpirole selectively impairs spatial learning in the Morris water maze
    Charles V Vorhees
    Department of Pediatrics, Cincinnati Children s Research Foundation, Cincinnati, OH 45229, USA
    Neurotoxicol Teratol 31:1-10. 2009
    ..The data suggest that caution is warranted concerning the developmental efficacy of quinpirole...
  13. ncbi request reprint Periadolescent rats (P41-50) exhibit increased susceptibility to D-methamphetamine-induced long-term spatial and sequential learning deficits compared to juvenile (P21-30 or P31-40) or adult rats (P51-60)
    Charles V Vorhees
    Division of Developmental Biology, Cincinnati Children s Research Foundation, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
    Neurotoxicol Teratol 27:117-34. 2005
    ..P41-50 is the periadolescent stage of brain development in rodents. The effects observed at this age may suggest a previously unrecognized period of susceptibility for MA-induced cognitive deficits...
  14. pmc Learning and memory after neonatal exposure to 3,4-methylenedioxymethamphetamine (ecstasy) in rats: interaction with exposure in adulthood
    Martha A Cohen
    Division of Neurology, Cincinnati Children s Research Foundation and University of Cincinnati College of Medicine, Cincinnati, Ohio 45229 3039, USA
    Synapse 57:148-59. 2005
    ..Correlational analyses suggested that the MWM reversal interaction involves multiple monoamine changes. The results indicate that developmental MDMA exposure can interact with adult exposure to interfere with some aspects of learning...
  15. ncbi request reprint Developmental 3,4-methylenedioxymethamphetamine (MDMA) impairs sequential and spatial but not cued learning independent of growth, litter effects or injection stress
    Michael T Williams
    Pharmacology Research Center, Cincinnati Children s Research Foundation and University of Cincinnati College of Medicine, 45229 3039, Cincinnati, OH, USA
    Brain Res 968:89-101. 2003
    ..The large litter approach offers a novel method to control for undernutrition during the preweaning period in rodents...
  16. ncbi request reprint Long-term effects of neonatal methamphetamine exposure in rats on spatial learning in the Barnes maze and on cliff avoidance, corticosterone release, and neurotoxicity in adulthood
    Michael T Williams
    Division of Child Neurology, Cincinnati Children s Research Foundation and University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
    Brain Res Dev Brain Res 147:163-75. 2003
    ....
  17. ncbi request reprint Metyrapone attenuates the sequential learning deficits but not monoamine depletions following d,l-fenfluramine administration to adult rats
    Matthew R Skelton
    Division of Developmental Biology, Cincinnati Children s Research Foundation and University of Cincinnati College of Medicine, Cincinnati, Ohio 45229 3039, USA
    Synapse 54:214-22. 2004
    ..Taken together, this suggests that a potential mechanism for the sequential learning deficits in FEN-treated animals is a result of prolonged increases in CORT output...
  18. pmc Effect of +-methamphetamine on path integration learning, novel object recognition, and neurotoxicity in rats
    Nicole R Herring
    Division of Neurology MLC 7044, Cincinnati Children s Research Foundation, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
    Psychopharmacology (Berl) 199:637-50. 2008
    ..Methamphetamine (MA) has been implicated in cognitive deficits in humans after chronic use. Animal models of neurotoxic MA exposure reveal persistent damage to monoaminergic systems but few associated cognitive effects...
  19. pmc Age-dependent effects of neonatal methamphetamine exposure on spatial learning
    Charles V Vorhees
    Division of Neurology, Cincinnati Children s Research Foundation, Cincinnati, Ohio 45229 3039, USA
    Behav Pharmacol 18:549-62. 2007
    ..The results demonstrate that neonatal MA treatment induces spatial learning and reference memory deficits that emerge early and persist until at least 1 year of age, suggesting permanence...
  20. pmc Comparison of monoamine and corticosterone levels 24 h following (+)methamphetamine, (+/-)3,4-methylenedioxymethamphetamine, cocaine, (+)fenfluramine or (+/-)methylphenidate administration in the neonatal rat
    Tori L Schaefer
    Divisin of Neurology, Cincinnati Children s Research Foundation and University of Cincinnati College of Medicine, Cincinnati, Ohio 45229 3039, USA
    J Neurochem 98:1369-78. 2006
    ....
  21. pmc Effects of inhibiting neonatal methamphetamine-induced corticosterone release in rats by adrenal autotransplantation on later learning, memory, and plasma corticosterone levels
    Curtis E Grace
    Division of Neurology, Dept of Pediatrics, Cincinnati Children s Research Foundation, Cincinnati, OH 45229 3039, United States
    Int J Dev Neurosci 28:331-42. 2010
    ..We previously developed a method to attenuate MA-induced corticosterone release using adrenal autotransplantation (ADXA) in neonatal rats. This exposure period corresponds to the second-half of human pregnancy...
  22. doi request reprint The effects of neonatal isoflurane exposure in mice on brain cell viability, adult behavior, learning, and memory
    Andreas W Loepke
    Department of Anesthesia, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    Anesth Analg 108:90-104. 2009
    ..We examined the effects of neonatal isoflurane exposure and blood glucose on brain cell viability, spontaneous locomotor activity, as well as spatial learning and memory in mice...
  23. pmc Comparison of the developmental effects of 5-methoxy-N,N-diisopropyltryptamine (Foxy) to (+/-)-3,4-methylenedioxymethamphetamine (ecstasy) in rats
    Matthew R Skelton
    Division of Neurology, Cincinnati Children s Research Foundation and University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
    Psychopharmacology (Berl) 204:287-97. 2009
    ..Recently, the club drug 5-methoxy-N,N-diisopropyltryptamine (5-MeO-DIPT) has gained popularity...
  24. ncbi request reprint Refining the critical period for methamphetamine-induced spatial deficits in the Morris water maze
    Michael T Williams
    Pharmacology Research Center, Cincinnati Children s Research Foundation and University of Cincinnati College of Medicine, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
    Psychopharmacology (Berl) 168:329-38. 2003
    ..We have demonstrated that the CORT response of animals on P11 to MA is protracted relative to administration on P15 or P20. Interestingly, the P11 animals are still in the stress hyporesponsive period...
  25. pmc (+/-)-3,4-Methylenedioxymethamphetamine treatment in adult rats impairs path integration learning: a comparison of single vs once per week treatment for 5 weeks
    Matthew R Skelton
    Division of Neurology, Cincinnati Children s Research Foundation and University of Cincinnati College of Medicine, Cincinnati, OH 45229 3039, USA
    Neuropharmacology 55:1121-30. 2008
    ..Taken together, the data show that a single-day regimen of MDMA induces deficits similar to that of multiple weekly treatments...
  26. pmc Abnormal response to stress and impaired NPS-induced hyperlocomotion, anxiolytic effect and corticosterone increase in mice lacking NPSR1
    Hongyan Zhu
    Division of Allergy and Immunology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Psychoneuroendocrinology 35:1119-32. 2010
    ..These findings demonstrate that NPSR1 is essential in mediating NPS effects on behavior...
  27. pmc (+)-Methamphetamine-induced monoamine reductions and impaired egocentric learning in adrenalectomized rats is independent of hyperthermia
    Nicole R Herring
    Division of Neurology, Cincinnati Children s Research Foundation and University of Cincinnati College of Medicine, Cincinnati, OH, USA
    Synapse 64:773-85. 2010
    ..The data demonstrate that MA-induced learning deficits can be dissociated from drug-induced increases in plasma corticosterone or hyperthermia, but co-occur with dopamine and serotonin reductions...
  28. pmc (+)-Methamphetamine increases corticosterone in plasma and BDNF in brain more than forced swim or isolation in neonatal rats
    Curtis E Grace
    Division of Neurology, Cincinnati Children s Research Foundation, Cincinnati, Ohio 45229 3039, USA
    Synapse 62:110-21. 2008
    ..The possible relationship between these changes and the long-term cognitive effects of developmental MA administration are discussed...
  29. pmc Neonatal (+)-methamphetamine increases brain derived neurotrophic factor, but not nerve growth factor, during treatment and results in long-term spatial learning deficits
    Matthew R Skelton
    Division of Neurology, Cincinnati Children s Research Foundation and Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA
    Psychoneuroendocrinology 32:734-45. 2007
    ..The findings indicate that early MA exposure induces hippocampal BDNF increases that precede the later emergence of spatial learning deficits...
  30. pmc 3,4-Methylenedioxymethamphetamine in adult rats produces deficits in path integration and spatial reference memory
    Jessica A Able
    Neuroscience Graduate Program, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    Biol Psychiatry 59:1219-26. 2006
    ..3,4-Methylenedioxymethamphetamine (MDMA) is a recreational drug that causes cognitive deficits in humans. A rat model for learning and memory deficits has not been established, although some cognitive deficits have been reported...
  31. ncbi request reprint Developmental D-methamphetamine treatment selectively induces spatial navigation impairments in reference memory in the Morris water maze while sparing working memory
    Michael T Williams
    Pharmacology Research Center, Children s Hospital Research Foundation and University of Cincinnati College of Medicine, Cincinnati, Ohio 45229 3039, USA
    Synapse 48:138-48. 2003
    ..The findings demonstrate that neonatal treatment with MA induces a selective impairment of reference memory-based spatial learning while sparing sequential, cued, and working memory-based learning...
  32. pmc Behavioral and growth effects induced by low dose methamphetamine administration during the neonatal period in rats
    Michael T Williams
    Division of Pediatric Neurology, Cincinnati Children s Research Foundation and University of Cincinnati College of Medicine, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
    Int J Dev Neurosci 22:273-83. 2004
    ..These data would caution against even casual use of methamphetamine by women during pregnancy since even low doses could alter the ability of the child to learn...
  33. ncbi request reprint Phosphodiesterase 1B knock-out mice exhibit exaggerated locomotor hyperactivity and DARPP-32 phosphorylation in response to dopamine agonists and display impaired spatial learning
    Tracy M Reed
    Division of Developmental Biology, Children s Hospital Research Foundation, Cincinnati, Ohio 45229 3039, USA
    J Neurosci 22:5188-97. 2002
    ....
  34. pmc Glucose and corticosterone changes in developing and adult rats following exposure to (+/-)-3,4-methylendioxymethamphetamine or 5-methoxydiisopropyltryptamine
    Devon L Graham
    Division of Neurology, Cincinnati Children s Research Foundation, and Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45229 3039, USA
    Neurotoxicol Teratol 32:152-7. 2010
    ..The data indicate that an acute exposure to these drugs alters CORT and glucose levels, raising the possibility that these changes may have effects on behavioral and cognitive function, as we and others have previously demonstrated...
  35. pmc Neonatal methamphetamine-induced corticosterone release in rats is inhibited by adrenal autotransplantation without altering the effect of the drug on hippocampal serotonin
    Curtis E Grace
    Division of Neurology, Dept of Pediatrics, Cincinnati Children s Research Foundation, 3333 Burnet Ave, Cincinnati, OH 45229 3039, United States
    Neurotoxicol Teratol 32:356-61. 2010
    ..The method should be applicable to other models of developmental stress/corticosterone release...
  36. pmc Specific saposin C deficiency: CNS impairment and acid beta-glucosidase effects in the mouse
    Ying Sun
    Division of Human Genetics, Cincinnati Children s Hospital Medical Center, Cincinnati, OH, USA
    Hum Mol Genet 19:634-47. 2010
    ..These results support the view that saposin C has multiple roles in glycosphingolipid (GSL) catabolism as well as a prominent function in CNS and axonal integrity independent of its role as an optimizer/stabilizer of GCase...
  37. ncbi request reprint Interactions of dopamine D1 and D2 receptor antagonists with D-methamphetamine-induced hyperthermia and striatal dopamine and serotonin reductions
    Harry W Broening
    Division of Developmental Biology, Cincinnati Children s Research Foundation, Cincinnati, Ohio 45229 3039, USA
    Synapse 56:84-93. 2005
    ..However this D2 mechanism does not apply to methamphetamine-induced striatal serotonin reductions...
  38. pmc Effect of a neurotoxic dose regimen of (+)-methamphetamine on behavior, plasma corticosterone, and brain monoamines in adult C57BL/6 mice
    Curtis E Grace
    Division of Neurology, Dept of Pediatrics, Cincinnati Children s Research Foundation, Cincinnati, Ohio, United States
    Neurotoxicol Teratol 32:346-55. 2010
    ..In rats, neurotoxic doses of methamphetamine (MA) induce astrogliosis, long lasting monoamine reductions, reuptake transporter down-regulation, and learning impairments...
  39. pmc Developmental effects of 3,4-methylenedioxymethamphetamine: a review
    Matthew R Skelton
    Division of Neurology, Cincinnati Children s Research Foundation, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
    Behav Pharmacol 19:91-111. 2008
    ..Taken together, the evidence shows that MDMA exposure has adverse effects on the developing brain and behavior. The animal and human data on developmental MDMA exposure are reviewed and their public health implications discussed...
  40. ncbi request reprint Deficiency in Na,K-ATPase alpha isoform genes alters spatial learning, motor activity, and anxiety in mice
    Amy E Moseley
    Department of Molecular Genetics, Biochemistry, and Microbiology, Cincinnati Children s Research Foundation, Cincinnati, Ohio 45229, USA
    J Neurosci 27:616-26. 2007
    ..The neurobehavioral changes seen in heterozygous mice suggest that these mouse models may be useful in future investigations of the associated human CNS disorders...
  41. ncbi request reprint Administration of D,L-fenfluramine to rats produces learning deficits in the Cincinnati water maze but not the Morris water maze: relationship to adrenal cortical output
    Michael T Williams
    Division of Developmental Biology, Children s Hospital Research Foundation and University of Cincinnati College of Medicine, 3333 Burnet Avenue, OH 45229 3039, USA
    Neurotoxicol Teratol 24:783-96. 2002
    ..Corticosterone levels were shown to be elevated during the behavioral testing period in animals exposed to FEN...
  42. pmc Short- and long-term effects of (+)-methamphetamine and (+/-)-3,4-methylenedioxymethamphetamine on monoamine and corticosterone levels in the neonatal rat following multiple days of treatment
    Tori L Schaefer
    Division of Neurology, Department of Pediatrics, Cincinnati Children s Research Foundation and University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    J Neurochem 104:1674-85. 2008
    ..Although the monoamine changes are transient, they may alter developing neural circuits sufficiently to permanently disrupt later learning and memory abilities...
  43. pmc Treatment with MDMA from P11-20 disrupts spatial learning and path integration learning in adolescent rats but only spatial learning in older rats
    Matthew R Skelton
    Division of Neurology, Cincinnati Children s Research Foundation, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
    Psychopharmacology (Berl) 189:307-18. 2006
    ..The emergence and permanence of these learning deficits are currently unknown...
  44. pmc Effects of developmental stress and lead (Pb) on corticosterone after chronic and acute stress, brain monoamines, and blood Pb levels in rats
    Devon L Graham
    Division of Neurology, Cincinnati Children s Research Foundation, Cincinnati, OH 45229 3039, USA
    Int J Dev Neurosci 29:45-55. 2011
    ..The model introduced here may be useful for investigating the interaction of Pb and chronic developmental stress...
  45. pmc Hypoxia-ischemia induces DNA synthesis without cell proliferation in dying neurons in adult rodent brain
    Chia Yi Kuan
    Department of Pediatrics, Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    J Neurosci 24:10763-72. 2004
    ..Manipulating the aberrant apoptosis-associated DNA synthesis that occurs with hypoxia-ischemia and perhaps neurodegenerative diseases could promote neuronal survival and neurogenesis...
  46. doi request reprint Desflurane, isoflurane, and sevoflurane provide limited neuroprotection against neonatal hypoxia-ischemia in a delayed preconditioning paradigm
    John J McAuliffe
    Department of Anesthesia, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, Ohio 45229 3036, USA
    Anesthesiology 111:533-46. 2009
    ..The authors used these agents in a delayed preconditioning model to test the hypothesis that they could provide neuroprotection against neonatal hypoxia-ischemia as assessed by a battery of behavioral tests...
  47. ncbi request reprint Abnormal neurodevelopment, neurosignaling and behaviour in Npas3-deficient mice
    Eric W Brunskill
    Division of Cardiology, University of Cincinnati College of Medicine, 231 Albert Sabin Way, Cincinnati, OH 45267, USA
    Eur J Neurosci 22:1265-76. 2005
    ..Together, our observations indicate an important role for Npas3 in controlling normal brain development and neurosignaling pathways...
  48. pmc 3,4-Methylenedioxymethamphetamine administration on postnatal day 11 in rats increases pituitary-adrenal output and reduces striatal and hippocampal serotonin without altering SERT activity
    Michael T Williams
    Division of Child Neurology, Cincinnati Children s Hospital Research Foundation and University of Cincinnati College of Medicine, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
    Brain Res 1039:97-107. 2005
    ....
  49. pmc Neonatal methamphetamine administration induces region-specific long-term neuronal morphological changes in the rat hippocampus, nucleus accumbens and parietal cortex
    Michael T Williams
    Division of Child Neurology, Cincinnati Children s Research Foundation and University of Cincinnati College of Medicine, 3333 Burnet Ave, Cincinnati, OH 45229 3039, USA
    Eur J Neurosci 19:3165-70. 2004
    ..The data suggest a potential cause for the learning and memory deficits induced by neonatal MA exposure; however, the underlying mechanism that produces these neuronal changes is unknown...
  50. ncbi request reprint Protein tyrosine phosphatase alpha (PTP alpha) knockout mice show deficits in Morris water maze learning, decreased locomotor activity, and decreases in anxiety
    Matthew R Skelton
    Division of Developmental Biology, Cincinnati Children s Hospital Research Foundation, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
    Brain Res 984:1-10. 2003
    ..The data suggest that PTPalpha serves a regulatory function in learning and other forms of neuroplasticity...
  51. ncbi request reprint Adult neurological function following neonatal hypoxia-ischemia in a mouse model of the term neonate: water maze performance is dependent on separable cognitive and motor components
    John J McAuliffe
    Department of Anesthesia, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Brain Res 1118:208-21. 2006
    ..This study was designed to assess the relationships between the duration of hypoxia-ischemia (HI) on P10 and the structural and functional neurological deficits that appear in the adult mouse as a consequence...
  52. pmc Alterations in body temperature, corticosterone, and behavior following the administration of 5-methoxy-diisopropyltryptamine ('foxy') to adult rats: a new drug of abuse
    Michael T Williams
    Division of Neurology, Cincinnati Children s Research Foundation, Cincinnati, OH 45229 3039, USA
    Neuropsychopharmacology 32:1404-20. 2007
    ..5-MEO-DIPT may have the potential to induce untoward effects in humans...
  53. pmc Ontogeny of the adrenal response to (+)-methamphetamine in neonatal rats: the effect of prior drug exposure
    Michael T Williams
    Division of Neurology, Cincinnati Children s Research Foundation and University of Cincinnati College of Medicine, Cincinnati, OH, 45229 3039, USA
    Stress 9:153-63. 2006
    ..The data demonstrate that (+)-methamphetamine is a robust activator of corticosterone release in developing animals and this release is extensively modified by age and previous drug exposure...
  54. ncbi request reprint Metallothionein I,II deficient mice do not exhibit significantly worse long-term behavioral outcomes following neonatal hypoxia-ischemia: MT-I,II deficient mice have inherent behavioral impairments
    John J McAuliffe
    Department of Anesthesia, Cincinnati Children s, Hospital Medical Center and The University of Cincinnati, Cincinnati OH 45229, USA
    Brain Res 1190:175-85. 2008
    ..The absence of functional MT-I,II proteins does not result in significantly worse injury following 45 min of HI on P10. The MT-I,II deficient mice have baseline impairments in spatial learning but not retention...
  55. ncbi request reprint Isoflurane-delayed preconditioning reduces immediate mortality and improves striatal function in adult mice after neonatal hypoxia-ischemia
    John J McAuliffe
    Department of Anesthesia, Cincinnati Children s Hospital and University of Cincinnati, Cincinnati, Ohio 45229, USA
    Anesth Analg 104:1066-77, tables of contents. 2007
    ..We investigated the long-term effects of delayed preconditioning with Iso, hypoxia, or room air on motor and cognitive function in mice that had 65 min of hypoxia-ischemia on postnatal day 10...
  56. pmc Progression of multiple behavioral deficits with various ages of onset in a murine model of Hurler syndrome
    Dao Pan
    Molecular and Gene Therapy Program, Division of Experimental Hematology, Cincinnati Children s Research Foundation, Cincinnati, OH 45249, USA
    Brain Res 1188:241-53. 2008
    ..This study would also provide guidelines for the experimental designs of behavioral evaluation on innovative therapies for the treatment of MPS type I...
  57. ncbi request reprint Methamphetamine exposure from postnatal day 11 to 20 causes impairments in both behavioral strategies and spatial learning in adult rats
    Michael T Williams
    Pharmacology Research Center, Children s Hospital Research Foundation and University of Cincinnati, 3333 Burnet Ave, Cincinnati, OH 45229 3039, USA
    Brain Res 958:312-21. 2002
    ..These data suggest that sensorimotor deficits do not account for the spatial learning and memory deficits in animals exposed neonatally to MA...
  58. pmc Protecting children from environmental toxins
    Bruce P Lanphear
    Environmental Health Center at Cincinnati Children s Hospital Medical Center, Ohio, USA
    PLoS Med 2:e61. 2005
  59. pmc Creatine transporter (CrT; Slc6a8) knockout mice as a model of human CrT deficiency
    Matthew R Skelton
    Division of Neurology, Cincinnati Children s Research Foundation, and Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America
    PLoS ONE 6:e16187. 2011
    ..Ubiquitous CrT knockout mice have learning and memory deficits resembling human CrT deficiency and this model should be useful in understanding this disorder...
  60. pmc Neuronopathic Gaucher disease in the mouse: viable combined selective saposin C deficiency and mutant glucocerebrosidase (V394L) mice with glucosylsphingosine and glucosylceramide accumulation and progressive neurological deficits
    Ying Sun
    The Division of Human Genetics, Cincinnati Children s Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45229 3039, USA
    Hum Mol Genet 19:1088-97. 2010
    ....
  61. pmc Neurological deficits and glycosphingolipid accumulation in saposin B deficient mice
    Ying Sun
    Division of Human Genetics, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229 3039, USA
    Hum Mol Genet 17:2345-56. 2008
    ..B-/- provide a useful model for understanding the contributions of this saposin to GSL metabolism and homeostasis...
  62. ncbi request reprint Na,K-ATPase and the role of alpha isoforms in behavior
    Jerry B Lingrel
    Department of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati, 3110 Medical Sciences Building, 231 Bethesda Avenue, P O Box 670524, Cincinnati, OH 45267 0524, USA
    J Bioenerg Biomembr 39:385-9. 2007
    ..We find that the haploinsufficiency of both alpha2 and alpha 3 isoforms result in behavioral defects...
  63. ncbi request reprint Hippocampal expression of c-fos is not essential for spatial learning
    Jianhua Zhang
    Department of Cell Biology, Neurobiology and Anatomy, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267, USA
    Synapse 46:91-9. 2002
    ..Our results suggest that hippocampal c-fos expression is not essential for spatial learning...
  64. ncbi request reprint DNA fragmentation factor 45 knockout mice exhibit longer memory retention in the novel object recognition task compared to wild-type mice
    Jill M Slane McQuade
    Department of Cell Biology, Neurobiology and Anatomy, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0521, USA
    Physiol Behav 76:315-20. 2002
    ..These results suggest that a lack of DFF45 facilitates hippocampus-dependent nonspatial memory, as well as hippocampus-dependent spatial memory...
  65. pmc Cerebral ischemia-hypoxia induces intravascular coagulation and autophagy
    Faisal Adhami
    Division of Developmental Biology, Cincinnati Children s Hospital Research Foundation, Room 3464, 3333 Burnet Ave, Cincinnati, OH 45229, USA
    Am J Pathol 169:566-83. 2006
    ..Together, these results suggest that ischemia-hypoxia is a powerful stimulus for spontaneous coagulation leading to reperfusion deficits and autophagic/lysosomal cell death in brain...
  66. ncbi request reprint Genetic differences in lethality of newborn mice treated in utero with coplanar versus non-coplanar hexabromobiphenyl
    Christine P Curran
    Department of Environmental Health, University of Cincinnati Medical Center, P O Box 670056, Cincinnati OH 45267 0056, USA
    Toxicol Sci 89:454-64. 2006
    ..Although dioxin in utero is well known to cause AHR-dependent cleft palate and hydronephrosis, cHBB did not; thus, chronic activation of the AHR appears to be necessary but not sufficient for AHR-mediated teratogenicity...
  67. ncbi request reprint Methamphetamine exposure during the preweanling period causes prolonged changes in dorsal striatal protein kinase A activity, dopamine D2-like binding sites, and dopamine content
    Cynthia A Crawford
    Department of Psychology, California State University, San Bernardino, California 92407, USA
    Synapse 48:131-7. 2003
    ..The ability of METH to cause long-term reductions in PKA activity may partially account for some of behavioral deficits exhibited by rats exposed to METH prior to weaning...
  68. pmc Neonatal 3,4-methylenedioxymethamphetamine (MDMA) exposure alters neuronal protein kinase A activity, serotonin and dopamine content, and [35S]GTPgammaS binding in adult rats
    Cynthia A Crawford
    Department of Psychology, California State University, San Bernardino, CA 92407, USA
    Brain Res 1077:178-86. 2006
    ..These data indicate that early MDMA exposure has long-term effects on the 5-HT and DA neurotransmitter systems that may be mediated, at least partially, by changes in 5-HT1A receptor sensitivity...
  69. ncbi request reprint Absorption and clearance of +/-3,4-methylenedioxymethamphetamine from the plasma of neonatal rats
    Michael T Williams
    Child Neurology, Cincinnati Children s Research Foundation and University of Cincinnati College of Medicine, OH, USA
    Neurotoxicol Teratol 26:849-56. 2004
    ..Although the data do not suggest a mechanism for the learning deficits, they indicate that pharmacokinetic differences may contribute to the effects seen when exposure is begun on P11...

Research Grants26

  1. Effects of Neonatal MDMA on Brain and Behavior
    Charles Vorhees; Fiscal Year: 2007
    ....
  2. DEVELOPMENTAL EFFECTS OF METHAMPHETAMINE-LIKE STIMULANTS
    Charles Vorhees; Fiscal Year: 2007
    ..The number of prenatally MA exposed children continues to grow. Our goal is to develop models of early MA exposure that permit an understanding of the long-term consequences on brain development and cognition. ..
  3. TRAINING GRANT IN TERATOLOGY
    Charles Vorhees; Fiscal Year: 2007
    ..This application represents a continuation of the strengths of the program from the past and adds new initiatives that will move teratology training to the next level in understanding the mechanisms of abnormal development ..
  4. DEVELOPMENTAL EFFECTS OF METHAMPHETAMINE-LIKE STIMULANTS
    Charles Vorhees; Fiscal Year: 2009
    ..The number of prenatally MA exposed children continues to grow. Our goal is to develop models of early MA exposure that permit an understanding of the long-term consequences on brain development and cognition. ..
  5. DEVELOPMENTAL EFFECTS OF METHAMPHETAMINE LIKE STIMULANTS
    Charles Vorhees; Fiscal Year: 2003
    ..abstract_text> ..
  6. DEVELOPMENTAL EFFECTS OF METHLENEDIOXYMETHAMPHETAMINE
    Charles Vorhees; Fiscal Year: 2002
    ..Such data will help identify risks associated with the prenatal use of MDMA on brain and cognitive development. ..
  7. DEVELOPMENTAL EFFECTS OF METHAMPHETAMINE-LIKE STIMULANTS
    Charles Vorhees; Fiscal Year: 1993
    ..A future goal is to compare the developmental effects of methamphetamine to that of related drugs...
  8. Effects of Neonatal MDMA on Brain and Behavior
    Charles V Vorhees; Fiscal Year: 2010
    ....