Brian M Varisco
Affiliation: Cincinnati Children's Hospital Medical Center
Liu S, Cimprich J, Varisco B. Mouse pneumonectomy model of compensatory lung growth. J Vis Exp. 2014;: pubmed publisher
..This technique may be utilized in conjunction with lineage tracing or other transgenic mouse models to define molecular and cellular mechanism of lung repair and regeneration. ..
Young S, Liu S, Joshi R, Batie M, Kofron M, Guo J, et al
. Localization and stretch-dependence of lung elastase activity in development and compensatory growth. J Appl Physiol (1985). 2015;118:921-31 pubmed publisher
..Our study demonstrates that lung elastase activity is stretch-dependent and supports a model in which externally applied forces influence the composition, structure, and function of the matrix during periods of alveolar septation. ..
Joshi R, Heinz A, Fan Q, Guo S, Monia B, Schmelzer C, et al
. Role for Cela1 in Postnatal Lung Remodeling and AAT-deficient Emphysema. Am J Respir Cell Mol Biol. 2018;: pubmed publisher
..AAT is an important regulator of this process. Our findings provide proof-of-concept for the development of anti-Cela1 therapies to prevent and/or treat AAT-deficient emphysema. ..
Varisco B, Ambalavanan N, Whitsett J, Hagood J. Thy-1 signals through PPAR? to promote lipofibroblast differentiation in the developing lung. Am J Respir Cell Mol Biol. 2012;46:765-72 pubmed publisher
..Thy-1 is important in the regulation of lipofibroblast differentiation in the developing lung. ..
Liu S, Young S, Varisco B. Dynamic expression of chymotrypsin-like elastase 1 over the course of murine lung development. Am J Physiol Lung Cell Mol Physiol. 2014;306:L1104-16 pubmed publisher
..Our data defines the temporal-spatial pattern of elastin remodeling during lung development, demonstrates an association of this remodeling with CELA1, and supports a role for elastin remodeling in regulating angiogenesis. ..
Joshi R, Liu S, Brown M, Young S, Batie M, Kofron J, et al
. Stretch regulates expression and binding of chymotrypsin-like elastase 1 in the postnatal lung. FASEB J. 2016;30:590-600 pubmed publisher
..The stretch-dependent expression and binding kinetics of Cela1 indicate an important role in stretch-dependent remodeling of the peripheral lung during development and regeneration. ..