Research Topics
| Bruce C TrapnellSummaryAffiliation: Cincinnati Children's Hospital Medical Center Country: USA Publications
Research Grants
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Detail Information
Publications
Fosfomycin/tobramycin for inhalation in patients with cystic fibrosis with pseudomonas airway infectionBruce C Trapnell
Cincinnati Children s Hospital Medical Center, OH 45229, USA
Am J Respir Crit Care Med 185:171-8. 2012..Fosfomycin/tobramycin for inhalation (FTI), a unique, broad-spectrum antibiotic combination, may have therapeutic potential for patients with cystic fibrosis (CF)...- Pulmonary alveolar proteinosis, a primary immunodeficiency of impaired GM-CSF stimulation of macrophagesBruce C Trapnell
Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH, USA
Curr Opin Immunol 21:514-21. 2009..PAP research has illuminated the crucial role of GM-CSF in innate immunity and led to novel therapy for PAP and the potential use of anti-GM-CSF therapy in other common disorders... 
Efficacy and safety of Creon 24,000 in subjects with exocrine pancreatic insufficiency due to cystic fibrosisBruce C Trapnell
Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, and Division of Pulmonary, Sleep, and Critical Care Medicine, University of Cincinnati, 3333 Burnet Avenue, Cincinnati, OH, 45229 3039, USA
J Cyst Fibros 8:370-7. 2009..Pancreatic enzyme replacement therapy is critical for adequate nutrition in cystic fibrosis (CF) patients with exocrine pancreatic insufficiency (EPI)...
Pulmonary alveolar proteinosisBruce C Trapnell
Division of Pulmonary Biology, Children's Hospital Medical Center, Cincinnati, OH 45229, USA
N Engl J Med 349:2527-39. 2003- Efficacy and safety of PANCREAZE® for treatment of exocrine pancreatic insufficiency due to cystic fibrosisBruce C Trapnell
Division of Pulmonary Medicine and Biology, Cincinnati Children s Hospital Medical Center, OH, USA
J Cyst Fibros 10:350-6. 2011..Pancreatic enzyme replacement therapy (PERT) is critical for correction of exocrine pancreatic insufficiency (EPI) in patients with cystic fibrosis (CF)... - Endocytic internalization of adenovirus, nonspecific phagocytosis, and cytoskeletal organization are coordinately regulated in alveolar macrophages by GM-CSF and PU.1Pierre Yves Berclaz
Division of Pulmonary Biology, Children s Hospital Medical Center, Cincinnati, OH 45229, USA
J Immunol 169:6332-42. 2002..1, regulates endocytosis of small ( approximately 100 nm) pathogens/inert particles and phagocytosis of very large inert particles and suggests regulation of cytoskeletal organization by GM-CSF/PU.1 as the molecular basis of this control... - Hereditary pulmonary alveolar proteinosis: pathogenesis, presentation, diagnosis, and therapyTakuji Suzuki
Cincinnati Children s Hospital Medical Center, OH 45229 3039, USA
Am J Respir Crit Care Med 182:1292-304. 2010..We identified a 6-year-old girl with pulmonary alveolar proteinosis (PAP), impaired granulocyte-macrophage colony-stimulating factor (GM-CSF) receptor function, and increased GM-CSF... - Patient-derived granulocyte/macrophage colony-stimulating factor autoantibodies reproduce pulmonary alveolar proteinosis in nonhuman primatesTakuro Sakagami
Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
Am J Respir Crit Care Med 182:49-61. 2010..However, levels of GMAb do not correlate with disease severity and GMAb are also present at low levels in healthy individuals... - Innate dysfunction promotes linear growth failure in pediatric Crohn's disease and growth hormone resistance in murine ileitisSharon D'Mello
Gastroenterology, Hepatology, and Nutrition, Cincinnati Children s Hospital Medical Center and University of Cincinnati College of Medicine, University of Cincinnati, Cincinnati, Ohio, USA
Inflamm Bowel Dis 18:236-45. 2012..We hypothesized that concurrent GM-CSF Ab and CARD15 risk allele carriage (C15(+) GMAb(+) ) would be associated with growth failure in CD and growth hormone (GH) resistance in murine ileitis... - GM-CSF regulates a PU.1-dependent transcriptional program determining the pulmonary response to LPSPierre Yves Berclaz
Cincinnati Children s Hospital Medical Center, Division of Pulmonary Biology, Cincinnati, OH 45229, USA
Am J Respir Cell Mol Biol 36:114-21. 2007..1-dependent. These results show that GM-CSF, via PU.1, enables AM responses to P. aeruginosa LPS by regulating expression of a specific subset of components of the TLR-4 signaling pathway... - GM-CSF autoantibodies and neutrophil dysfunction in pulmonary alveolar proteinosisKanji Uchida
Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229 3039, USA
N Engl J Med 356:567-79. 2007..We tested the hypothesis that neutrophil functions are impaired in patients with pulmonary alveolar proteinosis and that GM-CSF autoantibodies cause the dysfunction... - PU.1 redirects adenovirus to lysosomes in alveolar macrophages, uncoupling internalization from infectionBrenna Carey
Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
J Immunol 178:2440-7. 2007..1 redirects adenoviral trafficking by modulating integrin signaling. These results demonstrate that PU.1 uncouples infection from internalization in AMs, providing a mechanism for AMs to avoid infection by adenovirus during clearance... - Granulocyte/macrophage-colony-stimulating factor autoantibodies and myeloid cell immune functions in healthy subjectsKanji Uchida
Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229 3039, USA
Blood 113:2547-56. 2009.... - Granulocyte-macrophage colony-stimulating factor autoantibodies in murine ileitis and progressive ileal Crohn's diseaseXiaonan Han
Department of Gastroenterology, Hepatology, and Nutrition, Cincinnati Children s Hospital Medical Center and the University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA
Gastroenterology 136:1261-71, e1-3. 2009..We investigated whether GM-CSF Ab regulates neutrophil function in CD... - Familial pulmonary alveolar proteinosis caused by mutations in CSF2RATakuji Suzuki
Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
J Exp Med 205:2703-10. 2008..These results establish that GM-CSF signaling is critical for surfactant homeostasis in humans and demonstrate that mutations in CSF2RA cause familial PAP... - The molecular basis of pulmonary alveolar proteinosisBrenna Carey
Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, Division of Critical Care, Pulmonary and Sleep Medicine, University of Cincinnati, Cincinnati, OH 45229 3039, USA
Clin Immunol 135:223-35. 2010..PAP and related research has uncovered a critical and emerging role for GM-CSF in the regulation of pulmonary surfactant homeostasis, lung host defense, and systemic immunity... - Granulocyte-macrophage colony stimulating factor blockade promotes ccr9(+) lymphocyte expansion in Nod2 deficient miceCharles M Samson
Gastroenterology, Hepatology, and Nutrition, Children s Hospital Medical Center and The University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
Inflamm Bowel Dis 17:2443-55. 2011..We hypothesized that GM-CSF neutralization promotes ileal disease by modulating expression of CCL25 by IEC and CCR9 by T lymphocytes via Nod2-dependent and independent pathways... - Granulocyte macrophage-colony-stimulating factor autoantibodies and increased intestinal permeability in Crohn diseaseCade M Nylund
Department of Pediatrics, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
J Pediatr Gastroenterol Nutr 52:542-8. 2011..We hypothesized that children with CD with elevated GM-CSF Ab would exhibit increased intestinal permeability... - GM-CSF, via PU.1, regulates alveolar macrophage Fcgamma R-mediated phagocytosis and the IL-18/IFN-gamma -mediated molecular connection between innate and adaptive immunity in the lungPierre Yves Berclaz
Children s Hospital Medical Center, Cincinnati, OH 45229, USA
Blood 100:4193-200. 2002..1, regulates constitutive AM FcgammaR expression and opsonophagocytosis and is required for the IFN-gamma-dependent regulation of AM FcgammaR expression, enabling AMs to release IL-18/IL-12 during lung infection... - Efficacy and safety of sirolimus in lymphangioleiomyomatosisFrancis X McCormack
University of Cincinnati, Cincinnati, OH, USA
N Engl J Med 364:1595-606. 2011..Sirolimus (also called rapamycin) inhibits mTOR and has shown promise in phase 1-2 trials involving patients with LAM... - Gm-CSF regulates pulmonary surfactant homeostasis and alveolar macrophage-mediated innate host defenseBruce C Trapnell
Division of Pulmonary Biology, Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
Annu Rev Physiol 64:775-802. 2002..Together, these observations demonstrate that GM-CSF has a critical role in regulation of surfactant homeostasis and alveolar macrophage innate immune functions in the lung... - Genetic disorders influencing lung formation and function at birthJeffrey A Whitsett
Department of Pediatrics, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
Hum Mol Genet 13:R207-15. 2004..Inherited disorders of the surfactant system that affect neonatal respiratory adaptation at birth include hereditary surfactant protein B deficiency, mutations in surfactant protein C and the ABCA3 transporter... - Keratinocyte growth factor augments pulmonary innate immunity through epithelium-driven, GM-CSF-dependent paracrine activation of alveolar macrophagesHuixing Wu
Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Children s Hospital Medical Center, The University of Cincinnati, Cincinnati, Ohio 45267 0564, USA
J Biol Chem 286:14932-40. 2011..We conclude that KGF enhances alveolar host defense through GM-CSF-stimulated macrophage activation. KGF administration may constitute a promising therapeutic strategy to augment innate immune defenses in refractory pulmonary infections... - Serum vascular endothelial growth factor-D prospectively distinguishes lymphangioleiomyomatosis from other diseasesLisa R Young
Division of Pulmonary Medicine, Cincinnati Children s Hospital Medical Center, Cincinnati, OH, USA
Chest 138:674-81. 2010..The purpose of this study was to determine the prospective diagnostic usefulness of a serologic test for vascular endothelial growth factor-D (VEGF-D), a lymphangiogenic growth factor... - Diffuse lung disease in young children: application of a novel classification schemeGail H Deutsch
Divisions of Pathology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio, USA
Am J Respir Crit Care Med 176:1120-8. 2007..Considerable confusion exists regarding nomenclature, classification, and management of pediatric diffuse lung diseases due to the relative rarity and differences in the spectrum of disease between adults and young children... - PU.1 regulation of human alveolar macrophage differentiation requires granulocyte-macrophage colony-stimulating factorTracey L Bonfield
Department of Pulmonary and Critical Care Medicine, The Cleveland Clinic Foundation, Cleveland, Ohio 44195 5038, USA
Am J Physiol Lung Cell Mol Physiol 285:L1132-6. 2003..1 and M-CSFR expression in alveolar macrophages compared with healthy control and PAP patients before GM-CSF therapy. These observations suggest that PU.1 is critical in the terminal differentiation of human alveolar macrophages... - Characteristics of a large cohort of patients with autoimmune pulmonary alveolar proteinosis in JapanYoshikazu Inoue
Bioscience Medical Research Center, Niigata University Medical and Dental Hospital, 754 Ichibannchoh, Asahimachi Tohri, Niigata 951 8520, Japan
Am J Respir Crit Care Med 177:752-62. 2008..Because PAP is rare, prior reports were based on limited patient numbers or a synthesis of historical data... - High-affinity autoantibodies specifically eliminate granulocyte-macrophage colony-stimulating factor activity in the lungs of patients with idiopathic pulmonary alveolar proteinosisKanji Uchida
Department of Respiratory Diseases, Research Institute, International Medical Center of Japan, 1 21 1 Toyama, Shinjuku City, Tokyo 162 8655, Japan
Blood 103:1089-98. 2004..Our data strengthen the evidence associating anti-GM-CSF autoantibodies with the pathogenesis of this disease... - Disruption of granulocyte macrophage-colony stimulating factor production in the lungs severely affects the ability of mice to control Mycobacterium tuberculosis infectionMercedes Gonzalez-Juarrero
Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, 80523, USA
J Leukoc Biol 77:914-22. 2005..tuberculosis bacterial growth... - Anti-cytokine autoantibodies are ubiquitous in healthy individualsMasato Watanabe
Bioscience Medical Research Center, Niigata University Medical and Dental Hospital, Niigata 951 8520, Japan
FEBS Lett 581:2017-21. 2007..Autoantibodies against IL-4, IL-6, IL-10, and interferon-gamma were variously detected. Thus, we discovered that anti-cytokine autoantibodies to multiple cytokines are ubiquitous in healthy individuals...
Research Grants
- Pulmonary Alveolar Proteinosis Research ConferenceBruce Trapnell; Fiscal Year: 2005..This conference will provide a forum where thought leaders focused on the molecular and cellular basis or clinical management of PAP will present cutting edge research, integrate concepts, and chart innovative research directions. ..
- AAT Deficiency & Liver Diseases Caused by ProteinsBruce Trapnell; Fiscal Year: 2006....
- Fourth Annual International Pulmonary Alveolar Proteinosis Research ConferenceBruce Trapnell; Fiscal Year: 2006....
- Role of Anti-GM-CSF Antibodies in Myeloid Cell Function & Innate ImmunityBruce Trapnell; Fiscal Year: 2007..Clinical implications exist for PAP therapies, and also for anti-GM-CSF antibody-based therapies to treat serious inflammatory disorders, an approach for which significant commercial interest and development have now emerged. ..
- Rare Lung Disease Clinical Research NetworkBruce Trapnell; Fiscal Year: 2006..Ongoing clinical, basic and translational studies at the centers chosen have already yielded critical insights into molecular mechanisms underlying lung function and defense in health and disease. ..
- Role of Anti-GM-CSF Antibodies in Myeloid Cell Function & Innate ImmunityBruce Trapnell; Fiscal Year: 2009..Clinical implications exist for PAP therapies, and also for anti-GM-CSF antibody-based therapies to treat serious inflammatory disorders, an approach for which significant commercial interest and development have now emerged. ..
- Regulation of Alveolar Macrophage PhagocytosisBruce Trapnell; Fiscal Year: 2006..1, and Hck/SFKs in AMs. Results of this research are expected to help establish the feasibility of the therapeutic use of GM-CSF in the treatment of lung infections by a wide variety of microbial pathogens. ..
- Regulation of Alveolar Macrophage PhagocytosisBruce Trapnell; Fiscal Year: 2003..1, and Hck/SFKs in AMs. Results of this research are expected to help establish the feasibility of the therapeutic use of GM-CSF in the treatment of lung infections by a wide variety of microbial pathogens. ..
- GM-CSF & Alveolar Macrophage Antiviral Lung DefenseBruce Trapnell; Fiscal Year: 2004..abstract_text> ..
- Conference--Pulmonary Alveolar Proteinosis ResearchBruce Trapnell; Fiscal Year: 2004..Recent progress in PAP research represents a paradigm of the intersection of basic science, clinical medicine and translational research, which has taken this disease from obscurity to clarity in a decade. ..
- Role of Anti-GM-CSF Antibodies in Myeloid Cell Function & Innate ImmunityBruce C Trapnell; Fiscal Year: 2010..Clinical implications exist for PAP therapies, and also for anti-GM-CSF antibody-based therapies to treat serious inflammatory disorders, an approach for which significant commercial interest and development have now emerged. ..