Bruce C Trapnell

Summary

Affiliation: Cincinnati Children's Hospital Medical Center
Country: USA

Publications

  1. pmc GM-CSF regulates a PU.1-dependent transcriptional program determining the pulmonary response to LPS
    Pierre Yves Berclaz
    Cincinnati Children s Hospital Medical Center, Division of Pulmonary Biology, Cincinnati, OH 45229, USA
    Am J Respir Cell Mol Biol 36:114-21. 2007
  2. pmc Familial pulmonary alveolar proteinosis caused by mutations in CSF2RA
    Takuji Suzuki
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    J Exp Med 205:2703-10. 2008
  3. pmc The parallel lives of alpha1-antitrypsin deficiency and pulmonary alveolar proteinosis
    Bruce C Trapnell
    Department of Molecular Medicine, Pneumology Unit, San Matteo Hospital Foundation, University of Pavia, Piazza Golgi 1, Pavia 27100, Italy
    Orphanet J Rare Dis 8:153. 2013
  4. pmc Assessment and management of pulmonary alveolar proteinosis in a reference center
    Ilaria Campo
    Respiratory Disease Unit, Fondazione IRCCS Policlinico San Matteo, University of Pavia, Pavia, Italy
    Orphanet J Rare Dis 8:40. 2013
  5. pmc Fosfomycin/tobramycin for inhalation in patients with cystic fibrosis with pseudomonas airway infection
    Bruce C Trapnell
    Cincinnati Children s Hospital Medical Center, OH 45229, USA
    Am J Respir Crit Care Med 185:171-8. 2012
  6. pmc Pulmonary alveolar proteinosis, a primary immunodeficiency of impaired GM-CSF stimulation of macrophages
    Bruce C Trapnell
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH, USA
    Curr Opin Immunol 21:514-21. 2009
  7. doi Efficacy and safety of PANCREAZE® for treatment of exocrine pancreatic insufficiency due to cystic fibrosis
    Bruce C Trapnell
    Division of Pulmonary Medicine and Biology, Cincinnati Children s Hospital Medical Center, OH, USA
    J Cyst Fibros 10:350-6. 2011
  8. ncbi Pulmonary alveolar proteinosis
    Bruce C Trapnell
    Division of Pulmonary Biology, Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    N Engl J Med 349:2527-39. 2003
  9. ncbi Efficacy and safety of Creon 24,000 in subjects with exocrine pancreatic insufficiency due to cystic fibrosis
    Bruce C Trapnell
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, and Division of Pulmonary, Sleep, and Critical Care Medicine, University of Cincinnati, 3333 Burnet Avenue, Cincinnati, OH, 45229 3039, USA
    J Cyst Fibros 8:370-7. 2009
  10. ncbi Standardized serum GM-CSF autoantibody testing for the routine clinical diagnosis of autoimmune pulmonary alveolar proteinosis
    Kanji Uchida
    Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA Graduate School of Medicine, The University of Tokyo, Tokyo, Japan Electronic address
    J Immunol Methods 402:57-70. 2014

Detail Information

Publications34

  1. pmc GM-CSF regulates a PU.1-dependent transcriptional program determining the pulmonary response to LPS
    Pierre Yves Berclaz
    Cincinnati Children s Hospital Medical Center, Division of Pulmonary Biology, Cincinnati, OH 45229, USA
    Am J Respir Cell Mol Biol 36:114-21. 2007
    ..1-dependent. These results show that GM-CSF, via PU.1, enables AM responses to P. aeruginosa LPS by regulating expression of a specific subset of components of the TLR-4 signaling pathway...
  2. pmc Familial pulmonary alveolar proteinosis caused by mutations in CSF2RA
    Takuji Suzuki
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    J Exp Med 205:2703-10. 2008
    ..These results establish that GM-CSF signaling is critical for surfactant homeostasis in humans and demonstrate that mutations in CSF2RA cause familial PAP...
  3. pmc The parallel lives of alpha1-antitrypsin deficiency and pulmonary alveolar proteinosis
    Bruce C Trapnell
    Department of Molecular Medicine, Pneumology Unit, San Matteo Hospital Foundation, University of Pavia, Piazza Golgi 1, Pavia 27100, Italy
    Orphanet J Rare Dis 8:153. 2013
    ....
  4. pmc Assessment and management of pulmonary alveolar proteinosis in a reference center
    Ilaria Campo
    Respiratory Disease Unit, Fondazione IRCCS Policlinico San Matteo, University of Pavia, Pavia, Italy
    Orphanet J Rare Dis 8:40. 2013
    ..We conclude that patient cohorts with an ultra-rare disease, such as PAP, referred to a single reference center, can provide useful information on the natural history and clinical course of the disease...
  5. pmc Fosfomycin/tobramycin for inhalation in patients with cystic fibrosis with pseudomonas airway infection
    Bruce C Trapnell
    Cincinnati Children s Hospital Medical Center, OH 45229, USA
    Am J Respir Crit Care Med 185:171-8. 2012
    ..Fosfomycin/tobramycin for inhalation (FTI), a unique, broad-spectrum antibiotic combination, may have therapeutic potential for patients with cystic fibrosis (CF)...
  6. pmc Pulmonary alveolar proteinosis, a primary immunodeficiency of impaired GM-CSF stimulation of macrophages
    Bruce C Trapnell
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH, USA
    Curr Opin Immunol 21:514-21. 2009
    ..PAP research has illuminated the crucial role of GM-CSF in innate immunity and led to novel therapy for PAP and the potential use of anti-GM-CSF therapy in other common disorders...
  7. doi Efficacy and safety of PANCREAZE® for treatment of exocrine pancreatic insufficiency due to cystic fibrosis
    Bruce C Trapnell
    Division of Pulmonary Medicine and Biology, Cincinnati Children s Hospital Medical Center, OH, USA
    J Cyst Fibros 10:350-6. 2011
    ..Pancreatic enzyme replacement therapy (PERT) is critical for correction of exocrine pancreatic insufficiency (EPI) in patients with cystic fibrosis (CF)...
  8. ncbi Pulmonary alveolar proteinosis
    Bruce C Trapnell
    Division of Pulmonary Biology, Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    N Engl J Med 349:2527-39. 2003
  9. ncbi Efficacy and safety of Creon 24,000 in subjects with exocrine pancreatic insufficiency due to cystic fibrosis
    Bruce C Trapnell
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, and Division of Pulmonary, Sleep, and Critical Care Medicine, University of Cincinnati, 3333 Burnet Avenue, Cincinnati, OH, 45229 3039, USA
    J Cyst Fibros 8:370-7. 2009
    ..Pancreatic enzyme replacement therapy is critical for adequate nutrition in cystic fibrosis (CF) patients with exocrine pancreatic insufficiency (EPI)...
  10. ncbi Standardized serum GM-CSF autoantibody testing for the routine clinical diagnosis of autoimmune pulmonary alveolar proteinosis
    Kanji Uchida
    Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA Graduate School of Medicine, The University of Tokyo, Tokyo, Japan Electronic address
    J Immunol Methods 402:57-70. 2014
    ..These findings support the use of this GMAb ELISA for the routine clinical diagnosis of autoimmune PAP and introduce a new unit of measure to enable standardized reporting of serum GMAb data from different laboratories. ..
  11. ncbi Endocytic internalization of adenovirus, nonspecific phagocytosis, and cytoskeletal organization are coordinately regulated in alveolar macrophages by GM-CSF and PU.1
    Pierre Yves Berclaz
    Division of Pulmonary Biology, Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    J Immunol 169:6332-42. 2002
    ..1, regulates endocytosis of small ( approximately 100 nm) pathogens/inert particles and phagocytosis of very large inert particles and suggests regulation of cytoskeletal organization by GM-CSF/PU.1 as the molecular basis of this control...
  12. pmc Hereditary pulmonary alveolar proteinosis: pathogenesis, presentation, diagnosis, and therapy
    Takuji Suzuki
    Cincinnati Children s Hospital Medical Center, OH 45229 3039, USA
    Am J Respir Crit Care Med 182:1292-304. 2010
    ..We identified a 6-year-old girl with pulmonary alveolar proteinosis (PAP), impaired granulocyte-macrophage colony-stimulating factor (GM-CSF) receptor function, and increased GM-CSF...
  13. pmc Patient-derived granulocyte/macrophage colony-stimulating factor autoantibodies reproduce pulmonary alveolar proteinosis in nonhuman primates
    Takuro Sakagami
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
    Am J Respir Crit Care Med 182:49-61. 2010
    ..However, levels of GMAb do not correlate with disease severity and GMAb are also present at low levels in healthy individuals...
  14. pmc Granulocyte/macrophage-colony-stimulating factor autoantibodies and myeloid cell immune functions in healthy subjects
    Kanji Uchida
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229 3039, USA
    Blood 113:2547-56. 2009
    ....
  15. pmc Innate dysfunction promotes linear growth failure in pediatric Crohn's disease and growth hormone resistance in murine ileitis
    Sharon D'Mello
    Gastroenterology, Hepatology, and Nutrition, Cincinnati Children s Hospital Medical Center and University of Cincinnati College of Medicine, University of Cincinnati, Cincinnati, Ohio, USA
    Inflamm Bowel Dis 18:236-45. 2012
    ..We hypothesized that concurrent GM-CSF Ab and CARD15 risk allele carriage (C15(+) GMAb(+) ) would be associated with growth failure in CD and growth hormone (GH) resistance in murine ileitis...
  16. ncbi PU.1 redirects adenovirus to lysosomes in alveolar macrophages, uncoupling internalization from infection
    Brenna Carey
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    J Immunol 178:2440-7. 2007
    ..1 redirects adenoviral trafficking by modulating integrin signaling. These results demonstrate that PU.1 uncouples infection from internalization in AMs, providing a mechanism for AMs to avoid infection by adenovirus during clearance...
  17. ncbi GM-CSF autoantibodies and neutrophil dysfunction in pulmonary alveolar proteinosis
    Kanji Uchida
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229 3039, USA
    N Engl J Med 356:567-79. 2007
    ..We tested the hypothesis that neutrophil functions are impaired in patients with pulmonary alveolar proteinosis and that GM-CSF autoantibodies cause the dysfunction...
  18. doi Granulocyte-macrophage colony-stimulating factor autoantibodies in murine ileitis and progressive ileal Crohn's disease
    Xiaonan Han
    Department of Gastroenterology, Hepatology, and Nutrition, Cincinnati Children s Hospital Medical Center and the University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA
    Gastroenterology 136:1261-71, e1-3. 2009
    ..We investigated whether GM-CSF Ab regulates neutrophil function in CD...
  19. pmc The molecular basis of pulmonary alveolar proteinosis
    Brenna Carey
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, Division of Critical Care, Pulmonary and Sleep Medicine, University of Cincinnati, Cincinnati, OH 45229 3039, USA
    Clin Immunol 135:223-35. 2010
    ..PAP and related research has uncovered a critical and emerging role for GM-CSF in the regulation of pulmonary surfactant homeostasis, lung host defense, and systemic immunity...
  20. pmc Granulocyte-macrophage colony stimulating factor blockade promotes ccr9(+) lymphocyte expansion in Nod2 deficient mice
    Charles M Samson
    Gastroenterology, Hepatology, and Nutrition, Children s Hospital Medical Center and The University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    Inflamm Bowel Dis 17:2443-55. 2011
    ..We hypothesized that GM-CSF neutralization promotes ileal disease by modulating expression of CCL25 by IEC and CCR9 by T lymphocytes via Nod2-dependent and independent pathways...
  21. doi Granulocyte macrophage-colony-stimulating factor autoantibodies and increased intestinal permeability in Crohn disease
    Cade M Nylund
    Department of Pediatrics, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    J Pediatr Gastroenterol Nutr 52:542-8. 2011
    ..We hypothesized that children with CD with elevated GM-CSF Ab would exhibit increased intestinal permeability...
  22. pmc Increased prevalence of luminal narrowing and stricturing identified by enterography in pediatric Crohn's disease patients with elevated granulocyte-macrophage colony stimulating factor autoantibodies
    Dana M H Dykes
    Division of Gastroenterology, Hepatology, and Nutrition, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Inflamm Bowel Dis 19:2146-54. 2013
    ..The objective of this study was to determine whether CD patients with elevated GM-CSF Ab (≥1.6 μg/mL) have a higher prevalence of LN and stricturing on CTE or MRE...
  23. ncbi GM-CSF, via PU.1, regulates alveolar macrophage Fcgamma R-mediated phagocytosis and the IL-18/IFN-gamma -mediated molecular connection between innate and adaptive immunity in the lung
    Pierre Yves Berclaz
    Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Blood 100:4193-200. 2002
    ..1, regulates constitutive AM FcgammaR expression and opsonophagocytosis and is required for the IFN-gamma-dependent regulation of AM FcgammaR expression, enabling AMs to release IL-18/IL-12 during lung infection...
  24. ncbi Genetic disorders influencing lung formation and function at birth
    Jeffrey A Whitsett
    Department of Pediatrics, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
    Hum Mol Genet 13:R207-15. 2004
    ..Inherited disorders of the surfactant system that affect neonatal respiratory adaptation at birth include hereditary surfactant protein B deficiency, mutations in surfactant protein C and the ABCA3 transporter...
  25. pmc Efficacy and safety of sirolimus in lymphangioleiomyomatosis
    Francis X McCormack
    University of Cincinnati, Cincinnati, OH, USA
    N Engl J Med 364:1595-606. 2011
    ..Sirolimus (also called rapamycin) inhibits mTOR and has shown promise in phase 1-2 trials involving patients with LAM...
  26. ncbi Gm-CSF regulates pulmonary surfactant homeostasis and alveolar macrophage-mediated innate host defense
    Bruce C Trapnell
    Division of Pulmonary Biology, Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
    Annu Rev Physiol 64:775-802. 2002
    ..Together, these observations demonstrate that GM-CSF has a critical role in regulation of surfactant homeostasis and alveolar macrophage innate immune functions in the lung...
  27. pmc Diffuse lung disease in young children: application of a novel classification scheme
    Gail H Deutsch
    Divisions of Pathology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio, USA
    Am J Respir Crit Care Med 176:1120-8. 2007
    ..Considerable confusion exists regarding nomenclature, classification, and management of pediatric diffuse lung diseases due to the relative rarity and differences in the spectrum of disease between adults and young children...
  28. pmc Keratinocyte growth factor augments pulmonary innate immunity through epithelium-driven, GM-CSF-dependent paracrine activation of alveolar macrophages
    Huixing Wu
    Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Children s Hospital Medical Center, The University of Cincinnati, Cincinnati, Ohio 45267 0564, USA
    J Biol Chem 286:14932-40. 2011
    ..We conclude that KGF enhances alveolar host defense through GM-CSF-stimulated macrophage activation. KGF administration may constitute a promising therapeutic strategy to augment innate immune defenses in refractory pulmonary infections...
  29. pmc Serum vascular endothelial growth factor-D prospectively distinguishes lymphangioleiomyomatosis from other diseases
    Lisa R Young
    Division of Pulmonary Medicine, Cincinnati Children s Hospital Medical Center, Cincinnati, OH, USA
    Chest 138:674-81. 2010
    ..The purpose of this study was to determine the prospective diagnostic usefulness of a serologic test for vascular endothelial growth factor-D (VEGF-D), a lymphangiogenic growth factor...
  30. ncbi High-affinity autoantibodies specifically eliminate granulocyte-macrophage colony-stimulating factor activity in the lungs of patients with idiopathic pulmonary alveolar proteinosis
    Kanji Uchida
    Department of Respiratory Diseases, Research Institute, International Medical Center of Japan, 1 21 1 Toyama, Shinjuku City, Tokyo 162 8655, Japan
    Blood 103:1089-98. 2004
    ..Our data strengthen the evidence associating anti-GM-CSF autoantibodies with the pathogenesis of this disease...
  31. ncbi PU.1 regulation of human alveolar macrophage differentiation requires granulocyte-macrophage colony-stimulating factor
    Tracey L Bonfield
    Department of Pulmonary and Critical Care Medicine, The Cleveland Clinic Foundation, Cleveland, Ohio 44195 5038, USA
    Am J Physiol Lung Cell Mol Physiol 285:L1132-6. 2003
    ..1 and M-CSFR expression in alveolar macrophages compared with healthy control and PAP patients before GM-CSF therapy. These observations suggest that PU.1 is critical in the terminal differentiation of human alveolar macrophages...
  32. pmc Characteristics of a large cohort of patients with autoimmune pulmonary alveolar proteinosis in Japan
    Yoshikazu Inoue
    Bioscience Medical Research Center, Niigata University Medical and Dental Hospital, 754 Ichibannchoh, Asahimachi Tohri, Niigata 951 8520, Japan
    Am J Respir Crit Care Med 177:752-62. 2008
    ..Because PAP is rare, prior reports were based on limited patient numbers or a synthesis of historical data...
  33. ncbi Disruption of granulocyte macrophage-colony stimulating factor production in the lungs severely affects the ability of mice to control Mycobacterium tuberculosis infection
    Mercedes Gonzalez-Juarrero
    Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, 80523, USA
    J Leukoc Biol 77:914-22. 2005
    ..tuberculosis bacterial growth...
  34. ncbi Anti-cytokine autoantibodies are ubiquitous in healthy individuals
    Masato Watanabe
    Bioscience Medical Research Center, Niigata University Medical and Dental Hospital, Niigata 951 8520, Japan
    FEBS Lett 581:2017-21. 2007
    ..Autoantibodies against IL-4, IL-6, IL-10, and interferon-gamma were variously detected. Thus, we discovered that anti-cytokine autoantibodies to multiple cytokines are ubiquitous in healthy individuals...

Research Grants23

  1. Role of Anti-GM-CSF Antibodies in Myeloid Cell Function & Innate Immunity
    Bruce C Trapnell; Fiscal Year: 2010
    ..Clinical implications exist for PAP therapies, and also for anti-GM-CSF antibody-based therapies to treat serious inflammatory disorders, an approach for which significant commercial interest and development have now emerged. ..
  2. Pulmonary Alveolar Proteinosis Research Conference
    Bruce Trapnell; Fiscal Year: 2005
    ..This conference will provide a forum where thought leaders focused on the molecular and cellular basis or clinical management of PAP will present cutting edge research, integrate concepts, and chart innovative research directions. ..
  3. GM-CSF & Alveolar Macrophage Antiviral Lung Defense
    Bruce Trapnell; Fiscal Year: 2004
    ..abstract_text> ..
  4. Role of Anti-GM-CSF Antibodies in Myeloid Cell Function & Innate Immunity
    Bruce Trapnell; Fiscal Year: 2009
    ..Clinical implications exist for PAP therapies, and also for anti-GM-CSF antibody-based therapies to treat serious inflammatory disorders, an approach for which significant commercial interest and development have now emerged. ..
  5. AAT Deficiency & Liver Diseases Caused by Proteins
    Bruce Trapnell; Fiscal Year: 2006
    ....
  6. GM-CSF & Alveolar Macrophage Antiviral Lung Defense
    Bruce Trapnell; Fiscal Year: 2001
    ..abstract_text> ..
  7. Conference--Pulmonary Alveolar Proteinosis Research
    Bruce Trapnell; Fiscal Year: 2004
    ..Recent progress in PAP research represents a paradigm of the intersection of basic science, clinical medicine and translational research, which has taken this disease from obscurity to clarity in a decade. ..
  8. GM-CSF & Alveolar Macrophage Antiviral Lung Defense
    Bruce Trapnell; Fiscal Year: 2002
    ..abstract_text> ..
  9. Regulation of Alveolar Macrophage Phagocytosis
    Bruce Trapnell; Fiscal Year: 2003
    ..1, and Hck/SFKs in AMs. Results of this research are expected to help establish the feasibility of the therapeutic use of GM-CSF in the treatment of lung infections by a wide variety of microbial pathogens. ..
  10. GM-CSF & Alveolar Macrophage Antiviral Lung Defense
    Bruce Trapnell; Fiscal Year: 2003
    ..abstract_text> ..
  11. Rare Lung Disease Clinical Research Network
    Bruce Trapnell; Fiscal Year: 2003
    ..Ongoing clinical, basic and translational studies at the centers chosen have already yielded critical insights into molecular mechanisms underlying lung function and defense in health and disease. ..
  12. Rare Lung Disease Clinical Research Network
    Bruce Trapnell; Fiscal Year: 2006
    ..Ongoing clinical, basic and translational studies at the centers chosen have already yielded critical insights into molecular mechanisms underlying lung function and defense in health and disease. ..
  13. Role of Anti-GM-CSF Antibodies in Myeloid Cell Function & Innate Immunity
    Bruce Trapnell; Fiscal Year: 2007
    ..Clinical implications exist for PAP therapies, and also for anti-GM-CSF antibody-based therapies to treat serious inflammatory disorders, an approach for which significant commercial interest and development have now emerged. ..
  14. Fourth Annual International Pulmonary Alveolar Proteinosis Research Conference
    Bruce Trapnell; Fiscal Year: 2006
    ....
  15. Rare Lung Disease Clinical Research Network
    Bruce Trapnell; Fiscal Year: 2006
    ..Ongoing clinical, basic and translational studies at the centers chosen have already yielded critical insights into molecular mechanisms underlying lung function and defense in health and disease. ..
  16. Rare Lung Disease Clinical Research Network
    Bruce Trapnell; Fiscal Year: 2004
    ..Ongoing clinical, basic and translational studies at the centers chosen have already yielded critical insights into molecular mechanisms underlying lung function and defense in health and disease. ..
  17. Rare Lung Disease Clinical Research Network
    Bruce Trapnell; Fiscal Year: 2005
    ..Ongoing clinical, basic and translational studies at the centers chosen have already yielded critical insights into molecular mechanisms underlying lung function and defense in health and disease. ..
  18. Regulation of Alveolar Macrophage Phagocytosis
    Bruce Trapnell; Fiscal Year: 2006
    ..1, and Hck/SFKs in AMs. Results of this research are expected to help establish the feasibility of the therapeutic use of GM-CSF in the treatment of lung infections by a wide variety of microbial pathogens. ..