Susan Thompson

Summary

Affiliation: Cincinnati Children's Hospital Medical Center
Country: USA

Publications

  1. ncbi Genome-wide association analysis of juvenile idiopathic arthritis identifies a new susceptibility locus at chromosomal region 3q13
    Susan D Thompson
    Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio, USA
    Arthritis Rheum 64:2781-91. 2012
  2. ncbi Tapasin gene polymorphism in systemic onset juvenile rheumatoid arthritis: a family-based case-control study
    Hulya Bukulmez
    William S, Rowe Division of Pediatric Rheumatology, Cincinnati Children s Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio, USA
    Arthritis Res Ther 7:R285-90. 2005
  3. ncbi Immature cell populations and an erythropoiesis gene-expression signature in systemic juvenile idiopathic arthritis: implications for pathogenesis
    Claas H Hinze
    Division of Rheumatology, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
    Arthritis Res Ther 12:R123. 2010
  4. ncbi The susceptibility loci juvenile idiopathic arthritis shares with other autoimmune diseases extend to PTPN2, COG6, and ANGPT1
    Susan D Thompson
    Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    Arthritis Rheum 62:3265-76. 2010
  5. ncbi Juvenile rheumatoid arthritis affected sibpairs: extent of clinical phenotype concordance
    Marta B Moroldo
    Cincinnati Children s Hospital Medical Center, and University of Cincinnati, Ohio 45229 3039, USA
    Arthritis Rheum 50:1928-34. 2004
  6. ncbi Biologic similarities based on age at onset in oligoarticular and polyarticular subtypes of juvenile idiopathic arthritis
    Michael G Barnes
    William S Rowe Division of Pediatric Rheumatology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    Arthritis Rheum 62:3249-58. 2010
  7. ncbi Subtype-specific peripheral blood gene expression profiles in recent-onset juvenile idiopathic arthritis
    Michael G Barnes
    Division of Pediatric Rheumatology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    Arthritis Rheum 60:2102-12. 2009
  8. ncbi Gene expression signatures in polyarticular juvenile idiopathic arthritis demonstrate disease heterogeneity and offer a molecular classification of disease subsets
    Thomas A Griffin
    William S Rowe Division of Pediatric Rheumatology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    Arthritis Rheum 60:2113-23. 2009
  9. ncbi Macrophage activation syndrome in patients with systemic juvenile idiopathic arthritis is associated with MUNC13-4 polymorphisms
    Kejian Zhang
    Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    Arthritis Rheum 58:2892-6. 2008
  10. ncbi A genome-wide scan for juvenile rheumatoid arthritis in affected sibpair families provides evidence of linkage
    Susan D Thompson
    Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA
    Arthritis Rheum 50:2920-30. 2004

Research Grants

  1. Genomic Landscapes in Large Scale Integrated JRA Studies
    Susan Thompson; Fiscal Year: 2006

Collaborators

Detail Information

Publications17

  1. ncbi Genome-wide association analysis of juvenile idiopathic arthritis identifies a new susceptibility locus at chromosomal region 3q13
    Susan D Thompson
    Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio, USA
    Arthritis Rheum 64:2781-91. 2012
    ..The present study was undertaken to identify novel JIA-predisposing loci using genome-wide approaches...
  2. ncbi Tapasin gene polymorphism in systemic onset juvenile rheumatoid arthritis: a family-based case-control study
    Hulya Bukulmez
    William S, Rowe Division of Pediatric Rheumatology, Cincinnati Children s Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio, USA
    Arthritis Res Ther 7:R285-90. 2005
    ..These results suggest that there is a weak association between systemic onset JRA and the TPSN polymorphism, possibly due to linkage disequilibrium with an as yet unknown susceptibility allele in the centromeric part of chromosome 6...
  3. ncbi Immature cell populations and an erythropoiesis gene-expression signature in systemic juvenile idiopathic arthritis: implications for pathogenesis
    Claas H Hinze
    Division of Rheumatology, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
    Arthritis Res Ther 12:R123. 2010
    ..The aim of this study was to determine the association of this signature with peripheral blood mononuclear cell (PBMC) subpopulations and its specificity for sJIA as compared with related conditions...
  4. ncbi The susceptibility loci juvenile idiopathic arthritis shares with other autoimmune diseases extend to PTPN2, COG6, and ANGPT1
    Susan D Thompson
    Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    Arthritis Rheum 62:3265-76. 2010
    ..To test for associations between non-major histocompatibility complex susceptibility loci previously reported in autoimmune diseases and juvenile idiopathic arthritis (JIA)...
  5. ncbi Juvenile rheumatoid arthritis affected sibpairs: extent of clinical phenotype concordance
    Marta B Moroldo
    Cincinnati Children s Hospital Medical Center, and University of Cincinnati, Ohio 45229 3039, USA
    Arthritis Rheum 50:1928-34. 2004
    ....
  6. ncbi Biologic similarities based on age at onset in oligoarticular and polyarticular subtypes of juvenile idiopathic arthritis
    Michael G Barnes
    William S Rowe Division of Pediatric Rheumatology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    Arthritis Rheum 62:3249-58. 2010
    ..To explore biologic correlates to age at onset in patients with juvenile idiopathic arthritis (JIA) using peripheral blood mononuclear cell (PBMC) gene expression analysis...
  7. ncbi Subtype-specific peripheral blood gene expression profiles in recent-onset juvenile idiopathic arthritis
    Michael G Barnes
    Division of Pediatric Rheumatology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    Arthritis Rheum 60:2102-12. 2009
    ....
  8. ncbi Gene expression signatures in polyarticular juvenile idiopathic arthritis demonstrate disease heterogeneity and offer a molecular classification of disease subsets
    Thomas A Griffin
    William S Rowe Division of Pediatric Rheumatology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    Arthritis Rheum 60:2113-23. 2009
    ..To determine whether peripheral blood mononuclear cells (PBMCs) from children with recent-onset polyarticular juvenile idiopathic arthritis (JIA) exhibit biologically or clinically informative gene expression signatures...
  9. ncbi Macrophage activation syndrome in patients with systemic juvenile idiopathic arthritis is associated with MUNC13-4 polymorphisms
    Kejian Zhang
    Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    Arthritis Rheum 58:2892-6. 2008
    ..The development of familial HLH has been recently associated with mutations in MUNC13-4. The purpose of this study was to assess for possible sequence alterations in MUNC13-4 in patients with systemic JIA/macrophage activation syndrome...
  10. ncbi A genome-wide scan for juvenile rheumatoid arthritis in affected sibpair families provides evidence of linkage
    Susan D Thompson
    Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA
    Arthritis Rheum 50:2920-30. 2004
    ..These findings for JRA are consistent with findings for other autoimmune diseases and support the notion that common genetic regions contribute to an autoimmune phenotype...
  11. ncbi Genomic progress in pediatric arthritis: recent work and future goals
    James D Phelan
    William S. Rowe Division of Rheumatology, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229-3039, USA
    Curr Opin Rheumatol 18:482-9. 2006
    ....
  12. ncbi Interferon-gamma:interleukin 4 ratios and associated type 1 cytokine expression in juvenile rheumatoid arthritis synovial tissue
    Michael P Scola
    Department of Pediatrics, Children's Hospital Medical Center, Cincinnati, Ohio 45229-3039, USA
    J Rheumatol 29:369-78. 2002
    ..The strong correlation between IFN-gamma and IL-12 in JRA suggests a prominent role for IL-12 in promoting the type I bias, while IL-15 and IL-18 may also indirectly increase IFN-gamma expression and further bias the immune response...
  13. ncbi Lack of association of functional CTLA4 polymorphisms with juvenile idiopathic arthritis
    Sampath Prahalad
    Division of Immunology and Rheumatology, Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, UT 84158 1289, USA
    Arthritis Rheum 58:2147-52. 2008
    ..Single-nucleotide polymorphisms (SNPs) in CTLA4 have been implicated in susceptibility to several autoimmune disorders, including JIA. This study was undertaken to test 3 functional CTLA4 variants for association with JIA...
  14. ncbi Antibodies against cyclic citrullinated peptide are associated with HLA-DR4 in simplex and multiplex polyarticular-onset juvenile rheumatoid arthritis
    Elizabeth D Ferucci
    Division of Rheumatology, University of Colorado Health Sciences Center, 4200 East Ninth Avenue, Denver, CO 80262, USA
    Arthritis Rheum 52:239-46. 2005
    ..Anti-CCP antibodies in JRA are associated with polyarticular onset, a polyarticular course, and erosive disease...
  15. ncbi The -174G allele of the interleukin-6 gene confers susceptibility to systemic arthritis in children: a multicenter study using simplex and multiplex juvenile idiopathic arthritis families
    Emma M Ogilvie
    University College London, London, UK
    Arthritis Rheum 48:3202-6. 2003
    ..The significant excess transmission to patients with age at onset >5 years but not to those with age at onset < or =5 years suggests that there may be genetic heterogeneity between the 2 groups...
  16. ncbi Increased prevalence of familial autoimmunity in simplex and multiplex families with juvenile rheumatoid arthritis
    Sampath Prahalad
    Department of Pediatrics, University of Utah School of Medicine, Salt Lake City 84132, USA
    Arthritis Rheum 46:1851-6. 2002
    ..To determine if the prevalence of autoimmunity among relatives of patients with juvenile rheumatoid arthritis (JRA) is greater than that among relatives of healthy volunteer control subjects...
  17. ncbi Familial autoimmunity: maternal parent-of-origin effect in juvenile idiopathic arthritis
    Andrew Zeft
    Division of Immunology and Rheumatology, Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, UT 84158 1289, USA
    Clin Rheumatol 27:241-4. 2008
    ....

Research Grants6

  1. Genomic Landscapes in Large Scale Integrated JRA Studies
    Susan Thompson; Fiscal Year: 2006
    ..Furthermore, we address the hypothesis that a joint analysis of IL-4 and IL-6 expression levels and polymorphisms can be used for more accurate discrimination of polyarticular and systemic JRA versus pauciarticular JRA. ..