Ying Sun

Summary

Affiliation: Cincinnati Children's Hospital Medical Center
Country: USA

Publications

  1. pmc Temporal gene expression profiling reveals CEBPD as a candidate regulator of brain disease in prosaposin deficient mice
    Ying Sun
    Division of Human Genetics, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, MLC 4006, Cincinnati, OH, USA
    BMC Neurosci 9:76. 2008
  2. pmc Tissue-specific effects of saposin A and saposin B on glycosphingolipid degradation in mutant mice
    Ying Sun
    The Division of Human Genetics, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Hum Mol Genet 22:2435-50. 2013
  3. pmc In vivo and ex vivo evaluation of L-type calcium channel blockers on acid beta-glucosidase in Gaucher disease mouse models
    Ying Sun
    The Division of Human Genetics, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio, USA
    PLoS ONE 4:e7320. 2009
  4. pmc Specific saposin C deficiency: CNS impairment and acid beta-glucosidase effects in the mouse
    Ying Sun
    Division of Human Genetics, Cincinnati Children s Hospital Medical Center, Cincinnati, OH, USA
    Hum Mol Genet 19:634-47. 2010
  5. pmc Ex vivo and in vivo effects of isofagomine on acid β-glucosidase variants and substrate levels in Gaucher disease
    Ying Sun
    Division of Human Genetics, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
    J Biol Chem 287:4275-87. 2012
  6. pmc Neurological deficits and glycosphingolipid accumulation in saposin B deficient mice
    Ying Sun
    Division of Human Genetics, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229 3039, USA
    Hum Mol Genet 17:2345-56. 2008
  7. pmc Neuronopathic Gaucher disease in the mouse: viable combined selective saposin C deficiency and mutant glucocerebrosidase (V394L) mice with glucosylsphingosine and glucosylceramide accumulation and progressive neurological deficits
    Ying Sun
    The Division of Human Genetics, Cincinnati Children s Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45229 3039, USA
    Hum Mol Genet 19:1088-97. 2010
  8. pmc Substrate compositional variation with tissue/region and Gba1 mutations in mouse models--implications for Gaucher disease
    Ying Sun
    Division of Human Genetics, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America
    PLoS ONE 8:e57560. 2013
  9. ncbi request reprint Prosaposin: threshold rescue and analysis of the "neuritogenic" region in transgenic mice
    Ying Sun
    The Division and Program in Human Genetics, Children s Hospital Research Foundation, Cincinnati, OH 45229 3039, USA
    Mol Genet Metab 76:271-86. 2002
  10. ncbi request reprint Conditional expression of human acid beta-glucosidase improves the visceral phenotype in a Gaucher disease mouse model
    Ying Sun
    Division of Human Genetics, Children s Hospital Research Foundation and University of Cincinnati College of Medicine, Department of Pediatrics, Cincinnati, OH 45229 3039, USA
    J Lipid Res 47:2161-70. 2006

Collaborators

  • Li Jia
  • Xiaoyang Qi
  • Yusuf A Hannun
  • Sunghee Oh
  • Peng Jin
  • Xianlin Han
  • Bruce J Aronow
  • Junko Matsuda
  • G A Grabowski
  • Xiao Ping Yang
  • Charles Vorhees
  • Kang Chong
  • Chao Qin
  • M Bader
  • S M Opal
  • Christer Betsholtz
  • Michael Williams
  • Wei Liu
  • You Hai Xu
  • Liqun He
  • Minoru Takemoto
  • Nupur Dasgupta
  • Sonya Barnes
  • Ming Zhu Zhang
  • Chun Hua Sheng
  • Fang B Tao
  • Tore Samuelsson
  • Jenny Norlin
  • Emily C Lutterloh
  • Karl Tryggvason
  • Srinivas S Gampala
  • Stephen P Berasi
  • Janet E Paulsen
  • Ruth E Gimeno
  • Heather H Shih
  • Dongmei Li
  • Yu Ping Hua
  • Andrew C Lake
  • Xu Song
  • Zhengtao Chu
  • Jiang Xu
  • Mehdi Keddache
  • Brian Quinn
  • Keith Stringer
  • Wujuan Zhang
  • Matthew Zamzow
  • Kenneth D R Setchell
  • Mei Wu
  • Jing ping Liang
  • Chao Lun Li
  • Yu Cheng Zhang
  • Wei Jiang
  • Yun tao Jiang
  • Yong Jin
  • Jun Di
  • Gui Zhen Zhang
  • Rong Shu
  • Joshua M Gendron
  • Pu Y Su
  • Huanjing Chen
  • Min L Xu
  • Helen Palmer
  • Nicholas A Parejo
  • Noubar Kessimian
  • Mingyi Yi Bai
  • Zhiping Deng
  • Kim Milarski
  • Alma L Burlingame
  • James C Keith
  • Robert J Ferl
  • Debra D Pittman
  • Tae Wuk Kim
  • Brian M Clancy
  • Shenheng Guan
  • John E Palardy
  • Kun Huang
  • Soon D Kim
  • Xiang Yang Tan
  • Wenqiang Tang
  • David Ehrhardt
  • Nakako Shibagaki
  • Sylvie Lalonde
  • Zhi Yong Wang
  • Jun Xian He
  • Zhijie Xiao
  • Cecilia Bondjers
  • Eugene L Brown
  • Susan E Quaggin
  • Kari Alitalo
  • Robert V Martinez

Detail Information

Publications39

  1. pmc Temporal gene expression profiling reveals CEBPD as a candidate regulator of brain disease in prosaposin deficient mice
    Ying Sun
    Division of Human Genetics, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, MLC 4006, Cincinnati, OH, USA
    BMC Neurosci 9:76. 2008
    ..Extensive GSL storage occurs in various central nervous system regions in mammalian prosaposin deficiencies...
  2. pmc Tissue-specific effects of saposin A and saposin B on glycosphingolipid degradation in mutant mice
    Ying Sun
    The Division of Human Genetics, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Hum Mol Genet 22:2435-50. 2013
    ..These analyses of AB-/- mice continue to delineate the tissue differential interactions of saposins in GSL metabolism...
  3. pmc In vivo and ex vivo evaluation of L-type calcium channel blockers on acid beta-glucosidase in Gaucher disease mouse models
    Ying Sun
    The Division of Human Genetics, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio, USA
    PLoS ONE 4:e7320. 2009
    ..These results show that LTCC blockers had the ex vivo effects of increasing GCase activity and protein in the mouse fibroblasts, but these effects did not translate into similar changes in vivo even at very high drug doses...
  4. pmc Specific saposin C deficiency: CNS impairment and acid beta-glucosidase effects in the mouse
    Ying Sun
    Division of Human Genetics, Cincinnati Children s Hospital Medical Center, Cincinnati, OH, USA
    Hum Mol Genet 19:634-47. 2010
    ..These results support the view that saposin C has multiple roles in glycosphingolipid (GSL) catabolism as well as a prominent function in CNS and axonal integrity independent of its role as an optimizer/stabilizer of GCase...
  5. pmc Ex vivo and in vivo effects of isofagomine on acid β-glucosidase variants and substrate levels in Gaucher disease
    Ying Sun
    Division of Human Genetics, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
    J Biol Chem 287:4275-87. 2012
    ..Decreases of storage cells were correlated with >50% reductions in substrate levels. These results indicate that IFG stabilizes GCase in tissues and serum and can reduce visceral substrates in vivo...
  6. pmc Neurological deficits and glycosphingolipid accumulation in saposin B deficient mice
    Ying Sun
    Division of Human Genetics, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229 3039, USA
    Hum Mol Genet 17:2345-56. 2008
    ..B-/- provide a useful model for understanding the contributions of this saposin to GSL metabolism and homeostasis...
  7. pmc Neuronopathic Gaucher disease in the mouse: viable combined selective saposin C deficiency and mutant glucocerebrosidase (V394L) mice with glucosylsphingosine and glucosylceramide accumulation and progressive neurological deficits
    Ying Sun
    The Division of Human Genetics, Cincinnati Children s Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45229 3039, USA
    Hum Mol Genet 19:1088-97. 2010
    ....
  8. pmc Substrate compositional variation with tissue/region and Gba1 mutations in mouse models--implications for Gaucher disease
    Ying Sun
    Division of Human Genetics, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America
    PLoS ONE 8:e57560. 2013
    ..These results demonstrate age, organ, and mutation-specific quantitative differences in GC species and glucosylsphingosine accumulations that can have influence in the tissue/regional expression of Gaucher disease phenotypes...
  9. ncbi request reprint Prosaposin: threshold rescue and analysis of the "neuritogenic" region in transgenic mice
    Ying Sun
    The Division and Program in Human Genetics, Children s Hospital Research Foundation, Cincinnati, OH 45229 3039, USA
    Mol Genet Metab 76:271-86. 2002
    ..These studies also show in vivo localization of the GCase activation region to the carboxy terminal half of saposin C and the lack of a significant gross trophic effect of saposin C on CNS organization in vivo...
  10. ncbi request reprint Conditional expression of human acid beta-glucosidase improves the visceral phenotype in a Gaucher disease mouse model
    Ying Sun
    Division of Human Genetics, Children s Hospital Research Foundation and University of Cincinnati College of Medicine, Department of Pediatrics, Cincinnati, OH 45229 3039, USA
    J Lipid Res 47:2161-70. 2006
    ..This study demonstrates that conditionally expressed hGCase supplemented the existing mutant mouse GCase to control visceral substrate accumulation in vivo...
  11. ncbi request reprint Combined saposin C and D deficiencies in mice lead to a neuronopathic phenotype, glucosylceramide and alpha-hydroxy ceramide accumulation, and altered prosaposin trafficking
    Ying Sun
    Division of Human Genetics, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Hum Mol Genet 16:957-71. 2007
    ..This CD null mouse model provides a tool to explore the in vivo functional interactions of saposins in GSL metabolism and lysosomal storage diseases, and prosaposin's physiological effects...
  12. ncbi request reprint Gaucher disease mouse models: point mutations at the acid beta-glucosidase locus combined with low-level prosaposin expression lead to disease variants
    Ying Sun
    Division and Program in Human Genetics, Children s Hospital Research Foundation, Cincinnati, OH 45229 3039, USA
    J Lipid Res 46:2102-13. 2005
    ..These models mimic a more severe Gaucher disease phenotype and could be useful for therapeutic intervention studies...
  13. pmc Global gene expression profile progression in Gaucher disease mouse models
    You Hai Xu
    The Division of Human Genetics, Cincinnati Children s Hospital Research Foundation, Cincinnati, OH 45229 3039, USA
    BMC Genomics 12:20. 2011
    ..The pathogenic pathways resulting from lipid laden macrophages (Gaucher cells) in visceral organs and their abnormal functions are obscure...
  14. pmc Isofagomine in vivo effects in a neuronopathic Gaucher disease mouse
    Ying Sun
    The Division of Human Genetics, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America
    PLoS ONE 6:e19037. 2011
    ..However, this was not correlated with a reduction in the accumulation of lipid substrates...
  15. pmc Comparative therapeutic effects of velaglucerase alfa and imiglucerase in a Gaucher disease mouse model
    You Hai Xu
    Division of Human Genetics, Cincinnati Children s Hospital Research Foundation, Cincinnati, Ohio, USA
    PLoS ONE 5:e10750. 2010
    ..The responses of GC levels and storage cell numbers in Vela- and Imig-treated Gaucher mice at various doses provide a backdrop for clinical applications and decisions...
  16. ncbi request reprint Saposin C is required for normal resistance of acid beta-glucosidase to proteolytic degradation
    Ying Sun
    Division and Program in Human Genetics, Children s Hospital Research Foundation, Cincinnati, Ohio 45229 3039, USA
    J Biol Chem 278:31918-23. 2003
    ..Thus, diminished in vivo GCase activity would be greater than expected only from the lack of GCase activation by saposin C. These results indicate a new property for saposin C, an anti-proteolytic protective function toward GCase...
  17. pmc Multi-system disorders of glycosphingolipid and ganglioside metabolism
    You Hai Xu
    Division of Human Genetics, Cincinnati Children s Hospital Medical Center and the Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45229 3039, USA
    J Lipid Res 51:1643-75. 2010
    ..These are the focus of this review...
  18. pmc Analyses of temporal regulatory elements of the prosaposin gene in transgenic mice
    Ying Sun
    The Division and Program in Human Genetics, Children s Hospital Medical Center, 3333 Burnet Avenue, PAV 3 52, Cincinnati, OH 45229 3039, USA
    Biochem J 370:557-66. 2003
    ..Additional regulatory elements outside the 5' region of the 2400 bp promoter fragment appear to be essential for the physiological control of the prosaposin locus...
  19. pmc Gaucher disease: transcriptome analyses using microarray or mRNA sequencing in a Gba1 mutant mouse model treated with velaglucerase alfa or imiglucerase
    Nupur Dasgupta
    The Division of Human Genetics, Cincinnati Children s Hospital Research Foundation, Cincinnati, Ohio, United States of America
    PLoS ONE 8:e74912. 2013
    ..These results provide cross-validation for the mRNA-Seq and microarray platforms, and show differences between the molecular effects of two highly structurally similar ERT biopharmaceuticals. ..
  20. doi request reprint Impaired autophagosomes and lysosomes in neuronopathic Gaucher disease
    Ying Sun
    Division of Human Genetics, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH, USA
    Autophagy 6:648-9. 2010
    ..In the brain of this model, abnormal autophagosomes and lysosomes implicate autophagy in the neuronal degeneration of Gaucher disease...
  21. ncbi request reprint Ex vivo localization of the mouse saposin C activation region for acid beta-glucosidase
    Xiaoyang Qi
    The Division of Human Genetics, Children s Hospital Research Foundation and Department of Pediatrics, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
    Mol Genet Metab 76:189-200. 2002
    ..These results also show that the enzymatic activation domain is located at carboxyl-terminal half of saposin C and functions only in the context of the general saposin structure...
  22. ncbi request reprint Saposin C: neuronal effect and CNS delivery by liposomes
    Zhengtao Chu
    Division and Program in Human Genetics, Children s Hospital Research Foundation, University of Cincinnati, Ohio 45229 3039, USA
    Ann N Y Acad Sci 1053:237-46. 2005
    ..These studies may yield a new therapeutic approach for neuron protection, preservation, and regeneration...
  23. pmc The glomerular transcriptome and a predicted protein-protein interaction network
    Liqun He
    Division of Matrix Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, SE 171 77, Stockholm, Sweden
    J Am Soc Nephrol 19:260-8. 2008
    ....
  24. ncbi request reprint Lack of inducible NO synthase reduces oxidative stress and enhances cardiac response to isoproterenol in mice with deoxycorticosterone acetate-salt hypertension
    Ying Sun
    Hypertension and Vascular Research Division, Department of Internal Medicine, Henry Ford Health System, Wayne State University, Detroit, MI 48202 2689, USA
    Hypertension 46:1355-61. 2005
    ....
  25. ncbi request reprint Expression, regulation, and triglyceride hydrolase activity of Adiponutrin family members
    Andrew C Lake
    Biological Technologies, Wyeth Research, Cambridge, MA 02140, USA
    J Lipid Res 46:2477-87. 2005
    ..Our data support distinct functions for Adiponutrin and Desnutrin/ATGL and raise the possibility that GS2 may contribute significantly to lipolysis in human adipose tissue...
  26. pmc Roles of PSF protein and VL30 RNA in reversible gene regulation
    Xu Song
    Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06520, USA
    Proc Natl Acad Sci U S A 102:12189-93. 2005
    ..Human chromosome 11 has a VL30 retroelement, and a VL30 EST was identified in human blastocyst cells, indicating that the PSF-VL30 RNA regulatory mechanism also could function in human cells...
  27. ncbi request reprint Intestinal electric stimulation modulates neuronal activity in the nucleus of the solitary tract in rats
    Ying Sun
    Transneuronix Inc and VA Medical Center, 921 NE 13th Street, VREF 151, Oklahoma City, OK 73104, USA
    Neurosci Lett 385:64-9. 2005
    ..The modulatory effect of IES on the central neurons receiving vagal inputs may contribute to the neural mechanisms of IES therapy for the treatment of patients with obesity and gastrointestinal motility disorders...
  28. ncbi request reprint Gastric electrical stimulation modulates neuronal activity in nucleus tractus solitarii in rats
    Chao Qin
    Department of Physiology, University of Oklahoma Health Sciences Center, P O Box 26901, Oklahoma City, OK 73190, United States
    Auton Neurosci 119:1-8. 2005
    ..This modulatory effect of GES on the central neurons receiving vagal inputs may contribute to the neural mechanisms of GES therapy for the treatment of patients with obesity and gastric motility disorders...
  29. ncbi request reprint Role of the B1 kinin receptor in the regulation of cardiac function and remodeling after myocardial infarction
    Jiang Xu
    Hypertension and Vascular Research Division, Henry Ford Hospital, Detroit, Mich 48202 2689, USA
    Hypertension 45:747-53. 2005
    ..Dual blockade of both B1 and B2 eliminates this compensation, leading to further deterioration of cardiac dysfunction and remodeling after myocardial infarction...
  30. ncbi request reprint Primary survey of avian influenza virus and Newcastle disease virus infection in wild birds in some areas of Heilongjiang Province, China
    Yu Ping Hua
    College of Wildlife Resources, Northeast Forestry University, Harbin 150040, P R China
    J Vet Sci 6:311-5. 2005
    ..Whereas the NDV isolation in both two batches of specimens of mallard was negative, all of the 32 blood serum samples collected in December were negative for antibodies against AIV and NDV...
  31. pmc Large-scale identification of genes implicated in kidney glomerulus development and function
    Minoru Takemoto
    Division of Matrix Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden
    EMBO J 25:1160-74. 2006
    ..We surmise that studies on the other novel glomerulus-enriched transcripts identified in this study will provide new insight into glomerular development and pathomechanisms of disease...
  32. ncbi request reprint Inhibition of gluconeogenesis through transcriptional activation of EGR1 and DUSP4 by AMP-activated kinase
    Stephen P Berasi
    Department of Biological Technologies, Wyeth Research, Cambridge, Massachusetts 02140, USA
    J Biol Chem 281:27167-77. 2006
    ..These results suggest that the inhibition of hepatic gluconeogenesis by AMPK may, in part, be mediated by an immediate early gene response involving EGR1 and its target, DUSP4...
  33. ncbi request reprint The glomerular transcriptome and proteome
    Christer Betsholtz
    Division of Matrix Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden
    Nephron Exp Nephrol 106:e32-6. 2007
    ....
  34. pmc An essential role for 14-3-3 proteins in brassinosteroid signal transduction in Arabidopsis
    Srinivas S Gampala
    Department of Plant Biology, Carnegie Institution, Stanford, CA 94305, USA
    Dev Cell 13:177-89. 2007
    ..This study demonstrates that multiple mechanisms are required for BR regulation of gene expression and plant growth...
  35. ncbi request reprint Porphyromonas gingivalis infection accelerates intimal thickening in iliac arteries in a balloon-injured rabbit model
    Ming Zhu Zhang
    Department of Endodontics and Operative Dentistry, The Ninth People s Hospital, School of Stomatology, Shanghai Jiaotong University, Shanghai, China
    J Periodontol 79:1192-9. 2008
    ..To test this hypothesis, we investigated the effect of repeated systemic inoculations with Porphyromonas gingivalis (Pg) on intimal hyperplasia in iliac arteries in a rabbit model of balloon injury...
  36. doi request reprint Resistin is expressed in human hepatocytes and induces insulin resistance
    Chun Hua Sheng
    Department of Central Research, The Third Clinical College, Jilin University, Xiantai Street No 126, Changchun, 130033, China
    Endocrine 33:135-43. 2008
    ..We also concluded that Metformin reversed the effect of resistin and downregulated the expression of resistin in hepatocytes...
  37. doi request reprint Toll-like receptor 4 signaling plays a role in triggering periodontal infection
    Ying Sun
    Department of Periodontology, Ninth People s Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
    FEMS Immunol Med Microbiol 52:362-9. 2008
    ..This pattern of gene expression indicates that pathogens may trigger TLR4 signaling and cause periodontitis. Manipulating TLR4 signaling may potentially become one of the recognized therapies for periodontitis...
  38. pmc Inhibition of the RAGE products increases survival in experimental models of severe sepsis and systemic infection
    Emily C Lutterloh
    Division of Infectious Diseases, Memorial Hospital of Rhode Island, 111 Brewster St, Pawtucket, RI 02860, USA
    Crit Care 11:R122. 2007
    ..The receptor for advanced glycation end products (RAGE), a multi-ligand member of the immunoglobulin superfamily, contributes to acute and chronic disease processes, including sepsis...
  39. ncbi request reprint Physical activity might not be the protective factor for health risk behaviours and psychopathological symptoms in adolescents
    Fang B Tao
    School of Public Health, Anhui Medical University, Anhui, China
    J Paediatr Child Health 43:762-7. 2007
    ..This study aims to examine the effect of physical activity (PA) intensity on tobacco or alcohol abuse, suicide behaviours and psychopathological symptoms in junior and senior high school students in China...