Saulius Sumanas


Affiliation: Cincinnati Children's Hospital Medical Center
Country: USA


  1. Pociute K, Schumacher J, Sumanas S. Clec14a genetically interacts with Etv2 and Vegf signaling during vasculogenesis and angiogenesis in zebrafish. BMC Dev Biol. 2019;19:6 pubmed publisher
    ..These results argue that clec14a is involved in both vasculogenesis and angiogenesis, and suggest that Clec14a genetically interacts with Etv2 and Vegf signaling during vascular development in zebrafish embryos. ..
  2. Ton Q, Leino D, Mowery S, Bredemeier N, Lafontant P, Lubert A, et al. Collagen COL22A1 maintains vascular stability and mutations in COL22A1 are potentially associated with intracranial aneurysms. Dis Model Mech. 2018;11: pubmed publisher
    ..Altogether, these results argue that COL22A1 is required to maintain vascular integrity. These data further suggest that mutations in COL22A1 could be one of the risk factors for intracranial aneurysms in humans. ..
  3. Davis J, Koenig A, Lubert A, Chestnut B, Liu F, Palencia Desai S, et al. ETS transcription factor Etsrp / Etv2 is required for lymphangiogenesis and directly regulates vegfr3 / flt4 expression. Dev Biol. 2018;440:40-52 pubmed publisher
    ..Together these data support a model where Etv2 initiates lymphangiogenesis by directly promoting the expression of flt4 within the posterior cardinal vein. ..
  4. Craig M, Sumanas S. ETS transcription factors in embryonic vascular development. Angiogenesis. 2016;19:275-85 pubmed publisher
    ..This review summarizes our current understanding of the specific roles played by ETS factors in vasculogenesis and angiogenesis and the implications of functional redundancies between them. ..
  5. Craig M, Grajevskaja V, Liao H, Balciuniene J, Ekker S, Park J, et al. Etv2 and fli1b function together as key regulators of vasculogenesis and angiogenesis. Arterioscler Thromb Vasc Biol. 2015;35:865-76 pubmed publisher
    ..Etv2 alone is required for early vasculogenesis, whereas Etv2 and Fli1b function redundantly during late vasculogenesis and early embryonic angiogenesis. ..
  6. Palencia Desai S, Rost M, Schumacher J, Ton Q, Craig M, Baltrunaite K, et al. Myocardium and BMP signaling are required for endocardial differentiation. Development. 2015;142:2304-15 pubmed publisher
    ..Our results indicate that the myocardium is crucial for endocardial morphogenesis and differentiation, and identify BMP as a signal involved in endocardial differentiation. ..
  7. Koenig A, Baltrunaite K, Bower N, Rossi A, Stainier D, Hogan B, et al. Vegfa signaling promotes zebrafish intestinal vasculature development through endothelial cell migration from the posterior cardinal vein. Dev Biol. 2016;411:115-27 pubmed publisher
    ..It is likely that a similar mechanism is utilized during vascularization of other organs. ..
  8. Baltrunaite K, Craig M, Palencia Desai S, Chaturvedi P, Pandey R, Hegde R, et al. ETS transcription factors Etv2 and Fli1b are required for tumor angiogenesis. Angiogenesis. 2017;20:307-323 pubmed publisher
    ..These results demonstrate the requirement for Etv2 and Fli1b in tumor angiogenesis and suggest that inhibition of these ETS factors may present a novel strategy to inhibit tumor angiogenesis and reduce tumor growth. ..
  9. Casie Chetty S, Rost M, Enriquez J, Schumacher J, Baltrunaite K, Rossi A, et al. Vegf signaling promotes vascular endothelial differentiation by modulating etv2 expression. Dev Biol. 2017;424:147-161 pubmed publisher

More Information


  1. Sumanas S. Inducible Inhibition of Gene Function with Photomorpholinos. Methods Mol Biol. 2017;1565:51-57 pubmed publisher
    ..A similar approach should be also applicable to other model organisms. ..
  2. Sumanas S, Gomez G, Zhao Y, Park C, Choi K, Lin S. Interplay among Etsrp/ER71, Scl, and Alk8 signaling controls endothelial and myeloid cell formation. Blood. 2008;111:4500-10 pubmed publisher
    ..We further demonstrate that the choice of endothelial versus myeloid fate depends on a combinatorial effect of etsrp, scl, and alk8 genes. ..
  3. Suetsugu Maki R, Maki N, Nakamura K, Sumanas S, Zhu J, Del Rio Tsonis K, et al. Lens regeneration in axolotl: new evidence of developmental plasticity. BMC Biol. 2012;10:103 pubmed publisher
    ..Regeneration of the lens is possible in the axolotl, but differs from both frogs and newts. Thus the axolotl iris provides a novel and more plastic strategy for lens regeneration. ..