Kris A Steinbrecher
Affiliation: Cincinnati Children's Hospital Medical Center
Mann E, Harmel Laws E, Cohen M, Steinbrecher K. Guanylate cyclase C limits systemic dissemination of a murine enteric pathogen. BMC Gastroenterol. 2013;13:135 pubmed publisher
..Our aim was to determine if GC-C is required for host defense during infection by the murine enteric pathogen Citrobacter rodentium of the family Enterobacteriacea...
Amarachintha S, Harmel Laws E, Steinbrecher K. Guanylate cyclase C reduces invasion of intestinal epithelial cells by bacterial pathogens. Sci Rep. 2018;8:1521 pubmed publisher
..These studies suggest that early life susceptibility to STa-secreting enterotoxigenic E. coli may be counter-balanced by a critical role of GC-C in protecting the mucosa from non-STa producing, invasive bacterial pathogens. ..
Steinbrecher K, Harmel Laws E, Sitcheran R, Baldwin A. Loss of epithelial RelA results in deregulated intestinal proliferative/apoptotic homeostasis and susceptibility to inflammation. J Immunol. 2008;180:2588-99 pubmed
..We conclude that activation of RelA is required for homeostatic regulation of cell death and division in intestinal epithelia, as well as for protection from development of severe, acute inflammation of the intestine. ..
Steinbrecher K, Harmel Laws E, Garin Laflam M, Mann E, Bezerra L, Hogan S, et al
. Murine guanylate cyclase C regulates colonic injury and inflammation. J Immunol. 2011;186:7205-14 pubmed publisher
..These findings demonstrate a novel role for GC-C signaling in facilitating mucosal wounding and inflammation, and further suggest that this may be mediated, in part, through control of RELM? production. ..