Research Topics
Genomes and GenesSpecies | Matthew R SkeltonSummaryAffiliation: Cincinnati Children's Hospital Medical Center Country: USA Publications
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Publications
Creatine transporter (CrT; Slc6a8) knockout mice as a model of human CrT deficiencyMatthew R Skelton
Division of Neurology, Cincinnati Children s Research Foundation, and Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America
PLoS ONE 6:e16187. 2011..Ubiquitous CrT knockout mice have learning and memory deficits resembling human CrT deficiency and this model should be useful in understanding this disorder...
Distinct periods of developmental sensitivity to the effects of 3,4-(±)-methylenedioxymethamphetamine (MDMA) on behaviour and monoamines in ratsMatthew R Skelton
Division of Neurology, Cincinnati Children s Research Foundation and the Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA
Int J Neuropsychopharmacol 15:811-24. 2012..Other effects, such as those upon MK-801-stimulated locomotion showed greatest effects after PD 1-10 MDMA exposure. Hence, each effect has a different window of developmental susceptibility...- Effects of neonatal (+)-methamphetamine on path integration and spatial learning in rats: effects of dose and rearing conditionsCharles V Vorhees
Division of Neurology, Department of Pediatrics, Cincinnati Children s Research Foundation and University of Cincinnati College of Medicine, 3333 Burnet Avenue, Cincinnati, OH 45229, United States
Int J Dev Neurosci 26:599-610. 2008..The results demonstrate that a narrower exposure window (5 days) changes the long-term effects of MA treatment compared to longer exposures (10 days)... - (+/-)-3,4-Methylenedioxymethamphetamine treatment in adult rats impairs path integration learning: a comparison of single vs once per week treatment for 5 weeksMatthew R Skelton
Division of Neurology, Cincinnati Children s Research Foundation and University of Cincinnati College of Medicine, Cincinnati, OH 45229 3039, USA
Neuropharmacology 55:1121-30. 2008..Taken together, the data show that a single-day regimen of MDMA induces deficits similar to that of multiple weekly treatments... - Comparison of time-dependent effects of (+)-methamphetamine or forced swim on monoamines, corticosterone, glucose, creatine, and creatinine in ratsNicole R Herring
Division of Neurology, Cincinnati Children s Research Foundation and University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
BMC Neurosci 9:49. 2008..In order to compare MA's effects with stress, animals were subjected to a forced swim test in a temporal pattern similar to MA administration [i.e., (30 min/session) 4 times at 2 h intervals]... - Comparison of (+)-methamphetamine, ±-methylenedioxymethamphetamine, (+)-amphetamine and ±-fenfluramine in rats on egocentric learning in the Cincinnati water mazeCharles V Vorhees
Division of Neurology, Department of Pediatrics, Cincinnati Children s Research Foundation and University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA
Synapse 65:368-78. 2011..Given that FEN selectively and MDMA preferentially affect serotonin whereas AMPH selectively and MA preferentially affect DA, the data suggest that egocentric learning may be predominantly dopaminergically mediated... - Effects of inhibiting neonatal methamphetamine-induced corticosterone release in rats by adrenal autotransplantation on later learning, memory, and plasma corticosterone levelsCurtis E Grace
Division of Neurology, Dept of Pediatrics, Cincinnati Children s Research Foundation, Cincinnati, OH 45229 3039, United States
Int J Dev Neurosci 28:331-42. 2010..We previously developed a method to attenuate MA-induced corticosterone release using adrenal autotransplantation (ADXA) in neonatal rats. This exposure period corresponds to the second-half of human pregnancy... - (+)-Methamphetamine increases corticosterone in plasma and BDNF in brain more than forced swim or isolation in neonatal ratsCurtis E Grace
Division of Neurology, Cincinnati Children s Research Foundation, Cincinnati, Ohio 45229 3039, USA
Synapse 62:110-21. 2008..The possible relationship between these changes and the long-term cognitive effects of developmental MA administration are discussed... - Effect of a neurotoxic dose regimen of (+)-methamphetamine on behavior, plasma corticosterone, and brain monoamines in adult C57BL/6 miceCurtis E Grace
Division of Neurology, Dept of Pediatrics, Cincinnati Children s Research Foundation, Cincinnati, Ohio, United States
Neurotoxicol Teratol 32:346-55. 2010..In rats, neurotoxic doses of methamphetamine (MA) induce astrogliosis, long lasting monoamine reductions, reuptake transporter down-regulation, and learning impairments... - Prenatal immune challenge in rats: altered responses to dopaminergic and glutamatergic agents, prepulse inhibition of acoustic startle, and reduced route-based learning as a function of maternal body weight gain after prenatal exposure to poly ICCharles V Vorhees
Division of Neurology, Cincinnati Children s Research Foundation, Cincinnati, Ohio 45229, USA
Synapse 66:725-37. 2012.... - Alterations in body temperature, corticosterone, and behavior following the administration of 5-methoxy-diisopropyltryptamine ('foxy') to adult rats: a new drug of abuseMichael T Williams
Division of Neurology, Cincinnati Children s Research Foundation, Cincinnati, OH 45229 3039, USA
Neuropsychopharmacology 32:1404-20. 2007..5-MEO-DIPT may have the potential to induce untoward effects in humans... - Effects of (+)-methamphetamine on path integration and spatial learning, but not locomotor activity or acoustic startle, align with the stress hyporesponsive period in ratsCharles V Vorhees
Division of Neurology, Department of Pediatrics, Cincinnati Children s Research Foundation and University of Cincinnati College of Medicine, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
Int J Dev Neurosci 27:289-98. 2009..Cognitive deficits from neonatal MA treatment are associated with the SHRP and may be the product of hypothalamic-pituitary-adrenal (HPA) axis dysregulation during critical periods of brain development... - Comparison of the developmental effects of 5-methoxy-N,N-diisopropyltryptamine (Foxy) to (+/-)-3,4-methylenedioxymethamphetamine (ecstasy) in ratsMatthew R Skelton
Division of Neurology, Cincinnati Children s Research Foundation and University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
Psychopharmacology (Berl) 204:287-97. 2009..Recently, the club drug 5-methoxy-N,N-diisopropyltryptamine (5-MeO-DIPT) has gained popularity... - (+/-)3,4-Methylenedioxymethamphetamine (MDMA) dose-dependently impairs spatial learning in the morris water maze after exposure of rats to different five-day intervals from birth to postnatal day twentyCharles V Vorhees
Division of Neurology, Department of Pediatrics and Cincinnati Children s Research Foundation, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229 3039, USA
Dev Neurosci 31:107-20. 2009..However, since no effects on egocentric learning were found, but were apparent after PD 11-20 treatment, the results show that these 2 forms of learning have different exposure-duration sensitivities... - Age-dependent effects of neonatal methamphetamine exposure on spatial learningCharles V Vorhees
Division of Neurology, Cincinnati Children s Research Foundation, Cincinnati, Ohio 45229 3039, USA
Behav Pharmacol 18:549-62. 2007..The results demonstrate that neonatal MA treatment induces spatial learning and reference memory deficits that emerge early and persist until at least 1 year of age, suggesting permanence... - Effects of periadolescent fluoxetine and paroxetine on elevated plus-maze, acoustic startle, and swimming immobility in rats while on and off-drugCharles V Vorhees
Division of Neurology, Department of Pediatrics, Cincinnati Children s Research Foundation and University of Cincinnati College of Medicine, 3333 Burnet Ave, Cincinnati, OH 45229, USA
Behav Brain Funct 7:41. 2011..Whether selective serotonin reuptake inhibitors (SSRIs) exposure during adolescent brain development causes lasting effects remains unresolved... - Effects of developmental stress and lead (Pb) on corticosterone after chronic and acute stress, brain monoamines, and blood Pb levels in ratsDevon L Graham
Division of Neurology, Cincinnati Children s Research Foundation, Cincinnati, OH 45229 3039, USA
Int J Dev Neurosci 29:45-55. 2011..The model introduced here may be useful for investigating the interaction of Pb and chronic developmental stress... - Short- and long-term effects of (+)-methamphetamine and (+/-)-3,4-methylenedioxymethamphetamine on monoamine and corticosterone levels in the neonatal rat following multiple days of treatmentTori L Schaefer
Division of Neurology, Department of Pediatrics, Cincinnati Children s Research Foundation and University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
J Neurochem 104:1674-85. 2008..Although the monoamine changes are transient, they may alter developing neural circuits sufficiently to permanently disrupt later learning and memory abilities... - Learning and memory after neonatal exposure to 3,4-methylenedioxymethamphetamine (ecstasy) in rats: interaction with exposure in adulthoodMartha A Cohen
Division of Neurology, Cincinnati Children's Research Foundation and University of Cincinnati College of Medicine, Cincinnati, Ohio 45229-3039, USA
Synapse 57:148-59. 2005..Correlational analyses suggested that the MWM reversal interaction involves multiple monoamine changes. The results indicate that developmental MDMA exposure can interact with adult exposure to interfere with some aspects of learning... - Neonatal (+)-methamphetamine increases brain derived neurotrophic factor, but not nerve growth factor, during treatment and results in long-term spatial learning deficitsMatthew R Skelton
Division of Neurology, Cincinnati Children s Research Foundation and Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA
Psychoneuroendocrinology 32:734-45. 2007..The findings indicate that early MA exposure induces hippocampal BDNF increases that precede the later emergence of spatial learning deficits... - In utero and lactational exposure to PCBs in mice: adult offspring show altered learning and memory depending on Cyp1a2 and Ahr genotypesChristine P Curran
Department of Environmental Health and Center for Environmental Genetics, University of Cincinnati Medical Center, Cincinnati, Ohio, USA
Environ Health Perspect 119:1286-93. 2011.... - Treatment with MDMA from P11-20 disrupts spatial learning and path integration learning in adolescent rats but only spatial learning in older ratsMatthew R Skelton
Division of Neurology, Cincinnati Children's Research Foundation, 3333 Burnet Avenue, Cincinnati, OH 45229-3039, USA
Psychopharmacology (Berl) 189:307-18. 2006..CONCLUSION: The data suggest that the spatial learning and memory deficits induced by MDMA are long lasting, while the path integration deficits recover over time... - Neonatal +-methamphetamine exposure in rats alters adult locomotor responses to dopamine D1 and D2 agonists and to a glutamate NMDA receptor antagonist, but not to serotonin agonistsDevon L Graham
Division of Neurology, Cincinnati Children s Research Foundation, Cincinnati, OH 45229 3039, USA
Int J Neuropsychopharmacol 16:377-91. 2013.... - Developmental effects of 3,4-methylenedioxymethamphetamine: a reviewMatthew R Skelton
Division of Neurology, Cincinnati Children s Research Foundation, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
Behav Pharmacol 19:91-111. 2008..Taken together, the evidence shows that MDMA exposure has adverse effects on the developing brain and behavior. The animal and human data on developmental MDMA exposure are reviewed and their public health implications discussed... - Comparison of the elevated plus and elevated zero mazes in treated and untreated male Sprague-Dawley rats: effects of anxiolytic and anxiogenic agentsAmanda A Braun
Division of Neurology MLC 7044, Cincinnati Children s Research Foundation and Department of Pediatrics, University of Cincinnati College of Medicine, 3333 Burnet Ave, Cincinnati, Ohio 45229 3039, USA
Pharmacol Biochem Behav 97:406-15. 2011..Zero maze data can be analyzed directly because no center region exists; otherwise the two methods appear comparable following challenge... 
Exposure to 3,4-methylenedioxymethamphetamine (MDMA) on postnatal days 11-20 induces reference but not working memory deficits in the Morris water maze in rats: implications of prior learningCharles V Vorhees
Division of Developmental Biology MLC 7007, Cincinnati Children s Research Foundation and University of Cincinnati College of Medicine, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
Int J Dev Neurosci 22:247-59. 2004..No MDMA effects on the Barnes maze were found regardless of test order, however, the interpretation of this finding was compromised by the poor performance of the animals on this task...- Periadolescent rats (P41-50) exhibit increased susceptibility to D-methamphetamine-induced long-term spatial and sequential learning deficits compared to juvenile (P21-30 or P31-40) or adult rats (P51-60)Charles V Vorhees
Division of Developmental Biology, Cincinnati Children s Research Foundation, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
Neurotoxicol Teratol 27:117-34. 2005..P41-50 is the periadolescent stage of brain development in rodents. The effects observed at this age may suggest a previously unrecognized period of susceptibility for MA-induced cognitive deficits... - Neuronopathic Gaucher disease in the mouse: viable combined selective saposin C deficiency and mutant glucocerebrosidase (V394L) mice with glucosylsphingosine and glucosylceramide accumulation and progressive neurological deficitsYing Sun
The Division of Human Genetics, Cincinnati Children s Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45229 3039, USA
Hum Mol Genet 19:1088-97. 2010....