Matthew R Skelton

Summary

Affiliation: Cincinnati Children's Hospital Medical Center
Country: USA

Publications

  1. pmc Creatine transporter (CrT; Slc6a8) knockout mice as a model of human CrT deficiency
    Matthew R Skelton
    Division of Neurology, Cincinnati Children s Research Foundation, and Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America
    PLoS ONE 6:e16187. 2011
  2. doi request reprint Distinct periods of developmental sensitivity to the effects of 3,4-(±)-methylenedioxymethamphetamine (MDMA) on behaviour and monoamines in rats
    Matthew R Skelton
    Division of Neurology, Cincinnati Children s Research Foundation and the Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA
    Int J Neuropsychopharmacol 15:811-24. 2012
  3. pmc Effects of neonatal (+)-methamphetamine on path integration and spatial learning in rats: effects of dose and rearing conditions
    Charles V Vorhees
    Division of Neurology, Department of Pediatrics, Cincinnati Children s Research Foundation and University of Cincinnati College of Medicine, 3333 Burnet Avenue, Cincinnati, OH 45229, United States
    Int J Dev Neurosci 26:599-610. 2008
  4. pmc (+/-)-3,4-Methylenedioxymethamphetamine treatment in adult rats impairs path integration learning: a comparison of single vs once per week treatment for 5 weeks
    Matthew R Skelton
    Division of Neurology, Cincinnati Children s Research Foundation and University of Cincinnati College of Medicine, Cincinnati, OH 45229 3039, USA
    Neuropharmacology 55:1121-30. 2008
  5. pmc Comparison of time-dependent effects of (+)-methamphetamine or forced swim on monoamines, corticosterone, glucose, creatine, and creatinine in rats
    Nicole R Herring
    Division of Neurology, Cincinnati Children s Research Foundation and University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    BMC Neurosci 9:49. 2008
  6. pmc Comparison of (+)-methamphetamine, ±-methylenedioxymethamphetamine, (+)-amphetamine and ±-fenfluramine in rats on egocentric learning in the Cincinnati water maze
    Charles V Vorhees
    Division of Neurology, Department of Pediatrics, Cincinnati Children s Research Foundation and University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA
    Synapse 65:368-78. 2011
  7. pmc Effects of inhibiting neonatal methamphetamine-induced corticosterone release in rats by adrenal autotransplantation on later learning, memory, and plasma corticosterone levels
    Curtis E Grace
    Division of Neurology, Dept of Pediatrics, Cincinnati Children s Research Foundation, Cincinnati, OH 45229 3039, United States
    Int J Dev Neurosci 28:331-42. 2010
  8. pmc (+)-Methamphetamine increases corticosterone in plasma and BDNF in brain more than forced swim or isolation in neonatal rats
    Curtis E Grace
    Division of Neurology, Cincinnati Children s Research Foundation, Cincinnati, Ohio 45229 3039, USA
    Synapse 62:110-21. 2008
  9. pmc Effect of a neurotoxic dose regimen of (+)-methamphetamine on behavior, plasma corticosterone, and brain monoamines in adult C57BL/6 mice
    Curtis E Grace
    Division of Neurology, Dept of Pediatrics, Cincinnati Children s Research Foundation, Cincinnati, Ohio, United States
    Neurotoxicol Teratol 32:346-55. 2010
  10. pmc Prenatal immune challenge in rats: altered responses to dopaminergic and glutamatergic agents, prepulse inhibition of acoustic startle, and reduced route-based learning as a function of maternal body weight gain after prenatal exposure to poly IC
    Charles V Vorhees
    Division of Neurology, Cincinnati Children s Research Foundation, Cincinnati, Ohio 45229, USA
    Synapse 66:725-37. 2012

Collaborators

Detail Information

Publications29

  1. pmc Creatine transporter (CrT; Slc6a8) knockout mice as a model of human CrT deficiency
    Matthew R Skelton
    Division of Neurology, Cincinnati Children s Research Foundation, and Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America
    PLoS ONE 6:e16187. 2011
    ..Ubiquitous CrT knockout mice have learning and memory deficits resembling human CrT deficiency and this model should be useful in understanding this disorder...
  2. doi request reprint Distinct periods of developmental sensitivity to the effects of 3,4-(±)-methylenedioxymethamphetamine (MDMA) on behaviour and monoamines in rats
    Matthew R Skelton
    Division of Neurology, Cincinnati Children s Research Foundation and the Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA
    Int J Neuropsychopharmacol 15:811-24. 2012
    ..Other effects, such as those upon MK-801-stimulated locomotion showed greatest effects after PD 1-10 MDMA exposure. Hence, each effect has a different window of developmental susceptibility...
  3. pmc Effects of neonatal (+)-methamphetamine on path integration and spatial learning in rats: effects of dose and rearing conditions
    Charles V Vorhees
    Division of Neurology, Department of Pediatrics, Cincinnati Children s Research Foundation and University of Cincinnati College of Medicine, 3333 Burnet Avenue, Cincinnati, OH 45229, United States
    Int J Dev Neurosci 26:599-610. 2008
    ..The results demonstrate that a narrower exposure window (5 days) changes the long-term effects of MA treatment compared to longer exposures (10 days)...
  4. pmc (+/-)-3,4-Methylenedioxymethamphetamine treatment in adult rats impairs path integration learning: a comparison of single vs once per week treatment for 5 weeks
    Matthew R Skelton
    Division of Neurology, Cincinnati Children s Research Foundation and University of Cincinnati College of Medicine, Cincinnati, OH 45229 3039, USA
    Neuropharmacology 55:1121-30. 2008
    ..Taken together, the data show that a single-day regimen of MDMA induces deficits similar to that of multiple weekly treatments...
  5. pmc Comparison of time-dependent effects of (+)-methamphetamine or forced swim on monoamines, corticosterone, glucose, creatine, and creatinine in rats
    Nicole R Herring
    Division of Neurology, Cincinnati Children s Research Foundation and University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    BMC Neurosci 9:49. 2008
    ..In order to compare MA's effects with stress, animals were subjected to a forced swim test in a temporal pattern similar to MA administration [i.e., (30 min/session) 4 times at 2 h intervals]...
  6. pmc Comparison of (+)-methamphetamine, ±-methylenedioxymethamphetamine, (+)-amphetamine and ±-fenfluramine in rats on egocentric learning in the Cincinnati water maze
    Charles V Vorhees
    Division of Neurology, Department of Pediatrics, Cincinnati Children s Research Foundation and University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA
    Synapse 65:368-78. 2011
    ..Given that FEN selectively and MDMA preferentially affect serotonin whereas AMPH selectively and MA preferentially affect DA, the data suggest that egocentric learning may be predominantly dopaminergically mediated...
  7. pmc Effects of inhibiting neonatal methamphetamine-induced corticosterone release in rats by adrenal autotransplantation on later learning, memory, and plasma corticosterone levels
    Curtis E Grace
    Division of Neurology, Dept of Pediatrics, Cincinnati Children s Research Foundation, Cincinnati, OH 45229 3039, United States
    Int J Dev Neurosci 28:331-42. 2010
    ..We previously developed a method to attenuate MA-induced corticosterone release using adrenal autotransplantation (ADXA) in neonatal rats. This exposure period corresponds to the second-half of human pregnancy...
  8. pmc (+)-Methamphetamine increases corticosterone in plasma and BDNF in brain more than forced swim or isolation in neonatal rats
    Curtis E Grace
    Division of Neurology, Cincinnati Children s Research Foundation, Cincinnati, Ohio 45229 3039, USA
    Synapse 62:110-21. 2008
    ..The possible relationship between these changes and the long-term cognitive effects of developmental MA administration are discussed...
  9. pmc Effect of a neurotoxic dose regimen of (+)-methamphetamine on behavior, plasma corticosterone, and brain monoamines in adult C57BL/6 mice
    Curtis E Grace
    Division of Neurology, Dept of Pediatrics, Cincinnati Children s Research Foundation, Cincinnati, Ohio, United States
    Neurotoxicol Teratol 32:346-55. 2010
    ..In rats, neurotoxic doses of methamphetamine (MA) induce astrogliosis, long lasting monoamine reductions, reuptake transporter down-regulation, and learning impairments...
  10. pmc Prenatal immune challenge in rats: altered responses to dopaminergic and glutamatergic agents, prepulse inhibition of acoustic startle, and reduced route-based learning as a function of maternal body weight gain after prenatal exposure to poly IC
    Charles V Vorhees
    Division of Neurology, Cincinnati Children s Research Foundation, Cincinnati, Ohio 45229, USA
    Synapse 66:725-37. 2012
    ....
  11. pmc Alterations in body temperature, corticosterone, and behavior following the administration of 5-methoxy-diisopropyltryptamine ('foxy') to adult rats: a new drug of abuse
    Michael T Williams
    Division of Neurology, Cincinnati Children s Research Foundation, Cincinnati, OH 45229 3039, USA
    Neuropsychopharmacology 32:1404-20. 2007
    ..5-MEO-DIPT may have the potential to induce untoward effects in humans...
  12. pmc Effects of (+)-methamphetamine on path integration and spatial learning, but not locomotor activity or acoustic startle, align with the stress hyporesponsive period in rats
    Charles V Vorhees
    Division of Neurology, Department of Pediatrics, Cincinnati Children s Research Foundation and University of Cincinnati College of Medicine, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
    Int J Dev Neurosci 27:289-98. 2009
    ..Cognitive deficits from neonatal MA treatment are associated with the SHRP and may be the product of hypothalamic-pituitary-adrenal (HPA) axis dysregulation during critical periods of brain development...
  13. doi request reprint Neonatal +-methamphetamine exposure in rats alters adult locomotor responses to dopamine D1 and D2 agonists and to a glutamate NMDA receptor antagonist, but not to serotonin agonists
    Devon L Graham
    Division of Neurology, Cincinnati Children s Research Foundation, Cincinnati, OH 45229 3039, USA
    Int J Neuropsychopharmacol 16:377-91. 2013
    ....
  14. pmc Comparison of the developmental effects of 5-methoxy-N,N-diisopropyltryptamine (Foxy) to (+/-)-3,4-methylenedioxymethamphetamine (ecstasy) in rats
    Matthew R Skelton
    Division of Neurology, Cincinnati Children s Research Foundation and University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
    Psychopharmacology (Berl) 204:287-97. 2009
    ..Recently, the club drug 5-methoxy-N,N-diisopropyltryptamine (5-MeO-DIPT) has gained popularity...
  15. pmc Age-dependent effects of neonatal methamphetamine exposure on spatial learning
    Charles V Vorhees
    Division of Neurology, Cincinnati Children s Research Foundation, Cincinnati, Ohio 45229 3039, USA
    Behav Pharmacol 18:549-62. 2007
    ..The results demonstrate that neonatal MA treatment induces spatial learning and reference memory deficits that emerge early and persist until at least 1 year of age, suggesting permanence...
  16. pmc (+/-)3,4-Methylenedioxymethamphetamine (MDMA) dose-dependently impairs spatial learning in the morris water maze after exposure of rats to different five-day intervals from birth to postnatal day twenty
    Charles V Vorhees
    Division of Neurology, Department of Pediatrics and Cincinnati Children s Research Foundation, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229 3039, USA
    Dev Neurosci 31:107-20. 2009
    ..However, since no effects on egocentric learning were found, but were apparent after PD 11-20 treatment, the results show that these 2 forms of learning have different exposure-duration sensitivities...
  17. pmc Effects of periadolescent fluoxetine and paroxetine on elevated plus-maze, acoustic startle, and swimming immobility in rats while on and off-drug
    Charles V Vorhees
    Division of Neurology, Department of Pediatrics, Cincinnati Children s Research Foundation and University of Cincinnati College of Medicine, 3333 Burnet Ave, Cincinnati, OH 45229, USA
    Behav Brain Funct 7:41. 2011
    ..Whether selective serotonin reuptake inhibitors (SSRIs) exposure during adolescent brain development causes lasting effects remains unresolved...
  18. pmc Short- and long-term effects of (+)-methamphetamine and (+/-)-3,4-methylenedioxymethamphetamine on monoamine and corticosterone levels in the neonatal rat following multiple days of treatment
    Tori L Schaefer
    Division of Neurology, Department of Pediatrics, Cincinnati Children s Research Foundation and University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    J Neurochem 104:1674-85. 2008
    ..Although the monoamine changes are transient, they may alter developing neural circuits sufficiently to permanently disrupt later learning and memory abilities...
  19. pmc Effects of developmental stress and lead (Pb) on corticosterone after chronic and acute stress, brain monoamines, and blood Pb levels in rats
    Devon L Graham
    Division of Neurology, Cincinnati Children s Research Foundation, Cincinnati, OH 45229 3039, USA
    Int J Dev Neurosci 29:45-55. 2011
    ..The model introduced here may be useful for investigating the interaction of Pb and chronic developmental stress...
  20. pmc Learning and memory after neonatal exposure to 3,4-methylenedioxymethamphetamine (ecstasy) in rats: interaction with exposure in adulthood
    Martha A Cohen
    Division of Neurology, Cincinnati Children s Research Foundation and University of Cincinnati College of Medicine, Cincinnati, Ohio 45229 3039, USA
    Synapse 57:148-59. 2005
    ..Correlational analyses suggested that the MWM reversal interaction involves multiple monoamine changes. The results indicate that developmental MDMA exposure can interact with adult exposure to interfere with some aspects of learning...
  21. pmc Neonatal (+)-methamphetamine increases brain derived neurotrophic factor, but not nerve growth factor, during treatment and results in long-term spatial learning deficits
    Matthew R Skelton
    Division of Neurology, Cincinnati Children s Research Foundation and Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA
    Psychoneuroendocrinology 32:734-45. 2007
    ..The findings indicate that early MA exposure induces hippocampal BDNF increases that precede the later emergence of spatial learning deficits...
  22. pmc In utero and lactational exposure to PCBs in mice: adult offspring show altered learning and memory depending on Cyp1a2 and Ahr genotypes
    Christine P Curran
    Department of Environmental Health and Center for Environmental Genetics, University of Cincinnati Medical Center, Cincinnati, Ohio, USA
    Environ Health Perspect 119:1286-93. 2011
    ....
  23. pmc Treatment with MDMA from P11-20 disrupts spatial learning and path integration learning in adolescent rats but only spatial learning in older rats
    Matthew R Skelton
    Division of Neurology, Cincinnati Children s Research Foundation, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
    Psychopharmacology (Berl) 189:307-18. 2006
    ..The emergence and permanence of these learning deficits are currently unknown...
  24. pmc Developmental effects of 3,4-methylenedioxymethamphetamine: a review
    Matthew R Skelton
    Division of Neurology, Cincinnati Children s Research Foundation, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
    Behav Pharmacol 19:91-111. 2008
    ..Taken together, the evidence shows that MDMA exposure has adverse effects on the developing brain and behavior. The animal and human data on developmental MDMA exposure are reviewed and their public health implications discussed...
  25. pmc Comparison of the elevated plus and elevated zero mazes in treated and untreated male Sprague-Dawley rats: effects of anxiolytic and anxiogenic agents
    Amanda A Braun
    Division of Neurology MLC 7044, Cincinnati Children s Research Foundation and Department of Pediatrics, University of Cincinnati College of Medicine, 3333 Burnet Ave, Cincinnati, Ohio 45229 3039, USA
    Pharmacol Biochem Behav 97:406-15. 2011
    ..Zero maze data can be analyzed directly because no center region exists; otherwise the two methods appear comparable following challenge...
  26. ncbi request reprint Exposure to 3,4-methylenedioxymethamphetamine (MDMA) on postnatal days 11-20 induces reference but not working memory deficits in the Morris water maze in rats: implications of prior learning
    Charles V Vorhees
    Division of Developmental Biology MLC 7007, Cincinnati Children s Research Foundation and University of Cincinnati College of Medicine, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
    Int J Dev Neurosci 22:247-59. 2004
    ..No MDMA effects on the Barnes maze were found regardless of test order, however, the interpretation of this finding was compromised by the poor performance of the animals on this task...
  27. ncbi request reprint Periadolescent rats (P41-50) exhibit increased susceptibility to D-methamphetamine-induced long-term spatial and sequential learning deficits compared to juvenile (P21-30 or P31-40) or adult rats (P51-60)
    Charles V Vorhees
    Division of Developmental Biology, Cincinnati Children s Research Foundation, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
    Neurotoxicol Teratol 27:117-34. 2005
    ..P41-50 is the periadolescent stage of brain development in rodents. The effects observed at this age may suggest a previously unrecognized period of susceptibility for MA-induced cognitive deficits...
  28. doi request reprint Female mice heterozygous for creatine transporter deficiency show moderate cognitive deficits
    Emily R Hautman
    Division of Neurology, MLC 7044 Cincinnati Children s Research Foundation, 3333 Burnet Ave, Cincinnati, OH, 45229 3039, USA
    J Inherit Metab Dis 37:63-8. 2014
    ..Female CrT(+/-) mice show moderate cognitive deficits, which is consistent with some of the human data. Female CrT(+/-) mice could prove to be beneficial in further understanding CTD and testing therapeutic approaches. ..
  29. pmc Neuronopathic Gaucher disease in the mouse: viable combined selective saposin C deficiency and mutant glucocerebrosidase (V394L) mice with glucosylsphingosine and glucosylceramide accumulation and progressive neurological deficits
    Ying Sun
    The Division of Human Genetics, Cincinnati Children s Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45229 3039, USA
    Hum Mol Genet 19:1088-97. 2010
    ....