Kenneth Dr Setchell

Summary

Affiliation: Cincinnati Children's Hospital Medical Center
Country: USA

Publications

  1. ncbi request reprint The clinical importance of the metabolite equol-a clue to the effectiveness of soy and its isoflavones
    Kenneth D R Setchell
    Clinical Mass Spectrometry, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, OH 45229, USA
    J Nutr 132:3577-84. 2002
  2. ncbi request reprint Bioavailability, disposition, and dose-response effects of soy isoflavones when consumed by healthy women at physiologically typical dietary intakes
    Kenneth D R Setchell
    Division of Clinical Mass Spectrometry, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, OH, USA
    J Nutr 133:1027-35. 2003
  3. pmc Novel soy germ pasta improves endothelial function, blood pressure, and oxidative stress in patients with type 2 diabetes
    Carlo Clerici
    Clinic of Gastroenterology and Hepatology, University of Perugia, Perugia, Italy
    Diabetes Care 34:1946-8. 2011
  4. pmc Assessing risks and benefits of genistein and soy
    Kenneth D R Setchell
    Environ Health Perspect 114:A332-3. 2006
  5. doi request reprint Metabolism of secoisolariciresinol-diglycoside the dietary precursor to the intestinally derived lignan enterolactone in humans
    Kenneth D R Setchell
    Division of Pathology, Clinical Mass Spectrometry, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, Ohio 45229, USA
    Food Funct 5:491-501. 2014
  6. pmc Novel soy germ pasta enriched in isoflavones ameliorates gastroparesis in type 2 diabetes: a pilot study
    Kenneth D R Setchell
    Corresponding author Kenneth D R Setchell
    Diabetes Care 36:3495-7. 2013
  7. pmc A combination of mutations in AKR1D1 and SKIV2L in a family with severe infantile liver disease
    Neil V Morgan
    Department of Medical and Molecular Genetics and Centre for Rare Diseases and Personalised Medicine, University of Birmingham School of Medicine, Birmingham, UK
    Orphanet J Rare Dis 8:74. 2013
  8. doi request reprint Genetic defects in bile acid conjugation cause fat-soluble vitamin deficiency
    Kenneth D R Setchell
    Department of Pathology and Laboratory Medicine, Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Gastroenterology 144:945-955.e6; quiz e14-5. 2013
  9. pmc Diets high in selenium and isoflavones decrease androgen-regulated gene expression in healthy rat dorsolateral prostate
    Russell L Legg
    Department of Nutrition, Dietetics and Food Science, Brigham Young University, Provo, UT 84602, USA
    Reprod Biol Endocrinol 6:57. 2008
  10. pmc Timing of supplementation of selenium and isoflavones determines prostate cancer risk factor reduction in rats
    Jessica R Tolman
    Department of Nutrition, Dietetics and Food Science, Brigham Young University, Provo, Utah 84602, USA
    Nutr Metab (Lond) 5:31. 2008

Research Grants

  1. Soy Isoflavone Metabolite Equol--Formation and Fate
    Kenneth Setchell; Fiscal Year: 2007
  2. Chemopreventive Actions of Equol Enantiomers
    Kenneth Setchell; Fiscal Year: 2007

Collaborators

Detail Information

Publications36

  1. ncbi request reprint The clinical importance of the metabolite equol-a clue to the effectiveness of soy and its isoflavones
    Kenneth D R Setchell
    Clinical Mass Spectrometry, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, OH 45229, USA
    J Nutr 132:3577-84. 2002
    ..The failure to distinguish those subjects who are "equol-producers" from "nonequol producers" in previous clinical studies could plausibly explain the variance in reported data on the health benefits of soy...
  2. ncbi request reprint Bioavailability, disposition, and dose-response effects of soy isoflavones when consumed by healthy women at physiologically typical dietary intakes
    Kenneth D R Setchell
    Division of Clinical Mass Spectrometry, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, OH, USA
    J Nutr 133:1027-35. 2003
    ..On the basis of the pharmacokinetics, optimum steady-state serum isoflavone concentrations would be expected from modest intakes of soy foods consumed regularly throughout the day rather than from a single highly enriched product...
  3. pmc Novel soy germ pasta improves endothelial function, blood pressure, and oxidative stress in patients with type 2 diabetes
    Carlo Clerici
    Clinic of Gastroenterology and Hepatology, University of Perugia, Perugia, Italy
    Diabetes Care 34:1946-8. 2011
    ..To compare the effects of a novel soy germ-enriched pasta, containing isoflavone aglycons, with conventional pasta on endothelial function and cardiovascular risk markers in patients with type 2 diabetes (T2D)...
  4. pmc Assessing risks and benefits of genistein and soy
    Kenneth D R Setchell
    Environ Health Perspect 114:A332-3. 2006
  5. doi request reprint Metabolism of secoisolariciresinol-diglycoside the dietary precursor to the intestinally derived lignan enterolactone in humans
    Kenneth D R Setchell
    Division of Pathology, Clinical Mass Spectrometry, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, Ohio 45229, USA
    Food Funct 5:491-501. 2014
    ....
  6. pmc Novel soy germ pasta enriched in isoflavones ameliorates gastroparesis in type 2 diabetes: a pilot study
    Kenneth D R Setchell
    Corresponding author Kenneth D R Setchell
    Diabetes Care 36:3495-7. 2013
    ..To determine the effect of soy germ pasta enriched in biologically active isoflavone aglycons on gastric emptying in type 2 diabetic patients with gastroparesis...
  7. pmc A combination of mutations in AKR1D1 and SKIV2L in a family with severe infantile liver disease
    Neil V Morgan
    Department of Medical and Molecular Genetics and Centre for Rare Diseases and Personalised Medicine, University of Birmingham School of Medicine, Birmingham, UK
    Orphanet J Rare Dis 8:74. 2013
    ..Although the initial 2 affected cousins died in the first year of life, accurate diagnosis and management of the youngest patient led to successful treatment of the liver disease and disease-free survival...
  8. doi request reprint Genetic defects in bile acid conjugation cause fat-soluble vitamin deficiency
    Kenneth D R Setchell
    Department of Pathology and Laboratory Medicine, Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Gastroenterology 144:945-955.e6; quiz e14-5. 2013
    ....
  9. pmc Diets high in selenium and isoflavones decrease androgen-regulated gene expression in healthy rat dorsolateral prostate
    Russell L Legg
    Department of Nutrition, Dietetics and Food Science, Brigham Young University, Provo, UT 84602, USA
    Reprod Biol Endocrinol 6:57. 2008
    ..These components each affect androgen-regulated gene expression. The objective of this work was to determine the combined effects of selenium and isoflavones on androgen-regulated gene expression in rat prostate...
  10. pmc Timing of supplementation of selenium and isoflavones determines prostate cancer risk factor reduction in rats
    Jessica R Tolman
    Department of Nutrition, Dietetics and Food Science, Brigham Young University, Provo, Utah 84602, USA
    Nutr Metab (Lond) 5:31. 2008
    ..We tested whether combined supplementation of these two dietary components would reduce prostate cancer risk factors in rats more than supplementation of each component individually...
  11. pmc Neuromodulation by soy diets or equol: anti-depressive & anti-obesity-like influences, age- & hormone-dependent effects
    Crystal Blake
    Department of Physiology and Developmental Biology and the Neuroscience Center, Brigham Young University, Provo, Utah 84602, USA
    BMC Neurosci 12:28. 2011
    ....
  12. pmc Global gene expression profile progression in Gaucher disease mouse models
    You Hai Xu
    The Division of Human Genetics, Cincinnati Children s Hospital Research Foundation, Cincinnati, OH 45229 3039, USA
    BMC Genomics 12:20. 2011
    ..The pathogenic pathways resulting from lipid laden macrophages (Gaucher cells) in visceral organs and their abnormal functions are obscure...
  13. pmc Equol: pharmacokinetics and biological actions
    Kenneth D R Setchell
    Pathology and Laboratory Medicine, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    J Nutr 140:1363S-8S. 2010
    ..In this review, the plasma and urinary pharmacokinetics of S-(-)equol and R-(+)equol are reviewed and summarized, and some of the more recent evidence supporting potential biological effects of S-(-)equol is considered...
  14. doi request reprint The pharmacokinetics of S-(-)equol administered as SE5-OH tablets to healthy postmenopausal women
    Kenneth D R Setchell
    Division of Pathology and Laboratory Medicine, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    J Nutr 139:2037-43. 2009
    ..Three participants were determined to be equol-producers, representing a 25% frequency, and equol-producer status had no effect on natural S-(-)equol pharmacokinetics...
  15. pmc The pharmacokinetic behavior of the soy isoflavone metabolite S-(-)equol and its diastereoisomer R-(+)equol in healthy adults determined by using stable-isotope-labeled tracers
    Kenneth Dr Setchell
    Division of Pathology and Laboratory Medicine, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Am J Clin Nutr 90:1029-37. 2009
    ..Little is known about the pharmacokinetics of the diastereoisomers, despite current interest in developing equol as a nutraceutical or pharmaceutical agent...
  16. pmc Equol: history, chemistry, and formation
    Kenneth D R Setchell
    Pathology and Laboratory Medicine, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    J Nutr 140:1355S-62S. 2010
    ..The following review describes the history, chemistry, and factors governing the intestinal bacterial formation of equol...
  17. pmc Soy isoflavone phase II metabolism differs between rodents and humans: implications for the effect on breast cancer risk
    Kenneth D R Setchell
    Division of Pathology and Laboratory Medicine, Cincinnati Children s Hospital Medical Center, OH 45229, USA
    Am J Clin Nutr 94:1284-94. 2011
    ..Human and animal studies have produced conflicting results with regard to the effect of soy isoflavones on breast cancer risk. This may be due to differences in isoflavone metabolism...
  18. ncbi request reprint Method of defining equol-producer status and its frequency among vegetarians
    Kenneth D R Setchell
    Sanitarium Development and Innovation, Cooranbong, NSW 2265, Australia
    J Nutr 136:2188-93. 2006
    ....
  19. ncbi request reprint S-equol, a potent ligand for estrogen receptor beta, is the exclusive enantiomeric form of the soy isoflavone metabolite produced by human intestinal bacterial flora
    Kenneth D R Setchell
    Division of Pathology, Clinical Mass Spectrometry, Cincinnati Children s Hospital Medical Center, and the Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati 45229, OH, USA
    Am J Clin Nutr 81:1072-9. 2005
    ..Equol, unlike the soy isoflavones daidzein or genistein, has a chiral center and therefore can occur as 2 distinct diastereoisomers...
  20. ncbi request reprint Bioequivalence of a new liquid formulation of ursodeoxycholic acid (Ursofalk suspension) and Ursofalk capsules measured by plasma pharmacokinetics and biliary enrichment
    K D R Setchell
    Department of Pathology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Aliment Pharmacol Ther 21:709-21. 2005
    ..Ursodeoxycholic acid is an approved therapy for hepatobiliary disorders but in infants and children compliance is compromised because it is formulated exclusively as capsules, or tablets...
  21. ncbi request reprint Pharmacokinetics of a slow-release formulation of soybean isoflavones in healthy postmenopausal women
    Kenneth D R Setchell
    Division of Pathology, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    J Agric Food Chem 53:1938-44. 2005
    ..These findings show that it is feasible to employ polymer matrices that slow the aqueous dissolution for preparing sustained-release formulations of soy isoflavones. Further studies to optimize such formulations are warranted...
  22. ncbi request reprint Comparing the pharmacokinetics of daidzein and genistein with the use of 13C-labeled tracers in premenopausal women
    Kenneth D R Setchell
    Clinical Mass Spectrometry, Children s Hospital Medical Center, Cincinnati, OH, USA
    Am J Clin Nutr 77:411-9. 2003
    ..Despite significant interest in the risks and benefits of phytoestrogens to human health, few data exist on their pharmacokinetics in humans...
  23. ncbi request reprint Variations in isoflavone levels in soy foods and soy protein isolates and issues related to isoflavone databases and food labeling
    Kenneth D R Setchell
    Division of Clinical Mass Spectrometry, Department of Pediatrics, Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    J Agric Food Chem 51:4146-55. 2003
    ....
  24. ncbi request reprint Hemoglobins dioxygenate nitric oxide with high fidelity
    Paul R Gardner
    Division of Critical Care Medicine, Children s Hospital Medical Center, 3333 Burnet Ave, MLC7006, Cincinnati, OH 45229, USA
    J Inorg Biochem 100:542-50. 2006
    ..NO(2) to form nitrate. Hb functions as a .NO dioxygenase by controlling O(2) binding and electrochemistry, guiding .NO diffusion and reaction, and shielding highly reactive intermediates from solvent water and biomolecules...
  25. pmc Intestinal adaptation after ileal interposition surgery increases bile acid recycling and protects against obesity-related comorbidities
    Rohit Kohli
    Cincinnati Children s Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, Ohio, USA
    Am J Physiol Gastrointest Liver Physiol 299:G652-60. 2010
    ..Changes in serum bile acids or bile acid enterohepatic recycling may mediate the metabolic benefits seen after bariatric surgery...
  26. ncbi request reprint Evidence for lack of absorption of soy isoflavone glycosides in humans, supporting the crucial role of intestinal metabolism for bioavailability
    Kenneth D R Setchell
    Division of Clinical Mass Spectrometry, Department of Pediatrics, Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Am J Clin Nutr 76:447-53. 2002
    ....
  27. pmc The chemopreventive action of equol enantiomers in a chemically induced animal model of breast cancer
    Nadine M Brown
    Division of Pathology and Laboratory Medicine, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio, OH 45229, USA
    Carcinogenesis 31:886-93. 2010
    ..In conclusion, the novel finding that the unnatural enantiomer, R-(+)equol, was potently chemopreventive warrants investigation of its potential for breast cancer prevention and treatment...
  28. ncbi request reprint Liver disease caused by failure to racemize trihydroxycholestanoic acid: gene mutation and effect of bile acid therapy
    Kenneth D R Setchell
    Division of Clinical Mass Spectrometry, Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
    Gastroenterology 124:217-32. 2003
    ....
  29. ncbi request reprint Biliary diversion for progressive familial intrahepatic cholestasis: improved liver morphology and bile acid profile
    Amethyst C Kurbegov
    Pediatric Liver Center and Liver Transplantation Program, Department of Pediatrics, University of Colorado School of Medicine and The Children s Hospital, Denver, Colorado, USA
    Gastroenterology 125:1227-34. 2003
    ..Many patients require liver transplantation, but partial external biliary diversion (PEBD) has shown therapeutic promise. However, the effect of PEBD on liver morphology and bile composition has not been evaluated...
  30. ncbi request reprint Dietary phytoestrogens and their effect on bone: evidence from in vitro and in vivo, human observational, and dietary intervention studies
    Kenneth D R Setchell
    Department of Pediatrics, Clinical Mass Spectrometry, Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Am J Clin Nutr 78:593S-609S. 2003
    ..On balance, the collective data suggest that diets rich in phytoestrogens have bone-sparing effects in the long term, although the magnitude of the effect and the exact mechanism(s) of action are presently elusive or speculative...
  31. pmc The membrane protein ATPase class I type 8B member 1 signals through protein kinase C zeta to activate the farnesoid X receptor
    Tamara Frankenberg
    Department of Pediatrics, Mount Sinai School of Medicine, New York, NY, USA
    Hepatology 48:1896-905. 2008
    ..Benign recurrent intrahepatic cholestasis emanates from a partially functional FIC1 protein. Phosphorylation of FXR is an important mechanism for regulating its activity...
  32. ncbi request reprint Inborn errors of bile acid metabolism
    James E Heubi
    Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229 3039, USA
    Semin Liver Dis 27:282-94. 2007
    ..This review focuses on a description of the disorders of bile acid synthesis that are directly related to single defects in the metabolic pathway, their proposed pathogenesis, treatment, and prognosis...
  33. ncbi request reprint Defects in bile acid biosynthesis--diagnosis and treatment
    Kenneth D R Setchell
    Department of Pathology and Laboratory Medicine, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, OH, USA
    J Pediatr Gastroenterol Nutr 43:S17-22. 2006
    ..Bile-acid therapy using oral cholic acid has proven effective in most of these bile acid synthetic defects making early diagnosis crucial to optimum clinical prognosis...
  34. ncbi request reprint Bile acid synthetic defects and liver disease: a comprehensive review
    Kevin E Bove
    Department of Pathology, HT 4, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
    Pediatr Dev Pathol 7:315-34. 2004
    ..We hypothesize that immature hepatocytes of infants may fuse to form multinucleate hepatocytes whenever atypical or toxic bile acids are present and the pool of normal bile acids is critically reduced...
  35. ncbi request reprint Tauroursodeoxycholic acid (TUDCA) in the prevention of total parenteral nutrition-associated liver disease
    James E Heubi
    Division of Pediatric Gastroenterology, Department of Hepatology and Nutrition, the General Clinical Research Center, Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    J Pediatr 141:237-42. 2002
    ..To determine whether tauroursodeoxycholic acid (TUDCA) would prevent or ameliorate the liver injury in neonates treated with total parenteral nutrition (TPN)...
  36. ncbi request reprint Separation of micelles and vesicles within lumenal aspirates from healthy humans: solubilization of cholesterol after a meal
    Lihang Yao
    Departments of Pathology and Laboratory Medicine, University of Cincinnati Medical School, Cincinnati, OH 45267, USA
    J Lipid Res 43:654-60. 2002
    ....

Research Grants7

  1. Soy Isoflavone Metabolite Equol--Formation and Fate
    Kenneth Setchell; Fiscal Year: 2007
    ..abstract_text> ..
  2. Chemopreventive Actions of Equol Enantiomers
    Kenneth Setchell; Fiscal Year: 2007
    ..These studies are relevant to humans given the ammended health claim for soy and cancer risk-reduction currently being reviewed by the FDA. ..