Research Topics
Species | Kenneth Dr SetchellSummaryAffiliation: Cincinnati Children's Hospital Medical Center Country: USA Publications
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Publications
The clinical importance of the metabolite equol-a clue to the effectiveness of soy and its isoflavonesKenneth D R Setchell
Clinical Mass Spectrometry, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, OH 45229, USA
J Nutr 132:3577-84. 2002..The failure to distinguish those subjects who are "equol-producers" from "nonequol producers" in previous clinical studies could plausibly explain the variance in reported data on the health benefits of soy...- Bioavailability, disposition, and dose-response effects of soy isoflavones when consumed by healthy women at physiologically typical dietary intakesKenneth D R Setchell
Division of Clinical Mass Spectrometry, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, OH, USA
J Nutr 133:1027-35. 2003..On the basis of the pharmacokinetics, optimum steady-state serum isoflavone concentrations would be expected from modest intakes of soy foods consumed regularly throughout the day rather than from a single highly enriched product... - Diets high in selenium and isoflavones decrease androgen-regulated gene expression in healthy rat dorsolateral prostateRussell L Legg
Department of Nutrition, Dietetics and Food Science, Brigham Young University, Provo, UT 84602, USA
Reprod Biol Endocrinol 6:57. 2008..These components each affect androgen-regulated gene expression. The objective of this work was to determine the combined effects of selenium and isoflavones on androgen-regulated gene expression in rat prostate... - Timing of supplementation of selenium and isoflavones determines prostate cancer risk factor reduction in ratsJessica R Tolman
Department of Nutrition, Dietetics and Food Science, Brigham Young University, Provo, Utah 84602, USA
Nutr Metab (Lond) 5:31. 2008..We tested whether combined supplementation of these two dietary components would reduce prostate cancer risk factors in rats more than supplementation of each component individually... - Neuromodulation by soy diets or equol: anti-depressive & anti-obesity-like influences, age- & hormone-dependent effectsCrystal Blake
Department of Physiology and Developmental Biology and the Neuroscience Center, Brigham Young University, Provo, Utah 84602, USA
BMC Neurosci 12:28. 2011.... - Global gene expression profile progression in Gaucher disease mouse modelsYou Hai Xu
The Division of Human Genetics, Cincinnati Children s Hospital Research Foundation, Cincinnati, OH 45229 3039, USA
BMC Genomics 12:20. 2011..The pathogenic pathways resulting from lipid laden macrophages (Gaucher cells) in visceral organs and their abnormal functions are obscure... - Bioequivalence of a new liquid formulation of ursodeoxycholic acid (Ursofalk suspension) and Ursofalk capsules measured by plasma pharmacokinetics and biliary enrichmentK D R Setchell
Department of Pathology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
Aliment Pharmacol Ther 21:709-21. 2005..Ursodeoxycholic acid is an approved therapy for hepatobiliary disorders but in infants and children compliance is compromised because it is formulated exclusively as capsules, or tablets... - S-equol, a potent ligand for estrogen receptor beta, is the exclusive enantiomeric form of the soy isoflavone metabolite produced by human intestinal bacterial floraKenneth D R Setchell
Division of Pathology, Clinical Mass Spectrometry, Cincinnati Children s Hospital Medical Center, and the Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati 45229, OH, USA
Am J Clin Nutr 81:1072-9. 2005..Equol, unlike the soy isoflavones daidzein or genistein, has a chiral center and therefore can occur as 2 distinct diastereoisomers... - Method of defining equol-producer status and its frequency among vegetariansKenneth D R Setchell
Sanitarium Development and Innovation, Cooranbong, NSW 2265, Australia
J Nutr 136:2188-93. 2006.... - Equol: history, chemistry, and formationKenneth D R Setchell
Pathology and Laboratory Medicine, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
J Nutr 140:1355S-62S. 2010..The following review describes the history, chemistry, and factors governing the intestinal bacterial formation of equol... - The pharmacokinetic behavior of the soy isoflavone metabolite S-(-)equol and its diastereoisomer R-(+)equol in healthy adults determined by using stable-isotope-labeled tracersKenneth Dr Setchell
Division of Pathology and Laboratory Medicine, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
Am J Clin Nutr 90:1029-37. 2009..Little is known about the pharmacokinetics of the diastereoisomers, despite current interest in developing equol as a nutraceutical or pharmaceutical agent... - The pharmacokinetics of S-(-)equol administered as SE5-OH tablets to healthy postmenopausal womenKenneth D R Setchell
Division of Pathology and Laboratory Medicine, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
J Nutr 139:2037-43. 2009..Three participants were determined to be equol-producers, representing a 25% frequency, and equol-producer status had no effect on natural S-(-)equol pharmacokinetics... - Soy isoflavone phase II metabolism differs between rodents and humans: implications for the effect on breast cancer riskKenneth D R Setchell
Division of Pathology and Laboratory Medicine, Cincinnati Children s Hospital Medical Center, OH 45229, USA
Am J Clin Nutr 94:1284-94. 2011..Human and animal studies have produced conflicting results with regard to the effect of soy isoflavones on breast cancer risk. This may be due to differences in isoflavone metabolism... - Pharmacokinetics of a slow-release formulation of soybean isoflavones in healthy postmenopausal womenKenneth D R Setchell
Division of Pathology, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
J Agric Food Chem 53:1938-44. 2005..These findings show that it is feasible to employ polymer matrices that slow the aqueous dissolution for preparing sustained-release formulations of soy isoflavones. Further studies to optimize such formulations are warranted... - Equol: pharmacokinetics and biological actionsKenneth D R Setchell
Pathology and Laboratory Medicine, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
J Nutr 140:1363S-8S. 2010..In this review, the plasma and urinary pharmacokinetics of S-(-)equol and R-(+)equol are reviewed and summarized, and some of the more recent evidence supporting potential biological effects of S-(-)equol is considered... - Comparing the pharmacokinetics of daidzein and genistein with the use of 13C-labeled tracers in premenopausal womenKenneth D R Setchell
Clinical Mass Spectrometry, Children's Hospital Medical Center, Cincinnati, OH, USA
Am J Clin Nutr 77:411-9. 2003..The bioavailability of both isoflavones was nonlinear at higher intakes, suggesting that uptake is rate-limiting and saturable... - Variations in isoflavone levels in soy foods and soy protein isolates and issues related to isoflavone databases and food labelingKenneth D R Setchell
Division of Clinical Mass Spectrometry, Department of Pediatrics, Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
J Agric Food Chem 51:4146-55. 2003.... - Hemoglobins dioxygenate nitric oxide with high fidelityPaul R Gardner
Division of Critical Care Medicine, Children s Hospital Medical Center, 3333 Burnet Ave, MLC7006, Cincinnati, OH 45229, USA
J Inorg Biochem 100:542-50. 2006..NO(2) to form nitrate. Hb functions as a .NO dioxygenase by controlling O(2) binding and electrochemistry, guiding .NO diffusion and reaction, and shielding highly reactive intermediates from solvent water and biomolecules... - Intestinal adaptation after ileal interposition surgery increases bile acid recycling and protects against obesity-related comorbiditiesRohit Kohli
Cincinnati Children s Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, Ohio, USA
Am J Physiol Gastrointest Liver Physiol 299:G652-60. 2010..Changes in serum bile acids or bile acid enterohepatic recycling may mediate the metabolic benefits seen after bariatric surgery... - Evidence for lack of absorption of soy isoflavone glycosides in humans, supporting the crucial role of intestinal metabolism for bioavailabilityKenneth D R Setchell
Division of Clinical Mass Spectrometry, Department of Pediatrics, Children s Hospital Medical Center, Cincinnati, OH 45229, USA
Am J Clin Nutr 76:447-53. 2002.... - The chemopreventive action of equol enantiomers in a chemically induced animal model of breast cancerNadine M Brown
Division of Pathology and Laboratory Medicine, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio, OH 45229, USA
Carcinogenesis 31:886-93. 2010..In conclusion, the novel finding that the unnatural enantiomer, R-(+)equol, was potently chemopreventive warrants investigation of its potential for breast cancer prevention and treatment... - Liver disease caused by failure to racemize trihydroxycholestanoic acid: gene mutation and effect of bile acid therapyKenneth D R Setchell
Division of Clinical Mass Spectrometry, Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
Gastroenterology 124:217-32. 2003.... - Dietary phytoestrogens and their effect on bone: evidence from in vitro and in vivo, human observational, and dietary intervention studiesKenneth D R Setchell
Department of Pediatrics, Clinical Mass Spectrometry, Children s Hospital Medical Center, Cincinnati, OH 45229, USA
Am J Clin Nutr 78:593S-609S. 2003..On balance, the collective data suggest that diets rich in phytoestrogens have bone-sparing effects in the long term, although the magnitude of the effect and the exact mechanism(s) of action are presently elusive or speculative... - Biliary diversion for progressive familial intrahepatic cholestasis: improved liver morphology and bile acid profileAmethyst C Kurbegov
Pediatric Liver Center and Liver Transplantation Program, Department of Pediatrics, University of Colorado School of Medicine and The Children's Hospital, Denver, Colorado, USA
Gastroenterology 125:1227-34. 2003..The improved biliary bile acid composition suggests enhanced bile acid secretion after PEBD, perhaps by induction of alternative canalicular transport proteins... - Novel soy germ pasta improves endothelial function, blood pressure, and oxidative stress in patients with type 2 diabetesCarlo Clerici
Clinic of Gastroenterology and Hepatology, University of Perugia, Perugia, Italy
Diabetes Care 34:1946-8. 2011..To compare the effects of a novel soy germ-enriched pasta, containing isoflavone aglycons, with conventional pasta on endothelial function and cardiovascular risk markers in patients with type 2 diabetes (T2D)... - The membrane protein ATPase class I type 8B member 1 signals through protein kinase C zeta to activate the farnesoid X receptorTamara Frankenberg
Department of Pediatrics, Mount Sinai School of Medicine, New York, NY, USA
Hepatology 48:1896-905. 2008..Benign recurrent intrahepatic cholestasis emanates from a partially functional FIC1 protein. Phosphorylation of FXR is an important mechanism for regulating its activity... - Inborn errors of bile acid metabolismJames E Heubi
Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229 3039, USA
Semin Liver Dis 27:282-94. 2007..This review focuses on a description of the disorders of bile acid synthesis that are directly related to single defects in the metabolic pathway, their proposed pathogenesis, treatment, and prognosis... - Defects in bile acid biosynthesis--diagnosis and treatmentKenneth D R Setchell
Department of Pathology and Laboratory Medicine, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, OH, USA
J Pediatr Gastroenterol Nutr 43:S17-22. 2006..Bile-acid therapy using oral cholic acid has proven effective in most of these bile acid synthetic defects making early diagnosis crucial to optimum clinical prognosis... - Bile acid synthetic defects and liver disease: a comprehensive reviewKevin E Bove
Department of Pathology, HT 4, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
Pediatr Dev Pathol 7:315-34. 2004..We hypothesize that immature hepatocytes of infants may fuse to form multinucleate hepatocytes whenever atypical or toxic bile acids are present and the pool of normal bile acids is critically reduced... - Tauroursodeoxycholic acid (TUDCA) in the prevention of total parenteral nutrition-associated liver diseaseJames E Heubi
Division of Pediatric Gastroenterology, Department of Hepatology and Nutrition, the General Clinical Research Center, Children's Hospital Medical Center, Cincinnati, Ohio 45229, USA
J Pediatr 141:237-42. 2002..Erratic biliary enrichment and prolonged inability to initiate treatment may compromise the utility of enterically administered TUDCA for TPN-treated infants... - Separation of micelles and vesicles within lumenal aspirates from healthy humans: solubilization of cholesterol after a mealLihang Yao
Departments of Pathology and Laboratory Medicine, University of Cincinnati Medical School, Cincinnati, OH 45267, USA
J Lipid Res 43:654-60. 2002....
Research Grants
- Soy Isoflavone Metabolite Equol--Formation and FateKenneth Setchell; Fiscal Year: 2007..abstract_text> ..
- Chemopreventive Actions of Equol EnantiomersKenneth Setchell; Fiscal Year: 2007..These studies are relevant to humans given the ammended health claim for soy and cancer risk-reduction currently being reviewed by the FDA. ..