Senthilkumar Sadhasivam

Summary

Affiliation: Cincinnati Children's Hospital Medical Center
Country: USA

Publications

  1. doi request reprint Pharmacogenomics of opioids and perioperative pain management
    Senthilkumar Sadhasivam
    Department of Anesthesiology, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, MLC 2001, Cincinnati, OH 45229, USA
    Pharmacogenomics 13:1719-40. 2012
  2. pmc Race and unequal burden of perioperative pain and opioid related adverse effects in children
    Senthilkumar Sadhasivam
    Division of Human Genetics, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    Pediatrics 129:832-8. 2012
  3. ncbi request reprint Pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections - anesthetic implications and literature review
    Senthilkumar Sadhasivam
    Department of Anesthesiology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Paediatr Anaesth 16:573-7. 2006
  4. doi request reprint Real-time assessment of perioperative behaviors in children and parents: development and validation of the perioperative adult child behavioral interaction scale
    Senthilkumar Sadhasivam
    Department of Anesthesia, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Anesth Analg 110:1109-15. 2010
  5. doi request reprint Comparison of patient-controlled analgesia with and without dexmedetomidine following spine surgery in children
    Senthilkumar Sadhasivam
    Department of Anesthesiology, Cincinnati Children s Hospital Medical Center, MLC 2001, Cincinnati, OH 45229, USA
    J Clin Anesth 21:493-501. 2009
  6. doi request reprint Real-time assessment of perioperative behaviors and prediction of perioperative outcomes
    Senthilkumar Sadhasivam
    Department of Anesthesiology, Cincinnati Children s Hospital Medical Center, 3333 Burnet Ave, MLC 2001, Cincinnati, OH 45229, USA
    Anesth Analg 108:822-6. 2009
  7. doi request reprint Effect of increasing depth of dexmedetomidine anesthesia on upper airway morphology in children
    Mohamed Mahmoud
    Department of Anesthesiology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Paediatr Anaesth 20:506-15. 2010
  8. ncbi request reprint Anesthetic techniques for fetal surgery: effects of maternal anesthesia on intraoperative fetal outcomes in a sheep model
    Pornswan Ngamprasertwong
    Department of Anesthesiology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    Anesthesiology 118:796-808. 2013
  9. ncbi request reprint Morphine clearance in children: does race or genetics matter?
    Senthilkumar Sadhasivam
    Department of Anesthesia, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio, USA
    J Opioid Manag 8:217-26. 2012
  10. ncbi request reprint OCT1 genetic variants influence the pharmacokinetics of morphine in children
    Tsuyoshi Fukuda
    Division of Clinical Pharmacology, Cincinnati Children s Hospital Medical Center, OH, USA
    Pharmacogenomics 14:1141-51. 2013

Detail Information

Publications31

  1. doi request reprint Pharmacogenomics of opioids and perioperative pain management
    Senthilkumar Sadhasivam
    Department of Anesthesiology, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, MLC 2001, Cincinnati, OH 45229, USA
    Pharmacogenomics 13:1719-40. 2012
    ....
  2. pmc Race and unequal burden of perioperative pain and opioid related adverse effects in children
    Senthilkumar Sadhasivam
    Division of Human Genetics, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    Pediatrics 129:832-8. 2012
    ..Adult studies suggest pain management is influenced by patient's race. The objective of this study is to evaluate the influence of race on perioperative pain treatment in children...
  3. ncbi request reprint Pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections - anesthetic implications and literature review
    Senthilkumar Sadhasivam
    Department of Anesthesiology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Paediatr Anaesth 16:573-7. 2006
    ..Series of therapeutic plasmapheresis in these children may complicate their anesthesia management. We describe the first case of a patient with PANDAS and its anesthesia implications...
  4. doi request reprint Real-time assessment of perioperative behaviors in children and parents: development and validation of the perioperative adult child behavioral interaction scale
    Senthilkumar Sadhasivam
    Department of Anesthesia, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Anesth Analg 110:1109-15. 2010
    ....
  5. doi request reprint Comparison of patient-controlled analgesia with and without dexmedetomidine following spine surgery in children
    Senthilkumar Sadhasivam
    Department of Anesthesiology, Cincinnati Children s Hospital Medical Center, MLC 2001, Cincinnati, OH 45229, USA
    J Clin Anesth 21:493-501. 2009
    ..To evaluate the effect of dexmedetomidine as an adjunct to patient-controlled analgesia (PCA) with morphine...
  6. doi request reprint Real-time assessment of perioperative behaviors and prediction of perioperative outcomes
    Senthilkumar Sadhasivam
    Department of Anesthesiology, Cincinnati Children s Hospital Medical Center, 3333 Burnet Ave, MLC 2001, Cincinnati, OH 45229, USA
    Anesth Analg 108:822-6. 2009
    ....
  7. doi request reprint Effect of increasing depth of dexmedetomidine anesthesia on upper airway morphology in children
    Mohamed Mahmoud
    Department of Anesthesiology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Paediatr Anaesth 20:506-15. 2010
    ..This prospective study examines the dose-response effects of dexmedetomidine on upper airway morphology in children with no obstructive sleep apnea (OSA)...
  8. ncbi request reprint Anesthetic techniques for fetal surgery: effects of maternal anesthesia on intraoperative fetal outcomes in a sheep model
    Pornswan Ngamprasertwong
    Department of Anesthesiology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    Anesthesiology 118:796-808. 2013
    ..In this animal study, the authors compare maternal-fetal effects of high-dose desflurane anesthesia (HD-DES) and SIVA...
  9. ncbi request reprint Morphine clearance in children: does race or genetics matter?
    Senthilkumar Sadhasivam
    Department of Anesthesia, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio, USA
    J Opioid Manag 8:217-26. 2012
    ....
  10. ncbi request reprint OCT1 genetic variants influence the pharmacokinetics of morphine in children
    Tsuyoshi Fukuda
    Division of Clinical Pharmacology, Cincinnati Children s Hospital Medical Center, OH, USA
    Pharmacogenomics 14:1141-51. 2013
    ..To study variations in intravenous morphine pharmacokinetics in children, we examined the influence of genetic polymorphisms in OCT1...
  11. ncbi request reprint Supplementing desflurane with intravenous anesthesia reduces fetal cardiac dysfunction during open fetal surgery
    Anne Boat
    Department of Anesthesiology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Paediatr Anaesth 20:748-56. 2010
    ..To lower the incidence and severity of fetal cardiovascular depression during maternal fetal surgery under general anesthesia...
  12. ncbi request reprint Susceptibility of transcranial electric motor-evoked potentials to varying targeted blood levels of dexmedetomidine during spine surgery
    Mohamed Mahmoud
    Department of Anesthesiology, Division of Biostatistics and Epidemiology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    Anesthesiology 112:1364-73. 2010
    ....
  13. doi request reprint A comparison of dexmedetomidine with propofol for magnetic resonance imaging sleep studies in children
    Mohamed Mahmoud
    Department of Anesthesia, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Anesth Analg 109:745-53. 2009
    ....
  14. ncbi request reprint Codeine-related adverse drug reactions in children following tonsillectomy: a prospective study
    Cynthia A Prows
    Division of Human Genetics, University of Cincinnati, Cincinnati, Ohio Division of Pharmacy, University of Cincinnati, Cincinnati, Ohio
    Laryngoscope 124:1242-50. 2014
    ..To prospectively determine factors associated with codeine's adverse drug reactions (ADRs) at home in a large homogenous population of children undergoing outpatient tonsillectomy...
  15. ncbi request reprint Pharmacogenetics and anesthetic drugs
    Vidya Chidambaran
    Department of Anesthesiology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
    Curr Clin Pharmacol 7:78-101. 2012
    ....
  16. ncbi request reprint Loss of transcranial electric motor evoked potentials during pediatric spine surgery with dexmedetomidine
    Mohamed Mahmoud
    Department of Anesthesiology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    Anesthesiology 106:393-6. 2007
  17. doi request reprint Outcome for the extremely premature neonate: how far do we push the edge?
    Anne C Boat
    Department of Anesthesiology, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
    Paediatr Anaesth 21:765-70. 2011
    ..In this article, we will discuss the following questions: How far have we come in improving outcomes of extreme prematurity? And what will the future medical and societal challenges be, as we continue to redefine the limits of viability?..
  18. doi request reprint Genetics of pain perception, COMT and postoperative pain management in children
    Senthilkumar Sadhasivam
    Clinical Anaesthesia and Paediatrics, Acute and Perioperative Pain Service, Department of Anaesthesia, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, MLC 2001, Cincinnati, OH 45229, USA
    Pharmacogenomics 15:277-84. 2014
    ..Effective perioperative analgesia is lacking for children owing to interindividual variations and underdosing of opioids caused by fear of adverse effects. We investigated the role of COMT SNPs on postoperative pain management in children...
  19. doi request reprint Pharmacogenetics in perioperative medicine
    Mindy Cohen
    Department of Anesthesiology, Children s Hospital Colorado, Aurora, USA
    Curr Opin Anaesthesiol 25:419-27. 2012
    ..This review will discuss the most recent developments in pharmacogenetics of commonly used perioperative medications, new collaboration networks in the field of personalized medicine, and future clinical implications of pharmacogenetics...
  20. ncbi request reprint Future of pediatric tonsillectomy and perioperative outcomes
    Rajeev Subramanyam
    Department of Anesthesia, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Int J Pediatr Otorhinolaryngol 77:194-9. 2013
    ..We describe post-tonsillectomy outcomes including postanesthesia care unit stay, post discharge maladaptive behavioral outcomes and finally effective ways to identify children at risk for anesthesia and a few preventive strategies...
  21. ncbi request reprint Use of dexmedetomidine for monitored anesthesia care for diskography in adolescents
    James Furstein
    Liberty Campus of Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio, USA
    AANA J 79:421-5. 2011
    ..The clinical endpoints of sedation and analgesia were cooperative and still patients during needle placement in the intervertebral disks...
  22. ncbi request reprint Anesthetic implications of undiagnosed late onset central hypoventilation syndrome in a child: from elective tonsillectomy to tracheostomy
    Mohamed Mahmoud
    Department of Anesthesiology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Paediatr Anaesth 17:1001-5. 2007
    ..We present a child who had unanticipated respiratory complications following an elective tonsillectomy who eventually required a tracheostomy and long-term ventilatory support...
  23. ncbi request reprint Effect of age and sedative agent on the accuracy of bispectral index in detecting depth of sedation in children
    Shobha Malviya
    Section of Pediatrics, Department of Anesthesiology, University of Michigan Health Systems, F3900 Box 0211, 1500 E Medical Center Dr, Ann Arbor, MI 48109 0211, USA
    Pediatrics 120:e461-70. 2007
    ..This study evaluated age- and sedative agent-related differences in bispectral index across observed sedation levels in a large sample of children < 18 years of age...
  24. doi request reprint Anesthesia- and opioids-related malpractice claims following tonsillectomy in USA: LexisNexis claims database 1984-2012
    Rajeev Subramanyam
    Department of Anesthesia, Cincinnati Children s Hospital Medical Center, Cincinnati, OH, USA
    Paediatr Anaesth 24:412-20. 2014
    ..We have reviewed malpractice claims involving fatal and nonfatal injuries following tonsillectomy with an emphasis on anesthesia- and opioid-related claims and their characteristics...
  25. pmc Maternal hypotension during fetoscopic surgery: incidence and its impact on fetal survival outcomes
    Pornswan Ngamprasertwong
    Department of Anesthesia, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
    ScientificWorldJournal 2013:709059. 2013
    ..In patients who had intraoperative maternal hypotension, there was no correlation between the presence of maternal hypotension and postoperative fetal survival. ..
  26. pmc Characteristics of successful recruitment in prospective pediatric pharmacogenetic studies
    Shannon N Saldana
    Division of Clinical Pharmacology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio, USA
    Clin Ther 33:2072-81. 2011
    ..There is a need to explore feasible means of accruing an appropriate study cohort to help fill the knowledge gap between pharmacogenetic contributions to drug response and clinical application in the pediatric population...
  27. ncbi request reprint Comparison of postoperative analgesia with epidural butorphanol/bupivacaine versus fentanyl/bupivacaine following pediatric urological procedures
    Alexandra Szabova
    Department of Anesthesia, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio, USA
    J Opioid Manag 6:401-7. 2010
    ..The aim of this retrospective study is to compare safety and efficacy of postoperative epidural butorphanol/bupivacaine with the gold-standard epidural analgesic infusion fentanyl/bupivacaine in children...
  28. ncbi request reprint Utilization of optimal study design for maternal and fetal sheep propofol pharmacokinetics study: a preliminary study
    Catherine M T Sherwin
    Clinical Anesthesia and Pediatrics, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, MLC 2001, Cincinnati, OH 45229, USA
    Curr Clin Pharmacol 9:64-9. 2014
    ..Initial evaluation of samples collected from three sheep using the optimal design strategy confirmed the performance of the design in obtaining effective PK parameter estimates...
  29. doi request reprint Pediatric acute and surgical pain management: recent advances and future perspectives
    Vidya Chidambaran
    Departments of Anesthesia and Pediatrics, Cincinnati Children s Hospital Medical Center, Cincinnati, OH, USA
    Int Anesthesiol Clin 50:66-82. 2012
    ..Ongoing research provides hope that future integration of pharmacogenetics, metabolomics, and proteomics in clinical decision and analgesic selection/dosing processes will maximize analgesia and minimize adverse effects...
  30. ncbi request reprint Validation of the bispectral index monitor for measuring the depth of sedation in children
    Senthilkumar Sadhasivam
    Department of Anesthesiology, The Children s Hospital of Philadelphia, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Anesth Analg 102:383-8. 2006
    ..51, P < 0.001). We conclude that the BIS monitor is a quantitative, nondisruptive and easy to use depth of sedation monitor in children...
  31. ncbi request reprint Epinephrine prevents muscle blood flow increases after perineural injection of tetrodotoxin
    Takako Masuda
    Department of Anesthesiology, Perioperative and Pain Medicine, Children s Hospital, Boston, MA, USA
    Anesthesiology 101:1428-34. 2004
    ..The authors hypothesized that tetrodotoxin causes vasodilatation at its injection site, which accelerates its systemic uptake, and that this vasodilatation is attenuated by coinjected epinephrine...