Research Topics
| Senthilkumar SadhasivamSummaryAffiliation: Cincinnati Children's Hospital Medical Center Country: USA Publications
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Detail Information
Publications
Pharmacogenomics of opioids and perioperative pain managementSenthilkumar Sadhasivam
Department of Anesthesiology, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, MLC 2001, Cincinnati, OH 45229, USA
Pharmacogenomics 13:1719-40. 2012....
Race and unequal burden of perioperative pain and opioid related adverse effects in childrenSenthilkumar Sadhasivam
Division of Human Genetics, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
Pediatrics 129:832-8. 2012..Adult studies suggest pain management is influenced by patient's race. The objective of this study is to evaluate the influence of race on perioperative pain treatment in children...- Real-time assessment of perioperative behaviors in children and parents: development and validation of the perioperative adult child behavioral interaction scaleSenthilkumar Sadhasivam
Department of Anesthesia, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
Anesth Analg 110:1109-15. 2010.... - Comparison of patient-controlled analgesia with and without dexmedetomidine following spine surgery in childrenSenthilkumar Sadhasivam
Department of Anesthesiology, Cincinnati Children s Hospital Medical Center, MLC 2001, Cincinnati, OH 45229, USA
J Clin Anesth 21:493-501. 2009..To evaluate the effect of dexmedetomidine as an adjunct to patient-controlled analgesia (PCA) with morphine... - Real-time assessment of perioperative behaviors and prediction of perioperative outcomesSenthilkumar Sadhasivam
Department of Anesthesiology, Cincinnati Children s Hospital Medical Center, 3333 Burnet Ave, MLC 2001, Cincinnati, OH 45229, USA
Anesth Analg 108:822-6. 2009.... 
Pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections - anesthetic implications and literature reviewSenthilkumar Sadhasivam
Department of Anesthesiology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
Paediatr Anaesth 16:573-7. 2006..Series of therapeutic plasmapheresis in these children may complicate their anesthesia management. We describe the first case of a patient with PANDAS and its anesthesia implications...- Effect of increasing depth of dexmedetomidine anesthesia on upper airway morphology in childrenMohamed Mahmoud
Department of Anesthesiology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
Paediatr Anaesth 20:506-15. 2010..This prospective study examines the dose-response effects of dexmedetomidine on upper airway morphology in children with no obstructive sleep apnea (OSA)... - Morphine clearance in children: does race or genetics matter?Senthilkumar Sadhasivam
Department of Anesthesia, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio, USA
J Opioid Manag 8:217-26. 2012.... - Supplementing desflurane with intravenous anesthesia reduces fetal cardiac dysfunction during open fetal surgeryAnne Boat
Department of Anesthesiology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
Paediatr Anaesth 20:748-56. 2010..To lower the incidence and severity of fetal cardiovascular depression during maternal fetal surgery under general anesthesia... - Susceptibility of transcranial electric motor-evoked potentials to varying targeted blood levels of dexmedetomidine during spine surgeryMohamed Mahmoud
Department of Anesthesiology, Division of Biostatistics and Epidemiology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
Anesthesiology 112:1364-73. 2010.... - A comparison of dexmedetomidine with propofol for magnetic resonance imaging sleep studies in childrenMohamed Mahmoud
Department of Anesthesia, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
Anesth Analg 109:745-53. 2009.... - Loss of transcranial electric motor evoked potentials during pediatric spine surgery with dexmedetomidineMohamed Mahmoud
Department of Anesthesiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 45229, USA
Anesthesiology 106:393-6. 2007 - Outcome for the extremely premature neonate: how far do we push the edge?Anne C Boat
Department of Anesthesiology, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
Paediatr Anaesth 21:765-70. 2011..In this article, we will discuss the following questions: How far have we come in improving outcomes of extreme prematurity? And what will the future medical and societal challenges be, as we continue to redefine the limits of viability?.. - Pharmacogenetics in perioperative medicineMindy Cohen
Department of Anesthesiology, Children s Hospital Colorado, Aurora, USA
Curr Opin Anaesthesiol 25:419-27. 2012..This review will discuss the most recent developments in pharmacogenetics of commonly used perioperative medications, new collaboration networks in the field of personalized medicine, and future clinical implications of pharmacogenetics... - Pharmacogenetics and anesthetic drugsVidya Chidambaran
Department of Anesthesiology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
Curr Clin Pharmacol 7:78-101. 2012.... - Use of dexmedetomidine for monitored anesthesia care for diskography in adolescentsJames Furstein
Liberty Campus of Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio, USA
AANA J 79:421-5. 2011..The clinical endpoints of sedation and analgesia were cooperative and still patients during needle placement in the intervertebral disks... - Anesthetic implications of undiagnosed late onset central hypoventilation syndrome in a child: from elective tonsillectomy to tracheostomyMohamed Mahmoud
Department of Anesthesiology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
Paediatr Anaesth 17:1001-5. 2007..We present a child who had unanticipated respiratory complications following an elective tonsillectomy who eventually required a tracheostomy and long-term ventilatory support... - Effect of age and sedative agent on the accuracy of bispectral index in detecting depth of sedation in childrenShobha Malviya
Section of Pediatrics, Department of Anesthesiology, University of Michigan Health Systems, F3900 Box 0211, 1500 E Medical Center Dr, Ann Arbor, MI 48109 0211, USA
Pediatrics 120:e461-70. 2007..This study evaluated age- and sedative agent-related differences in bispectral index across observed sedation levels in a large sample of children < 18 years of age... - Anesthetic techniques for fetal surgery: effects of maternal anesthesia on intraoperative fetal outcomes in a sheep modelPornswan Ngamprasertwong
Department of Anesthesiology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
Anesthesiology 118:796-808. 2013..In this animal study, the authors compare maternal-fetal effects of high-dose desflurane anesthesia (HD-DES) and SIVA... - Comparison of postoperative analgesia with epidural butorphanol/bupivacaine versus fentanyl/bupivacaine following pediatric urological proceduresAlexandra Szabova
Department of Anesthesia, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio, USA
J Opioid Manag 6:401-7. 2010..The aim of this retrospective study is to compare safety and efficacy of postoperative epidural butorphanol/bupivacaine with the gold-standard epidural analgesic infusion fentanyl/bupivacaine in children... - Characteristics of successful recruitment in prospective pediatric pharmacogenetic studiesShannon N Saldana
Division of Clinical Pharmacology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio, USA
Clin Ther 33:2072-81. 2011..There is a need to explore feasible means of accruing an appropriate study cohort to help fill the knowledge gap between pharmacogenetic contributions to drug response and clinical application in the pediatric population... - Future of pediatric tonsillectomy and perioperative outcomesRajeev Subramanyam
Department of Anesthesia, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
Int J Pediatr Otorhinolaryngol 77:194-9. 2013..We describe post-tonsillectomy outcomes including postanesthesia care unit stay, post discharge maladaptive behavioral outcomes and finally effective ways to identify children at risk for anesthesia and a few preventive strategies... - Pediatric acute and surgical pain management: recent advances and future perspectivesVidya Chidambaran
Departments of Anesthesia and Pediatrics, Cincinnati Children s Hospital Medical Center, Cincinnati, OH, USA
Int Anesthesiol Clin 50:66-82. 2012..Ongoing research provides hope that future integration of pharmacogenetics, metabolomics, and proteomics in clinical decision and analgesic selection/dosing processes will maximize analgesia and minimize adverse effects... - Validation of the bispectral index monitor for measuring the depth of sedation in childrenSenthilkumar Sadhasivam
Department of Anesthesiology, The Children's Hospital of Philadelphia, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Anesth Analg 102:383-8. 2006..51, P < 0.001). We conclude that the BIS monitor is a quantitative, nondisruptive and easy to use depth of sedation monitor in children... - Epinephrine prevents muscle blood flow increases after perineural injection of tetrodotoxinTakako Masuda
Department of Anesthesiology, Perioperative and Pain Medicine, Children's Hospital, Boston, MA, USA
Anesthesiology 101:1428-34. 2004..CONCLUSIONS: Vasoconstriction in the perisciatic muscles by epinephrine may contribute to the prolongation of tetrodotoxin-induced sciatic nerve blocks and the reduction of systemic toxicity of tetrodotoxin...