Research Topics
| MARC ROTHENBERGSummaryAffiliation: Cincinnati Children's Hospital Medical Center Country: USA Publications
Research Grants
| Collaborators
|
Detail Information
Publications
Pediatric patients with eosinophilic esophagitis: an 8-year follow-upAmal H Assa'ad
Division of Allergy and Immunology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
J Allergy Clin Immunol 119:731-8. 2007..Eosinophilic esophagitis (EE) is a gastrointestinal disorder that is increasingly diagnosed in pediatric patients...
Development of a validated patient-reported symptom metric for pediatric eosinophilic esophagitis: qualitative methodsJames P Franciosi
Division of Gastroenterology, Hepatology and Nutrition, Cincinnati Children s Hospital Medical Center, Cincinnati, OH, USA
BMC Gastroenterol 11:126. 2011..We sought to identify and validate key patient self-reported and parent proxy-reported outcomes (PROs) specific to EoE...
Eosinophilic esophagitis: rapidly advancing insightsJ Pablo Abonia
Division of Allergy and Immunology, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
Annu Rev Med 63:421-34. 2012..The antigen-driven nature of EoE has been reinforced by the remarkable impact of therapies utilizing elemental formulas to control the disease as well as a number of reports linking aeroallergens to seasonal worsening of disease...- Eosinophil Function in Eosinophil-associated Gastrointestinal DisordersSimon P Hogan
Division of Allergy and Immunology, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
Curr Allergy Asthma Rep 6:65-71. 2006..We summarize recent experimental analysis examining the underlying contribution of eosinophils to disease pathogenesis and discuss possible therapeutic approaches for the treatment of these diverse diseases... - Analysis of the CCR3 promoter reveals a regulatory region in exon 1 that binds GATA-1Nives Zimmermann
Division of Allergy and Immunology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio, USA
BMC Immunol 6:7. 2005..It is therefore important to elucidate the molecular mechanisms regulating receptor expression... - The eosinophilMarc E Rothenberg
Division of Allergy and Immunology, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA
Annu Rev Immunol 24:147-74. 2006..Finally, strategies for targeted therapeutic intervention in eosinophil-mediated mucosal diseases are conceptualized... - Treatment of patients with the hypereosinophilic syndrome with mepolizumabMarc E Rothenberg
Division of Allergy and Immunology, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, University of Cincinnati, Cincinnati, OH 45229, USA
N Engl J Med 358:1215-28. 2008..Although most patients have a response to corticosteroids, side effects are common and can lead to considerable morbidity... - Clinical and immunopathologic effects of swallowed fluticasone for eosinophilic esophagitisRichard J Noel
Department of Pediatrics, Cincinnati Children s Medical Center, Universityof Cincinnati College of Medicine, OH 45229 3039, USA
Clin Gastroenterol Hepatol 2:568-75. 2004..Eosinophilic esophagitis (EE) is a recently recognized clinical disorder that is understood poorly. We aimed to determine the efficacy of swallowed fluticasone propionate on the immunopathologic features associated with EE... - 2007 E. Mead Johnson award: scientific pursuit of the allergy problemMarc E Rothenberg
Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA
Pediatr Res 64:110-5. 2008.... - Origin, regulation and physiological function of intestinal oeosinophilsPatricia C Fulkerson
Division of Allergy and Immunology, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
Best Pract Res Clin Gastroenterol 22:411-23. 2008..In addition, the regulation of oeosinophil survival by inhibitory and death receptors and the expanding role for oeosinophils in health and disease are reviewed... - Arginase I suppresses IL-12/IL-23p40-driven intestinal inflammation during acute schistosomiasisDe Broski R Herbert
Research Service, Cincinnati Veterans Administration Medical Center, Cincinnati, OH 45220, USA
J Immunol 184:6438-46. 2010..Thus, macrophage-derived Arg I protects hosts against excessive tissue injury caused by worm eggs during acute schistosomiasis by suppressing IL-12/IL-23p40 production and maintaining the Treg/Th17 balance within the intestinal mucosa... - Hypereosinophilic syndromes and new therapeutic approaches including anti-IL-5Miguel L Stein
University of Cincinnati College of Medicine, Division of Allergy and Immunology, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, MLC 7028, Cincinnati, OH 45229, USA
Expert Rev Clin Immunol 1:633-44. 2005..This review will analyze the etiology, classification and new options for the treatment of the hypereosinophilic syndromes, with particular emphasis on anti-interleukin-5 therapy... - Eosinophilic esophagitis: concepts, controversies, and evidencePhilip E Putnam
Division of Gastroenterology, Hepatology, and Nutrition, University of Cincinnati College of Medicine, Cincinnati Children s Hospital Medical Center, Cincinnati Center for Eosinophilic Disorders, Cincinnati, OH 45229, USA
Curr Gastroenterol Rep 11:220-5. 2009..Intense investigations to explain the underpinnings of the disorder and to discover effective therapy are ongoing... - Biology and treatment of eosinophilic esophagitisMarc E Rothenberg
Division of Allergy and Immunology, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA
Gastroenterology 137:1238-49. 2009..Therefore, eosinophilic esophagitis is a disease with unique features that include chronic esophagitis, atopy, immune sensitization to oral antigens, reversibility, and familial association... - Bone marrow cell derived arginase I is the major source of allergen-induced lung arginase but is not required for airway hyperresponsiveness, remodeling and lung inflammatory responses in miceKathryn A Niese
Division of Allergy and Immunology, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
BMC Immunol 10:33. 2009..Arginase is significantly upregulated in the lungs in murine models of asthma, as well as in human asthma, but its role in allergic airway inflammation has not been fully elucidated in mice... - Eosinophils and CCR3 regulate interleukin-13 transgene-induced pulmonary remodelingPatricia C Fulkerson
Deparmtnet of Molecular Genetics, Division of Allergy and Immunology, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, 3333 Burnet Ave, MLC 7028, Cincinnati, OH 45229, USA
Am J Pathol 169:2117-26. 2006..Taken together, these data definitively identify a functional contribution by eosinophils on the effects of chronic IL-13 expression in the lung... - Gastrointestinal eosinophiliaLi Zuo
Division of Allergy and Immunology, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, University of Cincinnati, College of Medicine, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
Immunol Allergy Clin North Am 27:443-55. 2007..All three groups of gastrointestinal eosinophila are described in this article, although the focus is on primary gastrointestinal eosinophilia... - Interplay of adaptive th2 immunity with eotaxin-3/c-C chemokine receptor 3 in eosinophilic esophagitisJennifer Z Bullock
Division of Allergy and Immunology, Cincinnati Children s Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45229 3039, USA
J Pediatr Gastroenterol Nutr 45:22-31. 2007..Although studies of esophageal tissue suggest that Th2 cytokines and eotaxin-3 may be crucial in disease pathogenesis, little is known about the systemic immunological phenotypes of children with EE... - Regulation of carcinogenesis by IL-5 and CCL11: a potential role for eosinophils in tumor immune surveillanceLjubov Simson
Division of Immunology and Genetics, John Curtin School of Medical Research, Australian National University, Mills Road Acton, Canberra, Australian Capital Territory, Australia
J Immunol 178:4222-9. 2007..In addition, subsequent in vitro studies found that eosinophils could directly kill MCA-induced fibrosarcoma cells. Collectively, our data support a potential role for the eosinophil as an effector cell in tumor immune surveillance... - Quantity and distribution of eosinophils in the gastrointestinal tract of childrenCharles W Debrosse
University of Cincinnati College of Medicine, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, OH 45229-3039, USA
Pediatr Dev Pathol 9:210-8. 2006..05). Atopic and nonatopic patients had comparable numbers of eosinophils. These data establish baseline gastrointestinal eosinophil values in pediatric patients without apparent pathological disease... - Critical role for adaptive T cell immunity in experimental eosinophilic esophagitis in miceAnil Mishra
Department of Pediatrics, Cincinnati Children s Hospital Medical Center, University of Cincinnati, College of Medicine, OH 45229, USA
J Leukoc Biol 81:916-24. 2007..Taken together, these studies indicate a role for CD4+ and CD4- cell populations in EE pathogenesis and demonstrate that experimental allergen-induced EE is dependent on adaptive T cell immunity... - A randomized, double-blind, placebo-controlled trial of fluticasone propionate for pediatric eosinophilic esophagitisMichael R Konikoff
Division of Pediatric Gastroenterology, Hepatology and Nutrition, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
Gastroenterology 131:1381-91. 2006..05). CONCLUSIONS: Swallowed FP is effective in inducing histologic remission in eosinophilic esophagitis, with a more pronounced effect in nonallergic and younger individuals, especially in the proximal esophagus... - Anti-IL-5 (mepolizumab) therapy for eosinophilic esophagitisMiguel L Stein
Division of Allergy and Immunology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA
J Allergy Clin Immunol 118:1312-9. 2006..CLINICAL IMPLICATIONS: Anti-IL-5 is a promising therapeutic intervention for EE... - Summary of the First International Gastrointestinal Eosinophil Research SymposiumChris A Liacouras
J Pediatr Gastroenterol Nutr 45:370-91. 2007 - An eosinophil hypothesis for functional dyspepsiaMarc E Rothenberg
Clin Gastroenterol Hepatol 5:1147-8. 2007 - Mitochondrial missile defenseVictor Nizet
Nat Med 14:910-2. 2008 - FIP1L1/PDGFRalpha synergizes with SCF to induce systemic mastocytosis in a murine model of chronic eosinophilic leukemia/hypereosinophilic syndromeYoshiyuki Yamada
Division of Allergy and Immunology, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, OH 45229 3039, USA
Blood 112:2500-7. 2008..The increased proliferation and survival correlated with increased SCF-induced Akt activation. In summary, F/P synergistically promotes MC development, activation, and survival in vivo and in vitro in response to SCF... - Clinical, pathologic, and molecular characterization of familial eosinophilic esophagitis compared with sporadic casesMargaret H Collins
Division of Pathology and Laboratory Medicine, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
Clin Gastroenterol Hepatol 6:621-9. 2008..Eosinophilic esophagitis (EE) occurs in families... - Anti-IL-5 (mepolizumab) therapy reduces eosinophil activation ex vivo and increases IL-5 and IL-5 receptor levelsMiguel L Stein
Division of Allergy and Immunology, Cincinnati Children s Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA
J Allergy Clin Immunol 121:1473-83, 1483.e1-4. 2008..Anti-IL-5 might be a useful therapeutic agent for eosinophilic disorders, yet its immunologic consequences have not been well characterized... - Eosinophils: biological properties and role in health and diseaseSimon P Hogan
Clin Exp Allergy 38:709-50. 2008..Finally, strategies for targeted therapeutic intervention in eosinophil-mediated mucosal diseases are conceptualized... - IL-9- and mast cell-mediated intestinal permeability predisposes to oral antigen hypersensitivityElizabeth E Forbes
Division of Allergy and Immunology, Cincinnati Children s Hospital Medical Center, USA
J Exp Med 205:897-913. 2008..These observations demonstrate a central role for IL-9 and mast cells in experimental intestinal permeability in oral antigen sensitization and suggest that IL-9-mediated mast cell responses have an important role in food allergy... - Esophageal remodeling develops as a consequence of tissue specific IL-5-induced eosinophiliaAnil Mishra
Division of Allergy and Immunology, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
Gastroenterology 134:204-14. 2008..We hypothesized that the development of EE in patients and in an experimental murine model would be associated with eosinophil-mediated tissue remodeling... - IL-13 involvement in eosinophilic esophagitis: transcriptome analysis and reversibility with glucocorticoidsCarine Blanchard
Division of Allergy and Immunology, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
J Allergy Clin Immunol 120:1292-300. 2007..Early studies have established that esophageal eosinophilia occurs in association with T(H)2 allergic responses, and we recently identified an EE-specific esophageal transcriptome that included eotaxin-3... - Basic pathogenesis of eosinophilic esophagitisCarine Blanchard
Division of Allergy and Immunology, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
Gastrointest Endosc Clin N Am 18:133-43; x. 2008.... - Eosinophilic esophagitis in children and adults: a systematic review and consensus recommendations for diagnosis and treatmentGlenn T Furuta
Section of Pediatric Gastroenterology, Hepatology, and Nutrition, The Children s Hospital, Denver, University of Colorado Medical School, Denver, Colorado, USA
Gastroenterology 133:1342-63. 2007..Since EE is a relatively new disease, the intent of this report is to provide current recommendations for care of affected patients and defining gaps in knowledge for future research studies... - Eosinophilic esophagitis: pathogenesis, genetics, and therapyCarine Blanchard
Division of Allergy, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA
J Allergy Clin Immunol 118:1054-9. 2006..We demonstrate that EE involves the interplay of numerous genes, especially the eosinophil chemoattractant eotaxin-3, allowing molecular distinction from other forms of esophagitis and consideration of targeted therapeutic intervention... - A central regulatory role for eosinophils and the eotaxin/CCR3 axis in chronic experimental allergic airway inflammationPatricia C Fulkerson
Department of Molecular Genetics, Biochemistry, and Microbiology, University of Cincinnati College of Medicine, 231 Bethesda Avenue, Cincinnati, OH 45257 0524, USA
Proc Natl Acad Sci U S A 103:16418-23. 2006..In summary, we present multiple lines of independent evidence that eosinophils via CCR3 have a central role in chronic allergic airway disease... - Potential of blood eosinophils, eosinophil-derived neurotoxin, and eotaxin-3 as biomarkers of eosinophilic esophagitisMichael R Konikoff
Division of Pediatric Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229-3039, USA
Clin Gastroenterol Hepatol 4:1328-36. 2006..CONCLUSIONS: These data show that blood levels of AEC, EDN, and eotaxin-3 may have value as noninvasive biomarkers for monitoring EE... - T helper-2 immunity regulates bronchial hyperresponsiveness in eosinophil-associated gastrointestinal disease in miceElizabeth Forbes
Allergy and Inflammation Research Group, Division of Molecular Bioscience, The John Curtin School of Medical Research, Australian National University, Canberra, Australian Capital Territory, Australia
Gastroenterology 127:105-18. 2004.... - Negative regulation of eosinophil recruitment to the lung by the chemokine monokine induced by IFN-gamma (Mig, CXCL9)Patricia C Fulkerson
Department of Molecular Genetics, Biochemistry, and Microbiology, University of Cincinnati College of Medicine, 231 Bethesda Avenue, Cincinnati, OH 45257 0524, USA
Proc Natl Acad Sci U S A 101:1987-92. 2004..The identification of a naturally occurring eosinophil inhibitory chemokine pathway in vivo provides a strategic basis for future therapeutic consideration... - Eosinophilic gastrointestinal disorders (EGID)Marc E Rothenberg
Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 45229-3039, USA
J Allergy Clin Immunol 113:11-28; quiz 29. 2004..An essential question is to determine the cellular and molecular basis for each of these clinical problems and the best treatment regimen, which is the main subject of this review... - Anti-interleukin-5 (mepolizumab) therapy for hypereosinophilic syndromesJennifer K Garrett
Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 45229, USA
J Allergy Clin Immunol 113:115-9. 2004..As such, anti-IL-5 may have significant therapeutic potential for hypereosinophilic syndromes... - Chemokines in eosinophil-associated gastrointestinal disordersSimon P Hogan
Division of Molecular Bioscience, John Curtin School of Medical Research, Australian National University, PO Box 334, Canberra, Australia 0200
Curr Allergy Asthma Rep 4:74-82. 2004..In this review, we describe the role of CD4+ T cells and eosinophils in the clinical manifestations of EGDs and discuss the current understanding of the role of chemokines in the recruitment of these cells in the expression of diseases... - Mast cells are required for experimental oral allergen-induced diarrheaEric B Brandt
Division of Allergy and Immunology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, Ohio 45229, USA
J Clin Invest 112:1666-77. 2003..These results demonstrate that oral allergen-induced diarrhea associated with experimental Th2 intestinal inflammation is largely mast cell, IgE, serotonin, and PAF dependent... - Eotaxin-2 and IL-5 cooperate in the lung to regulate IL-13 production and airway eosinophilia and hyperreactivityMing Yang
Division of Molecular Biosciences, The John Curtin School of Medical Research, Australian National University, Canberra, ACT
J Allergy Clin Immunol 112:935-43. 2003..CONCLUSION: These investigations demonstrate important cooperativity between eotaxin-2, IL-5, and IL-13 signaling systems and eosinophils for the development of hallmark features of allergic disease of the lung... - CD44--a sticky target for asthmaMarc E Rothenberg
Division of Allergy and Immunology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 45229, USA
J Clin Invest 111:1460-2. 2003 - Chemokines in asthma: cooperative interaction between chemokines and IL-13Nives Zimmermann
Divisions of Allergy and Immunology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229-3039, USA
J Allergy Clin Immunol 111:227-42; quiz 243. 2003.... - Constitutive overexpression of IL-5 induces extramedullary hematopoiesis in the spleenSophia Khaldoyanidi
Division of Vascular Biology, La Jolla Institute for Molecular Medicine, San Diego, CA 92121, USA
Blood 101:863-8. 2003..Overall, our results suggest that constitutive overexpression of IL-5 can potentially induce colonization of spleen with MSP cells, which provides the necessary microenvironment for establishment of hematopoiesis in extramedullary sites... - Eosinophil-associated gastrointestinal disorders: a world-wide-web based registryJesus R Guajardo
Division of Allergy and Immunology, Department of Pediatrics, Children's Hospital Medical Center, Cincinnati, Ohio 45229, USA
J Pediatr 141:576-81. 2002.... - Experimental analysis of eosinophil-associated gastrointestinal diseasesSimon P Hogan
Division of Biochemistry and Molecular Biology, John Curtin School of Medical Research, Australian National University, Canberra, Australia
Curr Opin Allergy Clin Immunol 2:239-48. 2002.... - Intrinsic defect in T cell production of interleukin (IL)-13 in the absence of both IL-5 and eotaxin precludes the development of eosinophilia and airways hyperreactivity in experimental asthmaJoerg Mattes
Division of Biochemistry and Molecular Biology, The John Curtin School of Medical Research, Australian National University, Canberra, ACT 0200, Australia
J Exp Med 195:1433-44. 2002.... - IL-5 promotes eosinophil trafficking to the esophagusAnil Mishra
Division of Allergy and Immunology, Department of Pediatrics, Children s Hospital Medical Center, Cincinnati, OH 45229, USA
J Immunol 168:2464-9. 2002..In conclusion, these studies demonstrate a central role for IL-5 in inducing eosinophil trafficking to the esophagus... - Eotaxin-1-regulated eosinophils have a critical role in innate immunity against experimental Brugia malayi infectionJonathan E Simons
School of Biological Sciences, University of Manchester, Manchester, UK
Eur J Immunol 35:189-97. 2005..Thus, our data show that the presence of eosinophils is critical for innate clearance of B. malayi Mf infection, whereas rapid clearance of secondary infections is independent of both eotaxin-1 and IL-5... - Expression and regulation of small proline-rich protein 2 in allergic inflammationNives Zimmermann
Division of Allergy and Immunology, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
Am J Respir Cell Mol Biol 32:428-35. 2005..Thus, SPRR2 is an allergen- and IL-13-induced gene in experimental allergic responses that may be involved in disease pathophysiology... - Intratracheal IL-13 induces eosinophilic esophagitis by an IL-5, eotaxin-1, and STAT6-dependent mechanismAnil Mishra
Division of Allergy and Immunology, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
Gastroenterology 125:1419-27. 2003..We aimed to determine whether delivery of a Th2 cytokine (interleukin [IL]-13) to the lung was sufficient for induction of EE... - CD48 is an allergen and IL-3-induced activation molecule on eosinophilsAriel Munitz
Department of Pharmacology, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem 91120, Israel
J Immunol 177:77-83. 2006..Additionally, anti-IL-3 reduces CD48 expression and the degree of airway inflammation. Thus, CD48 is an IL-3-induced activating receptor on eosinophils, likely involved in promoting allergic inflammation... - The role of Th2 cytokines, chemokines and parasite products in eosinophil recruitment to the gastrointestinal mucosa during helminth infectionHelen Dixon
Faculty of Life Sciences, University of Manchester, Manchester, UK
Eur J Immunol 36:1753-63. 2006..spiralis and T. muris products, suggest that CCL11 is the salient but not the sole eosinophil chemoattractant of biological significance during gastrointestinal helminth infection... - ICAM-1-dependent pathways regulate colonic eosinophilic inflammationElizabeth Forbes
Allergy and Inflammation Research Group, Division of Biochemistry and Molecular Biology, The John Curtin School of Medical Research, Australian National University, Canberra, Australia
J Leukoc Biol 80:330-41. 2006..These studies demonstrate that beta2 -integrin/ICAM-1-dependent pathways are integral to eosinophil recruitment into the colon during GI inflammation associated with colonic injury... - Persistent effects induced by IL-13 in the lungPatricia C Fulkerson
Department of Molecular Genetics, Biochemistry and Microbiology, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, 3333 Burnet Avenue, Cincinnati, Ohio 45229-3039, USA
Am J Respir Cell Mol Biol 35:337-46. 2006..Thus, several hallmark features of IL-13-induced lung pathology persist and are dissociated from eosinophilia after IL-13 overexpression ceases... - Enterocyte expression of the eotaxin and interleukin-5 transgenes induces compartmentalized dysregulation of eosinophil traffickingAnil Mishra
Department of Pediatrics, Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
J Biol Chem 277:4406-12. 2002.... - IL-17E upregulates the expression of proinflammatory cytokines in lung fibroblastsSeverine Letuve
Meakins Christie Laboratories, Department of Pathology and Medicine, McGill University, Montreal, Quebec, Canada
J Allergy Clin Immunol 117:590-6. 2006..IL-17E proinflammatory activity has been proposed to involve induction of cytokine and chemokine production. Recruitment of inflammatory cells may be mediated by tissue-resident cells... - The FIP1L1-PDGFRA fusion gene cooperates with IL-5 to induce murine hypereosinophilic syndrome (HES)/chronic eosinophilic leukemia (CEL)-like diseaseYoshiyuki Yamada
Division of Allergy and Immunology, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
Blood 107:4071-9. 2006..These results suggest that F/P is not sufficient to induce a HES/CEL-like disease but requires a second event associated with IL-5 overexpression... - Eosinophilic esophagitisRichard J Noel
Division of Pediatric Gastroenterology and Nutrition, Medical College of Wisconsin, Milwaukee, Wisconsin, USA
Curr Opin Pediatr 17:690-4. 2005.... - Epicutaneous antigen exposure primes for experimental eosinophilic esophagitis in miceHiroko Saito Akei
Division of Allergy and Immunology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA
Gastroenterology 129:985-94. 2005..CONCLUSIONS: These findings provide the first evidence that epicutaneous exposure to allergens potently primes for EE via a Th2-dependent mechanism... - Anti-IL-5 and hypereosinophilic syndromesSteven A Sutton
Division of Allergy and Immunology, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, MLC 7028, Cincinnati, OH 45229, USA
Clin Immunol 115:51-60. 2005..This review will discuss the etiology, classification, and treatment options for the hypereosinophilic syndromes, with particular emphasis on anti-interleukin-5 therapy... - CXCL9 inhibits eosinophil responses by a CCR3- and Rac2-dependent mechanismPatricia C Fulkerson
Department of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati College of Medicine, OH 45229 3039, USA
Blood 106:436-43. 2005..These results establish evidence that distinct chemokines can use CCR3 to induce opposing signals in eosinophils... - Suppressive effect of IL-4 on IL-13-induced genes in mouse lungFred D Finkelman
Division of Immunology, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
J Immunol 174:4630-8. 2005..These results provide a potential explanation for the dominant role of IL-13 in induction of goblet cell hyperplasia and airway hyperresponsiveness in asthma... - Experimental gastrointestinal allergy enhances pulmonary responses to specific and unrelated allergensEric B Brandt
Division of Allergy and Immunology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
J Allergy Clin Immunol 118:420-7. 2006.... - Resistin-like molecule-beta is an allergen-induced cytokine with inflammatory and remodeling activity in the murine lungAnil Mishra
Division of Allergy and Immunology, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
Am J Physiol Lung Cell Mol Physiol 293:L305-13. 2007..In vitro experiments demonstrated that RELM-beta had fibroblast motogenic activity. These results identify RELM-beta as a Th2-associated cytokine with potent inflammatory and remodeling activity...
Research Grants
- Anti-IL 5 for HypereosinophiliaMARC ROTHENBERG; Fiscal Year: 2005..Abstract Not Provided ..
- Role of arginase in allergic airway inflammationMARC ROTHENBERG; Fiscal Year: 2007..It is anticipated that the proposed studies will shed new light on the pathogenesis of experimental asthma and provide a rationale for possible novel therapeutic and diagnostic interventions in asthma. ..
- Regulation of Gastrointestinal EosinophilisMARC ROTHENBERG; Fiscal Year: 2007..g. anti-cytokine agents) that are currently being developed for the treatment of asthma, that may also be beneficial for EGID. ..
- Eosinophil, Chemokine and IL-13 Cooperativity in AsthmaMARC ROTHENBERG; Fiscal Year: 2007..Collectively, the proposed aims are designed to uncover the participation and mechanisms by which chemokines, eosinophils, and IL-13 cooperate in the induction of experimental asthma. ..
- IL-13 and Eosinophilic EsophagitisMARC ROTHENBERG; Fiscal Year: 2007..The goal of this grant is to understand the mechanism of this disease by focusing on a specific molecule called IL-13. ..
- IL-13 Associated Eosinophil Lung ResponsesMARC ROTHENBERG; Fiscal Year: 2009..g. anti-cytokines agents) that are currently being developed for the treatment of asthma; thus, helping to clarify the unique and comparative effects of interrupting IL-4, IL-13 and/or their receptors in asthma. ..
- IL-13 and Eosinophilic EsophagitisMARC ROTHENBERG; Fiscal Year: 2009..In addition, this internet based registry has great potential to serve as a platform for future comparative effectiveness investigations across several institutions nationwide. ..
- IL-13 and Eosinophilic EsophagitisMarc E Rothenberg; Fiscal Year: 2010..The goal of this grant is to understand the mechanism of this disease by focusing on a specific molecule called IL-13. ..
- Role of arginase in allergic airway inflammationMARC ROTHENBERG; Fiscal Year: 2006..It is anticipated that the proposed studies will shed new light on the pathogenesis of experimental asthma and provide a rationale for possible novel therapeutic and diagnostic interventions in asthma. ..
- MECHANISMS OF EOSINOPHILIA IN EXPERIMENTAL ASTHMAMARC ROTHENBERG; Fiscal Year: 2002..These gene products will provide future targets for therapeutic intervention and add novel insight into the poorly understood function of eosinophils. ..
- REGULATION OF GASTROINTESTINAL EOSINOPHILSMARC ROTHENBERG; Fiscal Year: 2002..abstract_text> ..
- Role of arginase in allergic airway inflammationMARC ROTHENBERG; Fiscal Year: 2003..It is anticipated that the proposed studies will shed new light on the pathogenesis of experimental asthma and provide a rationale for possible novel therapeutic and diagnostic interventions in asthma. ..
- IL-13 Associated Eosinophil Lung ResponsesMarc E Rothenberg; Fiscal Year: 2010..g. anti-cytokines agents) that are currently being developed for the treatment of asthma;thus, helping to clarify the unique and comparative effects of interrupting IL-4, IL-13 and/or their receptors in asthma. ..