MARC ROTHENBERG

Summary

Affiliation: Cincinnati Children's Hospital Medical Center
Country: USA

Publications

  1. ncbi request reprint Pediatric patients with eosinophilic esophagitis: an 8-year follow-up
    Amal H Assa'ad
    Division of Allergy and Immunology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    J Allergy Clin Immunol 119:731-8. 2007
  2. pmc Rank-based genome-wide analysis reveals the association of Ryanodine receptor-2 gene variants with childhood asthma among human populations
    Lili Ding
    Department of Pediatrics, Cincinnati Children s Hospital Medical Center, University of Cincinnati, Cincinnati, OH 45229, USA
    Hum Genomics 7:16. 2013
  3. pmc Development of a validated patient-reported symptom metric for pediatric eosinophilic esophagitis: qualitative methods
    James P Franciosi
    Division of Gastroenterology, Hepatology and Nutrition, Cincinnati Children s Hospital Medical Center, Cincinnati, OH, USA
    BMC Gastroenterol 11:126. 2011
  4. doi request reprint Eosinophilic esophagitis: rapidly advancing insights
    J Pablo Abonia
    Division of Allergy and Immunology, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
    Annu Rev Med 63:421-34. 2012
  5. ncbi request reprint Clinical and immunopathologic effects of swallowed fluticasone for eosinophilic esophagitis
    Richard J Noel
    Department of Pediatrics, Cincinnati Children s Medical Center, Universityof Cincinnati College of Medicine, OH 45229 3039, USA
    Clin Gastroenterol Hepatol 2:568-75. 2004
  6. ncbi request reprint The eosinophil
    Marc E Rothenberg
    Division of Allergy and Immunology, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA
    Annu Rev Immunol 24:147-74. 2006
  7. doi request reprint 2007 E. Mead Johnson award: scientific pursuit of the allergy problem
    Marc E Rothenberg
    Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA
    Pediatr Res 64:110-5. 2008
  8. pmc Analysis of the CCR3 promoter reveals a regulatory region in exon 1 that binds GATA-1
    Nives Zimmermann
    Division of Allergy and Immunology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio, USA
    BMC Immunol 6:7. 2005
  9. pmc Origin, regulation and physiological function of intestinal oeosinophils
    Patricia C Fulkerson
    Division of Allergy and Immunology, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
    Best Pract Res Clin Gastroenterol 22:411-23. 2008
  10. ncbi request reprint Eosinophil Function in Eosinophil-associated Gastrointestinal Disorders
    Simon P Hogan
    Division of Allergy and Immunology, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
    Curr Allergy Asthma Rep 6:65-71. 2006

Research Grants

  1. Anti-IL 5 for Hypereosinophilia
    MARC ROTHENBERG; Fiscal Year: 2005
  2. Role of arginase in allergic airway inflammation
    MARC ROTHENBERG; Fiscal Year: 2007
  3. Regulation of Gastrointestinal Eosinophilis
    MARC ROTHENBERG; Fiscal Year: 2007
  4. Eosinophil, Chemokine and IL-13 Cooperativity in Asthma
    MARC ROTHENBERG; Fiscal Year: 2007
  5. IL-13 and Eosinophilic Esophagitis
    MARC ROTHENBERG; Fiscal Year: 2007
  6. IL-13 Associated Eosinophil Lung Responses
    MARC ROTHENBERG; Fiscal Year: 2009
  7. IL-13 and Eosinophilic Esophagitis
    MARC ROTHENBERG; Fiscal Year: 2009
  8. IL-13 and Eosinophilic Esophagitis
    Marc E Rothenberg; Fiscal Year: 2010
  9. Role of arginase in allergic airway inflammation
    MARC ROTHENBERG; Fiscal Year: 2006
  10. MECHANISMS OF EOSINOPHILIA IN EXPERIMENTAL ASTHMA
    MARC ROTHENBERG; Fiscal Year: 2002

Detail Information

Publications70

  1. ncbi request reprint Pediatric patients with eosinophilic esophagitis: an 8-year follow-up
    Amal H Assa'ad
    Division of Allergy and Immunology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    J Allergy Clin Immunol 119:731-8. 2007
    ..Eosinophilic esophagitis (EE) is a gastrointestinal disorder that is increasingly diagnosed in pediatric patients...
  2. pmc Rank-based genome-wide analysis reveals the association of Ryanodine receptor-2 gene variants with childhood asthma among human populations
    Lili Ding
    Department of Pediatrics, Cincinnati Children s Hospital Medical Center, University of Cincinnati, Cincinnati, OH 45229, USA
    Hum Genomics 7:16. 2013
    ..We performed genome-wide association studies on 859,790 SNPs genotyped in 527 affected offspring trios of European, African, and Hispanic ancestry using publically available asthma database in the Genotypes and Phenotypes database...
  3. pmc Development of a validated patient-reported symptom metric for pediatric eosinophilic esophagitis: qualitative methods
    James P Franciosi
    Division of Gastroenterology, Hepatology and Nutrition, Cincinnati Children s Hospital Medical Center, Cincinnati, OH, USA
    BMC Gastroenterol 11:126. 2011
    ..We sought to identify and validate key patient self-reported and parent proxy-reported outcomes (PROs) specific to EoE...
  4. doi request reprint Eosinophilic esophagitis: rapidly advancing insights
    J Pablo Abonia
    Division of Allergy and Immunology, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
    Annu Rev Med 63:421-34. 2012
    ..The antigen-driven nature of EoE has been reinforced by the remarkable impact of therapies utilizing elemental formulas to control the disease as well as a number of reports linking aeroallergens to seasonal worsening of disease...
  5. ncbi request reprint Clinical and immunopathologic effects of swallowed fluticasone for eosinophilic esophagitis
    Richard J Noel
    Department of Pediatrics, Cincinnati Children s Medical Center, Universityof Cincinnati College of Medicine, OH 45229 3039, USA
    Clin Gastroenterol Hepatol 2:568-75. 2004
    ..Eosinophilic esophagitis (EE) is a recently recognized clinical disorder that is understood poorly. We aimed to determine the efficacy of swallowed fluticasone propionate on the immunopathologic features associated with EE...
  6. ncbi request reprint The eosinophil
    Marc E Rothenberg
    Division of Allergy and Immunology, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA
    Annu Rev Immunol 24:147-74. 2006
    ..Finally, strategies for targeted therapeutic intervention in eosinophil-mediated mucosal diseases are conceptualized...
  7. doi request reprint 2007 E. Mead Johnson award: scientific pursuit of the allergy problem
    Marc E Rothenberg
    Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA
    Pediatr Res 64:110-5. 2008
    ....
  8. pmc Analysis of the CCR3 promoter reveals a regulatory region in exon 1 that binds GATA-1
    Nives Zimmermann
    Division of Allergy and Immunology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio, USA
    BMC Immunol 6:7. 2005
    ..It is therefore important to elucidate the molecular mechanisms regulating receptor expression...
  9. pmc Origin, regulation and physiological function of intestinal oeosinophils
    Patricia C Fulkerson
    Division of Allergy and Immunology, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
    Best Pract Res Clin Gastroenterol 22:411-23. 2008
    ..In addition, the regulation of oeosinophil survival by inhibitory and death receptors and the expanding role for oeosinophils in health and disease are reviewed...
  10. ncbi request reprint Eosinophil Function in Eosinophil-associated Gastrointestinal Disorders
    Simon P Hogan
    Division of Allergy and Immunology, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
    Curr Allergy Asthma Rep 6:65-71. 2006
    ..We summarize recent experimental analysis examining the underlying contribution of eosinophils to disease pathogenesis and discuss possible therapeutic approaches for the treatment of these diverse diseases...
  11. doi request reprint Treatment of patients with the hypereosinophilic syndrome with mepolizumab
    Marc E Rothenberg
    Division of Allergy and Immunology, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, University of Cincinnati, Cincinnati, OH 45229, USA
    N Engl J Med 358:1215-28. 2008
    ..Although most patients have a response to corticosteroids, side effects are common and can lead to considerable morbidity...
  12. ncbi request reprint Eosinophilic esophagitis: concepts, controversies, and evidence
    Philip E Putnam
    Division of Gastroenterology, Hepatology, and Nutrition, University of Cincinnati College of Medicine, Cincinnati Children s Hospital Medical Center, Cincinnati Center for Eosinophilic Disorders, Cincinnati, OH 45229, USA
    Curr Gastroenterol Rep 11:220-5. 2009
    ..Intense investigations to explain the underpinnings of the disorder and to discover effective therapy are ongoing...
  13. pmc Bone marrow cell derived arginase I is the major source of allergen-induced lung arginase but is not required for airway hyperresponsiveness, remodeling and lung inflammatory responses in mice
    Kathryn A Niese
    Division of Allergy and Immunology, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    BMC Immunol 10:33. 2009
    ..Arginase is significantly upregulated in the lungs in murine models of asthma, as well as in human asthma, but its role in allergic airway inflammation has not been fully elucidated in mice...
  14. doi request reprint Biology and treatment of eosinophilic esophagitis
    Marc E Rothenberg
    Division of Allergy and Immunology, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA
    Gastroenterology 137:1238-49. 2009
    ..Therefore, eosinophilic esophagitis is a disease with unique features that include chronic esophagitis, atopy, immune sensitization to oral antigens, reversibility, and familial association...
  15. ncbi request reprint Hypereosinophilic syndromes and new therapeutic approaches including anti-IL-5
    Miguel L Stein
    University of Cincinnati College of Medicine, Division of Allergy and Immunology, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, MLC 7028, Cincinnati, OH 45229, USA
    Expert Rev Clin Immunol 1:633-44. 2005
    ..This review will analyze the etiology, classification and new options for the treatment of the hypereosinophilic syndromes, with particular emphasis on anti-interleukin-5 therapy...
  16. pmc Arginase I suppresses IL-12/IL-23p40-driven intestinal inflammation during acute schistosomiasis
    De Broski R Herbert
    Research Service, Cincinnati Veterans Administration Medical Center, Cincinnati, OH 45220, USA
    J Immunol 184:6438-46. 2010
    ..Thus, macrophage-derived Arg I protects hosts against excessive tissue injury caused by worm eggs during acute schistosomiasis by suppressing IL-12/IL-23p40 production and maintaining the Treg/Th17 balance within the intestinal mucosa...
  17. pmc Gastrointestinal eosinophilia
    Li Zuo
    Division of Allergy and Immunology, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, University of Cincinnati, College of Medicine, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
    Immunol Allergy Clin North Am 27:443-55. 2007
    ..All three groups of gastrointestinal eosinophila are described in this article, although the focus is on primary gastrointestinal eosinophilia...
  18. ncbi request reprint Interplay of adaptive th2 immunity with eotaxin-3/c-C chemokine receptor 3 in eosinophilic esophagitis
    Jennifer Z Bullock
    Division of Allergy and Immunology, Cincinnati Children s Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45229 3039, USA
    J Pediatr Gastroenterol Nutr 45:22-31. 2007
    ..Although studies of esophageal tissue suggest that Th2 cytokines and eotaxin-3 may be crucial in disease pathogenesis, little is known about the systemic immunological phenotypes of children with EE...
  19. ncbi request reprint Regulation of carcinogenesis by IL-5 and CCL11: a potential role for eosinophils in tumor immune surveillance
    Ljubov Simson
    Division of Immunology and Genetics, John Curtin School of Medical Research, Australian National University, Mills Road Acton, Canberra, Australian Capital Territory, Australia
    J Immunol 178:4222-9. 2007
    ..In addition, subsequent in vitro studies found that eosinophils could directly kill MCA-induced fibrosarcoma cells. Collectively, our data support a potential role for the eosinophil as an effector cell in tumor immune surveillance...
  20. ncbi request reprint Critical role for adaptive T cell immunity in experimental eosinophilic esophagitis in mice
    Anil Mishra
    Department of Pediatrics, Cincinnati Children s Hospital Medical Center, University of Cincinnati, College of Medicine, OH 45229, USA
    J Leukoc Biol 81:916-24. 2007
    ..Taken together, these studies indicate a role for CD4+ and CD4- cell populations in EE pathogenesis and demonstrate that experimental allergen-induced EE is dependent on adaptive T cell immunity...
  21. ncbi request reprint Anti-IL-5 (mepolizumab) therapy for eosinophilic esophagitis
    Miguel L Stein
    Division of Allergy and Immunology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    J Allergy Clin Immunol 118:1312-9. 2006
    ..IL-5 promotes eosinophil trafficking to the esophagus, and positively regulates eosinophil growth, activation, survival, and tissue recruitment...
  22. pmc Eosinophils and CCR3 regulate interleukin-13 transgene-induced pulmonary remodeling
    Patricia C Fulkerson
    Deparmtnet of Molecular Genetics, Division of Allergy and Immunology, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, 3333 Burnet Ave, MLC 7028, Cincinnati, OH 45229, USA
    Am J Pathol 169:2117-26. 2006
    ..Taken together, these data definitively identify a functional contribution by eosinophils on the effects of chronic IL-13 expression in the lung...
  23. ncbi request reprint A randomized, double-blind, placebo-controlled trial of fluticasone propionate for pediatric eosinophilic esophagitis
    Michael R Konikoff
    Division of Pediatric Gastroenterology, Hepatology and Nutrition, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    Gastroenterology 131:1381-91. 2006
    ..Although several therapies are advocated, no placebo-controlled trials have been conducted. We aimed to determine the efficacy of swallowed fluticasone propionate (FP) in the treatment of eosinophilic esophagitis...
  24. ncbi request reprint Summary of the First International Gastrointestinal Eosinophil Research Symposium
    Chris A Liacouras
    J Pediatr Gastroenterol Nutr 45:370-91. 2007
  25. ncbi request reprint An eosinophil hypothesis for functional dyspepsia
    Marc E Rothenberg
    Clin Gastroenterol Hepatol 5:1147-8. 2007
  26. ncbi request reprint Eosinophilic esophagitis in children and adults: a systematic review and consensus recommendations for diagnosis and treatment
    Glenn T Furuta
    Section of Pediatric Gastroenterology, Hepatology, and Nutrition, The Children s Hospital, Denver, University of Colorado Medical School, Denver, Colorado, USA
    Gastroenterology 133:1342-63. 2007
    ..Since EE is a relatively new disease, the intent of this report is to provide current recommendations for care of affected patients and defining gaps in knowledge for future research studies...
  27. ncbi request reprint Intratracheal IL-13 induces eosinophilic esophagitis by an IL-5, eotaxin-1, and STAT6-dependent mechanism
    Anil Mishra
    Division of Allergy and Immunology, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Gastroenterology 125:1419-27. 2003
    ..We aimed to determine whether delivery of a Th2 cytokine (interleukin [IL]-13) to the lung was sufficient for induction of EE...
  28. doi request reprint FIP1L1/PDGFRalpha synergizes with SCF to induce systemic mastocytosis in a murine model of chronic eosinophilic leukemia/hypereosinophilic syndrome
    Yoshiyuki Yamada
    Division of Allergy and Immunology, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, OH 45229 3039, USA
    Blood 112:2500-7. 2008
    ..The increased proliferation and survival correlated with increased SCF-induced Akt activation. In summary, F/P synergistically promotes MC development, activation, and survival in vivo and in vitro in response to SCF...
  29. pmc Clinical, pathologic, and molecular characterization of familial eosinophilic esophagitis compared with sporadic cases
    Margaret H Collins
    Division of Pathology and Laboratory Medicine, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    Clin Gastroenterol Hepatol 6:621-9. 2008
    ..Eosinophilic esophagitis (EE) occurs in families...
  30. pmc Anti-IL-5 (mepolizumab) therapy reduces eosinophil activation ex vivo and increases IL-5 and IL-5 receptor levels
    Miguel L Stein
    Division of Allergy and Immunology, Cincinnati Children s Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA
    J Allergy Clin Immunol 121:1473-83, 1483.e1-4. 2008
    ..Anti-IL-5 might be a useful therapeutic agent for eosinophilic disorders, yet its immunologic consequences have not been well characterized...
  31. doi request reprint Eosinophils: biological properties and role in health and disease
    Simon P Hogan
    Clin Exp Allergy 38:709-50. 2008
    ..Finally, strategies for targeted therapeutic intervention in eosinophil-mediated mucosal diseases are conceptualized...
  32. pmc IL-9- and mast cell-mediated intestinal permeability predisposes to oral antigen hypersensitivity
    Elizabeth E Forbes
    Division of Allergy and Immunology, Cincinnati Children s Hospital Medical Center, USA
    J Exp Med 205:897-913. 2008
    ..These observations demonstrate a central role for IL-9 and mast cells in experimental intestinal permeability in oral antigen sensitization and suggest that IL-9-mediated mast cell responses have an important role in food allergy...
  33. doi request reprint Mitochondrial missile defense
    Victor Nizet
    Nat Med 14:910-2. 2008
  34. pmc Esophageal remodeling develops as a consequence of tissue specific IL-5-induced eosinophilia
    Anil Mishra
    Division of Allergy and Immunology, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    Gastroenterology 134:204-14. 2008
    ..We hypothesized that the development of EE in patients and in an experimental murine model would be associated with eosinophil-mediated tissue remodeling...
  35. ncbi request reprint IL-13 involvement in eosinophilic esophagitis: transcriptome analysis and reversibility with glucocorticoids
    Carine Blanchard
    Division of Allergy and Immunology, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    J Allergy Clin Immunol 120:1292-300. 2007
    ..Early studies have established that esophageal eosinophilia occurs in association with T(H)2 allergic responses, and we recently identified an EE-specific esophageal transcriptome that included eotaxin-3...
  36. pmc Basic pathogenesis of eosinophilic esophagitis
    Carine Blanchard
    Division of Allergy and Immunology, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
    Gastrointest Endosc Clin N Am 18:133-43; x. 2008
    ....
  37. ncbi request reprint Eosinophilic esophagitis: pathogenesis, genetics, and therapy
    Carine Blanchard
    Division of Allergy, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    J Allergy Clin Immunol 118:1054-9. 2006
    ..We demonstrate that EE involves the interplay of numerous genes, especially the eosinophil chemoattractant eotaxin-3, allowing molecular distinction from other forms of esophagitis and consideration of targeted therapeutic intervention...
  38. pmc A central regulatory role for eosinophils and the eotaxin/CCR3 axis in chronic experimental allergic airway inflammation
    Patricia C Fulkerson
    Department of Molecular Genetics, Biochemistry, and Microbiology, University of Cincinnati College of Medicine, 231 Bethesda Avenue, Cincinnati, OH 45257 0524, USA
    Proc Natl Acad Sci U S A 103:16418-23. 2006
    ..In summary, we present multiple lines of independent evidence that eosinophils via CCR3 have a central role in chronic allergic airway disease...
  39. ncbi request reprint T helper-2 immunity regulates bronchial hyperresponsiveness in eosinophil-associated gastrointestinal disease in mice
    Elizabeth Forbes
    Allergy and Inflammation Research Group, Division of Molecular Bioscience, The John Curtin School of Medical Research, Australian National University, Canberra, Australian Capital Territory, Australia
    Gastroenterology 127:105-18. 2004
    ....
  40. pmc Negative regulation of eosinophil recruitment to the lung by the chemokine monokine induced by IFN-gamma (Mig, CXCL9)
    Patricia C Fulkerson
    Department of Molecular Genetics, Biochemistry, and Microbiology, University of Cincinnati College of Medicine, 231 Bethesda Avenue, Cincinnati, OH 45257 0524, USA
    Proc Natl Acad Sci U S A 101:1987-92. 2004
    ..The identification of a naturally occurring eosinophil inhibitory chemokine pathway in vivo provides a strategic basis for future therapeutic consideration...
  41. ncbi request reprint Eosinophilic gastrointestinal disorders (EGID)
    Marc E Rothenberg
    Department of Pediatrics, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
    J Allergy Clin Immunol 113:11-28; quiz 29. 2004
    ..An essential question is to determine the cellular and molecular basis for each of these clinical problems and the best treatment regimen, which is the main subject of this review...
  42. ncbi request reprint Anti-interleukin-5 (mepolizumab) therapy for hypereosinophilic syndromes
    Jennifer K Garrett
    Department of Pediatrics, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    J Allergy Clin Immunol 113:115-9. 2004
    ..As such, IL-5 may be involved in the pathogenesis of hypereosinophilic syndromes, a group of poorly treated diverse disorders characterized by sustained peripheral blood and/or tissue eosinophilia...
  43. ncbi request reprint Chemokines in eosinophil-associated gastrointestinal disorders
    Simon P Hogan
    Division of Molecular Bioscience, John Curtin School of Medical Research, Australian National University, PO Box 334, Canberra, Australia 0200
    Curr Allergy Asthma Rep 4:74-82. 2004
    ..In this review, we describe the role of CD4+ T cells and eosinophils in the clinical manifestations of EGDs and discuss the current understanding of the role of chemokines in the recruitment of these cells in the expression of diseases...
  44. pmc Mast cells are required for experimental oral allergen-induced diarrhea
    Eric B Brandt
    Division of Allergy and Immunology, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, Ohio 45229, USA
    J Clin Invest 112:1666-77. 2003
    ..These results demonstrate that oral allergen-induced diarrhea associated with experimental Th2 intestinal inflammation is largely mast cell, IgE, serotonin, and PAF dependent...
  45. ncbi request reprint Eotaxin-2 and IL-5 cooperate in the lung to regulate IL-13 production and airway eosinophilia and hyperreactivity
    Ming Yang
    Division of Molecular Biosciences, The John Curtin School of Medical Research, Australian National University, Canberra, ACT
    J Allergy Clin Immunol 112:935-43. 2003
    ..However, the contribution of eotaxin-2 to the development of defined pathogenic features of allergic disease remains to be defined...
  46. pmc CD44--a sticky target for asthma
    Marc E Rothenberg
    Division of Allergy and Immunology, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    J Clin Invest 111:1460-2. 2003
  47. ncbi request reprint Chemokines in asthma: cooperative interaction between chemokines and IL-13
    Nives Zimmermann
    Divisions of Allergy and Immunology, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
    J Allergy Clin Immunol 111:227-42; quiz 243. 2003
    ....
  48. ncbi request reprint Constitutive overexpression of IL-5 induces extramedullary hematopoiesis in the spleen
    Sophia Khaldoyanidi
    Division of Vascular Biology, La Jolla Institute for Molecular Medicine, San Diego, CA 92121, USA
    Blood 101:863-8. 2003
    ..Overall, our results suggest that constitutive overexpression of IL-5 can potentially induce colonization of spleen with MSP cells, which provides the necessary microenvironment for establishment of hematopoiesis in extramedullary sites...
  49. ncbi request reprint Eosinophil-associated gastrointestinal disorders: a world-wide-web based registry
    Jesus R Guajardo
    Division of Allergy and Immunology, Department of Pediatrics, Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    J Pediatr 141:576-81. 2002
    ....
  50. ncbi request reprint Experimental analysis of eosinophil-associated gastrointestinal diseases
    Simon P Hogan
    Division of Biochemistry and Molecular Biology, John Curtin School of Medical Research, Australian National University, Canberra, Australia
    Curr Opin Allergy Clin Immunol 2:239-48. 2002
    ....
  51. pmc Intrinsic defect in T cell production of interleukin (IL)-13 in the absence of both IL-5 and eotaxin precludes the development of eosinophilia and airways hyperreactivity in experimental asthma
    Joerg Mattes
    Division of Biochemistry and Molecular Biology, The John Curtin School of Medical Research, Australian National University, Canberra, ACT 0200, Australia
    J Exp Med 195:1433-44. 2002
    ....
  52. ncbi request reprint IL-5 promotes eosinophil trafficking to the esophagus
    Anil Mishra
    Division of Allergy and Immunology, Department of Pediatrics, Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    J Immunol 168:2464-9. 2002
    ..In conclusion, these studies demonstrate a central role for IL-5 in inducing eosinophil trafficking to the esophagus...
  53. ncbi request reprint Eotaxin-1-regulated eosinophils have a critical role in innate immunity against experimental Brugia malayi infection
    Jonathan E Simons
    School of Biological Sciences, University of Manchester, Manchester, UK
    Eur J Immunol 35:189-97. 2005
    ..Thus, our data show that the presence of eosinophils is critical for innate clearance of B. malayi Mf infection, whereas rapid clearance of secondary infections is independent of both eotaxin-1 and IL-5...
  54. ncbi request reprint Expression and regulation of small proline-rich protein 2 in allergic inflammation
    Nives Zimmermann
    Division of Allergy and Immunology, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
    Am J Respir Cell Mol Biol 32:428-35. 2005
    ..Thus, SPRR2 is an allergen- and IL-13-induced gene in experimental allergic responses that may be involved in disease pathophysiology...
  55. pmc CXCL9 inhibits eosinophil responses by a CCR3- and Rac2-dependent mechanism
    Patricia C Fulkerson
    Department of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati College of Medicine, OH 45229 3039, USA
    Blood 106:436-43. 2005
    ..These results establish evidence that distinct chemokines can use CCR3 to induce opposing signals in eosinophils...
  56. ncbi request reprint Potential of blood eosinophils, eosinophil-derived neurotoxin, and eotaxin-3 as biomarkers of eosinophilic esophagitis
    Michael R Konikoff
    Division of Pediatric Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229 3039, USA
    Clin Gastroenterol Hepatol 4:1328-36. 2006
    ..The aim of this study was to identify noninvasive biomarkers that correlated with disease activity and response to treatment as measured by esophageal eosinophilia...
  57. ncbi request reprint Quantity and distribution of eosinophils in the gastrointestinal tract of children
    Charles W Debrosse
    University of Cincinnati College of Medicine, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, OH 45229 3039, USA
    Pediatr Dev Pathol 9:210-8. 2006
    ..05). Atopic and nonatopic patients had comparable numbers of eosinophils. These data establish baseline gastrointestinal eosinophil values in pediatric patients without apparent pathological disease...
  58. ncbi request reprint CD48 is an allergen and IL-3-induced activation molecule on eosinophils
    Ariel Munitz
    Department of Pharmacology, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem 91120, Israel
    J Immunol 177:77-83. 2006
    ..Additionally, anti-IL-3 reduces CD48 expression and the degree of airway inflammation. Thus, CD48 is an IL-3-induced activating receptor on eosinophils, likely involved in promoting allergic inflammation...
  59. ncbi request reprint The role of Th2 cytokines, chemokines and parasite products in eosinophil recruitment to the gastrointestinal mucosa during helminth infection
    Helen Dixon
    Faculty of Life Sciences, University of Manchester, Manchester, UK
    Eur J Immunol 36:1753-63. 2006
    ..spiralis and T. muris products, suggest that CCL11 is the salient but not the sole eosinophil chemoattractant of biological significance during gastrointestinal helminth infection...
  60. ncbi request reprint ICAM-1-dependent pathways regulate colonic eosinophilic inflammation
    Elizabeth Forbes
    Allergy and Inflammation Research Group, Division of Biochemistry and Molecular Biology, The John Curtin School of Medical Research, Australian National University, Canberra, Australia
    J Leukoc Biol 80:330-41. 2006
    ..These studies demonstrate that beta2 -integrin/ICAM-1-dependent pathways are integral to eosinophil recruitment into the colon during GI inflammation associated with colonic injury...
  61. ncbi request reprint Enterocyte expression of the eotaxin and interleukin-5 transgenes induces compartmentalized dysregulation of eosinophil trafficking
    Anil Mishra
    Department of Pediatrics, Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    J Biol Chem 277:4406-12. 2002
    ....
  62. pmc Persistent effects induced by IL-13 in the lung
    Patricia C Fulkerson
    Department of Molecular Genetics, Biochemistry and Microbiology, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, 3333 Burnet Avenue, Cincinnati, Ohio 45229 3039, USA
    Am J Respir Cell Mol Biol 35:337-46. 2006
    ..Thus, several hallmark features of IL-13-induced lung pathology persist and are dissociated from eosinophilia after IL-13 overexpression ceases...
  63. ncbi request reprint IL-17E upregulates the expression of proinflammatory cytokines in lung fibroblasts
    Severine Letuve
    Meakins Christie Laboratories, Department of Pathology and Medicine, McGill University, Montreal, Quebec, Canada
    J Allergy Clin Immunol 117:590-6. 2006
    ..IL-17E proinflammatory activity has been proposed to involve induction of cytokine and chemokine production. Recruitment of inflammatory cells may be mediated by tissue-resident cells...
  64. pmc The FIP1L1-PDGFRA fusion gene cooperates with IL-5 to induce murine hypereosinophilic syndrome (HES)/chronic eosinophilic leukemia (CEL)-like disease
    Yoshiyuki Yamada
    Division of Allergy and Immunology, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
    Blood 107:4071-9. 2006
    ..These results suggest that F/P is not sufficient to induce a HES/CEL-like disease but requires a second event associated with IL-5 overexpression...
  65. ncbi request reprint Eosinophilic esophagitis
    Richard J Noel
    Division of Pediatric Gastroenterology and Nutrition, Medical College of Wisconsin, Milwaukee, Wisconsin, USA
    Curr Opin Pediatr 17:690-4. 2005
    ..In the last 3 years, the research focus has evolved into understanding its immunologic and demographic features as well as the development of efficacious therapies...
  66. ncbi request reprint Epicutaneous antigen exposure primes for experimental eosinophilic esophagitis in mice
    Hiroko Saito Akei
    Division of Allergy and Immunology, Department of Pediatrics, Cincinnati Children s Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA
    Gastroenterology 129:985-94. 2005
    ..Data are emerging that atopic skin may provide an early entry point for antigen sensitization. We aimed to test the hypothesis that epicutaneous exposure to antigen primes for subsequent respiratory antigen-induced EE...
  67. ncbi request reprint Anti-IL-5 and hypereosinophilic syndromes
    Steven A Sutton
    Division of Allergy and Immunology, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, MLC 7028, Cincinnati, OH 45229, USA
    Clin Immunol 115:51-60. 2005
    ..This review will discuss the etiology, classification, and treatment options for the hypereosinophilic syndromes, with particular emphasis on anti-interleukin-5 therapy...
  68. ncbi request reprint Experimental gastrointestinal allergy enhances pulmonary responses to specific and unrelated allergens
    Eric B Brandt
    Division of Allergy and Immunology, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
    J Allergy Clin Immunol 118:420-7. 2006
    ..Gastrointestinal allergy often precedes or coexists with respiratory allergy...
  69. ncbi request reprint Suppressive effect of IL-4 on IL-13-induced genes in mouse lung
    Fred D Finkelman
    Division of Immunology, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
    J Immunol 174:4630-8. 2005
    ..These results provide a potential explanation for the dominant role of IL-13 in induction of goblet cell hyperplasia and airway hyperresponsiveness in asthma...
  70. ncbi request reprint Resistin-like molecule-beta is an allergen-induced cytokine with inflammatory and remodeling activity in the murine lung
    Anil Mishra
    Division of Allergy and Immunology, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Am J Physiol Lung Cell Mol Physiol 293:L305-13. 2007
    ..In vitro experiments demonstrated that RELM-beta had fibroblast motogenic activity. These results identify RELM-beta as a Th2-associated cytokine with potent inflammatory and remodeling activity...

Research Grants31

  1. Anti-IL 5 for Hypereosinophilia
    MARC ROTHENBERG; Fiscal Year: 2005
    ..Abstract Not Provided ..
  2. Role of arginase in allergic airway inflammation
    MARC ROTHENBERG; Fiscal Year: 2007
    ..It is anticipated that the proposed studies will shed new light on the pathogenesis of experimental asthma and provide a rationale for possible novel therapeutic and diagnostic interventions in asthma. ..
  3. Regulation of Gastrointestinal Eosinophilis
    MARC ROTHENBERG; Fiscal Year: 2007
    ..g. anti-cytokine agents) that are currently being developed for the treatment of asthma, that may also be beneficial for EGID. ..
  4. Eosinophil, Chemokine and IL-13 Cooperativity in Asthma
    MARC ROTHENBERG; Fiscal Year: 2007
    ..Collectively, the proposed aims are designed to uncover the participation and mechanisms by which chemokines, eosinophils, and IL-13 cooperate in the induction of experimental asthma. ..
  5. IL-13 and Eosinophilic Esophagitis
    MARC ROTHENBERG; Fiscal Year: 2007
    ..The goal of this grant is to understand the mechanism of this disease by focusing on a specific molecule called IL-13. ..
  6. IL-13 Associated Eosinophil Lung Responses
    MARC ROTHENBERG; Fiscal Year: 2009
    ..g. anti-cytokines agents) that are currently being developed for the treatment of asthma; thus, helping to clarify the unique and comparative effects of interrupting IL-4, IL-13 and/or their receptors in asthma. ..
  7. IL-13 and Eosinophilic Esophagitis
    MARC ROTHENBERG; Fiscal Year: 2009
    ..In addition, this internet based registry has great potential to serve as a platform for future comparative effectiveness investigations across several institutions nationwide. ..
  8. IL-13 and Eosinophilic Esophagitis
    Marc E Rothenberg; Fiscal Year: 2010
    ..The goal of this grant is to understand the mechanism of this disease by focusing on a specific molecule called IL-13. ..
  9. Role of arginase in allergic airway inflammation
    MARC ROTHENBERG; Fiscal Year: 2006
    ..It is anticipated that the proposed studies will shed new light on the pathogenesis of experimental asthma and provide a rationale for possible novel therapeutic and diagnostic interventions in asthma. ..
  10. MECHANISMS OF EOSINOPHILIA IN EXPERIMENTAL ASTHMA
    MARC ROTHENBERG; Fiscal Year: 2002
    ..These gene products will provide future targets for therapeutic intervention and add novel insight into the poorly understood function of eosinophils. ..
  11. REGULATION OF GASTROINTESTINAL EOSINOPHILS
    MARC ROTHENBERG; Fiscal Year: 2002
    ..abstract_text> ..
  12. Role of arginase in allergic airway inflammation
    MARC ROTHENBERG; Fiscal Year: 2003
    ..It is anticipated that the proposed studies will shed new light on the pathogenesis of experimental asthma and provide a rationale for possible novel therapeutic and diagnostic interventions in asthma. ..
  13. IL-13 Associated Eosinophil Lung Responses
    Marc E Rothenberg; Fiscal Year: 2010
    ..g. anti-cytokines agents) that are currently being developed for the treatment of asthma;thus, helping to clarify the unique and comparative effects of interrupting IL-4, IL-13 and/or their receptors in asthma. ..