Nancy Ratner


Affiliation: Cincinnati Children's Hospital Medical Center
Country: USA


  1. Ramkissoon A, Chaney K, Milewski D, Williams K, Williams R, Choi K, et al. Targeted Inhibition of the Dual Specificity Phosphatases DUSP1 and DUSP6 Suppress MPNST Growth via JNK. Clin Cancer Res. 2019;: pubmed publisher
    ..The data support further investigation of DUSP inhibition in MPNSTs. ..
  2. Fletcher J, Springer M, Choi K, Jousma E, Rizvi T, Dombi E, et al. STAT3 inhibition reduces macrophage number and tumor growth in neurofibroma. Oncogene. 2019;38:2876-2884 pubmed publisher
    ..The functions of STAT3 signaling in neurofibroma Schwann cells and macrophages, and its relevance as a therapeutic target in neurofibroma, merit further investigation. ..
  3. Coover R, Healy T, Guo L, Chaney K, Hennigan R, Thomson C, et al. Tonic ATP-mediated growth suppression in peripheral nerve glia requires arrestin-PP2 and is evaded in NF1. Acta Neuropathol Commun. 2018;6:127 pubmed publisher
    ..Additionally, we identify a mechanism through which NF1 SCs may evade growth suppression in nerve tumors. ..
  4. Wu J, Keng V, Patmore D, Kendall J, Patel A, Jousma E, et al. Insertional Mutagenesis Identifies a STAT3/Arid1b/β-catenin Pathway Driving Neurofibroma Initiation. Cell Rep. 2016;14:1979-90 pubmed publisher
    ..Our data map a neural tumorigenesis pathway and support testing JAK/STAT and Wnt/β-catenin pathway inhibitors in neurofibroma therapeutic trials. ..
  5. Patel A, Chaney K, Choi K, Largaespada D, Kumar A, Ratner N. An ShRNA Screen Identifies MEIS1 as a Driver of Malignant Peripheral Nerve Sheath Tumors. EBioMedicine. 2016;9:110-119 pubmed publisher
    ..Mechanistically, MEIS1 drives MPNST cell growth via the transcription factor ID1, thereby suppressing expression of the cell cycle inhibitor p27(Kip) and maintaining cell survival. ..
  6. López Juárez A, Titus H, Silbak S, Pressler J, Rizvi T, Bogard M, et al. Oligodendrocyte Nf1 Controls Aberrant Notch Activation and Regulates Myelin Structure and Behavior. Cell Rep. 2017;19:545-557 pubmed publisher
    ..We thus identify Notch as an Nf1 effector regulating myelin structure and behavior in a RASopathy and suggest that inhibition of Notch signaling may be a therapeutic strategy for NF1. ..