Affiliation: Cincinnati Children's Hospital Medical Center
Ramkissoon A, Chaney K, Milewski D, Williams K, Williams R, Choi K, et al
. Targeted Inhibition of the Dual Specificity Phosphatases DUSP1 and DUSP6 Suppress MPNST Growth via JNK. Clin Cancer Res. 2019;: pubmed publisher
..The data support further investigation of DUSP inhibition in MPNSTs. ..
Fletcher J, Springer M, Choi K, Jousma E, Rizvi T, Dombi E, et al
. STAT3 inhibition reduces macrophage number and tumor growth in neurofibroma. Oncogene. 2019;38:2876-2884 pubmed publisher
..The functions of STAT3 signaling in neurofibroma Schwann cells and macrophages, and its relevance as a therapeutic target in neurofibroma, merit further investigation. ..
Coover R, Healy T, Guo L, Chaney K, Hennigan R, Thomson C, et al
. Tonic ATP-mediated growth suppression in peripheral nerve glia requires arrestin-PP2 and is evaded in NF1. Acta Neuropathol Commun. 2018;6:127 pubmed publisher
..Additionally, we identify a mechanism through which NF1 SCs may evade growth suppression in nerve tumors. ..
Wu J, Keng V, Patmore D, Kendall J, Patel A, Jousma E, et al
. Insertional Mutagenesis Identifies a STAT3/Arid1b/β-catenin Pathway Driving Neurofibroma Initiation. Cell Rep. 2016;14:1979-90 pubmed publisher
..Our data map a neural tumorigenesis pathway and support testing JAK/STAT and Wnt/β-catenin pathway inhibitors in neurofibroma therapeutic trials. ..
Patel A, Chaney K, Choi K, Largaespada D, Kumar A, Ratner N. An ShRNA Screen Identifies MEIS1 as a Driver of Malignant Peripheral Nerve Sheath Tumors. EBioMedicine. 2016;9:110-119 pubmed publisher
..Mechanistically, MEIS1 drives MPNST cell growth via the transcription factor ID1, thereby suppressing expression of the cell cycle inhibitor p27(Kip) and maintaining cell survival. ..
LÃ³pez JuÃ¡rez A, Titus H, Silbak S, Pressler J, Rizvi T, Bogard M, et al
. Oligodendrocyte Nf1 Controls Aberrant Notch Activation and Regulates Myelin Structure and Behavior. Cell Rep. 2017;19:545-557 pubmed publisher
..We thus identify Notch as an Nf1 effector regulating myelin structure and behavior in a RASopathy and suggest that inhibition of Notch signaling may be a therapeutic strategy for NF1. ..