Research Topics
| Charles T QuinnSummaryAffiliation: Cincinnati Children's Hospital Medical Center Country: USA Publications
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Detail Information
Publications
Cerebral tissue hemoglobin saturation in children with sickle cell diseaseCharles T Quinn
Division of Hematology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45220, USA
Pediatr Blood Cancer 59:881-7. 2012..Absolute cerebral oximetry has not been studied in sickle cell disease (SCD), a group at very high risk of cerebral infarction in whom prevention of brain injury is key...
Renal dysfunction in patients with thalassaemiaCharles T Quinn
U T Southwestern Medical Center, Dallas, TX, USA
Br J Haematol 153:111-7. 2011..The transfusion effect needs to be better understood. Awareness of underlying renal dysfunction in thalassaemia can inform decisions now about the use and monitoring of iron chelation...- Tapered oral dexamethasone for the acute chest syndrome of sickle cell diseaseCharles T Quinn
Cincinnati Children s Hospital Medical Center, Hematology Oncology, Cincinnati, OH 45220, USA
Br J Haematol 155:263-7. 2011..This ACS assessment tool was feasibly applied, and sL-selectin is a promising biomarker of ACS therapy... - Acute silent cerebral ischemic events in children with sickle cell anemiaCharles T Quinn
Department of Hematology, Cincinnati Children s Hospital Medical Center, Cincinnati, USA
JAMA Neurol 70:58-65. 2013..Ongoing ischemia in other organs is common in SCA but has never been documented in the brain... - Haemoglobin oxygen saturation is a determinant of cerebral artery blood flow velocity in children with sickle cell anaemiaCharles T Quinn
Hematology Oncology, Department of Pediatrics, UT Southwestern Medical Center, Dallas, TX 75390 9063, USA
Br J Haematol 145:500-5. 2009..In conclusion, Hb saturation is a determinant of TCD velocity and a risk factor for stroke in children with Hb SS... - Prevalence of intracardiac shunting in children with sickle cell disease and strokeMichael M Dowling
Department of Pediatrics, Division of Pediatric Neurology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390 9063, USA
J Pediatr 156:645-50. 2010..To determine the prevalence of potential intracardiac shunts, including patent foramen ovale (PFO), in children with sickle cell disease (SCD) and stroke... - Acute silent cerebral infarction in children with sickle cell anemiaMichael M Dowling
Department of Pediatrics, The University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390 9063, USA
Pediatr Blood Cancer 54:461-4. 2010..Our observations suggest that SCI are detectible in the acute phase, present with subtle neurologic symptoms, result in permanent neurologic injury, and may be caused by acute anemic events... - Improved survival of children and adolescents with sickle cell diseaseCharles T Quinn
Division of Hematology Oncology, Department of Pediatrics, The University of Texas Southwestern Medical Center, Dallas, TX, USA
Blood 115:3447-52. 2010..In summary, most children with SCD now survive the childhood years, but young adults who transition to adult medical care are at high risk for early death... - Acute silent cerebral ischemia and infarction during acute anemia in children with and without sickle cell diseaseMichael M Dowling
Departments of Pediatrics, University of Texas Southwestern Medical Center and Children s Medical Center, Dallas, TX 75390 9063, USA
Blood 120:3891-7. 2012..Some ASCIE (1 of 4 in our study) may be reversible. Alterations in management may be warranted for children with severe anemia to identify unrecognized ischemic brain injury that may have permanent neurocognitive sequelae... - Prognostic significance of early vaso-occlusive complications in children with sickle cell anemiaCharles T Quinn
Division of Hematology Oncology, Department of Pediatrics, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390, USA
Blood 109:40-5. 2007..Although we still lack a useful prognostic framework for young children with SS, those who experience early ACS might be candidates for higher risk interventions to mitigate or cure their disease... - National trends in incidence rates of hospitalization for stroke in children with sickle cell diseaseTimothy L McCavit
Division of Pediatric Hematology Oncology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9063, USA
Pediatr Blood Cancer 60:823-7. 2013..Therefore, we aimed to generate national incidence rates of hospitalization for stroke in children with sickle cell disease (SCD) before and after publication of the Stroke Prevention Trial in Sickle Cell Anemia (STOP trial) in 1998... - Daytime steady-state haemoglobin desaturation is a risk factor for overt stroke in children with sickle cell anaemiaCharles T Quinn
Center for Cancer and Blood Disorders, Children s Medical Center Dallas, Dallas, TX, USA
Br J Haematol 140:336-9. 2008..Decline in SpO(2) over time further increases this risk. Hb desaturation is easily measured, potentially modifiable, and could be used to identify children with SS at increased risk of stroke... - Hospitalization for invasive pneumococcal disease in a national sample of children with sickle cell disease before and after PCV7 licensureTimothy L McCavit
University of Texas Southwestern Medical Center, Dallas, TX, USA
Pediatr Blood Cancer 58:945-9. 2012..To estimate national hospitalization rates for invasive pneumococcal disease (IPD) in children with sickle cell disease (SCD) before and after the 2000 licensure of the heptavalent pneumococcal conjugate vaccine (PCV7)... - Increase in invasive Streptococcus pneumoniae infections in children with sickle cell disease since pneumococcal conjugate vaccine licensureTimothy L McCavit
Division of Hematology Oncology, Department of Pediatrics, University of Texas Southwestern Medical Center at Dallas, Dallas, TX, USA
J Pediatr 158:505-7. 2011..We report 10 IPD cases since pneumococcal protein-conjugate vaccine licensure, including a recent surge of non-vaccine serotypes. IPD continues to be a serious risk in sickle cell disease... - Pilot study of continuous co-infusion of morphine and naloxone in children with sickle cell pain crisisJosh Koch
Division of Critical Care, Department of Pediatrics, University of Texas Southwestern Medical Center Dallas, Dallas, Texas 75390 9063, USA
Am J Hematol 83:728-31. 2008..A quantitative pruritus score allowed us to systematically measure pruritus. Further evaluation by randomized, placebo-controlled study of 1 mcg/kg x hr naloxone in this setting is required... - Stroke in sickle cell anemia: alternative etiologiesMichael M Dowling
Department of Pediatrics, The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9063, USA
Pediatr Neurol 41:124-6. 2009..The present case suggests that the more traditional etiologies for pediatric stroke may also cause stroke in children with sickle cell anemia... - Clinical correlates of steady-state oxyhaemoglobin desaturation in children who have sickle cell diseaseCharles T Quinn
Division of Hematology Oncology, Department of Pediatrics, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390 9063, USA
Br J Haematol 131:129-34. 2005..We conclude that steady-state desaturation is common in individuals with SCD, but it appears to be unrelated to prior episodes of ACS and largely unexplained by chronic anaemia... - Bordetella holmesii bacteremia in sickle cell diseaseTimothy L McCavit
Division of Hematology Oncology, Department of Pediatrics, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9063, USA
Pediatr Blood Cancer 51:814-6. 2008..holmesii infection from other invasive bacterial infections in SCD. Providers for patients with SCD should be aware of this pathogen and ensure that their microbiology laboratories are capable of isolating and identifying this organism...