Charles T Quinn

Summary

Affiliation: Cincinnati Children's Hospital Medical Center
Country: USA

Publications

  1. doi request reprint Sickle cell disease in childhood: from newborn screening through transition to adult medical care
    Charles T Quinn
    Division of Hematology, Cincinnati Children s Hospital Medical Center, MC 11027, 3333 Burnet Avenue, Cincinnati, OH 45229, USA Department of Pediatrics, University of Cincinnati College of Medicine, 231 Albert Sabin Way, Cincinnati, OH 45229, USA Electronic address
    Pediatr Clin North Am 60:1363-81. 2013
  2. pmc Beliefs about chelation among thalassemia patients
    Felicia L Trachtenberg
    New England Research Institutes, 9 Galen Street, Watertown, MA, 02472, USA
    Health Qual Life Outcomes 10:148. 2012
  3. pmc Cerebral tissue hemoglobin saturation in children with sickle cell disease
    Charles T Quinn
    Division of Hematology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45220, USA
    Pediatr Blood Cancer 59:881-7. 2012
  4. pmc Tapered oral dexamethasone for the acute chest syndrome of sickle cell disease
    Charles T Quinn
    Cincinnati Children s Hospital Medical Center, Hematology Oncology, Cincinnati, OH 45220, USA
    Br J Haematol 155:263-7. 2011
  5. doi request reprint Renal dysfunction in patients with thalassaemia
    Charles T Quinn
    U T Southwestern Medical Center, Dallas, TX, USA
    Br J Haematol 153:111-7. 2011
  6. pmc Headache and migraine in children with sickle cell disease are associated with lower hemoglobin and higher pain event rates but not silent cerebral infarction
    Michael M Dowling
    Department of Pediatrics and Neurology and Neurotherapeutics, University of Texas Southwestern Medical Center, Dallas, TX
    J Pediatr 164:1175-1180.e1. 2014
  7. pmc Acute silent cerebral ischemic events in children with sickle cell anemia
    Charles T Quinn
    Department of Hematology, Cincinnati Children s Hospital Medical Center, Cincinnati, USA
    JAMA Neurol 70:58-65. 2013
  8. pmc Haemoglobin oxygen saturation is a determinant of cerebral artery blood flow velocity in children with sickle cell anaemia
    Charles T Quinn
    Hematology Oncology, Department of Pediatrics, UT Southwestern Medical Center, Dallas, TX 75390 9063, USA
    Br J Haematol 145:500-5. 2009
  9. doi request reprint Prevalence of intracardiac shunting in children with sickle cell disease and stroke
    Michael M Dowling
    Department of Pediatrics, Division of Pediatric Neurology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390 9063, USA
    J Pediatr 156:645-50. 2010
  10. doi request reprint National trends in incidence rates of hospitalization for stroke in children with sickle cell disease
    Timothy L McCavit
    Division of Pediatric Hematology Oncology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9063, USA
    Pediatr Blood Cancer 60:823-7. 2013

Detail Information

Publications21

  1. doi request reprint Sickle cell disease in childhood: from newborn screening through transition to adult medical care
    Charles T Quinn
    Division of Hematology, Cincinnati Children s Hospital Medical Center, MC 11027, 3333 Burnet Avenue, Cincinnati, OH 45229, USA Department of Pediatrics, University of Cincinnati College of Medicine, 231 Albert Sabin Way, Cincinnati, OH 45229, USA Electronic address
    Pediatr Clin North Am 60:1363-81. 2013
    ..This article provides a broad overview of SCD in childhood, from newborn screening through transition to adult medical care. ..
  2. pmc Beliefs about chelation among thalassemia patients
    Felicia L Trachtenberg
    New England Research Institutes, 9 Galen Street, Watertown, MA, 02472, USA
    Health Qual Life Outcomes 10:148. 2012
    ..Understanding patients' views about medication is crucial to maximize adherence. Thalassemia is a congenital blood disorder requiring chronic blood transfusions and daily iron chelation therapy...
  3. pmc Cerebral tissue hemoglobin saturation in children with sickle cell disease
    Charles T Quinn
    Division of Hematology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45220, USA
    Pediatr Blood Cancer 59:881-7. 2012
    ..Absolute cerebral oximetry has not been studied in sickle cell disease (SCD), a group at very high risk of cerebral infarction in whom prevention of brain injury is key...
  4. pmc Tapered oral dexamethasone for the acute chest syndrome of sickle cell disease
    Charles T Quinn
    Cincinnati Children s Hospital Medical Center, Hematology Oncology, Cincinnati, OH 45220, USA
    Br J Haematol 155:263-7. 2011
    ..This ACS assessment tool was feasibly applied, and sL-selectin is a promising biomarker of ACS therapy...
  5. doi request reprint Renal dysfunction in patients with thalassaemia
    Charles T Quinn
    U T Southwestern Medical Center, Dallas, TX, USA
    Br J Haematol 153:111-7. 2011
    ..The transfusion effect needs to be better understood. Awareness of underlying renal dysfunction in thalassaemia can inform decisions now about the use and monitoring of iron chelation...
  6. pmc Headache and migraine in children with sickle cell disease are associated with lower hemoglobin and higher pain event rates but not silent cerebral infarction
    Michael M Dowling
    Department of Pediatrics and Neurology and Neurotherapeutics, University of Texas Southwestern Medical Center, Dallas, TX
    J Pediatr 164:1175-1180.e1. 2014
    ..To identify risk factors for headache and migraine in children with sickle cell disease and test the hypothesis that either or both are independently associated with silent cerebral infarcts...
  7. pmc Acute silent cerebral ischemic events in children with sickle cell anemia
    Charles T Quinn
    Department of Hematology, Cincinnati Children s Hospital Medical Center, Cincinnati, USA
    JAMA Neurol 70:58-65. 2013
    ..Ongoing ischemia in other organs is common in SCA but has never been documented in the brain...
  8. pmc Haemoglobin oxygen saturation is a determinant of cerebral artery blood flow velocity in children with sickle cell anaemia
    Charles T Quinn
    Hematology Oncology, Department of Pediatrics, UT Southwestern Medical Center, Dallas, TX 75390 9063, USA
    Br J Haematol 145:500-5. 2009
    ..In conclusion, Hb saturation is a determinant of TCD velocity and a risk factor for stroke in children with Hb SS...
  9. doi request reprint Prevalence of intracardiac shunting in children with sickle cell disease and stroke
    Michael M Dowling
    Department of Pediatrics, Division of Pediatric Neurology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390 9063, USA
    J Pediatr 156:645-50. 2010
    ..To determine the prevalence of potential intracardiac shunts, including patent foramen ovale (PFO), in children with sickle cell disease (SCD) and stroke...
  10. doi request reprint National trends in incidence rates of hospitalization for stroke in children with sickle cell disease
    Timothy L McCavit
    Division of Pediatric Hematology Oncology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9063, USA
    Pediatr Blood Cancer 60:823-7. 2013
    ..Therefore, we aimed to generate national incidence rates of hospitalization for stroke in children with sickle cell disease (SCD) before and after publication of the Stroke Prevention Trial in Sickle Cell Anemia (STOP trial) in 1998...
  11. pmc Improved survival of children and adolescents with sickle cell disease
    Charles T Quinn
    Division of Hematology Oncology, Department of Pediatrics, The University of Texas Southwestern Medical Center, Dallas, TX, USA
    Blood 115:3447-52. 2010
    ..In summary, most children with SCD now survive the childhood years, but young adults who transition to adult medical care are at high risk for early death...
  12. pmc Acute silent cerebral infarction in children with sickle cell anemia
    Michael M Dowling
    Department of Pediatrics, The University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390 9063, USA
    Pediatr Blood Cancer 54:461-4. 2010
    ..Our observations suggest that SCI are detectible in the acute phase, present with subtle neurologic symptoms, result in permanent neurologic injury, and may be caused by acute anemic events...
  13. pmc Acute silent cerebral ischemia and infarction during acute anemia in children with and without sickle cell disease
    Michael M Dowling
    Departments of Pediatrics, University of Texas Southwestern Medical Center and Children s Medical Center, Dallas, TX 75390 9063, USA
    Blood 120:3891-7. 2012
    ..Some ASCIE (1 of 4 in our study) may be reversible. Alterations in management may be warranted for children with severe anemia to identify unrecognized ischemic brain injury that may have permanent neurocognitive sequelae...
  14. pmc Prognostic significance of early vaso-occlusive complications in children with sickle cell anemia
    Charles T Quinn
    Division of Hematology Oncology, Department of Pediatrics, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390, USA
    Blood 109:40-5. 2007
    ..Although we still lack a useful prognostic framework for young children with SS, those who experience early ACS might be candidates for higher risk interventions to mitigate or cure their disease...
  15. pmc Daytime steady-state haemoglobin desaturation is a risk factor for overt stroke in children with sickle cell anaemia
    Charles T Quinn
    Center for Cancer and Blood Disorders, Children s Medical Center Dallas, Dallas, TX, USA
    Br J Haematol 140:336-9. 2008
    ..Decline in SpO(2) over time further increases this risk. Hb desaturation is easily measured, potentially modifiable, and could be used to identify children with SS at increased risk of stroke...
  16. doi request reprint Hospitalization for invasive pneumococcal disease in a national sample of children with sickle cell disease before and after PCV7 licensure
    Timothy L McCavit
    University of Texas Southwestern Medical Center, Dallas, TX, USA
    Pediatr Blood Cancer 58:945-9. 2012
    ..To estimate national hospitalization rates for invasive pneumococcal disease (IPD) in children with sickle cell disease (SCD) before and after the 2000 licensure of the heptavalent pneumococcal conjugate vaccine (PCV7)...
  17. pmc Increase in invasive Streptococcus pneumoniae infections in children with sickle cell disease since pneumococcal conjugate vaccine licensure
    Timothy L McCavit
    Division of Hematology Oncology, Department of Pediatrics, University of Texas Southwestern Medical Center at Dallas, Dallas, TX, USA
    J Pediatr 158:505-7. 2011
    ..We report 10 IPD cases since pneumococcal protein-conjugate vaccine licensure, including a recent surge of non-vaccine serotypes. IPD continues to be a serious risk in sickle cell disease...
  18. doi request reprint Pilot study of continuous co-infusion of morphine and naloxone in children with sickle cell pain crisis
    Josh Koch
    Division of Critical Care, Department of Pediatrics, University of Texas Southwestern Medical Center Dallas, Dallas, Texas 75390 9063, USA
    Am J Hematol 83:728-31. 2008
    ..A quantitative pruritus score allowed us to systematically measure pruritus. Further evaluation by randomized, placebo-controlled study of 1 mcg/kg x hr naloxone in this setting is required...
  19. pmc Stroke in sickle cell anemia: alternative etiologies
    Michael M Dowling
    Department of Pediatrics, The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9063, USA
    Pediatr Neurol 41:124-6. 2009
    ..The present case suggests that the more traditional etiologies for pediatric stroke may also cause stroke in children with sickle cell anemia...
  20. pmc Clinical correlates of steady-state oxyhaemoglobin desaturation in children who have sickle cell disease
    Charles T Quinn
    Division of Hematology Oncology, Department of Pediatrics, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390 9063, USA
    Br J Haematol 131:129-34. 2005
    ..We conclude that steady-state desaturation is common in individuals with SCD, but it appears to be unrelated to prior episodes of ACS and largely unexplained by chronic anaemia...
  21. doi request reprint Bordetella holmesii bacteremia in sickle cell disease
    Timothy L McCavit
    Division of Hematology Oncology, Department of Pediatrics, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9063, USA
    Pediatr Blood Cancer 51:814-6. 2008
    ..holmesii infection from other invasive bacterial infections in SCD. Providers for patients with SCD should be aware of this pathogen and ensure that their microbiology laboratories are capable of isolating and identifying this organism...