Joseph E Qualls
Affiliation: Cincinnati Children's Hospital Medical Center
Lange S, McKell M, Schmidt S, Zhao J, Crowther R, Green L, et al
. l-Arginine Synthesis from l-Citrulline in Myeloid Cells Drives Host Defense against Mycobacteria In Vivo. J Immunol. 2019;202:1747-1754 pubmed publisher
Rapovy S, Zhao J, Bricker R, Schmidt S, Setchell K, Qualls J. Differential Requirements for L-Citrulline and L-Arginine during Antimycobacterial Macrophage Activity. J Immunol. 2015;195:3293-300 pubmed publisher
..We expect that defining the consequences of L-citrulline metabolism in MΦs will provide novel approaches for enhancing immunity, especially in the context of mycobacterial disease. ..
Kratochvill F, Neale G, Haverkamp J, Van De Velde L, Smith A, Kawauchi D, et al
. TNF Counterbalances the Emergence of M2 Tumor Macrophages. Cell Rep. 2015;12:1902-14 pubmed publisher
..Our results show macrophage polarization in cancer is dynamic and dependent on the balance between TNF and IL-13, thus providing a strategy for manipulating TAMs. ..
Qualls J, Murray P. Immunometabolism within the tuberculosis granuloma: amino acids, hypoxia, and cellular respiration. Semin Immunopathol. 2016;38:139-52 pubmed publisher
..While elimination of the TB bacilli is often the goal of any anti-TB therapy, host-directed approaches must also account for the possibility of immunopathologic damage to the lung. ..