DANIEL PROWS

Summary

Affiliation: Cincinnati Children's Hospital Medical Center
Country: USA

Publications

  1. pmc Synchronizing allelic effects of opposing quantitative trait loci confirmed a major epistatic interaction affecting acute lung injury survival in mice
    Daniel R Prows
    Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America
    PLoS ONE 7:e38177. 2012
  2. ncbi request reprint A genetic mouse model to investigate hyperoxic acute lung injury survival
    Daniel R Prows
    Department of Pediatrics, University of Cincinnati College of Medicine, Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
    Physiol Genomics 30:262-70. 2007
  3. pmc Reciprocal congenic lines of mice capture the aliq1 effect on acute lung injury survival time
    Daniel R Prows
    Children s Hospital Medical Center, Division and Program in Human Genetics, 3333 Burnet Ave, MLC 7016, Building R, Room 1464, Cincinnati, OH 45229 3039, USA
    Am J Respir Cell Mol Biol 38:68-77. 2008
  4. ncbi request reprint Genetic susceptibility to nickel-induced acute lung injury
    Daniel R Prows
    Department of Environmental Health, University of Cincinnati, Cincinnati, OH 45267 0056, USA
    Chemosphere 51:1139-48. 2003
  5. pmc Reciprocal backcross mice confirm major loci linked to hyperoxic acute lung injury survival time
    Daniel R Prows
    Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    Physiol Genomics 38:158-68. 2009
  6. ncbi request reprint Genetic analysis of hyperoxic acute lung injury survival in reciprocal intercross mice
    Daniel R Prows
    Department of Pediatrics, University of Cincinnati College of Medicine, Children s Hospital Medical Center, Cincinnati, Ohio, USA
    Physiol Genomics 30:271-81. 2007
  7. pmc Genomewide association analysis of respiratory syncytial virus infection in mice
    James M Stark
    Department of Pediatrics, University of Texas Health Science Center, Houston, Texas, USA
    J Virol 84:2257-69. 2010
  8. ncbi request reprint Acute lung injury: functional genomics and genetic susceptibility
    George D Leikauf
    Department of Environmental Health, University of Cincinnati, Cincinnati, OH 45267 0056, USA
    Chest 121:70S-75S. 2002
  9. pmc The role of metallothionein in the pathogenesis of acute lung injury
    Scott C Wesselkamper
    Department of Environmental Health, University of Cincinnati Medical Center, Cincinnati, OH 45267 0056, USA
    Am J Respir Cell Mol Biol 34:73-82. 2006
  10. ncbi request reprint Genetic susceptibility to respiratory syncytial virus infection in inbred mice
    James M Stark
    Department of Pulmonary Medicine, Allergy and Clinical Immunology, Children s Hospital Medical Center, Cincinnati, Ohio, USA
    J Med Virol 67:92-100. 2002

Research Grants

Detail Information

Publications19

  1. pmc Synchronizing allelic effects of opposing quantitative trait loci confirmed a major epistatic interaction affecting acute lung injury survival in mice
    Daniel R Prows
    Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America
    PLoS ONE 7:e38177. 2012
    ....
  2. ncbi request reprint A genetic mouse model to investigate hyperoxic acute lung injury survival
    Daniel R Prows
    Department of Pediatrics, University of Cincinnati College of Medicine, Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
    Physiol Genomics 30:262-70. 2007
    ..HALI survival is multigenic with a complex mode of inheritance, which should be amenable to genetic dissection with this mouse model...
  3. pmc Reciprocal congenic lines of mice capture the aliq1 effect on acute lung injury survival time
    Daniel R Prows
    Children s Hospital Medical Center, Division and Program in Human Genetics, 3333 Burnet Ave, MLC 7016, Building R, Room 1464, Cincinnati, OH 45229 3039, USA
    Am J Respir Cell Mol Biol 38:68-77. 2008
    ..Together, these findings support most of the previously identified QTLs linked to ALI survival and established lines of mice to further resolve Aliq1...
  4. ncbi request reprint Genetic susceptibility to nickel-induced acute lung injury
    Daniel R Prows
    Department of Environmental Health, University of Cincinnati, Cincinnati, OH 45267 0056, USA
    Chemosphere 51:1139-48. 2003
    ..Together, results from QTL and microarray analyses of nickel-induced acute lung injury survival allowed us to generate a short list of candidate genes...
  5. pmc Reciprocal backcross mice confirm major loci linked to hyperoxic acute lung injury survival time
    Daniel R Prows
    Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    Physiol Genomics 38:158-68. 2009
    ....
  6. ncbi request reprint Genetic analysis of hyperoxic acute lung injury survival in reciprocal intercross mice
    Daniel R Prows
    Department of Pediatrics, University of Cincinnati College of Medicine, Children s Hospital Medical Center, Cincinnati, Ohio, USA
    Physiol Genomics 30:271-81. 2007
    ..QTL results confirmed that both parental strains contribute dominant resistance alleles to their offspring to determine individual HALI susceptibility...
  7. pmc Genomewide association analysis of respiratory syncytial virus infection in mice
    James M Stark
    Department of Pediatrics, University of Texas Health Science Center, Houston, Texas, USA
    J Virol 84:2257-69. 2010
    ..These findings add to our understanding of individual RSV susceptibility and strongly support a modifier role for CFTR in RSV infection, a significant cause of respiratory morbidity in infants with cystic fibrosis...
  8. ncbi request reprint Acute lung injury: functional genomics and genetic susceptibility
    George D Leikauf
    Department of Environmental Health, University of Cincinnati, Cincinnati, OH 45267 0056, USA
    Chest 121:70S-75S. 2002
    ..Thus, the functional genomic approaches of large gene set expression (complementary DNA microarray) and genome-wide analyses continue to provide novel insights into the genetic susceptibility of lung injury...
  9. pmc The role of metallothionein in the pathogenesis of acute lung injury
    Scott C Wesselkamper
    Department of Environmental Health, University of Cincinnati Medical Center, Cincinnati, OH 45267 0056, USA
    Am J Respir Cell Mol Biol 34:73-82. 2006
    ....
  10. ncbi request reprint Genetic susceptibility to respiratory syncytial virus infection in inbred mice
    James M Stark
    Department of Pulmonary Medicine, Allergy and Clinical Immunology, Children s Hospital Medical Center, Cincinnati, Ohio, USA
    J Med Virol 67:92-100. 2002
    ..These data suggest that RSV susceptibility is a multigenic trait that should be amenable to resolution by genomic analysis...
  11. ncbi request reprint Dose-related protection from nickel-induced lung injury in transgenic mice expressing human transforming growth factor-alpha
    William D Hardie
    Division of Pulmonary Medicine, Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
    Am J Respir Cell Mol Biol 26:430-7. 2002
    ..In the TGF-alpha transgenic mouse model, TGF-alpha protects against nickel-induced acute lung injury, at least in part, by attenuating the inflammatory response, reducing pulmonary edema, and preserving levels of SP-B...
  12. ncbi request reprint Macrophage dysfunction and susceptibility to pulmonary Pseudomonas aeruginosa infection in surfactant protein C-deficient mice
    Stephan W Glasser
    Division of Pulmonary Biology, Department of Pediatrics, Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229 3039, USA
    J Immunol 181:621-8. 2008
    ..SP-C plays an important role in innate host defense of the lung, enhancing macrophage-mediated Pseudomonas phagocytosis, clearance and limiting pulmonary inflammatory responses...
  13. pmc Surfactant protein C-deficient mice are susceptible to respiratory syncytial virus infection
    Stephan W Glasser
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
    Am J Physiol Lung Cell Mol Physiol 297:L64-72. 2009
    ..Preparations of purified SP-C and synthetic phospholipids blocked poly(I:C)-induced TLR3 signaling in vitro. SP-C deficiency increases the severity of RSV-induced pulmonary inflammation through regulation of TLR3 signaling...
  14. ncbi request reprint The role of the receptor tyrosine kinase Ron in nickel-induced acute lung injury
    Susan A McDowell
    Department of Environmental Health, University of Cincinnati, Cincinnati, OH, USA
    Am J Respir Cell Mol Biol 26:99-104. 2002
    ..These analyses indicate a role for the tyrosine kinase receptor Ron in ALI...
  15. ncbi request reprint Medication selection by genotype: How genetics is changing drug prescribing and efficacy
    Cynthia A Prows
    Department of Patient Services, Division of Nursing, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229 3039, USA
    Am J Nurs 104:60-70; quiz 71. 2004
  16. ncbi request reprint Inhibition of nitric oxide restores surfactant gene expression following nickel-induced acute lung injury
    Susan A McDowell
    University of Cincinnati, and Children s Hospital Medical Center, Cincinnati, OH 45267 0056, USA
    Am J Respir Cell Mol Biol 28:188-98. 2003
    ..Rather, systemic L-NAME treatment appears to attenuate pulmonary endothelial NOS activity, subsequent cytokine expression, inflammation, and protein permeability, and thereby restores surfactant gene expression and increases survival...
  17. ncbi request reprint Parental genetic contributions in the AXB and BXA recombinant inbred mouse strains
    Daniel R Prows
    Department of Environmental Health, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0056, USA
    Mamm Genome 13:127-33. 2002
    ..Two examples are presented to demonstrate potential uses of the generated chromosome maps: to select RI strains to construct congenic lines and to perform an RIST for Aliq1, a QTL linked to ozone-induced acute lung injury survival...
  18. ncbi request reprint Mucin apoprotein expression in COPD
    George D Leikauf
    Molecular Toxicology Division, Department of Environmental Health, University of Cincinnati, Cincinnati, OH 45267 0056, USA
    Chest 121:166S-182S. 2002
    ..As our understanding of the functional genomics of mucin biology increases, further clinical targets and therapeutic strategies are likely to emerge...
  19. ncbi request reprint The Collaborative Cross, a community resource for the genetic analysis of complex traits
    Gary A Churchill
    The Jackson Laboratory, 600 Main Street Bar Harbor, Maine 04609, USA
    Nat Genet 36:1133-7. 2004
    ..The Collaborative Cross will provide a common reference panel specifically designed for the integrative analysis of complex systems and will change the way we approach human health and disease...

Research Grants7

  1. Genetic analysis of hyperoxia-induced acute lung injury
    DANIEL PROWS; Fiscal Year: 2007
    ..abstract_text> ..
  2. Genetic Analysis of Hyperoxia Induced Acute Lung Injury
    DANIEL PROWS; Fiscal Year: 2009
    ..The primary objective of this application is to set the stage for identifying the major gene(s) controlling survival by generating and testing genetically-refined mouse models containing susceptibility alleles in a fixed background. ..
  3. Genetic Analysis of Hyperoxia Induced Acute Lung Injury
    Daniel R Prows; Fiscal Year: 2010
    ..The primary objective of this application is to set the stage for identifying the major gene(s) controlling survival by generating and testing genetically-refined mouse models containing susceptibility alleles in a fixed background. ..