Research Topics
| DANIEL PROWSSummaryAffiliation: Cincinnati Children's Hospital Medical Center Country: USA Publications
Research Grants
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Detail Information
Publications
Synchronizing allelic effects of opposing quantitative trait loci confirmed a major epistatic interaction affecting acute lung injury survival in miceDaniel R Prows
Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America
PLoS ONE 7:e38177. 2012....
A genetic mouse model to investigate hyperoxic acute lung injury survivalDaniel R Prows
Department of Pediatrics, University of Cincinnati College of Medicine, Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
Physiol Genomics 30:262-70. 2007..HALI survival is multigenic with a complex mode of inheritance, which should be amenable to genetic dissection with this mouse model...- Reciprocal congenic lines of mice capture the aliq1 effect on acute lung injury survival timeDaniel R Prows
Children s Hospital Medical Center, Division and Program in Human Genetics, 3333 Burnet Ave, MLC 7016, Building R, Room 1464, Cincinnati, OH 45229 3039, USA
Am J Respir Cell Mol Biol 38:68-77. 2008..Together, these findings support most of the previously identified QTLs linked to ALI survival and established lines of mice to further resolve Aliq1... - Genetic susceptibility to nickel-induced acute lung injuryDaniel R Prows
Department of Environmental Health, University of Cincinnati, Cincinnati, OH 45267 0056, USA
Chemosphere 51:1139-48. 2003..Together, results from QTL and microarray analyses of nickel-induced acute lung injury survival allowed us to generate a short list of candidate genes... - Reciprocal backcross mice confirm major loci linked to hyperoxic acute lung injury survival timeDaniel R Prows
Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
Physiol Genomics 38:158-68. 2009.... - Genetic analysis of hyperoxic acute lung injury survival in reciprocal intercross miceDaniel R Prows
Department of Pediatrics, University of Cincinnati College of Medicine, Children s Hospital Medical Center, Cincinnati, Ohio, USA
Physiol Genomics 30:271-81. 2007..QTL results confirmed that both parental strains contribute dominant resistance alleles to their offspring to determine individual HALI susceptibility... - Genomewide association analysis of respiratory syncytial virus infection in miceJames M Stark
Department of Pediatrics, University of Texas Health Science Center, Houston, Texas, USA
J Virol 84:2257-69. 2010..These findings add to our understanding of individual RSV susceptibility and strongly support a modifier role for CFTR in RSV infection, a significant cause of respiratory morbidity in infants with cystic fibrosis... - Acute lung injury: functional genomics and genetic susceptibilityGeorge D Leikauf
Department of Environmental Health, University of Cincinnati, Cincinnati, OH 45267 0056, USA
Chest 121:70S-75S. 2002..Thus, the functional genomic approaches of large gene set expression (complementary DNA microarray) and genome-wide analyses continue to provide novel insights into the genetic susceptibility of lung injury... - The role of metallothionein in the pathogenesis of acute lung injuryScott C Wesselkamper
Department of Environmental Health, University of Cincinnati Medical Center, Cincinnati, OH 45267 0056, USA
Am J Respir Cell Mol Biol 34:73-82. 2006.... - Genetic susceptibility to respiratory syncytial virus infection in inbred miceJames M Stark
Department of Pulmonary Medicine, Allergy and Clinical Immunology, Children s Hospital Medical Center, Cincinnati, Ohio, USA
J Med Virol 67:92-100. 2002..These data suggest that RSV susceptibility is a multigenic trait that should be amenable to resolution by genomic analysis... - Dose-related protection from nickel-induced lung injury in transgenic mice expressing human transforming growth factor-alphaWilliam D Hardie
Division of Pulmonary Medicine, Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
Am J Respir Cell Mol Biol 26:430-7. 2002..In the TGF-alpha transgenic mouse model, TGF-alpha protects against nickel-induced acute lung injury, at least in part, by attenuating the inflammatory response, reducing pulmonary edema, and preserving levels of SP-B... - Macrophage dysfunction and susceptibility to pulmonary Pseudomonas aeruginosa infection in surfactant protein C-deficient miceStephan W Glasser
Division of Pulmonary Biology, Department of Pediatrics, Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229 3039, USA
J Immunol 181:621-8. 2008..SP-C plays an important role in innate host defense of the lung, enhancing macrophage-mediated Pseudomonas phagocytosis, clearance and limiting pulmonary inflammatory responses... - Surfactant protein C-deficient mice are susceptible to respiratory syncytial virus infectionStephan W Glasser
Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
Am J Physiol Lung Cell Mol Physiol 297:L64-72. 2009..Preparations of purified SP-C and synthetic phospholipids blocked poly(I:C)-induced TLR3 signaling in vitro. SP-C deficiency increases the severity of RSV-induced pulmonary inflammation through regulation of TLR3 signaling... - The role of the receptor tyrosine kinase Ron in nickel-induced acute lung injurySusan A McDowell
Department of Environmental Health, University of Cincinnati, Cincinnati, OH, USA
Am J Respir Cell Mol Biol 26:99-104. 2002..These analyses indicate a role for the tyrosine kinase receptor Ron in ALI... - Medication selection by genotype: How genetics is changing drug prescribing and efficacyCynthia A Prows
Department of Patient Services, Division of Nursing, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229-3039, USA
Am J Nurs 104:60-70; quiz 71. 2004 - Inhibition of nitric oxide restores surfactant gene expression following nickel-induced acute lung injurySusan A McDowell
University of Cincinnati, and Children's Hospital Medical Center, Cincinnati, OH 45267-0056, USA
Am J Respir Cell Mol Biol 28:188-98. 2003..Rather, systemic L-NAME treatment appears to attenuate pulmonary endothelial NOS activity, subsequent cytokine expression, inflammation, and protein permeability, and thereby restores surfactant gene expression and increases survival... - Parental genetic contributions in the AXB and BXA recombinant inbred mouse strainsDaniel R Prows
Department of Environmental Health, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0056, USA
Mamm Genome 13:127-33. 2002..Two examples are presented to demonstrate potential uses of the generated chromosome maps: to select RI strains to construct congenic lines and to perform an RIST for Aliq1, a QTL linked to ozone-induced acute lung injury survival... - Mucin apoprotein expression in COPDGeorge D Leikauf
Molecular Toxicology Division, Department of Environmental Health, University of Cincinnati, Cincinnati, OH 45267 0056, USA
Chest 121:166S-182S. 2002..As our understanding of the functional genomics of mucin biology increases, further clinical targets and therapeutic strategies are likely to emerge... - The Collaborative Cross, a community resource for the genetic analysis of complex traitsGary A Churchill
The Jackson Laboratory, 600 Main Street Bar Harbor, Maine 04609, USA
Nat Genet 36:1133-7. 2004..The Collaborative Cross will provide a common reference panel specifically designed for the integrative analysis of complex systems and will change the way we approach human health and disease...
Research Grants
- Genetic analysis of hyperoxia-induced acute lung injuryDANIEL PROWS; Fiscal Year: 2007..abstract_text> ..
- Genetic Analysis of Hyperoxia Induced Acute Lung InjuryDANIEL PROWS; Fiscal Year: 2009..The primary objective of this application is to set the stage for identifying the major gene(s) controlling survival by generating and testing genetically-refined mouse models containing susceptibility alleles in a fixed background. ..
- Genetic Analysis of Hyperoxia Induced Acute Lung InjuryDaniel R Prows; Fiscal Year: 2010..The primary objective of this application is to set the stage for identifying the major gene(s) controlling survival by generating and testing genetically-refined mouse models containing susceptibility alleles in a fixed background. ..