S Potter

Summary

Affiliation: Cincinnati Children's Hospital Medical Center
Country: USA

Publications

  1. pmc Gene expression programs of mouse endothelial cells in kidney development and disease
    Eric W Brunskill
    Division of Developmental Biology, Children s Hospital Medical Center, Cincinnati, Ohio, United States of America
    PLoS ONE 5:e12034. 2010
  2. pmc Defining the molecular character of the developing and adult kidney podocyte
    Eric W Brunskill
    Division of Developmental Biology, Cincinnati Children s Hospital Medical Center and the University of Cincinnati School of Medicine, Cincinnati, Ohio, United States of America
    PLoS ONE 6:e24640. 2011
  3. pmc Changes in the gene expression programs of renal mesangial cells during diabetic nephropathy
    Eric W Brunskill
    Division of Developmental Biology, Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    BMC Nephrol 13:70. 2012
  4. doi request reprint Laser capture
    S Steven Potter
    Division of Developmental Biology, Children s Hospital Medical Center, Cincinnati, OH, USA
    Methods Mol Biol 886:211-21. 2012
  5. pmc Epigenetic inheritance based evolution of antibiotic resistance in bacteria
    Mike Adam
    Division of Developmental Biology, Children s Hospital Research Foundation, 3333 Burnet Ave, Cincinnati, OH 45229, USA
    BMC Evol Biol 8:52. 2008
  6. pmc Microarrays and RNA-Seq identify molecular mechanisms driving the end of nephron production
    Eric W Brunskill
    Division of Nephrology and Hypertension, Cincinnati Children s Hospital Medical Center and the University of Cincinnati School of Medicine, 3333 Burnet Avenue, Cincinnati, Ohio 45229, USA
    BMC Dev Biol 11:15. 2011
  7. pmc Pygo1 and Pygo2 roles in Wnt signaling in mammalian kidney development
    Kristopher R Schwab
    Division of Developmental Biology, Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    BMC Biol 5:15. 2007
  8. ncbi request reprint Laser capture-microarray analysis of Lim1 mutant kidney development
    S Steven Potter
    Division of Developmental Biology, Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
    Genesis 45:432-9. 2007
  9. pmc Microdissection of the gene expression codes driving nephrogenesis
    S Steven Potter
    Division of Developmental Biology, Children s Hospital Medical Center, Cincinnati, OH, USA
    Organogenesis 6:263-9. 2010
  10. doi request reprint Defining the genetic blueprint of kidney development
    S Steven Potter
    Division of Developmental Biology, Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
    Pediatr Nephrol 26:1469-78. 2011

Research Grants

Collaborators

Detail Information

Publications30

  1. pmc Gene expression programs of mouse endothelial cells in kidney development and disease
    Eric W Brunskill
    Division of Developmental Biology, Children s Hospital Medical Center, Cincinnati, Ohio, United States of America
    PLoS ONE 5:e12034. 2010
    ..These studies provide a rich resource to facilitate further investigations of endothelial cell functions in kidney development, adult compartments, and disease...
  2. pmc Defining the molecular character of the developing and adult kidney podocyte
    Eric W Brunskill
    Division of Developmental Biology, Cincinnati Children s Hospital Medical Center and the University of Cincinnati School of Medicine, Cincinnati, Ohio, United States of America
    PLoS ONE 6:e24640. 2011
    ..The podocytes are a subject of keen interest because of their key roles in kidney development and disease...
  3. pmc Changes in the gene expression programs of renal mesangial cells during diabetic nephropathy
    Eric W Brunskill
    Division of Developmental Biology, Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    BMC Nephrol 13:70. 2012
    ..The purpose of the study is to better define the unique character of normal mesangial cells, and to characterize their pathogenic and protective responses during diabetic nephropathy...
  4. doi request reprint Laser capture
    S Steven Potter
    Division of Developmental Biology, Children s Hospital Medical Center, Cincinnati, OH, USA
    Methods Mol Biol 886:211-21. 2012
    ..Notes describe the fine points of each operation, which can often mean the difference between success and failure...
  5. pmc Epigenetic inheritance based evolution of antibiotic resistance in bacteria
    Mike Adam
    Division of Developmental Biology, Children s Hospital Research Foundation, 3333 Burnet Ave, Cincinnati, OH 45229, USA
    BMC Evol Biol 8:52. 2008
    ..Evolution is the result of natural selection acting on variant phenotypes. Both the rigid base sequence of DNA and the more plastic expression patterns of the genes present define phenotype...
  6. pmc Microarrays and RNA-Seq identify molecular mechanisms driving the end of nephron production
    Eric W Brunskill
    Division of Nephrology and Hypertension, Cincinnati Children s Hospital Medical Center and the University of Cincinnati School of Medicine, 3333 Burnet Avenue, Cincinnati, Ohio 45229, USA
    BMC Dev Biol 11:15. 2011
    ..This strategy allowed us to define the changing gene expression states following induction and the onset of differentiation after birth...
  7. pmc Pygo1 and Pygo2 roles in Wnt signaling in mammalian kidney development
    Kristopher R Schwab
    Division of Developmental Biology, Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    BMC Biol 5:15. 2007
    ..To better understand the functions of Pygopus-mediated canonical Wnt signaling in kidney development, targeted mutations were made in the two mammalian orthologs, Pygo1 and Pygo2...
  8. ncbi request reprint Laser capture-microarray analysis of Lim1 mutant kidney development
    S Steven Potter
    Division of Developmental Biology, Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
    Genesis 45:432-9. 2007
    ..This was confirmed by in situ hybridizations. It is interesting to note that Lim1 and Dkk1 mutant mice have striking similarities in phenoytpe. These results suggest that the Dkk1 gene might be a key downstream effector of Lim1 function...
  9. pmc Microdissection of the gene expression codes driving nephrogenesis
    S Steven Potter
    Division of Developmental Biology, Children s Hospital Medical Center, Cincinnati, OH, USA
    Organogenesis 6:263-9. 2010
    ....
  10. doi request reprint Defining the genetic blueprint of kidney development
    S Steven Potter
    Division of Developmental Biology, Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
    Pediatr Nephrol 26:1469-78. 2011
    ..Advancing technologies are even allowing robust gene expression profiling of single cells. The final goal is the production of an exquisitely detailed atlas of the gene expression program that drives kidney development...
  11. ncbi request reprint Comprehensive microarray analysis of Hoxa11/Hoxd11 mutant kidney development
    Kristopher Schwab
    Division of Developmental Biology, Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
    Dev Biol 293:540-54. 2006
    ..These results identify the multiple molecular pathways downstream of Hox11 function in the developing kidney...
  12. ncbi request reprint The zinc finger transcription factor Sp8 regulates the generation and diversity of olfactory bulb interneurons
    Ronald R Waclaw
    Division of Developmental Biology, Department of Pediatrics, Children s Hospital Medical Center, University of Cincinnati College of Medicine, 3333 Burnet Avenue, Cincinnati, Ohio 45229, USA
    Neuron 49:503-16. 2006
    ....
  13. ncbi request reprint Microarray analysis of novel cell lines representing two stages of metanephric mesenchyme differentiation
    M Todd Valerius
    Division of Developmental Biology, Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
    Mech Dev 110:151-64. 2002
    ..In situ hybridizations were used to confirm that selected novel genes were expressed in the developing kidney...
  14. ncbi request reprint Microarray analysis of novel cell lines representing two stages of metanephric mesenchyme differentiation
    M Todd Valerius
    Division of Developmental Biology, Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
    Mech Dev 112:219-32. 2002
    ..In situ hybridizations were used to confirm that selected novel genes were expressed in the developing kidney...
  15. ncbi request reprint Profiling gene expression in kidney development
    Larry T Patterson
    Division of Nephrology, Children s Hospital Research Foundation, Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    Nephron Exp Nephrol 98:e109-13. 2004
    ..The resulting detailed molecular portrait of normal kidney development provides a baseline for studies of the many mouse mutants available with abnormal kidney development...
  16. ncbi request reprint A catalogue of gene expression in the developing kidney
    Kristopher Schwab
    Division of Developmental Biology, Division of Nephrology, Children s Hospital Research Foundation, Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    Kidney Int 64:1588-604. 2003
    ..Although many genes with important function in kidney morphogenesis have been described, it is clear that many more remain to be discovered. Microarrays allow a more global analysis of the genetic basis of kidney organogenesis...
  17. ncbi request reprint Atlas of Hox gene expression in the developing kidney
    Larry T Patterson
    Division of Nephrology and Hypertension, The Children s Hospital Research Foundation, Cincinnati, Ohio, USA
    Dev Dyn 229:771-9. 2004
    ..In summary, the resulting atlas of Hox gene expression provides a foundation for further study of the overlapping functions Hox genes in the developing kidney...
  18. pmc Sp8 is crucial for limb outgrowth and neuropore closure
    Sheila M Bell
    Division of Developmental Biology, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
    Proc Natl Acad Sci U S A 100:12195-200. 2003
    ..These observations indicate that Sp8 functions downstream of Wnt3, Fgf10, and Bmpr1a in the signaling cascade that mediates AER formation...
  19. pmc Atlas of gene expression in the developing kidney at microanatomic resolution
    Eric W Brunskill
    Division of Developmental Biology, Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
    Dev Cell 15:781-91. 2008
    ..In addition, the results provide deeper insight into the genetic regulatory mechanisms of kidney development...
  20. pmc Hoxa 11 is upstream of Integrin alpha8 expression in the developing kidney
    M Todd Valerius
    Division of Developmental Biology, Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
    Proc Natl Acad Sci U S A 99:8090-5. 2002
    ..This work suggests that the Integrin alpha8 gene may be a major effector of Hoxa 11/Hoxd 11 function in the developing kidney...
  21. ncbi request reprint Large-scale reprogramming of cranial neural crest gene expression by retinoic acid exposure
    Sarah S Williams
    Division of Biomedical Informatics, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    Physiol Genomics 19:184-97. 2004
    ....
  22. ncbi request reprint Functional comparison of the Hoxa 4, Hoxa 10, and Hoxa 11 homeoboxes
    Yuanxiang Zhao
    Division of Developmental Biology, Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, Ohio 45224, USA
    Dev Biol 244:21-36. 2002
    ..It is interesting that Hox homeoboxes are interchangeable in this process, but are functionally distinct in other aspects of development...
  23. ncbi request reprint Abnormal neurodevelopment, neurosignaling and behaviour in Npas3-deficient mice
    Eric W Brunskill
    Division of Cardiology, University of Cincinnati College of Medicine, 231 Albert Sabin Way, Cincinnati, OH 45267, USA
    Eur J Neurosci 22:1265-76. 2005
    ..Together, our observations indicate an important role for Npas3 in controlling normal brain development and neurosignaling pathways...
  24. ncbi request reprint Laser capture microdissection-microarray analysis of focal segmental glomerulosclerosis glomeruli
    Michael R Bennett
    Division of Nephrology and Hypertension, Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    Nephron Exp Nephrol 107:e30-40. 2007
    ..These results confirm old findings, and indicate the involvement of new genetic pathways in the cause and progression of FSGS...
  25. ncbi request reprint Microarray analysis of focal segmental glomerulosclerosis
    Kristopher Schwab
    Division of Developmental Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    Am J Nephrol 24:438-47. 2004
    ..Here we use oligonucleotide microarrays to obtain a global gene expression profile of kidney biopsy specimens from patients with FSGS in order to better understand the pathogenesis of this disease...
  26. ncbi request reprint Hox genes and kidney patterning
    Larry T Patterson
    Division of Nephrology, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    Curr Opin Nephrol Hypertens 12:19-23. 2003
    ..Multiple Hox genes are expressed in the kidney and mutation in at least one group of paralogous genes results in severe renal defects...
  27. ncbi request reprint Early orchiopexy restores fertility in the Hoxa 11 gene knockout mouse
    Alfor G Lewis
    Division of Pediatric Urology, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
    J Urol 170:302-5. 2003
    ..We investigated whether infertility could be reversed in cryptorchid mice (with disrupted expression of the homeobox gene Hoxa 11) by orchiopexy and mating such animals with females of proven fertility...
  28. ncbi request reprint Phylogenetic analysis of Hoxa 11 sequences reveals absence of transposable elements, conservation of transcription factor binding sites, and suggests antisense coding function
    Diane M Bodenmiller
    Division of Developmental Biology, Children s Hospital Medical Center, TCHRF 3007, 3333 Burnet Ave, Cincinnati, OH 45229, USA
    DNA Seq 13:77-83. 2002
    ..Comparison of this region in mouse and chicken showed seven insertion/deletions, with each a multiple of three bases, thereby preserving open reading frame...
  29. ncbi request reprint GeneChip microarrays facilitate identification of Protease Nexin-1 as a target gene of the Prx2 (S8) homeoprotein
    Karen K Scott
    Medical University of South Carolina, Department of Cell Biology and Anatomy, Charleston, South Carolina 29425 2204, USA
    DNA Cell Biol 22:95-105. 2003
    ..The GeneChip analysis generated a prioritized list of other potential targets. The utility and limitations of cell culture models combined with microarray analysis for elucidating complex regulatory cascades are discussed...
  30. pmc Behavioral and regulatory abnormalities in mice deficient in the NPAS1 and NPAS3 transcription factors
    Claudia Erbel-Sieler
    Departments of Biochemistry and Neurology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    Proc Natl Acad Sci U S A 101:13648-53. 2004
    ..These observations raise the possibility that a regulatory program controlled in inhibitory interneurons by the NPAS1 and NPAS3 transcription factors may be either substantively or tangentially relevant to psychosis...

Research Grants28

  1. Glomerulosclerosis in Human FSGS and Animal Models
    S Steven Potter; Fiscal Year: 2010
    ....
  2. Legless Transgene Insertion Mutation
    S Potter; Fiscal Year: 2004
    ..The results will provide deeper insight into the genetic program of limb development and might also find function for these genes in the formation of the brain and other organs. ..
  3. Legless Transgene Insertion Mutation
    S Potter; Fiscal Year: 2002
    ..The results will provide deeper insight into the genetic program of limb development and might also find function for these genes in the formation of the brain and other organs. ..
  4. Development of the Metanephric Mesenchyme
    S Potter; Fiscal Year: 2002
    ..We propose to confirm these targets, to determine if they are direct or indirect, and to identify additional downstream genes responsive to Hoxa 11 or Lim1 expression. ..
  5. Development of the Metanephric Mesenchyme
    S Potter; Fiscal Year: 2007
    ....
  6. EMBRYOLOGY AND DEVELOPMENT STUDIED IN TRANSGENIC MICE
    S Potter; Fiscal Year: 1991
    ..Each aspect of analysis complements the others, providing a more complete understanding of the developmental process...
  7. Development of the Metanephric Mesenchyme
    S Potter; Fiscal Year: 2004
    ..We propose to confirm these targets, to determine if they are direct or indirect, and to identify additional downstream genes responsive to Hoxa 11 or Lim1 expression. ..
  8. Development of the Metanephric Mesenchyme
    S Potter; Fiscal Year: 2009
    ..abstract_text> ..
  9. Development of the Metanephric Mesenchyme
    S Potter; Fiscal Year: 2006
    ....
  10. Global Gene Expression Atlas of the Developing Kidney
    S Potter; Fiscal Year: 2007
    ..Analysis of the complex orchestrations of gene expression defined in Specific Aim 1 will provide deeper insight into the genetic basis of the development of the distinct parts of the nephron. ..
  11. Development of the Metanephric Mesenchyme
    S Potter; Fiscal Year: 2005
    ..We propose to confirm these targets, to determine if they are direct or indirect, and to identify additional downstream genes responsive to Hoxa 11 or Lim1 expression. ..
  12. Glomerulosclerosis in Human FSGS and Animal Models
    S Potter; Fiscal Year: 2009
    ....
  13. Legless Transgene Insertion Mutation
    S Potter; Fiscal Year: 2003
    ..The results will provide deeper insight into the genetic program of limb development and might also find function for these genes in the formation of the brain and other organs. ..
  14. LEGLESS TRANSGENE INSERTIONAL MUTATION
    S Potter; Fiscal Year: 1999
    ..We also propose to use direct selection to identify additional genes from the deleted region which are expressed in the limb and may be the source of the disruption in this signaling cascade. ..
  15. EMBRYOLOGY AND DEVELOPMENT STUDIED IN TRANSGENIC MICE
    S Potter; Fiscal Year: 1990
    ..Each aspect of analysis complements the others, providing a more complete understanding of the developmental process...
  16. EMBRYOLOGY AND DEVELOPMENT STUDIED IN TRANSGENIC MICE
    S Potter; Fiscal Year: 1992
    ..Each aspect of analysis complements the others, providing a more complete understanding of the developmental process...
  17. LEGLESS TRANSGENE INSERTIONAL MUTATION
    S Potter; Fiscal Year: 2000
    ..We also propose to use direct selection to identify additional genes from the deleted region which are expressed in the limb and may be the source of the disruption in this signaling cascade. ..
  18. LEGLESS TRANSGENE INSERTIONAL MUTATION
    S Potter; Fiscal Year: 2001
    ..We also propose to use direct selection to identify additional genes from the deleted region which are expressed in the limb and may be the source of the disruption in this signaling cascade. ..
  19. Development of the Metanephric Mesenchyme
    S Potter; Fiscal Year: 2003
    ..We propose to confirm these targets, to determine if they are direct or indirect, and to identify additional downstream genes responsive to Hoxa 11 or Lim1 expression. ..